Surgical technology international最新文献

{"title":"Modern Plasma Medicine and Orthopaedic Surgery: A Brief History and Outlook.","authors":"Moritz J Sharabianlou Korth, Robert Manasherob, Sankalp Mrutyunjaya, Abiram Bala, Pier F Indelli, Nicholas J Giori, Derek F Amanatullah","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Modern plasma medicine is a field of medical research combining plasma physics, life sciences, and clinical medicine. It aims to achieve direct application of physical plasma on or in the human body for therapeutic purposes. In medical contexts, the term plasma denotes the liquid component of blood, while in the physical sciences, it refers to ionized gas-also known as the fourth state of matter alongside solid, liquid, and gas. The biological effects of plasma are based on various mechanisms, involving synergistic actions of reactive species such as ionized argon gas molecules and ultraviolet light. Cold-atmospheric plasma (CAP), a specific subtype of plasma, maintain temperatures below 104°F/40°C at the application point, allowing plasma treatment on living tissue at tissue tolerable temperatures. The invention of CAP generating devices has expanded the possibilities for clinical application of plasma in medicine, with growing evidence supporting its efficacy in bacterial load reduction and potential biofilm eradication through debridement. Its antimicrobial effect, coupled with minimal adverse effects on healthy cells, positions it as a promising alternative or additional therapy option. This review provides an overview of current clinical applications of plasma medicine and explores potential roles for plasma application in orthopaedic surgery.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the ArthroSim™ Shoulder Simulation Discriminate Between the Novice and Expert User? An External Validation Study of the ArthroSim™ Shoulder Arthroscopy Simulator.","authors":"Zafar Ahmad, Faisal Mehmood, Samuelson E Osifo, Ali Noorani, Kash Akhtar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Our aim is to investigate the face validity and the construct validity of the ArthroSim™ virtual reality shoulder arthroscopy simulator (Touch of Life Technologies, Inc., Aurora, Colorado).</p><p><strong>Materials and methods: </strong>Fifteen doctors participated, with five from each of the following levels: novice with no arthroscopies performed, intermediate with less than 50 arthroscopies performed, and expert with over 100 arthroscopies performed. They first undertook a simulation task on the ArthroSim™ simulator, with the simulation and their body movements recorded. Each participant then completed a Likert scale questionnaire after their simulation task evaluating the face validity of the machine. The video recordings were rated by two shoulder surgeons independently using the Global Rating Scale for Shoulder Arthroplasty (GRSSA), Arthroscopic Surgical Skill Evaluation Tool (ASSET), and Imperial Global Arthroscopy Rating Scale (IGARS) scoring systems for construct validation.</p><p><strong>Results: </strong>All three scales demonstrated high internal consistency GRSSA (0.976 ), ASSET (0.980), and IGARS (0.979). The intraclass correlation coefficient demonstrated high agreement between the assessors: GRSSA (0.88), ASSET (0.90), and IGARS (0.89). Construct validity was evaluated using Kruskal-Wallis one-way analysis of variance: GRSSA (chi square test: 19.828; p<0.001); ASSET (chi square test: 19.62; p<0.001); and IGARS (chi square test: 19.63; p<0.001). This demonstrates that the three scoring systems distinguish significantly between participants with different levels of experience utilizing a virtual reality simulator.</p><p><strong>Conclusion: </strong>Our study has shown that the ArthoSim™ simulator can accurately distinguish between experience level of the participants. It is more effective in reproducing a training environment as reality for less experienced surgeons. All participants agreed that it is valuable in developing surgical training for the novice and intermediate skill level.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Cases of Pylorus-Preserving Pancreatoduodenectomy with Remnant Stomach Preservation in Patients Who Have Undergone Proximal Gastrectomy.","authors":"Motoyasu Tabuchi, Shinya Sakamoto, Teppei Tokumaru, Rika Yoshimatsu, Manabu Matsumoto, Jun Iwata, Takehiro Okabayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreaticoduodenectomy after proximal gastrectomy (PG) presents technical challenges owing to the need to preserve blood flow in the remnant stomach. Considering the oncological factors and preservation of the remnant stomach blood supply, it is crucial to preserve or reconstruct the right gastric artery (RGA) and/or right gastroepiploic artery (RGEA). In cases where the RGEA is preserved, technical considerations for reconstruction arise owing to the poor motility of the remnant stomach.</p><p><strong>Case presentation: </strong>A 79-year-old man was diagnosed with pancreatic head cancer and underwent pylorus-preserving pancreatoduodenectomy (PPPD) three years after PG for gastric cancer. The second patient, a 64-year-old man with a history of PG for esophagogastric junction cancer two years prior, was diagnosed with distal cholangiocarcinoma and underwent PPPD. In both cases, preserving the RGEA while ensuring adequate oncological resection margins was considered feasible. We were able to safely preserve the RGA, RGEA, and remnant stomach. The jejunum was mobilized from the right mesocolon, and all anastomoses (pancreatojejunostomy, choledochojejunostomy, and duodenojejunostomy [D-J]) were performed on the proximal side of the transverse mesocolon to minimize the tension on the D-J anastomosis.</p><p><strong>Conclusion: </strong>Pancreatoduodenectomy after PG requires careful consideration of curability and surgical invasiveness. It is crucial to devise reconstruction techniques that minimize tension on the D-J anastomosis.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic-Arm Assisted THA: Improved Acetabular Component Accuracy and Patient-Reported Outcome Measures.","authors":"Benjamin F Giertych, Adam E Klein, Matthew J Dietz, Brock A Lindsey, Benjamin M Frye","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Acetabular component placement is critical for total hip arthroplasty (THA) stability and clinical outcomes. We investigated cup placement with robotic-arm assisted (RA) and conventional manual (CM) THA and compared patient-reported outcome measures (PROMs) and dislocations.</p><p><strong>Materials and methods: </strong>Thirty-seven patients were randomized to undergo RA or CM primary THA. Computed tomography scans were completed preoperatively and at three months. Component version and inclination were analyzed with target anteversion of 20° and inclination of 40°. PROMs were collected to assess early clinical outcomes.</p><p><strong>Results: </strong>Seventeen RA and 20 CM THAs were performed. Overall, 1/17 RA and 8/20 CM components fell outside the Lewinnek safe zone. No RA components fell outside the safe zone for inclination and one did for version. Three CM components were outside the inclination safe zone and six were outside for version. There were no dislocations in either group. Improvements in all Hip Disability and Osteoarthritis Outcome Score (HOOS) subtype scores reached substantial clinical benefit thresholds in both groups. One-year HOOS symptom and sports score improvements were significantly higher in the RA group. PROMIS-10 mental health improvement was significantly higher in the CM group at six months, but not at one year.</p><p><strong>Conclusions: </strong>Robotic-arm assistance may result in more consistent placement within the Lewinnek safe zone. There were improvements in PROMs in both groups, but there were different effects on individual PROMS between groups. Further study is necessary to determine the clinical significance of these improvements.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Sensor-Based Rehabilitation (SR) on Chronic Knee Pain (CKP) Outcomes-A Systematic Review and Meta-Analysis (SRMA).","authors":"Leeu Jun Jie, Tao Xinyu, Angeline Ai Ling, Hamid Rahmatullah","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to evaluate the effect of sensor-based rehabilitation (SR) on chronic knee pain (CKP) outcomes.</p><p><strong>Materials and methods: </strong>PubMed, Embase, CINAHL, SCOPUS, Cochrane Library, grey literature, and bibliographic references were searched from inception to April 2023. Only randomized controlled trials (RCTs) and cohort studies evaluating the outcomes of SR on CKP were included. Inclusion and exclusion criteria were based on type of study, research subjects, intervention, outcome, language, and availability of data. Out of 937 studies screened, a total of 10 studies with 4347 patients met selection criteria. Comparison of outcomes following intervention was conducted across studies. Meta-analysis of KOOS subscales was also conducted. Literature retrieval and data extraction were conducted by three independent reviewers. Two reviewers performed quantitative data extraction independently before compilation and cross-referencing on Covidence with a third researcher assisting in the cross-referencing process independently to minimise judgment errors.</p><p><strong>Results: </strong>The sensors utilized included wearable sensors, plantar-controlled sensors, embedded sensors, and optical sensors. There was a high degree of variability in the conduct of the intervention programs and timepoint of assessment. There was an improvement in the KOOS aggregate scores from baseline to post intervention with better improvements seen in studies incorporating avatar-based biofeedback. However, meta-analysis of the KOOS subscales did not show clinically significant differences between control and intervention groups.</p><p><strong>Conclusion: </strong>There is insufficient evidence to support the routine use of SR in patients with CKP. However, there is some evidence to suggest that incorporation of SR with avatar-based biofeedback in a multi-faceted treatment approach may yield better outcomes than the use of sensors as merely activity trackers.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Total Knee Arthroplasty Implant Balance with a Passive Knee Drop Test.","authors":"Kevin Abbruzzese, Michael Dunbar, Jared Weir, Stefano Bini, Sean B Sequeira, Michael A Mont, Sally LiArno","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Soft-tissue balancing is a critical component of total knee arthroplasty (TKA), though most current modalities to evaluate this intraoperatively are subjective and based upon empiric observation. A modified pendulum knee drop (PKD) technique has been developed to quantitatively evaluate knee joint soft-tissue stiffness. By measuring the amplitude and decay rate of oscillations when the leg is passively swung from extension to flexion, the modified PKD test offers a novel approach to evaluating knee stiffness in a reproducible manner. The purpose of this study was to explore the ability of the modified PKD test to quantify changes in stiffness induced by insert thickness in a cadaveric TKA model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;There were eleven (N=11) fresh frozen cadaver specimens that underwent a robotic-assisted total knee arthroplasty (RATKA) procedure. Nine of the 11 specimens underwent an RATKA with a cruciate-retaining (CR) femoral implant, and the remaining two specimens underwent an RATKA with a posterior-stabilized (PS) implant. The modified PKD test was performed on each RATKA specimen, where a planned insert was targeted to achieve an anatomically balanced knee and then increased by 2mm increments to simulate stiffer knee joints (in two cases, an additional 2mm insert was utilized for a total 4mm increment). An inertial measurement unit (IMU) sensor was placed on the tibia to record the range of motion (ROM). The thigh of the specimen was abducted over the side of the surgical table and positioned parallel to the floor to allow the shank to oscillate freely. The knee was then flexed to 45 degrees, calibrated in this reference position, and released, allowing the joint to oscillate until coming to rest. The procedure was repeated three times for each of the insert thicknesses. The IMU sensor was used to measure knee ROM, and the log-decrement ratio was calculated for each condition to estimate knee stiffness and was averaged over the three trials. The data was normally distributed, and paired sample t-tests were used to assess significance within specimens. Stiffness ratios were calculated as the log-decrement values of the thickest tibial inserts divided by the log-decrement value of the thinnest tibial inserts and were used to estimate the magnitude of stiffness increases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The modified PKD was able to detect the increased stiffness caused by increasing insert thickness in all specimens. This increase in stiffness was not impacted by implant design or implant size. The modified PKD test was able to reproducibly demonstrate an increase in stiffness when the same specimen was trialed with 2 to 4mm thicker polyethylene inserts. The modified PKD demonstrated reproducible results with respect to log decrement estimations, with an average standard deviation of 0.02 for all trials.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This study investigated the ability of a modifi","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on the Utilization of Percutaneous Deep Vein Arterialization in End-Stage Peripheral Arterial Disease.","authors":"Akila Pai, Krystina N Choinski, Prashanth Palvannan, Ajit G Rao, Rami O Tadros","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Progressive peripheral artery disease, especially in the tibial and pedal vessels, can severely limit the interventions that vascular surgeons and interventionalists can provide to patients. End-stage peripheral arterial disease is often described as a disease where there are no distal targets available in the foot. Traditionally, amputation has been the only option for these patients. However with advancements in surgical and endovascular technology, surgical and now peripheral deep vein arterialization (pDVA) can be utilized. In pDVA, an arteriovenous channel is created between a tibial artery and vein and reinforced with covered stent grafts in order to increase distal limb perfusion and improve amputation-free survival. Many techniques have been described, but currently the only formal device marketed and under investigation for pDVA is the LimFlow System (LimFlow SA, Paris, France). Our institution has performed pDVA for multiple vascular patients with no other available surgical interventions. We describe the technique, postoperative care, and outcomes for these patients. Additionally, we will explore updated outcomes and applicability of the LimFlow System in the current vascular practice today.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of Lymph Node Metastasis to the Pancreatic Head Region in Patients with Ampulla of Vater Carcinoma.","authors":"Motoyasu Tabuchi, Shinya Sakamoto, Teppei Tokumaru, Jun Iwata, Manabu Matsumoto, Rika Yoshimatsu, Tatsuo Iiyama, Yasuhiro Shimada, Takehiro Okabayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Owing to their rarity, clinicopathologic variables and postoperative outcomes in patients with ampulla of Vater carcinoma (AVC) have not been fully elucidated.</p><p><strong>Materials and methods: </strong>A retrospective review of the clinical records of patients who underwent surgical exploration for AVC was performed using univariate and multivariate analyses.</p><p><strong>Results: </strong>One-, three-, and five-year overall survival rates after surgery were 97.4%, 71.8%, and 63.0%, respectively. The most frequently observed sites of recurrence were lymph nodes in 11 patients (52%), followed by the liver in eight (38%), lung in six (29%), local in three (14%), and peritoneal dissemination in three (14%). On multivariate analysis, only the presence of lymph node metastasis extending to the pancreatic head region predicted inferior relapse-free survival. A significant correlation between postoperative recurrence and pathological lymph node metastasis was observed.</p><p><strong>Conclusions: </strong>Lymph node metastasis, especially that extends to the pancreatic head region, was clearly identified as a prognostic indicator of reduced relapse-free survival in patients with AVC.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic Partial Meniscectomy Using a Needle Arthroscope for Visualization Resulted in Greater Retention of Postoperative Quadriceps Muscle Strength Compared to Traditional Arthroscope.","authors":"Elizabeth Ford, Manuel Pontes, Dylan Chayes, Sean McMillan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study is to prospectively evaluate differences in post-arthroscopic partial meniscectomy patients based upon the use of a small-bore needle arthroscope or traditional arthroscope for intraoperative visualization.</p><p><strong>Materials and methods: </strong>Sixty-eight patients were randomized in a 1:1 fashion to have the visualization for arthroscopic partial meniscectomy performed with either a needle arthroscope or traditional arthroscope. Prior to surgery and one-week post procedure, patients underwent peak torque isometric knee extension testing using a handheld dynamometer and Visual Analog Scale (VAS) score collection. The intraoperative arthroscopic fluid volume used was collected. Exclusion criterion included: age under 18, non-English speaking, Kellen-Lawrence Grade 3 or higher, previous ipsilateral knee surgery within six months, and any patient in which arthroscopic partial meniscectomy (APM) was not considered the primary surgical procedure. Tourniquet was not utilized for either study group.</p><p><strong>Results: </strong>Two group comparisons were performed between patients in the needle arthroscope (NA) group (n=34) and patients in the traditional arthroscope (TA) group (n=34). For the operated knee, patients in the NA group had greater postop leg strength (lbs) (24.7 vs. 18.5, t=3.76, p<0.001) and a smaller decrease in leg strength after surgery (-2.8 vs. -8.7, t=9.96, p<0.001). In contrast, results also showed that the leg strength of the non-operated leg was higher postop in both the NA group (0.6, p<0.001) and TA (0.8, p<0.001) arthroscopy group. Significantly less arthroscopic fluid was required for completion of the procedure in the NA group (479 ml) compared to patients in the TA group (2,568ml t=-38.51, p<0.001). Mean VAS score was significantly lower in the NA group (2.5) versus the TA (M=3.1, t=-3.25, p=0.002). The reduction in VAS pain scores was lower in the NA group (M=-1.8) versus the TA group (M=-1.1, t=-3.45, p=0.001).</p><p><strong>Conclusion: </strong>The use of a small-bore needle arthroscope for visualization during arthroscopic partial meniscectomy is associated with improved retention of quadriceps function and less postoperative pain in the early postoperative period compared to a traditional arthroscope.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single-Arm, Prospective Study of a Proprietary Synthetic Acellular Self-Assembling Peptide Wound Matrix, AC5® Advanced Wound System, for Treatment of Hard-to-Heal Wounds.","authors":"Terry Treadwell, Johnnie Alston, Lyudmila Nikolaychook","doi":"10.52198/25.STI.45.WH1828","DOIUrl":"10.52198/25.STI.45.WH1828","url":null,"abstract":"<p><strong>Introduction: </strong>When wounds do not respond to standard treatments, advanced therapies are recommended. One such therapy, a proprietary synthetic peptide, self-assembles into a wound matrix when applied to a wound to provide a physical-mechanical barrier that mitigates contamination, modulates inflammation, and becomes a scaffold for cell proliferation and growth. This study evaluated the safety and performance of the AC5 ® Advanced Wound System (Arch Therapeutics Inc. Framingham, Massachusetts) in the management of long-duration, non-healing, and challenging acute and chronic wounds that failed prior therapy.</p><p><strong>Materials and methods: </strong>Fifteen participants were assigned to receive treatment with AC5 ® weekly or every other week. AC5 ® was evaluated for ease of use, and participants were evaluated for wound condition, healing progress, and local and systemic adverse reactions.</p><p><strong>Results: </strong>64% of participants treated weekly had a >50% reduction in wound area at four weeks and 73% had a >60% reduction at eight weeks. For patients treated every other week, 25% achieved 50% wound area reduction at four weeks and 50% had a >50% reduction at eight weeks. The product was easy to apply contiguously to uneven wound geometry. There were no adverse events.</p><p><strong>Conclusion: </strong>The synthetic self-assembling peptide wound matrix was shown to be safe, effective, and simple to use in the treatment of hard-to-heal wounds. Because AC5® is easy to apply, has an unusual ability to self-assemble into a wound matrix in vivo, and affixes itself contiguously to the interstices of the tissue, AC5 ® may be particularly useful for undermined and tunneled wounds, whether acute or chronic. The results of this study imply that a once-weekly application may result in the best outcome. Further studies are suggested to confirm optimal application frequency for different wound types.</p>","PeriodicalId":22194,"journal":{"name":"Surgical technology international","volume":"45 ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}