Lecithin-cholesterol acryltransferase activity in patients with coronary artery disease examined by coronary angiography.

The clinical investigator Pub Date : 1994-12-01 DOI:10.1007/BF00577734

N Solajić-Bozicević, A Stavljenić-Rukavina, M Sesto

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引用次数: 28

Abstract

This study grew out of observations of certain lecithin:cholesterol acyltransferase (LCAT) abnormalities in patients with atherosclerosis. We studied the interrelationships among LCAT, and total cholesterol, free and esterified cholesterol, cholesterol in individual lipoprotein fractions, triglycerides, phospholipids, free fatty acids, L-lactates in 90 angiographically examined patients with coronary artery disease and 30 control subjects without clinical manifestations of coronary artery disease. Results of the study showed LCAT activity to be significantly decreased (P < 0.05) in patients with single-, double-, or triple-vessel disease than in disease-free subjects. LCAT was also found to follow the stage of coronary artery disease in angiographically examined patients. Decreased LCAT activity was accompanied by lower high-density lipoprotein cholesterol, elevated ratio of unesterified to esterified cholesterol, and increased levels of L-lactates, free fatty acids, and low-density lipoprotein cholesterol. Total cholesterol and triglycerides were within or slightly above the normal limits. The results show LCAT to be a significantly better indicator of the risk of coronary artery disease than either total cholesterol or triglycerides.

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冠状动脉造影检查冠心病患者卵磷脂-胆固醇丙烯转移酶活性

这项研究源于对动脉粥样硬化患者中某些卵磷脂:胆固醇酰基转移酶(LCAT)异常的观察。我们研究了90例经血管造影检查的冠心病患者和30例无冠心病临床表现的对照组的LCAT与总胆固醇、游离胆固醇和酯化胆固醇、单个脂蛋白部分胆固醇、甘油三酯、磷脂、游离脂肪酸、l -乳酸盐之间的相互关系。研究结果显示，LCAT活性在单血管、双血管或三血管疾病患者中显著低于无疾病患者(P < 0.05)。在血管造影检查的患者中，LCAT也被发现与冠状动脉疾病的分期有关。LCAT活性降低伴随着高密度脂蛋白胆固醇降低，未酯化胆固醇与酯化胆固醇之比升高，l -乳酸盐、游离脂肪酸和低密度脂蛋白胆固醇水平升高。总胆固醇和甘油三酯在正常范围内或略高于正常范围。结果显示，LCAT是比总胆固醇或甘油三酯更好的冠状动脉疾病风险指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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