The Bulletin of Tokyo Medical and Dental University最新文献

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Effects of dialyzable leukocyte extracts (DLE) and inosine on stimulated lymphocytes. 可透析白细胞提取物(DLE)和肌苷对受刺激淋巴细胞的影响。
F Komatsu
{"title":"Effects of dialyzable leukocyte extracts (DLE) and inosine on stimulated lymphocytes.","authors":"F Komatsu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of dialyzable leukocyte extracts (DLE) on the lymphocytes were examined. The crude DLE suppressed the blast-formation of the PHA-stimulated lymphocytes and proliferation of the leukemic cell-lines but enhanced that of the fibroblastic cells. A certain fraction of the DLE caused the ATP level of the stimulated lymphocytes to rise, after incubation for 24 hours. The fraction was further purified and the inosine eluted from it. The inosine increased the ATP level and markedly enhanced the lymphocyte blast-formation and proliferation of the fibroblastic cells and leukemic cell-lines. It is suggested that when the DLE show some effects on the lymphocytes, the inosine contained in the DLE may show important effects. The effect of inosine was inhibited by other substances contained in the DLE, especially deoxynucleotides. These substances suppressed the blast-formation of the lymphocytes and the proliferation of the leukemic-cell lines. It remains to determine why the fibroblastic cells were not suppressed by them.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13773487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery. 正常妊娠、分娩、产褥期和剖宫产的血凝纤溶因子水平。
A Tei, S Mutoh, Y Yaoi, M Saito
{"title":"Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery.","authors":"A Tei,&nbsp;S Mutoh,&nbsp;Y Yaoi,&nbsp;M Saito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma levels of fibrinopeptide A (FPA), fibrinopeptide B beta 15-42 (FPB beta 15-42), high molecular weight kininogen (HMW-kg), kinin, prekallikrein and kallikrein inhibitor during pregnancy, labor, cesarean section and puerperium were studied in 170 cases of full term normal delivery and 20 cases of cesarean section delivery with 30 non-pregnant women taken as control. Significant increases of FPA, FPB beta 15-42 and kinin during normal delivery and puerperium were found. There was also a significant increase of FPA in the uterine venous blood during cesarean section. Significant decrease of HMW-kg during normal labor and also significant decrease of prekallikrein and kallikrein inhibitor after cesarean section were also seen. Our findings suggested that the hypercoagulable state during pregnancy is due to the increase of thrombin and plasmin activity, and the kallikrein-kinin system may be related to the onset of labor and post-delivery uterine contraction. Increase of the FPA in the uterine blood promoted localised coagulation activity during cesarean section.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13916117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery. 正常妊娠、分娩、产褥期和剖宫产的血凝纤溶因子水平。
The Bulletin of Tokyo Medical and Dental University Pub Date : 1989-06-01 DOI: 10.11480/BTMD.360202
A. Tei, S. Mutoh, Y. Yaoi, M. Saito
{"title":"Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery.","authors":"A. Tei, S. Mutoh, Y. Yaoi, M. Saito","doi":"10.11480/BTMD.360202","DOIUrl":"https://doi.org/10.11480/BTMD.360202","url":null,"abstract":"Plasma levels of fibrinopeptide A (FPA), fibrinopeptide B beta 15-42 (FPB beta 15-42), high molecular weight kininogen (HMW-kg), kinin, prekallikrein and kallikrein inhibitor during pregnancy, labor, cesarean section and puerperium were studied in 170 cases of full term normal delivery and 20 cases of cesarean section delivery with 30 non-pregnant women taken as control. Significant increases of FPA, FPB beta 15-42 and kinin during normal delivery and puerperium were found. There was also a significant increase of FPA in the uterine venous blood during cesarean section. Significant decrease of HMW-kg during normal labor and also significant decrease of prekallikrein and kallikrein inhibitor after cesarean section were also seen. Our findings suggested that the hypercoagulable state during pregnancy is due to the increase of thrombin and plasmin activity, and the kallikrein-kinin system may be related to the onset of labor and post-delivery uterine contraction. Increase of the FPA in the uterine blood promoted localised coagulation activity during cesarean section.","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89923673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis. 抗双链DNA独特型在混合性结缔组织病和进行性系统性硬化症中的表达。
T Kubota, Y Kanai
{"title":"Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis.","authors":"T Kubota,&nbsp;Y Kanai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13928361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis. 抗双链DNA独特型在混合性结缔组织病和进行性系统性硬化症中的表达。
The Bulletin of Tokyo Medical and Dental University Pub Date : 1989-06-01 DOI: 10.11480/BTMD.360201
T. Kubota, Y. Kanai
{"title":"Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis.","authors":"T. Kubota, Y. Kanai","doi":"10.11480/BTMD.360201","DOIUrl":"https://doi.org/10.11480/BTMD.360201","url":null,"abstract":"The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76283642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of porous and dense hydroxyapatite implantation on periodontal tissue regeneration in monkeys. 多孔致密羟基磷灰石植入对猴牙周组织再生的影响。
C J Lin, I Ishikawa
{"title":"Effect of porous and dense hydroxyapatite implantation on periodontal tissue regeneration in monkeys.","authors":"C J Lin,&nbsp;I Ishikawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two different kinds of hydroxyapatite (HA) granules (size: 400-630 microns), 1) porous HA fabricated by the H2O2 bubbling method and 2) dense HA, were placed into the experimentally created, 3-wall, wide periodontal defects in two monkeys to evaluate whether the different structures of hydroxyapatite influence the periodontal response after implantation. Defects without HA implantation served as controls. The HA implant groups showed excellent biocompatibility. Both the porous HA and the dense HA showed a greater amount of \"connective tissue attachment or adhesion\" than the control group. The amount of the increase by the porous HA group was statistically significant when compared with the control group. However, the three groups showed a similar amount of new cementum formation. These results indicate that the improvement of tissue regeneration by hydroxyapatite implantation was probably due to the prevention of the epithelial downgrowth rather than to the acceleration of the coronal proliferation of the periodontal ligament cells. In the porous HA group, ingrowth of fibrous and osseous tissue in the HA and indefinite tissue-apatite interface were observed. These findings suggest that the porous HA granules formed a firmer attachment to the surrounding periodontal tissue.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13844790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of Hobel's high-risk pregnancy scoring system. Hobel高危妊娠评分系统的临床应用。
A Tei, H Oiyama, S Okawa, M Saito
{"title":"Clinical application of Hobel's high-risk pregnancy scoring system.","authors":"A Tei,&nbsp;H Oiyama,&nbsp;S Okawa,&nbsp;M Saito","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hobel's high-risk pregnancy screening scoring system was applied to 1,000 deliveries prospectively to test the validity of the screening system. Our results showed that the incidence of high-risk neonates increased significantly as the risk scores during the prenatal and intrapartum periods increased. In this series, 57.7% of the patients belonged to the low-low risk group and 9.8% was classified as the high-high risk group. The incidence of high-risk neonates in the low-low risk group was 13.5% whereas it was 32.0% in the high-high risk group. Further, maternal hypocapnia during delivery was found to be closely related to the incidence of neonatal hyperbilirubinemia in this series and proper management of maternal ventilations during delivery could reduce the incidence of neonatal hyperbilirubinemia.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13923123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous histopathologic evaluation of liver in treatment of non-Hodgkin's lymphoma. 非霍奇金淋巴瘤治疗中肝脏经皮组织病理学评价。
S Yoshimatsu
{"title":"Percutaneous histopathologic evaluation of liver in treatment of non-Hodgkin's lymphoma.","authors":"S Yoshimatsu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of 25 percutaneous biopsies of the liver from 24 patients with non-Hodgkin's lymphoma are reported. In all cases, the value of their serum biochemistry (LDH, GOT, GPT and/or alkaline phosphatase) was abnormal and sufficient tissue material was biopsied to obtain a histopathological evaluation. Specimens from five ultrasonically suspected lymphoma of the liver showed tumor involvement histopathologically. Diffuse tumor involvement was also histologically found in three ultrasonically unsuspected livers. Six liver specimens showed degenerative and/or fibrotic change in the new and previously treated patients.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14201107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between subjective pain estimation and somatosensory evoked potentials by electrical tooth stimulation. 牙电刺激下主观疼痛估计与体感诱发电位的关系。
M Umino, H Sano, T Ohwatari, S Oka, Y Kubota
{"title":"Relationship between subjective pain estimation and somatosensory evoked potentials by electrical tooth stimulation.","authors":"M Umino,&nbsp;H Sano,&nbsp;T Ohwatari,&nbsp;S Oka,&nbsp;Y Kubota","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship between the amplitude of somatosensory evoked potentials (SEP) and the subjective pain estimation using a visual analogue scale (VAS) was examined in 8 volunteers undergoing randomized electrical tooth stimulation with 3 different intensities. Randomized stimulation was used instead of repetitive stimulation with a fixed intensity in order to minimize the phenomena of habituation and expectancy in recording the SEP and VAS. The VAS scores increased significantly with the stimulus intensity. The amplitude with a latency between 160 and 300 msec (N160-P300) showed a significant increase with the increased intensity. But the amplitudes between 60 and 110 msec (N60-P110) and between 110 and 160 msec (P110-N160) showed no significant change. There was a significant correlation between the amplitude of N160-P300 and the VAS scores. These findings indicate that the component between 160 and 300 msec reflects the perceived pain intensity and the psychological evaluation processes such as cognition, meaning, interpretation and appreciation of pain. The method of randomized stimulation can serve as a simple and useful way for the objective or subjective pain estimation.</p>","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14362900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of evoked endocardial response for assessment of antiarrhythmic drug effects on myocardium. 应用诱发心内膜反应评价抗心律失常药物对心肌的影响。
The Bulletin of Tokyo Medical and Dental University Pub Date : 1988-09-01 DOI: 10.11480/BTMD.350302
T. Furukawa, K. Taniguchi, J. Takeuchi
{"title":"The use of evoked endocardial response for assessment of antiarrhythmic drug effects on myocardium.","authors":"T. Furukawa, K. Taniguchi, J. Takeuchi","doi":"10.11480/BTMD.350302","DOIUrl":"https://doi.org/10.11480/BTMD.350302","url":null,"abstract":"The technique \"asymmetric biphasic stimulation\" which paces the heart and neutralizes the post-stimulus polarization at the electrode-tissue interface allows for the recording of the entire evoked endocardial response via a single electrode for both pacing and recording. Using this system the effects of antiarrhythmic drugs, procainamide and N-acetylprocainamide, on the myocardium were studied in 20 dogs. Before and during the five-step drug infusion, the evoked endocardial responses were recorded during bipolar and unipolar at the rates of 120, 150 and 200/min. The plasma concentration of the procainamide ranged from 1.7 to 32.5 mg/l and that of N-acetylprocainamide ranged from 8.1 to 116.1 mg/l. Procainamide significantly prolonged both the depolarization duration and the repolarization duration at a low plasma concentration (Class I antiarrhythmic drug property). N-acetylprocainamide significantly prolonged the repolarization duration at a low plasma concentration, while the depolarization duration was not significantly changed at a low or therapeutic plasma concentration (Class III antiarrhythmic drug property). The prolongation of the depolarization duration by procainamide and N-acetylprocainamide was rate-dependent; the faster the rate the greater the prolongation. This simple and accurate assessment of the antiarrhythmic drug effects on the myocardium may provide a future means for the pharmacologic antiarrhythmic therapy.","PeriodicalId":22311,"journal":{"name":"The Bulletin of Tokyo Medical and Dental University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73579688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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