[A study of clinical blood test parameters as potential predictors of atrial fibrillation].

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Terapevticheskii Arkhiv Pub Date : 2026-02-15 DOI:10.26442/00403660.2026.01.203498

A G Plisyuk, P P Poletskov, E A Zhdanova, I A Orlova

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引用次数: 0

Abstract

Aim: To evaluate the relationship of inflammatory parameters and calculated inflammatory indices obtained from clinical blood test with the presence of atrial fibrillation (AF) in patients.

Materials and methods: A retrospective analysis of the data of 5,041 patients aged 18 to 99 years was conducted. A group of 470 patients without AF, comparable in age, gender, and presence of cardiovascular diseases to a group of 470 patients with AF, was selected using propensity score matching. The groups were compared by key parameters of clinical blood test and calculated inflammatory indices. For the parameters that showed significant differences when comparing groups, optimal thresholds were determined using ROC analysis. To assess the predictive ability of inflammatory parameters, a logistic regression analysis with the calculation of the odds ratio of the presence of AF was applied.

Results: When comparing the groups, the following parameters showed significant differences: the number of neutrophils, monocytes, immature granulocytes, and most inflammatory indices were significantly higher, while the number of lymphocytes and the LMR index were significantly lower in the AF group. The most significant predictors were SIRI values of more than 1.3 and LMR values of more than 4.84 (the odds of AF according to multivariate logistic analysis increased by 2.13 times and decreased by 2.27 times, respectively).

Conclusion: Biomarkers of chronic systemic inflammation were associated with the presence of AF regardless of gender, age, and concomitant diseases. Thus, markers of systemic inflammation detected in routine blood tests have the potential to be used as predictors of the presence of AF.

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[临床血液检查参数作为房颤潜在预测因素的研究]。

目的：探讨临床血检炎症参数及计算炎症指数与心房颤动（AF）的关系。材料与方法：回顾性分析5041例18 ~ 99岁患者的资料。采用倾向评分匹配法选择470名无房颤患者，这些患者在年龄、性别和心血管疾病方面与470名房颤患者相当。比较两组临床血检关键参数及计算炎症指标。对于组间差异显著的参数，采用ROC分析确定最佳阈值。为了评估炎症参数的预测能力，采用逻辑回归分析并计算AF存在的优势比。结果：组间比较，中性粒细胞、单核细胞、未成熟粒细胞数量及多数炎症指标均显著升高，AF组淋巴细胞数量及LMR指数均显著降低。最显著的预测因子是SIRI值大于1.3和LMR值大于4.84（多因素logistic分析显示AF的几率分别增加2.13倍和减少2.27倍）。结论：慢性全身性炎症的生物标志物与房颤的存在相关，与性别、年龄和伴发疾病无关。因此，在常规血液检查中检测到的全身性炎症标志物有可能被用作房颤存在的预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.