抗双链DNA独特型在混合性结缔组织病和进行性系统性硬化症中的表达。

T Kubota, Y Kanai
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引用次数: 0

摘要

研究了混合结缔组织病(MCTD)和进行性系统性硬化症(PSS)患者抗双链(ds) DNA独特型2C10的发生情况。2c10独特型最初是在狼疮易感性MRL/Mp-lpr/lpr (MRL/l)小鼠的dsdna特异性单克隆抗体上鉴定出来的,并且已经证明它存在于系统性红斑狼疮(SLE)患者和MRL/l小鼠的血清中。本研究显示,3 / 10的MCTD患者和5 / 10的PSS患者血清中2c10独特型的滴度高于正常人。MCTD的抗dsdna活性与独特型水平有良好的相关性(r = 0.85),而PSS的抗dsdna活性与独特型水平无相关性(r = -0.38)。这些结果表明,携带2c10独特型的抗体在MCTD中比在PSS中更容易获得dsdna结合活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of anti-double stranded DNA idiotype in mixed connective tissue disease and progressive systemic sclerosis.

The occurrence of anti-double stranded(ds) DNA idiotype 2C10 was studied in patients with mixed connective tissue disease (MCTD) and progressive systemic sclerosis (PSS). The 2C10-idiotype was originally identified on a dsDNA-specific monoclonal antibody from a lupus-prone MRL/Mp-lpr/lpr (MRL/l) mouse, and it has been demonstrated to be present in the sera of patients with systemic lupus erythematosus (SLE) as well as MRL/l mice. This study showed that three out of ten patients with MCTD and five out of ten with PSS had higher titers of 2C10-idiotype in their sera than the normal subjects. There was a good correlation between the anti-dsDNA activities and the idiotype levels in MCTD (r = 0.85) but not in PSS (r = -0.38). These results suggest that the 2C10-idiotype-bearing antibodies acquire the dsDNA-binding activity more easily in MCTD than in PSS.

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