Terapevticheskii Arkhiv最新文献

{"title":"[Efficacy of rabeprazole for the treatment of gastroesophageal reflux disease in a 7-day non-interventional trial].","authors":"V V Tsukanov, E V Onuchina, A V Vasyutin, B B Dambaeva, J L Tonkikh, N V Pavlova","doi":"10.26442/00403660.2024.08.202895","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202895","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy of seven-day treatment with rabeprazole (Razo^®) 20 mg once daily in patients with NERD and esophagitis based on monitoring the results of pH-impedancemetry of the stomach and esophagus and assessment of clinical symptoms.</p><p><strong>Materials and methods: </strong>Thirty patients with typical GERD manifestations were examined. The study included patients who underwent pH-impedancemetry, endoscopic examination, and were prescribed treatment with rabeprazole at a dose of 20 mg once a day. Clinical monitoring was performed during three visits: before treatment, after 3 days, and after 7 days of treatment. Control pH-impedancemetry was performed after 7 days of therapy. The third visit was the endpoint of the study.</p><p><strong>Results: </strong>After 7 days of treatment, the response rate for heartburn was 86.7% in the overall group of patients with GERD, 94.4% in those with NERD, and 75.0% in patients with esophagitis stage A and B. After 7 days of therapy with rabeprazole, we registered a significant decrease in the total number of refluxes (from 88 to 54; <i>p<</i>0.001), the number of acid refluxes (from 53 to 22; <i>p<</i>0.001), the DeMeester index (from 23.81 to 7.62; <i>p<</i>0.001), and AET (from 7.54 to 2.01; <i>p<</i>0.001) in the esophagus and an increase in the median daily pH (from 1.8 to 5.4; <i>p<</i>0.001) and the time with pH>4 in the stomach (from 2.57 hours and 10.7% up to 12.3 hours and 51.3%; <i>p<</i>0.001). 7-day therapy with rabeprazole was accompanied by a significant improvement in GERD patients in all parameters of quality of life. 100% of patients with GERD rated their satisfaction with therapy as \"good\" and \"very good\".</p><p><strong>Conclusion: </strong>As a result of 7-day therapy of patients with NERD and esophagitis with Razo^® at a dose of 20 mg per day, an excellent clinical response was obtained, confirmed by a marked optimization of pH-impedancemetry parameters.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The relationship between diabetes mellitus and non-alcoholic fatty liver disease: a clinical and instrumental paired study].","authors":"A N Sasunova, A А Goncharov, K M Gapparova, V A Isakov","doi":"10.26442/00403660.2024.08.202810","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202810","url":null,"abstract":"<p><strong>Aim: </strong>To study the impact of type 2 diabetes mellitus (DM2) on the severity of liver steatosis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).</p><p><strong>Materials and methods: </strong>To conduct a paired case-control study 2989 patients were examined at the Federal Research Center of Nutrition, Biotechnology and Food Safety. Pairs were matched by gender and age and distributed into groups: NAFLD + DM2+ (<i>n</i>=313), NAFLD + DM2- (n=313) and a control group of patients without NAFLD and without DM2 (<i>n</i>=313). The severity of liver steatosis was determined by measuring the controlled attenuation parameter. The severity of liver fibrosis was determined by measuring the liver stiffness measurement. Body composition of the patients was determined using bioimpedance measurements. Indicators of lipid and carbohydrate metabolism, and the serum activity of liver enzymes was determined by standard biochemical methods.</p><p><strong>Results: </strong>In NAFLD + DM2+ group compared to NAFLD + DM2- group, and in NAFLDM + DM2-compared to the control group, weight, BMI, waist and hip circumference, waist-to-hip ratio were higher, while in all. In NAFLD + DM2+ and NAFLD + DM2- groups the volume of fat mass directly correlated with the level of blood triglycerides (<i>r</i>=0.21), HbA₁_с (<i>r</i>=0.32) and fasting blood glucose (<i>r</i>=0.35), and inversely correlated with high-density lipoproteins (<i>r</i>=-0.19). In NAFLD + DM2+ group versus NAFLD + DM2- group severe steatosis (S3, 78% versus 59.4%; <i>p<</i>0.001) and severe fibrosis (F4, 8% vs 2.6%; <i>p<</i>0.001) was more common; 70% of patients in the NAFLD + DM2- group had no liver fibrosis according to elastography (F0), while in the NAFLD + DM2+ group only 43.2% of patients had no liver fibrosis (<i>p<</i>0.0001).</p><p><strong>Conclusion: </strong>When NAFLD is accompanied by DM2, there is an increase in total fat mass, the severity of steatosis and liver fibrosis, and an associated deterioration of lipid metabolism. More than half of these patients have various stages of liver fibrosis, which indicates the progressive nature of the disease.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Possibilities of post-processing of multislice computed tomography results in non-invasive diagnosis of pancreatic fibrosis].","authors":"I E Khatkov, K A Lesko, E A Dubtsova, S G Khomeriki, N S Karnaukhov, L V Vinokurova, E I Shurygina, N V Makarenko, R E Izrailov, I V Savina, D A Salimgereeva, M A Kiriukova, D S Bordin","doi":"10.26442/00403660.2024.08.202831","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202831","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the possibilities of post-processing of multidetector computed tomography (CT) results in the non-invasive diagnosis of pancreatic fibrosis (PF).</p><p><strong>Materials and methods: </strong>The study included 165 patients aged 57.91±13.5 years who underwent preoperative CT during surgical treatment for chronic pancreatitis and pancreatic cancer from April 2022 to February 2024. The normalized contrast ratios of pancreatic tissue in the pancreatic (NCPP) and venous (NCVP) phases, as well as the contrast ratio (CR) were measured. Pathomorphological assessment of PF performed in tissues outside neoplasm or desmoplastic reaction by the Kloppel and Maillet scale.</p><p><strong>Results: </strong>The values of post-processing CT results were compared in groups with different degrees of PF. Mean CR values were significantly higher (<i>p=</i>0.001) in patients with severe PF (CR 1.16±0.65 HU) than in patients with mild PF (CR 0.78±0.31 HU). CR value significant increase (<i>p=</i>0.03) was found in patients with signs of inflammatory changes in the pancreas tissue (CR 1.14±0.6 HU) than in those without them (CR 0.81±0.3 HU). There were no significant differences between the values of NCPP and NCVP, and the degree of PF.</p><p><strong>Conclusion: </strong>The CR value increased in patients with severe degree of PF. There was a relationship between CR value increase and the radiological density of pancreatic tissue in non-contrast phase and presence of early signs of pancreatic inflammatory changes. Thus, there was a relationship between CT postprocessing results and morphological signs of PF, which can be used for pancreatic fibrosis non-invasive diagnosis and identification of additional signs of early chronic pancreatitis.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The prevalence of mutations underlying development of Helicobacter pylori resistance to antibiotics in Kazan].","authors":"E A Kupriyanova, S R Abdulkhakov, R К Ismagilova, D D Safina, A R Akhtereeva, R R Galimova, A G Safin, T V Grigoryeva, R А Abdulkhakov","doi":"10.26442/00403660.2024.08.202813","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202813","url":null,"abstract":"<p><strong>Background: </strong>One of the reasons for the decrease of <i>Helicobacter pylori</i> eradication effectiveness is its resistance to antibiotics.</p><p><strong>Aim: </strong>To examine the prevalence of <i>H. pylori</i> point mutations responsible for clarithromycin and levofloxacin resistance among the patients with upper gastrointestinal (GI) tract disorders in Kazan.</p><p><strong>Materials and methods: </strong>The study included 203 patients with symptoms of dyspepsia who underwent upper GI endoscopy at the University Hospital of Kazan Federal University (Kazan, Russia) in 2019-2021. DNA isolation from gastric antrum mucosal biopsies was performed using PureLink Genomic DNA Mini Kits (Thermo Fisher Scientific, USA). Polymerase chain reaction was performed using primers specific for the V-region of the <i>23S</i> gene and the A subunit DNA gyrase encoding <i>gyrA</i> gene region. The sequencing of obtained DNA fragments was performed on 3730 DNA Analyzer. The sequences were searched for point mutations responsible for <i>H. pylori</i> resistance to clarithromycin (A2143G, A2142G and A2142C193 mutations) and levofloxacin (mutations of the <i>gyrA</i> gene).</p><p><strong>Results: </strong><i>H. pylori</i> was detected in 47.78% of biopsy specimens using polymerase chain reaction. The proportion of <i>H. pylori</i> strains with mutations leading to clarithromycin resistance was 17.53%. Amino acid substitutions in the <i>gyrA </i>gene were found in 12.37% of samples. In case of two <i>H. pylori</i> strains (2.06%), dual resistance to clarithromycin and levofloxacin was found.</p><p><strong>Conclusion: </strong>So high incidence of mutations underlying the development of <i>H. pylori</i> resistance to clarithromycin and levofloxacin was observed among examined patients in Kazan.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[On the institutionalization of Russian pulmonology: the second and third stages of its history].","authors":"V I Borodulin, E N Banzelyuk, A V Topolyanskiy","doi":"10.26442/00403660.2024.08.202808","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202808","url":null,"abstract":"<p><p>For the first time, the authors conducted a historical analysis of primary sources and identified 3 stages in the history of Russian pulmonology, naming 8 of its founders. The content is disclosed in two articles (the first one was published in No. 3 of our journal for 2024). This article tells about the second (pulmonology as an independent scientific and educational discipline within the clinic of internal diseases) and the third (as a new medical specialty) stages of the history of Russian pulmonology in the XX century.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ferritin as a biomarker of aging: geroprotective peptides of standardized human placental hydrolysate. A review].","authors":"O A Gromova, I I Torshin, A G Chuchalin","doi":"10.26442/00403660.2024.08.202811","DOIUrl":"10.26442/00403660.2024.08.202811","url":null,"abstract":"<p><p>Ferritin, an iron transport protein, is an acute phase protein of inflammation and oxidative stress (OS), a biomarker of cytolysis and ferroptosis. Inflammation, OS and iron overload are characteristic processes of the pathophysiology of aging. Human placental hydrolysates (HPHs) are promising hepatoprotective agents for anti-aging therapy. The goal of the team of authors was to systematize data on ferritin as a marker of aging and to identify peptides that counteract the aging pathophysiology, including through the regulation of iron and ferritin metabolism, in the HPH Laennec (manufactured by Japan Bioproducts). The results of basic and clinical studies confirm the above relationships and indicate that blood ferritin levels characterize the chronological and biological aging of the human body.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence of gastroesophageal reflux disease in Russia: a meta-analysis of population-based studies].","authors":"D N Andreev, I V Maev, D S Bordin, S R Abdulkhakov, R I Shaburov, P S Sokolov","doi":"10.26442/00403660.2024.08.202807","DOIUrl":"10.26442/00403660.2024.08.202807","url":null,"abstract":"<p><strong>Aim: </strong>To systematize data on the prevalence of gastroesophageal reflux disease (GERD) in the adult population of Russia.</p><p><strong>Materials and methods: </strong>The search for studies was conducted in the electronic databases MEDLINE/PubMed, EMBASE, and RSCI (Russian Science Citation Index) from January 2000 to December 2022. The review included relevant publications in peer-reviewed periodicals in English or Russian, publications with data from cross-sectional epidemiological studies assessing the prevalence of GERD in the Russian population, studies on adult patients with GERD, and publications with detailed descriptive statistics that allow using the data in the meta-analysis.</p><p><strong>Results: </strong>The final analysis included 6 studies involving 34,192 subjects. The overall prevalence of GERD (prevalence of heartburn ± regurgitation once a week or more frequently) in the analyzed studies was 25.605% (95% confidence interval [CI] 17.913-34.147). The analysis used a random effect model, as there was significant heterogeneity between the results in both groups (I2=99.63%; <i>p<</i>0.0001). The overall mean age of GERD patients in the study population was 48.14 (95% CI 32.25-4.03) years. The prevalence of GERD in the male population was 23.653% (95% CI 13.351-35.832) and 25.457% (95% CI 17.094-34.849) in females.</p><p><strong>Conclusion: </strong>This meta-analysis demonstrated that GERD is a common esophageal disease in the Russian population, affecting approximately one in four country residents.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The influence of comorbidities on treatment outcomes in patients with tuberculosis].","authors":"D A Ivanova, E M Belilovskiy, E M Bogorodskaya, M N Reshetnikov, D V Plotkin, V B Avdentova","doi":"10.26442/00403660.2024.08.202812","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202812","url":null,"abstract":"<p><strong>Aim: </strong>To study the association of comorbidities and treatment outcomes in tuberculosis (TB) patients.</p><p><strong>Materials and methods: </strong>A retrospective study includes all TB patients aged 18 years and older registered for treatment in Moscow in period 2021 the end of the 3rd quarter of 2022 using data of regional epidemiological TB monitoring system, a total of 3039 patients. The frequency and spectrum of comorbidities, its impact on the risk of adverse treatment outcome (ATO) and mortality using univariate and regression analysis were assessed.</p><p><strong>Results: </strong>Comorbidities were identified in 1528 (50.3%) patients (95% confidence interval - CI 48.5-52.1); HIV infection (18.0%), chronic nonspecific lung disease (9.6%) and cardiovascular disease (8.2%) were predominant. The presence of comorbid pathology increased the odds of uneffective treatment (odds ratio - OR 2.56, 95% CI 2.22-3.03) and death (OR 2.45, 95% СI 1.67-3.59). Independent risk factors for ATO were HIV infection (OR 4.10, 95% CI 3.36-5.10), substance use (OR 2.57, 95% CI 1.70-3.66), chronic nonspecific lung disease (OR 1.39, 95% CI 1.04-1.88), diabetes mellitus (OR 1.69, 95% CI 1.15-2.48), liver pathology (OR 2.10, 95% CI 1.46-3.03), mental illness (OR 2.01, 95% CI 1.32-3.06). The death rate was 13.4%; the most significant predictors of mortality were HIV infection (OR 3.89, 95% CI 2.42-6.22) and liver disease (OR 1.90, 95% CI 1.27-2.82). A comorbidome model was constructed to assess the importance of different comorbidities for patient prognosis.</p><p><strong>Conclusion: </strong>The presence of comorbidity (predominantly HIV infection and liver disease) is a significant risk factor for ATO and mortality in TB patients, which should be taken into account when organizing and providing TB care to comorbid patients.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Hyaluronic acid in the treatment of osteoarthritis: innovations in injection therapy. A review].","authors":"I V Menshikova","doi":"10.26442/00403660.2024.08.202916","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202916","url":null,"abstract":"<p><p>The review briefly presents modern understanding heterogeneity of osteoarthritis (OA) which is based on pathophysiological features of its variants. The concept of the phenotypes and endotypes of OA reflects these differences. In clinical recommendations description the emphasis on the place of hyaluronic acid is made. The mechanisms of action of sodium hyaluronate with different molecular mass are studied in detail. The results of foreign and Russian studies on efficacy and safety of different forms of hyaluronic acid are given. Personalized treatment of patients with different phenotypes of OA is shown by an example of a line of Flexotron series.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence of colorectal cancer in patients with diverticular disease of the colon].","authors":"A А Svistunov, M A Osadchuk, E D Mironova, I S Krylova","doi":"10.26442/00403660.2024.08.202818","DOIUrl":"https://doi.org/10.26442/00403660.2024.08.202818","url":null,"abstract":"<p><strong>Aim: </strong>To define the role of clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence and course of colorectal cancer (CRC) in patients with diverticular disease of the colon (DDC).</p><p><strong>Materials and methods: </strong>One hundred and seventy five people with DDC were examined, divided into 3 groups: group 1 - 85 patients with DDC; group 2 - 45 with DDC in combination with adenomatous polyps (AP); 3rd group - 45 with DDC with established CRC (I or II stage). The control group consisted of 30 practically healthy people. Patients and healthy people were examined according to a single program: clinical, laboratory, instrumental data and immunomorphological research methods [use of primary antibodies to p53 (mAb clone DO-7 product no. PA0057, Leica Biosystems, Leica Bond III) and Ki-67 (Ab16667, Abcam, UK)].</p><p><strong>Results: </strong>Among the main complaints in patients with DDC and CRC, constipation was more common than in patients with DDC and DDC with AP (<i>p<</i>0.05). In patients with DDC and colorectal neoplasia, a positive reaction to occult blood in the feces was more often verified, compared with the group with DDC (<i>p<</i>0.05). Higher levels of glucose and cholesterol in blood plasma, as well as body mass index were found in patients with DDC with AP and CRC, compared with the DDC group (<i>p<</i>0.05). A higher level of expression of Ki-67 and p53 was found in patients with DDC combined with AP and CRC, compared with patients with DDC without colorectal neoplasia (<i>p<</i>0.05). At the same time, in patients with DDC with CRC, the expression level of Ki-67 and p53 was higher than in patients with DDC with AP (<i>p<</i>0.05) Conclusion. In patients with DDC combined with AP and CRC, higher levels of glucose, plasma cholesterol, as well as body mass index were observed compared to the group of patients with DDC alone (<i>p<</i>0.05). Of note, the results of the determination of Ki-67 and p53 in the mucous membrane of the colon should be considered important prognostic markers for the development of CRC in patients with DDC.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}