Spine Surgery and Related Research最新文献

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Awake Early Manual Reduction Is Highly Effective for Subaxial Cervical Spine Dislocation. 颈椎轴下脱位的清醒早期手法复位疗效显著
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-12-27 eCollection Date: 2024-07-27 DOI: 10.22603/ssrr.2023-0229
Takuya Taoka, Tomoyuki Takigawa, Takuya Morita, Genta Fukumoto, Yukihisa Yagata, Keitarou Tada, Takahiko Ishimaru, Takeshi Ishihara, Yasuo Ito
{"title":"Awake Early Manual Reduction Is Highly Effective for Subaxial Cervical Spine Dislocation.","authors":"Takuya Taoka, Tomoyuki Takigawa, Takuya Morita, Genta Fukumoto, Yukihisa Yagata, Keitarou Tada, Takahiko Ishimaru, Takeshi Ishihara, Yasuo Ito","doi":"10.22603/ssrr.2023-0229","DOIUrl":"10.22603/ssrr.2023-0229","url":null,"abstract":"<p><strong>Introduction: </strong>Guidelines published in 2013 recommend early closed reduction for cervical spine dislocation. There are two types of closed reduction: manual reduction and traction. Manual reduction can be performed early. In addition, it can correct rotation and requires a short time for complete reduction. We perform manual reduction for cervical spine dislocation. This study aimed to evaluate early manual reduction's success rate and safety for cervical dislocation. We also examined the relationship between time to reduction and improvement in paralysis.</p><p><strong>Methods: </strong>This retrospective cohort study included 361 patients with cervical spine injuries treated at our hospital between July 2010 and December 2021. We assigned patients to the early group if the time from injury to reduction was ≤6 hours and to the late group if >6 hours. We performed awake manual reduction on the patients. Furthermore, we compared reduction's success rate and safety, including neurological outcomes.</p><p><strong>Results: </strong>Overall, 46 patients were included in the study: 31 and 15 in the early and late groups, respectively. The success rate of reduction was 93%, and no neurological complications from reduction were observed. The neurological outcomes and reduction success rates were significantly superior in the early group than in the late group.</p><p><strong>Conclusions: </strong>Neurological outcomes were significantly superior when reduction was performed within 6 hours than after 6 hours. Manual reduction can be performed early, safely, and easily. It is effective for cervical spine dislocation requiring early reduction for an excellent neurologic prognosis.</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"8 4","pages":"383-390"},"PeriodicalIF":1.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Surgical Outcomes in Patients with Degenerative Cervical Myelopathy Using the 25-Question Geriatric Locomotive Function Scale: A Longitudinal Observational Study. 使用 25 题老年运动功能量表评估颈椎退行性病变患者的手术效果:一项纵向观察研究
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-12-27 eCollection Date: 2024-05-27 DOI: 10.22603/ssrr.2023-0191
Hiroki Takeda, Takehiro Michikawa, Sota Nagai, Soya Kawabata, Kei Ito, Daiki Ikeda, Nobuyuki Fujita, Shinjiro Kaneko
{"title":"Assessment of Surgical Outcomes in Patients with Degenerative Cervical Myelopathy Using the 25-Question Geriatric Locomotive Function Scale: A Longitudinal Observational Study.","authors":"Hiroki Takeda, Takehiro Michikawa, Sota Nagai, Soya Kawabata, Kei Ito, Daiki Ikeda, Nobuyuki Fujita, Shinjiro Kaneko","doi":"10.22603/ssrr.2023-0191","DOIUrl":"10.22603/ssrr.2023-0191","url":null,"abstract":"<p><strong>Introduction: </strong>Locomotive syndrome caused by degenerative musculoskeletal diseases is reported to improve with surgical treatment. However, it is unclear whether surgical treatment is effective for the locomotive syndrome developing in patients with degenerative cervical myelopathy (DCM). Thus, this study primarily aimed to longitudinally assess the change in locomotive syndrome stage before and after cervical spinal surgery for patients with DCM using the 25-question geriatric locomotive function scale (GLFS-25). A secondary objective was to identify factors associated with the postoperative improvement in the locomotive syndrome stage.</p><p><strong>Methods: </strong>We retrospectively reviewed clinical data of patients undergoing cervical spine surgery at our institution from April 2020 to May 2022 who had answered the Japanese Orthopaedic Association Cervical Myelopathy Assessment Questionnaire, visual analog scale, and GLFS-25 preoperatively and at 6 months and 1 year postoperatively. We collected demographic data, medical history, preoperative radiographic parameters, presence or absence of posterior longitudinal ligament ossification, and surgical data.</p><p><strong>Results: </strong>We enrolled 115 patients (78 men and 37 women) in the present study. Preoperatively, using the GLFS-25, 73.9% of patients had stage 3, 10.4% had stage 2, 9.6% had stage 1, 6.1% had no locomotive syndrome. The stage distribution of locomotive syndrome improved significantly at 6-months and 1-year postoperatively. The multivariable Poisson regression analysis revealed that better preoperative lower extremity function (relative risk: 3.0; 95% confidence interval: 1.01-8.8) was significantly associated with postoperative improvement in the locomotive syndrome stage.</p><p><strong>Conclusions: </strong>This is the first study to longitudinally assess the locomotive syndrome stage in patients with DCM using GLFS-25. Our results indicated that patients with DCM experienced significant improvement in the locomotive syndrome stage following cervical spine surgery. Particularly, the preoperative lower extremity function was significant in postoperative improvement in the locomotive syndrome stage.</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"8 3","pages":"287-296"},"PeriodicalIF":1.2,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11165504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to the Editor Regarding the Article: A Modified Spinal Reconstruction Method Reduces Instrumentation Failure in Total En Bloc Spondylectomy for Spinal Tumors. 给编辑的回复修改后的脊柱重建方法可减少脊柱肿瘤全脊椎切除术中的器械失败。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-11-27 DOI: 10.22603/ssrr.2023-0216
Satoshi Kato, Satoru Demura, Kazuya Shinmura, Noriaki Yokogawa, Hideki Murakami
{"title":"Reply to the Editor Regarding the Article: A Modified Spinal Reconstruction Method Reduces Instrumentation Failure in Total En Bloc Spondylectomy for Spinal Tumors.","authors":"Satoshi Kato, Satoru Demura, Kazuya Shinmura, Noriaki Yokogawa, Hideki Murakami","doi":"10.22603/ssrr.2023-0216","DOIUrl":"https://doi.org/10.22603/ssrr.2023-0216","url":null,"abstract":"","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"7 6","pages":"561-562"},"PeriodicalIF":1.2,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor Concerning "A Modified Spinal Reconstruction Method Reduces Instrumentation Failure in Total En Bloc Spondylectomy for Spinal Tumors," by Shinmura et al. 致编辑的信,内容涉及 Shinmura 等人撰写的《一种改良的脊柱重建方法可减少脊柱肿瘤全脊椎切除术中的器械故障》。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-10-13 eCollection Date: 2023-11-27 DOI: 10.22603/ssrr.2023-0107
Shun Umeki, Tadatsugu Morimoto, Hirohito Hirata, Masaaki Mawatari
{"title":"Letter to the Editor Concerning \"A Modified Spinal Reconstruction Method Reduces Instrumentation Failure in Total En Bloc Spondylectomy for Spinal Tumors,\" by Shinmura et al.","authors":"Shun Umeki, Tadatsugu Morimoto, Hirohito Hirata, Masaaki Mawatari","doi":"10.22603/ssrr.2023-0107","DOIUrl":"https://doi.org/10.22603/ssrr.2023-0107","url":null,"abstract":"","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"7 6","pages":"560"},"PeriodicalIF":1.2,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for A Novel Technique for Pars Defect Direct Repair with a Modified Smiley Face Rod for Spondylolysis and Isthmic Spondylolisthesis. 用改良笑脸棒直接修复Pars缺损的新技术勘误表。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-09-27 DOI: 10.22603/ssrr.2023-0021-er
Masaki Tatsumura, Shun Okuwaki, Hisarnori Gamada, Reo Asai, Fumihiko Eto, Katsuya Nagashima, Yosuke Takeuchi, Toru Funayama, Masashi Yamazaki
{"title":"Erratum for A Novel Technique for Pars Defect Direct Repair with a Modified Smiley Face Rod for Spondylolysis and Isthmic Spondylolisthesis.","authors":"Masaki Tatsumura,&nbsp;Shun Okuwaki,&nbsp;Hisarnori Gamada,&nbsp;Reo Asai,&nbsp;Fumihiko Eto,&nbsp;Katsuya Nagashima,&nbsp;Yosuke Takeuchi,&nbsp;Toru Funayama,&nbsp;Masashi Yamazaki","doi":"10.22603/ssrr.2023-0021-er","DOIUrl":"10.22603/ssrr.2023-0021-er","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.22603/ssrr.2023-0021.].</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"7 5","pages":"473"},"PeriodicalIF":1.2,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/6c/2432-261X-7-0473.PMC10569805.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41238697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sagittal Balance in Professional Brazilian Football Players. 巴西职业足球运动员的矢状体平衡。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-09-04 eCollection Date: 2023-11-27 DOI: 10.22603/ssrr.2023-0013
Paulo Daniel Sousa Santa Cruz, Michel Kanas, Marcelo Wajchenberg
{"title":"Sagittal Balance in Professional Brazilian Football Players.","authors":"Paulo Daniel Sousa Santa Cruz, Michel Kanas, Marcelo Wajchenberg","doi":"10.22603/ssrr.2023-0013","DOIUrl":"10.22603/ssrr.2023-0013","url":null,"abstract":"<p><strong>Introduction: </strong>Football soccer practice involves considerable risks of lesions, making it difficult to strike a balance between adequate preparation and the demand imposed on athletes. A high incidence of postural disorders among adolescents leads to questions about the influence of sports activity on the athletes' posture and sagittal balance.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from panoramic spine radiographs of 110 professional Brazilian football (soccer) players. They were male and aged between 20 and 30 years. Measurements of pelvic incidence, pelvic tilt (PT), sacral slope, sagittal vertical axis (SVA), and lumbar lordosis were obtained by using the Surgimap<sup>Ⓡ</sup> software. Measurement values were compared with the Brazilian literature data. Lordosis type was categorized according to the classification of Roussouly et al., and the presence of spondylolysis and spondylolisthesis was analyzed.</p><p><strong>Results: </strong>Findings indicated that (1) among 110 radiographs analyzed, 104 had appropriate measurement quality; (2) values compared with the Brazilian mean demonstrated that PT and SVA were statistically lower in professional players (P=0.013 and P=0.037, respectively); (3) according to Roussouly et al. most participants presented Type 3 lordosis (54.8%), followed by Type 4 (26.9%); (4) eight athletes (7.7%) had spondylolysis, and among them, seven (6.7%) had spondylolisthesis.</p><p><strong>Conclusions: </strong>Significant differences in PT and SVA were found in professional athletes. The most common type of lordosis was the same as that found in the general population (Type 3), and the incidence of spondylolysis and spondylolisthesis was higher than that found in the general population, but lower than that found in football (soccer) players.</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"1 1","pages":"504-511"},"PeriodicalIF":1.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68230015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Objective Assessment of Sleep Disorders in Patients with Lumbar Spinal Stenosis Using Wearable Trackers. 使用可穿戴追踪器客观评估腰椎管狭窄症患者的睡眠障碍
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-09-04 eCollection Date: 2023-11-27 DOI: 10.22603/ssrr.2023-0116
Masahiro Inoue, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki-Narita, Yasuhiro Shiga, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Yawara Eguchi, Tsutomu Akazawa, Yasuchika Aoki, Yuki Shiko, Masahiko Suzuki, Yohei Kawasaki, Seiji Ohtori
{"title":"Objective Assessment of Sleep Disorders in Patients with Lumbar Spinal Stenosis Using Wearable Trackers.","authors":"Masahiro Inoue, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki-Narita, Yasuhiro Shiga, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Yawara Eguchi, Tsutomu Akazawa, Yasuchika Aoki, Yuki Shiko, Masahiko Suzuki, Yohei Kawasaki, Seiji Ohtori","doi":"10.22603/ssrr.2023-0116","DOIUrl":"10.22603/ssrr.2023-0116","url":null,"abstract":"<p><strong>Introduction: </strong>Low-back pain causes sleep disorders, which impairs the quality of life (QOL) of patients. Sleep disorders are associated with lumbar spinal stenosis (LSS); however, the postoperative effects of LSS surgery on sleep disorders are unknown. This study aimed to assess sleep disorders in patients with LSS using wearable activity trackers and determine whether surgery improves sleep quality.</p><p><strong>Methods: </strong>A total of 39 patients scheduled for LSS surgery (mean age 71.1±8.7 years; 22 men and 17 women) were studied. Sleep disorders in the participants were objectively evaluated using a wearable Motionlogger Micro system. Sleep efficiency (SEf), mean active count (MAC), and wake after sleep onset (WASO) were measured before and 6 months following surgery. Furthermore, the patient-based outcomes of pain and QOL-related scores were measured and compared with those of healthy participants. The group with improved SEf following surgery was designated as \"nonpoor sleepers,\" whereas the group that did not exhibit improvements was designated as \"poor sleepers.\" The two groups were compared based on patient factors, patient-based questionnaires, and sleep disorder measurements.</p><p><strong>Results: </strong>The SEf and WASO were significantly worse in patients with LSS compared with healthy participants (<i>P</i><0.05). Furthermore, the SEf in patients with LSS was associated with the Oswestry Disability Index scores. No improvement was observed in the SEf, MAC, and WASO before and after surgery. Evaluation of each case revealed 21 and 12 cases of nonpoor and poor sleepers, respectively. Preoperative low-back pain was significantly associated with improvement in postoperative sleep quality.</p><p><strong>Conclusions: </strong>Sleep disorders in patients with LSS were evaluated, and improvement in sleep disorders following surgery was associated with the intensity of preoperative low-back pain. Sleep disorders are associated with QOL disorders, suggesting that focusing on the treatment of sleep disorders is important in the management of patients with LSS.</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"1 1","pages":"533-539"},"PeriodicalIF":1.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68230439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Neurofibromatosis 1 with Myelopathy Due to Intracanal Rib Head and Kyphoscoliosis in an Adult. 一例神经纤维瘤病 1 伴有肋骨内侧和脊柱后凸的成人脊髓病。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-09-04 eCollection Date: 2024-01-27 DOI: 10.22603/ssrr.2023-0087
Takuji Yamamoto, Yohshiro Nitobe, Kanichiro Wada, Gentaro Kumagai, Toru Asari, Kotaro Aburakawa, Yasuyuki Ishibashi
{"title":"A Case of Neurofibromatosis 1 with Myelopathy Due to Intracanal Rib Head and Kyphoscoliosis in an Adult.","authors":"Takuji Yamamoto, Yohshiro Nitobe, Kanichiro Wada, Gentaro Kumagai, Toru Asari, Kotaro Aburakawa, Yasuyuki Ishibashi","doi":"10.22603/ssrr.2023-0087","DOIUrl":"10.22603/ssrr.2023-0087","url":null,"abstract":"","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"1 1","pages":"106-109"},"PeriodicalIF":1.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68230619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the COVID-19 Pandemic on Outcomes and Perioperative Factors Associated with Posterior Cervical Fusion. COVID-19 大流行对颈椎后路融合术疗效和围手术期相关因素的影响。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-09-04 eCollection Date: 2024-01-27 DOI: 10.22603/ssrr.2023-0094
Austen D Katz, Junho Song, Priya Duvvuri, Alex Ngan, Terence Ng, Sayyida Hasan, Sohrab Virk, Jeff Silber, David Essig
{"title":"Impact of the COVID-19 Pandemic on Outcomes and Perioperative Factors Associated with Posterior Cervical Fusion.","authors":"Austen D Katz, Junho Song, Priya Duvvuri, Alex Ngan, Terence Ng, Sayyida Hasan, Sohrab Virk, Jeff Silber, David Essig","doi":"10.22603/ssrr.2023-0094","DOIUrl":"10.22603/ssrr.2023-0094","url":null,"abstract":"<p><strong>Introduction: </strong>While there is anecdotal evidence that the coronavirus disease 2019 (COVID-19) pandemic altered perioperative decision-making in patients requiring posterior cervical fusion (PCF), a national-level analysis to examine the significance of this hypothesis has not yet been conducted. This study aimed to determine the potential differences in perioperative variables and surgical outcomes of PCF performed before vs. during the COVID-19 pandemic.</p><p><strong>Methods: </strong>Adults who underwent PCF were identified in the 2019 (prepandemic) and 2020 (intrapandemic) NSQIP datasets. Differences in 30-day readmission, reoperation, and morbidity were evaluated using multivariate logistic regression. On the other hand, differences in operative time and relative value units (RVUs) were estimated using quantile regression. Furthermore, the odds ratios (OR) for length of stay (LOS) were estimated using negative binomial regression. Secondary outcomes included rates of nonhome discharge and outpatient surgery.</p><p><strong>Results: </strong>A total of 3,444 patients were included in this study (50.7% from 2020). Readmission, reoperation, morbidity, operative time, and RVUs per minute were similar between cohorts (<i>p</i>>0.05). The LOS (OR 1.086, <i>p</i><0.001) and RVUs-per-case (coefficient +0.360, <i>p</i>=0.037) were significantly greater in 2020 compared to 2019. Operation year 2020 was also associated with lower rates of nonhome discharge (22.3% vs. 25.8%, <i>p</i>=0.017) and higher rates of outpatient surgery (4.8% vs. 3.0%, <i>p</i>=0.006).</p><p><strong>Conclusions: </strong>During the COVID-19 pandemic, a 28% decreased odds of nonhome discharge following PCF and a 72% increased odds of PCF being performed in an outpatient setting were observed. The readmission, reoperation, and morbidity rates remained unchanged during this period. This is notable given that patients in the 2020 group were more frail. This suggests that patients were shifted to outpatient centers possibly to make up for potentially reduced case volume, highlighting the potential to evaluate rehabilitation-discharge criteria. Further research should evaluate these findings in more detail and on a regional basis.</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"1 1","pages":"29-34"},"PeriodicalIF":1.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68230660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regenerative Medicine for Spinal Cord Injury Using Induced Pluripotent Stem Cells. 利用诱导多能干细胞治疗脊髓损伤的再生医学。
IF 1.2
Spine Surgery and Related Research Pub Date : 2023-09-04 eCollection Date: 2024-01-27 DOI: 10.22603/ssrr.2023-0135
Narihito Nagoshi, Keiko Sugai, Hideyuki Okano, Masaya Nakamura
{"title":"Regenerative Medicine for Spinal Cord Injury Using Induced Pluripotent Stem Cells.","authors":"Narihito Nagoshi, Keiko Sugai, Hideyuki Okano, Masaya Nakamura","doi":"10.22603/ssrr.2023-0135","DOIUrl":"10.22603/ssrr.2023-0135","url":null,"abstract":"<p><p>Spinal cord injury (SCI) is a devastating injury that causes permanent neurological dysfunction. To develop a new treatment strategy for SCI, a clinical trial of transplantation of human-induced pluripotent stem cell-derived neural precursor cells (NPCs) in patients in the subacute phase of SCI was recently initiated. The formation of synaptic connections with host neural tissues is one of the therapeutic mechanisms of cell transplantation, and this beneficial efficacy has been directly demonstrated using a chemogenetic tool. This research focuses on the establishment of cell therapy for chronic SCI, which is more challenging owing to cavity and scar formation. Thus, neurogenic NPC transplantation is more effective in forming functional synapses with the host neurons. Furthermore, combinatory rehabilitation therapy is useful to enhance the efficacy of this strategy, and a valid rehabilitative training program has been established for SCI animal models that received NPC transplantation in the chronic phase. Therefore, the use of regenerative medicine for chronic SCI is expected to increase.</p>","PeriodicalId":22253,"journal":{"name":"Spine Surgery and Related Research","volume":"1 1","pages":"22-28"},"PeriodicalIF":1.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68231072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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