Terapevticheskii Arkhiv最新文献

{"title":"[Aldosterone: mechanisms of normal and impaired regulation and the possibility of their correction in arterial hypertension. Consensus of Russian Medical Society on Arterial Hypertension (RSH) experts].","authors":"N M Chikhladze, N V Blinova, O I Trushina, V I Podzolkov, A E Bragina, I E Chazova","doi":"10.26442/00403660.2026.07.203747","DOIUrl":"10.26442/00403660.2026.07.203747","url":null,"abstract":"<p><p>In recent years, studies have been carried out that have expanded the understanding of the role of pathophysiological mechanisms underlying impaired regulation of aldosterone and activation of mineralocorticoid receptors in arterial hypertension. The aim of this consensus is to consider the association between aldosterone dysregulation and the development of cardiovascular complications, as well as to assess the effectivity and safety of novel nonsteroidal mineralocorticoid receptor antagonists, to expand the understanding of their potential in ensuring the prevention of target organ damage and cardiovascular complications in the treatment of patients with hypertension, to analyze the potential of a new class of drugs - aldosterone synthase inhibitors - in ensuring the suppression of genomic and non-genomic effects of aldosterone and their adverse effects in patients with hypertension, to assess the efficacy of drug therapy including nonsteroidal mineralocorticoid receptor antagonists and aldosterone synthase inhibitors in the category of patients at high cardiovascular risk - in hypertension due to primary hyperaldosteronism.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 7","pages":"391-412"},"PeriodicalIF":0.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Therapeutic drug monitoring in the treatment of patients with drug-resistant tuberculosis].","authors":"D A Ivanova, E I Yurovskaya, K Y Galkina, M N Reshetnikov, D V Plotkin, N V Litvinova","doi":"10.26442/00403660.2026.07.203678","DOIUrl":"https://doi.org/10.26442/00403660.2026.07.203678","url":null,"abstract":"<p><strong>Aim: </strong>Testing of therapeutic drug monitoring in the treatment of drug-resistant tuberculosis.</p><p><strong>Materials and methods: </strong>We conducted a pilot prospective study including 15 patients with drug-resistant tuberculosis. Serum concentrations of bedaquiline, linezolid, fluoroquinolone, cycloserine, delamanid (C_2h) were determined by high-performance liquid chromatography and mass spectrometry. The influence of clinical and pharmacogenetic factors were evaluated.</p><p><strong>Results: </strong>In most patients, C_2h of the drugs were subtherapeutic (57.1% for bedaquiline, 73.3% for linezolid). C_2h of bedaquiline were higher in patients with homozygous rs776746 in the <i>CYP3A5</i> gene (<i>p</i>=0.04), in case of simultaneous omeprazole (<i>p</i>=0.015), high drug load (<i>p</i>=0.005); linezolid - in patients with rs776746 in the <i>CYP3A5</i> gene (<i>p</i>=0.038) and rs34351236 in the P-glycoprotein gene (<i>p</i>=0.014). The course of chemotherapy was effective in 14 of 15 patients. A factor for cavity closure was a C_2h/critical concentration ratio above 1.0 for fluoroquinolone (odds ratio 3.5, 95% confidence interval 1.08-11.24).</p><p><strong>Conclusion: </strong>Therapeutic drug monitoring is a perspective tool for personalized approach to improve treatment outcomes in high-risk drug-resistant tuberculosis patients.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 7","pages":"413-418"},"PeriodicalIF":0.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics of patients undergoing major orthopaedic surgery in a real-world clinical practice: a physician's perspective].","authors":"E A Okisheva, O I Trushina, A V Lychagin, V V Fomin","doi":"10.26442/00403660.2026.07.203673","DOIUrl":"https://doi.org/10.26442/00403660.2026.07.203673","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the prevalence of risk factors in patients undergoing large joint arthroplasty in real-world practice.</p><p><strong>Materials and methods: </strong>Medical history, information about concomitant diseases and previously prescribed drug therapy was recorded in all participants. In addition, essential laboratory and instrumental examination was performed.</p><p><strong>Results: </strong>The study population included 617 (35.6%) males and 1116 (64.4%) females. The mean age was 64.7±10.4 years, and in 90.5% of patients the mean body mass index exceeded 25 kg/m². The majority (77.6%) of patients had hypertension and other cardiovascular diseases. Glycemic disorders had 371 (21.4%) patients, with glycemic control being inadequate in 14 (3,8%) of these patients. Chronic kidney disease stages II-V was found in 1,330 (76.7%) patients and all of them also had obesity and hypertension. At study entry, 262 (15.1%) patients were taking different anticoagulants, and 534 (30.9%) patients were taking antiplatelet agents.</p><p><strong>Conclusion: </strong>The primary patient population undergoing large-joint arthroplasty of the lower extremities consists of elderly individuals with a high burden of comorbidities (obesity, hypertension, chronic kidney disease, and diabetes), which increases the risk of perioperative complications. The published literature contains limited information regarding the necessary scope of preoperative assessment in these patient subpopulations with various concomitant diseases, as well as potential adjustments to postoperative management strategies. It may be necessary to conduct large-scale prospective studies specifically focusing on various patient cohorts, accompanied by pharmacoeconomic analyses, to determine the necessity and scope of expanded diagnostic workups in this population at high risk for perioperative complications.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 7","pages":"419-424"},"PeriodicalIF":0.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The evolution of the treadmill test in cardiology: from clinical observation to a global standard of functional diagnostics].","authors":"O I Trushina, E A Okisheva","doi":"10.26442/00403660.2026.07.203674","DOIUrl":"10.26442/00403660.2026.07.203674","url":null,"abstract":"<p><p>The article describes the history of the development and implementation of stress tests in cardiology for the diagnosis of coronary heart disease, with a particular attention to the creation, implementation and development of the treadmill test.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 7","pages":"425-428"},"PeriodicalIF":0.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The Nobel Peace Prize and the role of the medical movement in addressing global challenges: the review].","authors":"O I Trushina","doi":"10.26442/00403660.2026.07.203762","DOIUrl":"10.26442/00403660.2026.07.203762","url":null,"abstract":"<p><p>The article is devoted to an overview of the current stage of development of the movement of doctors, which received the Nobel Peace Prize in 1985 and was founded by Evgeny Ivanovich Chazov and Bernard Lown. In the year of the fortieth anniversary of the Chernobyl disaster, it is extremely important for the entire medical community to remember the stages of the organization's development, as well as to understand the current state of medical and scientific diplomacy, the development of which is the key to the continued existence of mankind and the protection of the health of the population as a whole.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 7","pages":"388-390"},"PeriodicalIF":0.3,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The problem of osteoarthritis in patients with atopy].","authors":"T V Beketova, E L Nasonov","doi":"10.26442/00403660.2026.05.203676","DOIUrl":"10.26442/00403660.2026.05.203676","url":null,"abstract":"<p><p>The problem of osteoarthritis (OA) in patients with atopy (bronchial asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis) discussed. In patients with atopy, the risk of OA is significantly higher (36-58%) than in the general population. Possible mechanisms of OA in atopy are considered. Further research may help decipher the pathogenesis of OA and improve pharmacotherapy.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 5","pages":"270-274"},"PeriodicalIF":0.3,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[History of the Moscow Scientific Society of Cardiology].","authors":"A S Panferov, E A Okisheva, O I Trushina","doi":"10.26442/00403660.2026.05.203612","DOIUrl":"10.26442/00403660.2026.05.203612","url":null,"abstract":"<p><p>The article describes the history of the formation and development of scientific medical societies in Russia, with particular attention to the development of the Moscow Scientific Society of Cardiology.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 5","pages":"330-332"},"PeriodicalIF":0.3,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Combined comorbid pathology in axial spondyloarthritis].","authors":"Y L Korsakova, T V Korotaeva, T V Dubinina, E E Gubar, E Y Loginova, L D Vorobyeva, P O Tremaskina, E M Agafonova, K V Sakharova, T S Panevin, S I Glukhova, M V Podryadnova","doi":"10.26442/00403660.2026.05.203605","DOIUrl":"10.26442/00403660.2026.05.203605","url":null,"abstract":"<p><strong>Aim: </strong>To analyze the frequency of combined comorbid pathology and its effect on clinical and instrumental characteristics in axial spondyloarthritis (SpA), including axial psoriatic arthritis.</p><p><strong>Materials and methods: </strong>222 patients were included in the study: 108 with axial SpA, 114 with axial psoriatic arthritis. The average age was 40.9±12.4 years, and the duration of inflammatory back pain was 68±53.3 months. A standard rheumatological examination, X-ray of the cervical and lumbar spine, and pelvis were performed. The activity of spondylitis was determined by BASDAI and ASDAS-CRP. The patients were divided into 3 groups: 1st - without comorbid diseases (CD) - 66 (29.7%) patients, 2nd - with 1-2 CD - 78 (35.1%), 3rd - with ≥3 CD - 78 (35.1%).</p><p><strong>Results: </strong>The patients in 3rd group were older than in the other groups (in 1st group - 39±12.1 years, in 2nd - 39±11.2, in 3rd - 44.5±13.1; <i>p</i>_1-3=0.039, <i>p</i>_2-3=0.028), they had a higher level of Pain (in the 1st - 54.3±19.7 mm VAS, in the 2nd - 51.1±22.7, in the 3rd - 63.3±19.4; <i>p</i>=0.01 for all comparisons), the ASDAS-CRP value was higher than in the 1st group (in the 1st - 2.2±1.1, in the 2nd - 2.6±1.1, 3rd - 2.7±0.9; <i>p</i>_1-3=0.01), syndesmophytes were more common in the cervical and/or lumbar spine, ankylosis of the faceted joints in the cervical spine (<i>p</i>< 0.05). The results of the cluster analysis allowed us to group the features into 4 main clusters. The first cluster, in which the ASDAS-CRP and BASDAI indices were grouped, is combined, on the one hand, with a cluster with the presence of psoriasis, comorbidity (≥3), and structural changes in the spine, on the other hand, with other CD and extra-skeletal manifestations of SpA.</p><p><strong>Conclusion: </strong>The presence of a combination of CD was associated with higher activity of spondylitis, more common structural injuries of the spine. The choice of therapy, taking into account СD and extra-skeletal manifestations of SpA, should improve patient treatment outcomes.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 5","pages":"282-289"},"PeriodicalIF":0.3,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Antiphospholipid syndrome: ophthalmologic manifestations. A review].","authors":"F R Sayfullina, A A Novozhilova, G V Cherepnev","doi":"10.26442/00403660.2026.05.203611","DOIUrl":"10.26442/00403660.2026.05.203611","url":null,"abstract":"<p><p>Antiphospholipid syndrome presents with a variety of symptoms, including eye damage. Vision pathologies associated with this syndrome affect both the anterior and posterior segments of the eye, causing a variety of changes. Diagnosis of ophthalmologic abnormalities associated with antiphospholipid syndrome requires a comprehensive examination, including fundus fluorescein angiography, duplex scanning of the ocular and orbital vessels, optical coherence tomography with angiography, computed perimetry, and electroretinography.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 5","pages":"325-329"},"PeriodicalIF":0.3,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of diabetes mellitus with high activity and radiographic progression of psoriatic arthritis].","authors":"A A Neupokoeva, T V Korotaeva, T S Panevin, S I Glukhova, Y L Korsakova, E L Nasonov","doi":"10.26442/00403660.2026.05.203606","DOIUrl":"10.26442/00403660.2026.05.203606","url":null,"abstract":"<p><strong>Background: </strong>Psoriatic arthritis (PsA) exhibits the greatest predisposition to the development of metabolic disorders compared to other inflammatory joint diseases, including those with a high risk of type 2 diabetes mellitus (T2DM).</p><p><strong>Aim: </strong>To study the clinical and imaging characteristics of patients with PsA depending on the presence of DM.</p><p><strong>Materials and methods: </strong>This retrospective study included 309 patients (219 men and 90 women) with PsA. Patients were divided into subgroups based on the presence or absence of T2DM. A comparative analysis of quantitative and qualitative indicators, as well as a correction analysis, was conducted.</p><p><strong>Results: </strong>The proportion of patients with diabetes in the study sample was 13.9%. Patients with concomitant T2DM were characterized by a less frequent presence of advanced stages of sacroiliitis, but more often had a higher BASDAI index (Bath Ankylosing Spondylitis Disease Activity Index) (6.4±1.9 vs 5.4±1.5; <i>p</i>< 0.001), as well as a greater number of painful joints (13.0 [7.3; 20.0] vs 7.0 [3.0; 15.0]; <i>p</i>=0.01) and erythrocyte sedimentation rate level (25.0 [16.0; 40.0] vs 16.0 [6.0; 34.0]; <i>p</i>=0.02), more often had nail psoriasis, and were characterized by more advanced stages of functional impairment. Patients with T2DM were more likely to be currently receiving methotrexate, sulfasalazine, leflunomide, and nonsteroidal anti-inflammatory drugs, and were also more likely to have a history of intra-articular glucocorticoid administration with a comparable history of anti-cytokine therapy. Furthermore, patients with T2DM were more likely to be obese (25.0% vs 8.24%; <i>p</i>< 0.001) and have cardiovascular disease (72.09% vs 27.82%; <i>p</i>< 0.001).</p><p><strong>Conclusion: </strong>The presence of diabetes was associated with higher PsA activity and radiographic progression.</p>","PeriodicalId":22209,"journal":{"name":"Terapevticheskii Arkhiv","volume":"98 5","pages":"290-298"},"PeriodicalIF":0.3,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}