Sexual health最新文献

{"title":"The role of sequential sexual acts on Neisseria gonorrhoea transmissions between anatomical sites in men who have sex with men: a mathematical modelling study.","authors":"Mengjie Wang, Hao Lai, Christopher K Fairley, Nyi Nyi Soe, Phyu Mon Latt, Mingwang Shen, Shu Su, Rui Zhao, Leilei Zhang, Yi Zhou, Pingyu Zhou, Zengbin Li, Lei Zhang","doi":"10.1071/SH25128","DOIUrl":"10.1071/SH25128","url":null,"abstract":"<p><strong>Background: </strong>To investigate which sequential sexual acts involving different anatomical sites had the most affect on the transmission of gonorrhoea in men who have sex with men (MSM).</p><p><strong>Methods: </strong>A mathematical model was constructed to simulate gonorrhoea transmission between the sequential sexual acts involving the oropharynx, urethra and anorectum. We simulated 1,000,000 sexual episodes using data of the sexual behaviours of a recent cohort of MSM, and identified which acts contributed most to transmission events. The potential impact of condom use on gonorrhoea transmissions was also evaluated.</p><p><strong>Results: </strong>We used data on 2286 sex episodes that involved 294 different sexual patterns from 312 MSM followed for 12 weeks. Of the 1,000,000 model-simulated sexual episodes, 83.50% of 2468 transmissions occurred in sexual episodes that involved the oropharynx, with kissing accounting for the majority (68.85%). The three most frequent individual sexual behavioural patterns were 'kissing only', 'kissing-receptive oral sex-insertive anal sex' and 'kissing-insertive oral sex-receptive anal sex'. These contributed to 341, 209 and 166 transmissions, respectively. The increasing coverage of condoms (80%) could potentially reduce gonorrhoea transmissions by 8.49% to 2259 cases/million sex episodes.</p><p><strong>Conclusions: </strong>Oropharynx-related sexual acts contribute to most gonorrhoea transmission. Condom use has a limited impact on gonorrhoea transmission.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing sexual function in women with HPV-related precancerous genital lesions against other benign gynaecological pathologies: a cross-sectional study.","authors":"Esther Patricia Escamilla Galindo, Janed Lourdes Santana Mateo, Jesús María González Martín, Norberto Fidel Medina Ramos, Alicia Inmaculada Martín Martínez","doi":"10.1071/SH25080","DOIUrl":"10.1071/SH25080","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is the leading cause of sexually transmitted infections worldwide. However, its impact on sexual health is not well understood. The aim of this study was to evaluate the impact of an HPV infection diagnosis on women's sexual function and to compare it with that of other benign gynaecological diagnoses.</p><p><strong>Methods: </strong>Cross-sectional study conducted between 2020 and 2021, at the Hospital Universitario Materno-Infantil of Gran Canaria, with 245 women in two groups: 126 women with pre-malignant HPV lesions recruited at the Hospital's Lower-Genital-Tract Unit (HPV-group), and 119 women with benign gynaecological conditions or seeking family-planning advice, recruited at the gynaecology outpatient clinics (Gyne-group). Women completed sexual function self-administered questionnaires.</p><p><strong>Results: </strong>The mean age was 34 ± 5.5 years. A total of 24.5% of women reported sexual dissatisfaction; 57.1% (33) of them belonged to the HPV-group and 42.9% (27) to the Gyne-group (P = 0.69). In the HPV-group, 54% reported using condoms more often after receiving counselling. A total of 32.6% (41) attributed their HPV infection to their partner's infidelity. The two groups demonstrated a decrease in the sexual response cycle domains, statistically significant only in the domain of desire (58% (49) vs 41.2% (73), P < 0.001). A higher proportion of women in the HPV-group reported experiencing anxiety during sexual activity when compared with women in the Gyne-group (38.1% (48) vs 24.3% (29), P < 0.001).</p><p><strong>Conclusion: </strong>The impact of a gynaecological disease diagnosis on women's sexual function is mainly characterised by anxiety before intercourse and decrease desire, which are more pronounced in case of HPV diagnosis. It is essential to provide women with sexual health information to minimise the impact on women's sexual function and reduce anxiety.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV self-testing secondary distribution among index with different HIV status in China: a pooled analysis of three trials.","authors":"Siyue Hu, Yi Zhou, Fengshi Jing, Xinyuan Zhang, Wei Ai, Hang Lyu, Xi He, Jie Fan, Dan Wu, Weiming Tang","doi":"10.1071/SH25127","DOIUrl":"10.1071/SH25127","url":null,"abstract":"<p><strong>Background: </strong>Secondary distribution of HIV self-testing (HIVST) may improve HIV testing coverage and facilitate the diagnosis of people living with HIV, but whether this effect is similar among index men who have sex with men (MSM) with different HIV status is still not clear.</p><p><strong>Methods: </strong>This study is a pooled analysis of three trials (ChiCTR1900025433, ChiCTR2000039632 and ChiCTR2200064517) conducted by our study team. These three trials aimed to evaluate the effectiveness of monetary incentives in promoting the secondary distribution of HIVST in China. MSM who participated in the three trials were grouped into four groups based on their HIV and intervention status. The control group followed a standard HIVST distribution process in which participants (defined as 'index') distributed the HIVST kits to members of their social network (defined as 'alter'), whereas the intervention group received monetary incentives for promoting altered testing.</p><p><strong>Results: </strong>Between June 2018 and December 2023, 891 unique MSM from 68 cities in China were recruited as index participants, with 55, 54, 390 and 392 categorized into the positive control, positive intervention, negative control and negative intervention groups, respectively. A total of 1035 alters tested for HIV, including 962 motivated by 782 HIV-negative index participants and 73 motivated by 109 index participants living with HIV. The negative intervention group motivated significantly more unique alters to test than the negative control group (IRR 2.46, 95% CI: 1.85, 3.28). With intervention, index living with HIV was less likely to motivate alters for HIV testing (IRR 0.36, 95% CI: 0.23, 0.57). An interaction was not detected between intervention and HIV status. The proportion of newly tested testers among alters was 52%, 48%, 38% and 40% in the positive control, positive intervention, negative control and negative intervention groups, respectively. A total of 41 alters were diagnosed with HIV (5 motivated by index participants living with HIV).</p><p><strong>Conclusions: </strong>The effect of monetary incentive was lower among MSM living with HIV, even though they tend to identify alters with HIV-reactive results. Integrating incentive-based HIVST secondary distribution into routine HIV prevention and care services is recommended.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of sexually transmitted infections among pregnant women in southern Ethiopia: evidence from routine laboratory diagnosis.","authors":"Meskerem Jisso Ebido, Zeleke Mekonnen, Carl Lachat, Bruno Levecke, Taye Gari, Elizaveta Padalko","doi":"10.1071/SH25171","DOIUrl":"10.1071/SH25171","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs) remain a major public health concern among pregnant women in low-resource settings, such as Ethiopia. Today, their true prevalence is underestimated due to syndromic management, which misses asymptomatic infections. Indeed, limited resources restrict a test-and-treat approach, and routine antenatal care screening is usually confined to HIV and syphilis. This study assessed the prevalence of common STIs using routinely available diagnostics to demonstrate their potential integration into routine antenatal care services.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from July to December 2024 among 743 pregnant women at ≤16 weeks gestation. Vaginal swabs were examined for Trichomonas vaginalis using wet mount and Gram-negative diplococci suggestive of Neisseria gonorrhoeae using Gram stain. HIV and syphilis screening were performed using SD BIOLINE Duo kit. Participants' data were collected with REDCap, and complex-sample logistic regression analyzed factors associated with STIs.</p><p><strong>Results: </strong>Of 743 women, 91 (12.2%; 95% CI: 10.1-14.8) had at least one STI, of which 62.6% (57/91) were asymptomatic. Risk factors associated with STIs included being merchants (AOR 1.80; 95% CI: 1.05-3.11), no media usage (AOR 0.60; 95% CI: 0.39-0.91), low wealth index (AOR 1.51; 95% CI: 1.08-2.10) and the presence of clue cells (AOR 3.47; 95% CI: 1.29-9.35).</p><p><strong>Conclusion: </strong>STIs remain prevalent and frequently asymptomatic, highlighting the inadequacy of syndromic management in antenatal care. Social, economic and biological factors predict infection, emphasizing the need for routine laboratory-based screening and targeted interventions. Future research should use molecular diagnostics to capture comprehensive STIs prevalence.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'They'll think you're infected': perceived barriers and facilitators of HIV/STI awareness and testing among young Rohingya refugee women in Bangladesh.","authors":"Muhammad Anwar Hossain, Shailendra Sawleshwarkar, Iryna Zablotska-Manos","doi":"10.1071/SH25143","DOIUrl":"10.1071/SH25143","url":null,"abstract":"<p><strong>Background: </strong>Young Rohingya refugee women in Cox's Bazar, Bangladesh have limited knowledge of the human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs), and low testing rates. This study explores socio-cultural and structural barriers and facilitators, including the cross-cutting issue of information challenges, affecting their HIV/STI literacy and testing. We present perspectives of young women, men, community leaders and healthcare providers.</p><p><strong>Methods: </strong>We used purposive sampling to select young Rohingya women, men, community leaders and healthcare providers, and conducted a total of 40 in-depth interviews and five focus group discussions. The data were thematically analysed using a socio-ecological framework.</p><p><strong>Results: </strong>Knowledge about HIV/STIs was limited, and misconceptions were common. Access to information and testing was restricted by social and gender norms, as well as structural challenges, such as strict health policies for refugees, the limited of youth-friendly services and fragmented referral systems. Participants also noted the lack of male-friendly HIV/STI services, which matters for women, because untreated male partners increase the risk of reinfection and undermine the effectiveness of women-focused interventions. Mistrust in the healthcare system and poor communication also contributed to lower testing rates. However, participants identified several community-based facilitators that helped raise awareness and increase testing, including home-based HIV/STI education delivered by female health workers, peer testimonies and support, messages from religious leaders, and dedicated youth-friendly spaces.</p><p><strong>Conclusions: </strong>These findings underscore the value of culturally-tailored, community-led approaches that address gender norms and systemic barriers. Female-led education, peer support, and positive faith-based messaging offer promising avenues to improve HIV/STI awareness and testing among young Rohingya refugee women.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between sexual orientation-related stigma and sleep quality in gay men: a moderated mediation model.","authors":"Bukuan Sun, Jiaxiao Jiang, Guanghui Nie, Binfeng Zhang, Lu Wang, Peixuan Tan, Gaomei Luo, Xiuxia Li","doi":"10.1071/SH24249","DOIUrl":"10.1071/SH24249","url":null,"abstract":"<p><strong>Background: </strong>This study aims to explore the relationship between sexual orientation-related stigma and sleep quality in gay men, the mediating roles of depression and perceived social support in this relationship, and the moderating mediation effects of living alone and being only children.</p><p><strong>Methods: </strong>Between April and August 2022, 528 gay men were recruited. All participants completed the Sexual Orientation-related Stigma Scale, the Chinese version of the Patient Health Questionnaire, the Multidimensional Survey of Perceived Social Support and the Pittsburgh Sleep Quality Index. Structural equation models were constructed for mediation and moderated mediation analysis.</p><p><strong>Results: </strong>Sexual orientation-related stigma significantly impacts the sleep quality of gay men, with depression and social support playing a chain-mediated role in this relationship. Being an only child moderates the relationship between sexual orientation-related stigma and social support, whereas living alone moderates the relationship between sexual orientation-related stigma and depression.</p><p><strong>Conclusions: </strong>The results emphasize the importance of sexual orientation-related stigma in the mental health and sleep quality of gay men. Reducing stigma, increasing social support, and considering individual differences related to family structure and living arrangements are all crucial for enhancing the mental health and sleep quality of gay men. Future research should delve deeper into these complex relationships to develop more effective interventions; thus, improving the overall quality of life and happiness of gay men.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145640186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of amoxicillin exposure before penicillin administration on Jarisch-Herxheimer incidence in people with early syphilis: a retrospective study.","authors":"Francesco Caruso, Samuel Lazzarin, Francesco Petri, Chiara Fusetti, Federico Barone, Maddalena Matone, Maria Vittoria Cossu, Cristina Gervasoni, Spinello Antinori, Andrea Gori, Andrea Giacomelli, Davide Moschese","doi":"10.1071/SH25120","DOIUrl":"10.1071/SH25120","url":null,"abstract":"<p><strong>Background: </strong>Jarisch-Herxheimer reaction (JHR) is a potential adverse effect of penicillin treatment in patients with syphilis, occurring more frequently when treatment is administered during the early stages of infection. We aimed to assess whether prior exposure to amoxicillin, an antibiotic effective against Treponema pallidum, reduces the incidence of JHR in patients with early syphilis.</p><p><strong>Methods: </strong>In this retrospective observational study, individuals with early syphilis were categorized as exposed or unexposed to amoxicillin on the basis of whether they received a ≥24-h course of treatment in the 7 days preceding penicillin administration. JHR was defined as the occurrence of fever, chills, headache, myalgia, or rash within 24 h of penicillin administration. Logistic regression analyses were performed to evaluate the association between prior amoxicillin exposure and JHR occurrence in patients with early syphilis.</p><p><strong>Results: </strong>The study included 347 participants, of whom 210 had early syphilis and were included in the analysis. Most patients (75.2%) received amoxicillin before penicillin administration. A total of 16 cases of JHR were recorded (7.6%; 95% CI: 4.0-11%), with fever being the most common symptom (62.5%). After adjusting for age, sex assigned at birth and rapid plasma reagin titer, amoxicillin exposure was significantly associated with reduced odds of JHR (adjusted odds ratio 0.24, 95% CI: 0.08-0.68; P = 0.008).</p><p><strong>Conclusions: </strong>Exposure to amoxicillin prior to penicillin treatment may reduce the risk of JHR in patients with early syphilis.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic disparities in access to antiretroviral therapy, current use and unmet need of modern contraception among women living with HIV in Ibadan, Nigeria.","authors":"Olunike Rebecca Abodunrin, Folahanmi Tomiwa Akinsolu, Denis Okova, Akim Tafadzwa Lukwa, Paidamoyo Bodzo, Oluwabukola Mary Ola, Gift Modupe Adelaja, Dolapo Omotayo Raji, Lilian Ogochukwu Ezechi, Plaxcedes Chiwire, Oliver Chukwujekwu Ezechi","doi":"10.1071/SH25184","DOIUrl":"10.1071/SH25184","url":null,"abstract":"<p><strong>Background: </strong>Despite expanded antiretroviral therapy (ART) coverage in Nigeria, socioeconomic disparities continue to limit equitable access to HIV and reproductive health services, especially for women living with HIV (WLHIV). This study examines socioeconomic inequalities in ART access, modern contraceptive use, and unmet need for modern contraception. It further decomposes contributing factors and assesses marginal effects of key predictors.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among WLHIV (aged 18-49 years) at three HIV treatment centers in Ibadan, Nigeria. We used Erreygers-normalized concentration indices (ENCIs), Lorenz curves, dominance testing, Erreygers decomposition, and marginal effects regression to assess inequalities.</p><p><strong>Results: </strong>Modern contraceptive use was significantly pro-poor (ENCI = -0.09, P = 0.03), whereas unmet need was pro-rich (ENCI = 0.08, P = 0.11), and access to HIV care was pro-poor (ENCI = -0.05, P = 0.40), although both were not statistically significant. Dominance tests confirmed systematic inequality across all outcomes. Decomposition revealed education as the dominant driver; primary education explained 24.49% of the pro-poor pattern in contraceptive use, 23.30% of the pro-rich inequality in unmet need, and 10.96% of the pro-poor inequality in HIV care access. Marginal effects indicated that employed women were 15% more likely to access HIV care, contraceptive use declined by 0.5% with each additional year of age, and unmet need was 17% higher among women with comorbidities.</p><p><strong>Conclusion: </strong>Contrary to most population-level evidence in Nigeria and sub-Saharan Africa, contraceptive use was more concentrated among poorer WLHIV, possibly reflecting the success of targeted family planning interventions. Policy should consolidate pro-poor gains in contraceptive use while safeguarding method choice, tailor services across the life course, and integrate family planning with HIV and chronic care to reduce unmet need and strengthen equity.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive chemsex harm reduction services for young MSM in Thailand: a four-pronged approach informed by multi-stakeholder perspectives (CLYMAX-1).","authors":"Akarin Hiransuthikul, Jakkrapatara Boonruang, Jarunee Siriphan, Arunrat Tangmunkongvorakul, Thitipun Sripitathanasakul, Pornpit Khomshuk, Sudarat Thongsuksangcharoen, Piranun Hongchookiat, Siriporn Nonenoy, Nittaya Phanuphak","doi":"10.1071/SH25109","DOIUrl":"10.1071/SH25109","url":null,"abstract":"<p><strong>Background: </strong>The lack of knowledge regarding the essential components of comprehensive chemsex services for men who have sex with men (MSM) in Thailand poses a substantial obstacle to the development of such services. We explored perspectives from various stakeholders on the necessary components of comprehensive chemsex services.</p><p><strong>Methods: </strong>Semi-structured, in-depth interviews were conducted in-person with 60 key informants: 40 MSM who use chemsex, 10 peers/family members and 10 service providers. A codebook was developed based on a priori themes of the interview guide and emergent themes from transcripts.</p><p><strong>Results: </strong>We identified four components that should be incorporated into comprehensive chemsex services. First, promoting substance use literacy is the top priority. In particular, people who use chemsex value a reliable source of information on chemsex-related harms and mitigating strategies. Second, mental health counseling from specialists, such as psychologists or psychiatrists, due to relationships between mental health and chemsex use. Third, sexual health services, including routine sexually transmitted infections screening, and the provision of preventive measures, such as PrEP and condoms. Fourth, legal and stigma consultation are crucial in the context of the country's punitive laws and common abusive practices toward people who use substances. Some MSM prefer onsite services for a more professional feel and effective communication, whereas others prefer online services due to experienced/anticipated stigma and discrimination.</p><p><strong>Conclusion: </strong>Chemsex-specific literacy, mental health services, sexual health services, and legal and stigma consultation were identified as key chemsex service components, and their inclusion in comprehensive chemsex services for MSM in Thailand should be further explored.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance to macrolides and quinolones among HIV-positive MSM infected with Mycoplasma genitalium.","authors":"Roee Launer Wachs, Shiraz Gefen Halevi, Rachel Hamias, Anat Wieder-Feinsod, Vladislav Litchevski, Liraz Olmer, Galia Rahav, Sharon Amit, Itzchak Levy","doi":"10.1071/SH25079","DOIUrl":"10.1071/SH25079","url":null,"abstract":"<p><strong>Background: </strong>The high prevalence of asymptomatic Mycoplasma genitalium (MG) infection, combined with limited treatment options due to emerging antimicrobial resistance, raises important questions about the necessity of routine screening and treatment, particularly among men who have sex with men (MSM). This study aimed to determine the prevalence of macrolide and quinolone resistance in MG among HIV-positive MSM and assess its clinical relevance.</p><p><strong>Methods: </strong>HIV-positive MSM were screened for sexually transmitted infections at the HIV clinic in Sheba Medical Center over a 43-month period, with demographic and clinical parameters recorded upon each visit. A subset of the patients underwent genetic resistance testing for macrolides and quinolones using real-time polymerase chain reaction assays.</p><p><strong>Results: </strong>A total of 317 patients were screened during the study period. MG was detected in 80 (25.2%) patients, covering 150 episodes, at least once during follow-up. In 15 of these episodes (10.0%), patients reported symptoms that might be explained by MG infection. Among the 35 patients who were tested for resistance, 28 (82.3%) harbored macrolide resistance-associated mutations, whereas 11 of 33 (33.3%) exhibited quinolone resistance-associated mutations.</p><p><strong>Conclusions: </strong>The findings highlight a high prevalence of macrolide-resistant MG infections among HIV-positive MSM, with a notable proportion also exhibiting macrolide quinolone resistance. Given the asymptomatic nature of many MG infections and the increasing challenge of antimicrobial resistance, routine screening for MG in this population may provide limited clinical benefits.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 6","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}