Modern Plasma Medicine and Orthopaedic Surgery: A Brief History and Outlook.

IF 0.8 Q4 SURGERY
Surgical technology international Pub Date : 2024-12-09
Moritz J Sharabianlou Korth, Robert Manasherob, Sankalp Mrutyunjaya, Abiram Bala, Pier F Indelli, Nicholas J Giori, Derek F Amanatullah
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Abstract

Modern plasma medicine is a field of medical research combining plasma physics, life sciences, and clinical medicine. It aims to achieve direct application of physical plasma on or in the human body for therapeutic purposes. In medical contexts, the term plasma denotes the liquid component of blood, while in the physical sciences, it refers to ionized gas-also known as the fourth state of matter alongside solid, liquid, and gas. The biological effects of plasma are based on various mechanisms, involving synergistic actions of reactive species such as ionized argon gas molecules and ultraviolet light. Cold-atmospheric plasma (CAP), a specific subtype of plasma, maintain temperatures below 104°F/40°C at the application point, allowing plasma treatment on living tissue at tissue tolerable temperatures. The invention of CAP generating devices has expanded the possibilities for clinical application of plasma in medicine, with growing evidence supporting its efficacy in bacterial load reduction and potential biofilm eradication through debridement. Its antimicrobial effect, coupled with minimal adverse effects on healthy cells, positions it as a promising alternative or additional therapy option. This review provides an overview of current clinical applications of plasma medicine and explores potential roles for plasma application in orthopaedic surgery.

现代血浆医学与整形外科:简史与展望。
现代血浆医学是等离子体物理学、生命科学和临床医学相结合的医学研究领域。它旨在实现物理血浆在人体上或体内的直接应用,以达到治疗目的。在医学语境中,血浆指的是血液中的液体成分,而在物理科学中,它指的是电离气体——也被称为固体、液体和气体之外的第四种物质状态。等离子体的生物学效应基于多种机制,包括电离氩气分子和紫外光等反应物质的协同作用。冷大气等离子体(CAP)是等离子体的一种特殊亚型,在应用点保持温度低于104°F/40°C,允许等离子体在组织可耐受的温度下对活组织进行治疗。CAP产生装置的发明扩大了血浆在医学中的临床应用的可能性,越来越多的证据支持其在减少细菌负荷和通过清创消除生物膜方面的功效。它的抗菌作用,加上对健康细胞的不良影响最小,使其成为一种有希望的替代或额外的治疗选择。本文综述了血浆医学的临床应用现状,并探讨了血浆在骨科手术中的潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.00
自引率
0.00%
发文量
141
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