Tanaffos最新文献

{"title":"Fatal COVID-19-Associated Pulmonary Aspergillosis Due to <i>Aspergillus niger</i> Complicated By Pneumothorax: A Case Report.","authors":"Cheng Wei Li, Larry Ellee Nyanti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>COVID-19-associated pulmonary aspergillosis (CAPA) carries high mortality. <i>Aspergillus niger</i> is not commonly associated with CAPA. A middle-aged woman presented with cough, fever, and dyspnea for ten days and was subsequently diagnosed with COVID-19. She was mechanically ventilated and given methylprednisolone and broad-spectrum antibiotics. The initial computed tomography pulmonary angiogram (CTPA) was negative for pulmonary embolism, yet the patient's condition continued to worsen. A repeat CT scan of the thorax on day 17 revealed two new cavities. Ensuing tracheal culture was positive for <i>Aspergillus niger</i>, and later complicated with pneumothorax. She was treated with amphotericin B, but her clinical course was complicated by a pneumothorax, for which a chest tube was inserted. Despite all efforts, the patient eventually succumbed. <i>Aspergillus niger</i> infection can have devastating consequences in the setting of severe COVID-19 infection. It raises urgent questions about the need for antifungal prophylaxis. Pneumothorax is a potential complication of CAPA, especially when the cavities are very peripheral.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"308-310"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracoplasty: A Collapse Therapy for Extra-Pulmonary Drug-Resistant Tuberculosis with Persistent Bronchopleural Fistula and Empyema Cavity.","authors":"Klein Dantis, Chandan Kumar Dey, Roopali Phuli, Vinod Kumar Ramavath","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Multi-drug-resistant tuberculosis (MDR-TB) has become a significant health problem worldwide. As per the Global Tuberculosis Report 2021, chemotherapy has only benefitted 59% of individuals. As many patients do not benefit from radical surgery due to their poor pulmonary reserve, bacterial overload, and prognosis, collapse therapy has an essential role in improving the effectiveness of complex anti-tubercular therapy.</p><p><strong>Case presentation: </strong>A 35-year-old male with a low body mass index and persistent air leak on an intercostal tube not responding to medical management underwent thoracoscopic decortication. He was diagnosed with multi-drug-resistant tuberculosis (MDR-TB) according to the pleural specimen. Postoperatively, the lung did not seem to expand due to the extensive disease, and the air leak persisted. Hence, he received a short-term MDR-TB regimen and underwent open window thoracostomy followed by limited thoracoplasty for postoperative persistent infected pleural space.</p><p><strong>Conclusion: </strong>Though pleural MDR-TB is a rare presentation, managing the infected pleural space is challenging as patients tend to have significant morbidity due to various factors.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"304-307"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4-Related Lung Disease in a Patient with Chronic Granulomatous Disease: A Case Report.","authors":"Javad Enayat, Mazdak Fallahi, Mehrnaz Mesdaghi, Saeid Sadr, Maryam Kazemi Aghdam, Maryam Parvizi, Seyyedeh Narjes Ahmadizadeh, Mitra Khalili, Seyed Yasin Tabatabaeimehr, Mohammad Faranoush, Mahnaz Jamee, Zahra Chavoshzadeh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>IgG4-related disease may initially present with pulmonary pseudotumor, making the diagnosis challenging particularly in patients prone to granulomatous inflammation. Here, we describe the first case of chronic granulomatous disease with associated lung IgG4RD.</p><p><strong>Case presentation: </strong>An 8.5-year-old male was hospitalized two years ago with exertional dyspnea, mild cough, chest pain, and nocturnal sweating and was found to have a tumor-like mass in the right lung. The histopathologic findings were consistent with extensive peripheral fibrosis and infiltration of mixed inflammatory cells without any evidence of acid-fast bacilli/fungal elements. Treatment with prednisolone resulted in considerable symptom resolution. Following the discontinuation of prednisolone by the patient, symptoms recurred, gradually exacerbated, and he developed anorexia and weight loss. The next chest spiral computed tomography (CT) scan showed a larger mass in the right lung, right lung collapse, and mediastinal metastasis. The abdominal ultrasound and CT scan were normal. In laboratory evaluation, low counts of B and T cells, normal natural killer cells, high levels of IgG4, and high inflammatory markers were detected. The nitro blue tetrazolium test was zero in two consecutive evaluations. In virtue of high IgG4 level, organ-specific mass, notable tissue fibrosis, and mixed inflammatory cell infiltrate, he was diagnosed with concurrent CGD and IgG4RD, but progressed to respiratory failure and died despite the reinstitution of steroid therapy.</p><p><strong>Conclusion: </strong>The overlap between inborn errors of immunity and IgG4RD is not common. Further studies to investigate IgG subsets among IEI patients can help elucidate clinicopathological correlations between these two immune-mediated disorders.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"311-318"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Laboratory Markers in COVID-19 Patients with Gastrointestinal Impairments as Prognosticators of the Disease Severity.","authors":"Nayebali Ahmadi, Maryam Shahali, Ashkan Alamdary, Alireaza Gholami, Rasul Moukhah, Mohammadjavad Hossein Tehrani, Delaram Doroud, Ariana Alavi, Rajab Mardani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The new coronavirus infectious disease, COVID-19, is constantly killing people around the world. The main clinical symptoms of COVID-19 include fever, cough, shortness of breath, weakness, fatigue, and sputum/discharge. Gastrointestinal (GI) impairments are often associated with respiratory manifestations in COVID-19 patients. The current study aimed to examine potential laboratory markers in COVID-19 patients with gastrointestinal impairments as prognosticators of disease severity.</p><p><strong>Materials and methods: </strong>In the present study, hospitalized COVID-19 patients with respiratory symptoms as the main clinical manifestations and gastrointestinal symptoms were studied to evaluate relevant blood biomarkers including vitamins B12, D, and K in addition to albumin, pre-albumin, calcium, and magnesium.</p><p><strong>Results: </strong>Sixty individuals (29 males and 31 females) participated in the study aged between 29 and 72 years, with a mean of 45.87 years. Our results showed a significant increase in albumin, pre-albumin, transferrin, and vitamin K and a significant decrease in magnesium and vitamin B12. Decreases in calcium and vitamin D were modestly associated with the clinical picture of the patient group.</p><p><strong>Conclusion: </strong>Our findings suggest that monitoring laboratory markers such as transferrin, serum albumin, vitamin K, and magnesium-to-calcium ratio could be valuable prognosticators for COVID-19 infection. They could assist in better patient management and disease control.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 3","pages":"238-245"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting the Medical Coding Errors of COVID-19 Hospital Records: A Cross-Sectional Study in East Iran.","authors":"Ali Garavand, Erfan Esmaeeli, Fatemeh Bahador, Azam Sabahi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, disease coding significantly influenced national and international strategies for prevention, treatment, and control. This study aimed to assess the factors influencing COVID-19 records' coding errors in teaching hospitals in South Khorasan province.</p><p><strong>Materials and methods: </strong>In 2022, researchers conducted a cross-sectional study in South Khorasan Province, Iran. Data was gathered using a self-developed questionnaire distributed among medical coders in all hospitals. Descriptive statistics were employed in the data analysis using SPSS version 19.</p><p><strong>Results: </strong>The study's results showed that non-observance of diagnostic principles by physicians (66 out of 92), a lack of specialized medical coding specialists (52 out of 92), and the use of ambiguous and non-standard abbreviations (51 out of 92) were the most significant factors affecting COVID-19 coding errors. Among the three main factors affecting COVID-19 records' coding errors, factors related to the medical coder (47.66 out of 92), factors related to healthcare providers (29.8 out of 92), and organizational and environmental factors (21.4 out of 92) were the most significant.</p><p><strong>Conclusion: </strong>This study revealed that multiple factors contribute to coding errors in COVID-19 records, with the most critical being physicians' non-adherence to diagnostic principles, the shortage of medical coding specialists, the use of unclear and non-standard abbreviations, and the absence of COVID-19 coding continuing education. Therefore, we recommend conducting workshops on diagnosis and coding for medical coders, particularly emphasizing the precise coding of COVID-19 records.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 2","pages":"189-197"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Errors and Its Relationship with Patient Safety Culture: Evidence from Nurses' Viewpoint During COVID-19 Pandemic.","authors":"Peivand Bastani, Eshagh Barfar, Ali Reza Yusefi, Ehsan Movahed, Neda Dastyar, Sisira Edirippulige","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Medication errors can lead to damage to patients with various disabilities or death. This study aims to identify factors affecting the incidence of medication error and its association with patient safety culture from the nurse's perspective during the COVID-19 pandemic.</p><p><strong>Materials and methods: </strong>This cross-sectional study was conducted among 340 employed in the hospitals affiliated with Shiraz University of Medical Sciences in 2021. Data were collected by applying a questionnaire for medication error and the standard questionnaire of the Hospital Survey on Patient Safety Culture. Descriptive statistics, the independent t-test, ANOVA, and Pearson correlation were applied using SPSS software version 23.</p><p><strong>Results: </strong>The main reasons for medication errors were fatigue due to the workload (3.13±1.16 out of 5), method of supervision in the hospital units (3.06±0.98 out of 5), and massive pile-up of duties (3.00±1.19 out of 5). Other results indicated a significant negative association between factors affecting medication error and patient safety culture (r=-0.574, p=0.002). A significant correlation was observed among factors affecting medication error and patient safety culture with demographic determinants of age and years of working experience (p<0.05). Significant differences were also observed among the two main studied variables, the number of monthly work shifts, and the number of patients (p<0.05).</p><p><strong>Conclusion: </strong>Applying strategies for the reduction of physical fatigue and mental exhaustion along with balancing work shifts and managing the accumulative duties and massive tasks can help decrease the rates of medication errors.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 2","pages":"198-208"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Unnecessary to Assess Tumor Stroma-Infiltrating Lymphocytes in Localized Lung Adenocarcinomas?","authors":"Mona Mlika, Abir Rais, Omar El Mnif, Chokri Haddouchi, Mehdi Abdennadher, Rahma Ayadi, Emna Braham, Olfa Ismail, Adel Marghli, Faouzi Mezni","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>During the last decade, more attention was paid to the tumor cell microenvironment, especially to tumor stroma-infiltrating lymphocytes (TILs). This study aimed to assess the prognostic impact of different TILs subpopulations and PD-L1 positive tumor cells in localized lung adenocarcinomas.</p><p><strong>Materials and methods: </strong>We conducted a retrospective descriptive study, which included localized adenocarcinomas diagnosed in the department of pathology and resected in the Thoracic Surgery Department of the same hospital between 2015 and 2020. TILs were analyzed using the immunohistochemical method for Fox-P3, CD4, CD8, CD20, and CD3. Besides, the PD-L1 antibody was used to assess tumor cell expression. Intra-tumoral and stromal labeled lymphocytes were quantified by manual counting at high magnification (X400). Fox-P3+/CD8+, Fox-P3+/CD4+, FoxP3+/PD-L1+, and CD8+/CD4+ ratios were subsequently calculated. The prognostic value of TILs was assessed with respect to overall survival (OS) and recurrence free survival (ReFS).</p><p><strong>Results: </strong>A total of 44 localized adenocarcinomas were included. In the univariate analysis, the prognostic factors influencing OS included gender, adenocarcinoma subtype, Tumor-Infiltrating Lymphocyte (TIL) score, TIL grade, PD-L1 expression, PD-L1 grade, tumor immunity in the microenvironment, and the expressions of various immune markers: CD3, CD4, CD8, CD20, and FoxP3. The analysis also considered the FoxP3 ratio, FIL score, and different ratios involving immune markers, such as CD8/CD4 ratio, FoxP3/CD8 ratio, FoxP3/CD4 ratio, and FoxP3/PD-L1 ratio. The prognostic factors influencing the ReFS consisted of gender, the adenocarcinoma subtype, TIL score, TIL grade, PD-L1, PD-L1 grade, TIM, CD8 expression, CD20 expression, FIL score, Fox-P3/CD8 ratio, Fox-P3/CD4 ratio, and Fox-P3/PD-L1 ratio. Multivariate analysis revealed no independent predictive factors of OS or ReFS.</p><p><strong>Conclusion: </strong>Despite the limitations of this study, the results highlighted that TILs may not represent an independent prognostic factor in localized adenocarcinomas and don't play a major role in comparison to the tumor stage.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 2","pages":"129-138"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Flow Nasal Cannula versus Conventional Oxygen Therapy for Patients with Acute Respiratory Failure in the Emergency Department: A Randomized Controlled Trial.","authors":"Mohammad Emami Ardestani, Mohammad Nasr-Esfahani, Fatemeh Sadat MirMohammad Sadeghi, Reza Azizkhani, Farhad Heydari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>To compare the efficacy of a high-flow nasal cannula (HFNC) versus conventional oxygen therapy (COT) in the treatment of patients admitted to the emergency department (ED) for acute respiratory failure (ARF).</p><p><strong>Materials and methods: </strong>In this prospective randomized clinical trial, 66 patients aged 18 years or older who presented with ARF to the ED were enrolled and assigned into two equal groups to receive either COT or HFNC for 60 minutes. The primary outcome was the intubation rates. The secondary outcomes were the effect of intervention on oxygenation, ICU admission rate, and effect on physiologic variables.</p><p><strong>Results: </strong>33 patients were treated in each group. The main causes of ARF were chronic obstructive pulmonary disease (COPD), pneumonia, and asthma. The need for intubation was higher in COT than in HFNC (42.5% vs 12.1%, P = 0.004). Patients with HFNC had a higher dyspnea improvement than those treated with COT (93.9% vs 63.7%, P = 0.002). They also showed greater improvement in oxygen saturation (increase in SpO₂ was 8.3% vs. -0.5, difference 8.8% (6.8 to 10.9)), and in respiratory rate (decrease 3.0 beats/min vs 0.2 beats/min, differences 2.8(0.8 to 4.6)). The ICU admission was higher in the COT group (51.5 vs 15.2, P=0.002).</p><p><strong>Conclusion: </strong>HFNC reduced the need for intubation and ICU admission in the patients presenting to the ED with ARF compared with COT. In addition, HFNC was associated with a greater reduction in RR and improvement in SpO₂ compared with COT.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 2","pages":"156-162"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation of Immunoglobulin M and Immunoglobulin G Serum Levels in Seropositive COVID-19 Patients in Mazandaran, Iran: A Six-Month Investigation.","authors":"Seyed Abbas Mousavi, Faezeh Sadat Movahedi, Fatemeh Safari Hajikalai, Jamshid Yazdani Charati, Abolghasem Ajami, Seyed Mohsen Soleimani, Zainab Bandalizadeh, Saeed Kaviani Charati","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Forecasting the longevity of patients' immune stability could be the most effective approach to preventing illnesses. This study investigates immunoglobulin M (IgM) serum longevity, immunoglobulin G (IgG), and corresponding risk factors in the first phase seropositive patients in Mazandaran, Iran.</p><p><strong>Materials and methods: </strong>This descriptive cross-sectional study aimed to assess IgM and IgG serum levels in a cohort of 184 seropositive patients during six months. The data analysis involved various statistical methods including descriptive statistics, the chi-square test, independent and paired t-tests, and single and multivariate logistic regression.</p><p><strong>Results: </strong>A total of 103 (56%) patients lacked the necessary antibodies, whereas 81 (44%) remained seropositive. According to the results of multivariable logistic regression, patients with a travel history, hospital admissions, and end-stage renal disease (ESRD) had 3.24 (P=0.04), 12.63 (P=0.018), and 9.79 (P=0.001) times higher chances of stable seropositivity, respectively. The average IgG and IgM serum levels fell by 4.5 and 3 units, respectively (P<0.001). In addition, serum levels of IgM and IgG increased by 12% and 12.5%, respectively, and dropped by 75.5% in both serums. There was no increase in either serum level for any of the patients.</p><p><strong>Conclusion: </strong>The duration of immune serum stability in patients can significantly reduce disease mortality. The concurrent detection of IgM and IgG antibodies also assists in identifying the infectious stage.</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 2","pages":"183-188"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Non-Invasive Ventilation a Good Choice in All Patients with Severe COVID-19? A Cohort Retrospective Study.","authors":"Ramin Sami, Babak Amra, Forogh Soltaninejad, Zohre Naderi, Marjan Mansourian, Mina Nickpour, Media Babahajiani, Marzieh Hashemi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The recent outbreak of Coronavirus 2019 (COVID-19) is a respiratory disorder caused by the Acute Respiratory Syndrome Coronavirus 2. At the start of the epidemic, early intubation was the optimal strategy for managing ARDS caused by COVID-19. Several non-invasive methods for respiratory support in patients with moderate to severe COVID-19 may reduce intubation, disease severity, ventilator use, and hospitalization in the intensive care unit (ICU). In this study, the characteristics of COVID-19 patients who failed NIV therapy were compared with those who had successful NIV.</p><p><strong>Materials and methods: </strong>The present descriptive-analytical study was conducted at the COVID-19 center of KHORSHID University Hospital. Patients were aged > 18 years with confirmed COVID-19 and hospitalized in the ICU from the beginning of January to the end of March 2021. They had an oxygen level of < 88% despite receiving 15 L of oxygen with reserve masks and were undergoing non-invasive ventilation (NIV) treatment. Data collection included patients' demographic information, vital signs, and test results upon hospital admission, and assessed disease severity using APACHE, SAPS, and SOFA scores. Patients were categorized into responders (R) and non-responders (NR) to determine predictors of non-invasive ventilation (NIV) success, with follow-up based on device tolerance and changes in vital signs.</p><p><strong>Results: </strong>71 Individuals were candidates for NIV. Twenty patients were excluded from the study, and 51 patients were included in the study. Of these, 35 patients underwent NIV treatment failure (NR). On the other hand, 16 (31.4%) patients completely recovered after receiving NIV (R) and they were discharged from the ICU.</p><p><strong>Conclusion: </strong>Serum Albumin and BMI levels of COVID-19 patients undergoing NIV therapy seem to affect their responses to treatment. Hence, it is recommended to evaluate the nutritional status of patients before the start of NIV .</p>","PeriodicalId":22247,"journal":{"name":"Tanaffos","volume":"23 2","pages":"176-182"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}