Serum levels of coagulation-fibrinolysis factors in normal pregnancy, labor and puerperium and in cesarean section delivery.

The Bulletin of Tokyo Medical and Dental University Pub Date : 1989-06-01 DOI:10.11480/BTMD.360202

A. Tei, S. Mutoh, Y. Yaoi, M. Saito

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引用次数: 5

Abstract

Plasma levels of fibrinopeptide A (FPA), fibrinopeptide B beta 15-42 (FPB beta 15-42), high molecular weight kininogen (HMW-kg), kinin, prekallikrein and kallikrein inhibitor during pregnancy, labor, cesarean section and puerperium were studied in 170 cases of full term normal delivery and 20 cases of cesarean section delivery with 30 non-pregnant women taken as control. Significant increases of FPA, FPB beta 15-42 and kinin during normal delivery and puerperium were found. There was also a significant increase of FPA in the uterine venous blood during cesarean section. Significant decrease of HMW-kg during normal labor and also significant decrease of prekallikrein and kallikrein inhibitor after cesarean section were also seen. Our findings suggested that the hypercoagulable state during pregnancy is due to the increase of thrombin and plasmin activity, and the kallikrein-kinin system may be related to the onset of labor and post-delivery uterine contraction. Increase of the FPA in the uterine blood promoted localised coagulation activity during cesarean section.

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正常妊娠、分娩、产褥期和剖宫产的血凝纤溶因子水平。

本文研究了170例足月正常分娩和20例剖宫产妇女(30例非妊娠妇女为对照)妊娠、分娩、剖宫产及产褥期血浆纤维蛋白肽A (FPA)、纤维蛋白肽B β 15-42 (FPB β 15-42)、高分子量激肽原(hw -kg)、激肽、激肽预激肽及激肽抑制因子水平。正常分娩和产褥期FPA、FPB β 15-42和激肽均显著升高。剖宫产术中子宫静脉血FPA含量明显升高。正常分娩时HMW-kg显著降低，剖宫产后钾化钙素预激肽和钾化钙素抑制剂显著降低。我们的研究结果提示，妊娠期的高凝状态是由于凝血酶和纤溶酶活性的增加，而钾likrein-kinin系统可能与分娩的开始和分娩后子宫收缩有关。剖宫产术中子宫血FPA升高可促进局部凝血活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Bulletin of Tokyo Medical and Dental University

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