Surgical NeurologyPub Date : 2009-12-01DOI: 10.1016/j.surneu.2009.06.007
Tao-Chen Lee MD , Nyuk-Kong Chang DVM , Feng-Wen Su MD , Yu-Lin Yang PhD , Thung-Ming Su MD , Yu-Jun Lin MD , Wan-Ching Lin BS , Hsiu-Yu Huang MD
{"title":"Systemic and local reactions of a water-soluble copolymer bone on a bony defect of rabbit model","authors":"Tao-Chen Lee MD , Nyuk-Kong Chang DVM , Feng-Wen Su MD , Yu-Lin Yang PhD , Thung-Ming Su MD , Yu-Jun Lin MD , Wan-Ching Lin BS , Hsiu-Yu Huang MD","doi":"10.1016/j.surneu.2009.06.007","DOIUrl":"10.1016/j.surneu.2009.06.007","url":null,"abstract":"<div><h3>Background</h3><p>Ostene®, a synthetic water-soluble bone hemostatic agent, is commercially available. In the current study, we evaluated the systemic and local effects of this copolymer in a rabbit model.</p></div><div><h3>Methods</h3><p>Eighteen rabbits underwent creation of a bony defect at right iliac crest. These rabbits were then evenly divided into 3 groups. In group 1, the defect surfaces were treated with bone wax; in group 2, the defect surfaces were treated with Ostene®; in group 3, the defect surfaces were not treated with anything. Then, the animals underwent blood examinations, including WBC count, CRP, and ESR at 0, 1, 3, and 6 weeks, and were killed at 6 weeks for histologic examination. Another 6 rabbits (group 4) underwent the same surgical treatment of group 2 animals but had blood examinations of BUN and creatinine.</p></div><div><h3>Results</h3><p>The blood examinations showed that the WBC count, CRP, and ESR of all the animals in the first 3 groups were within normal limits in the postoperative periods. Microscopic examinations demonstrated residual bone wax and fibrotic tissue at the defect surfaces in group 1 animals. However, there was no Ostene® at the defect surfaces in group 2 animals. The groups 2 and 3 animals showed no fibrotic tissue at the defect surfaces. The group 4 animals showed normal serum levels of BUN and creatinine in the postoperative periods.</p></div><div><h3>Conclusion</h3><p>Ostene® is absorbable and induces no systemic inflammation (including acute renal damage) and local inflammation in animal bodies.</p></div>","PeriodicalId":22153,"journal":{"name":"Surgical Neurology","volume":"72 ","pages":"Pages S75-S79"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.surneu.2009.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40021327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A note of appreciation to the editorial board","authors":"James I. Ausman MD, PhD (Editor)","doi":"10.1016/j.wneu.2009.09.012","DOIUrl":"10.1016/j.wneu.2009.09.012","url":null,"abstract":"","PeriodicalId":22153,"journal":{"name":"Surgical Neurology","volume":"72 6","pages":"Page 560"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.wneu.2009.09.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55278018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgical NeurologyPub Date : 2009-12-01DOI: 10.1016/j.surneu.2009.05.015
Jamie J. Van Gompel MD , Yasin A. Khan BSc , Eric L. Bloomfield MD , John F. Pallanch MD , John L.D. Atkinson MD
{"title":"Rhabdomyolysis after transnasal repair of anterior basal encephalocele","authors":"Jamie J. Van Gompel MD , Yasin A. Khan BSc , Eric L. Bloomfield MD , John F. Pallanch MD , John L.D. Atkinson MD","doi":"10.1016/j.surneu.2009.05.015","DOIUrl":"10.1016/j.surneu.2009.05.015","url":null,"abstract":"<div><h3>Background</h3><p>Postoperative Rhabdomyolysis (RM) is rare after neurosurgical procedures. Furthermore, it has not been observed after transnasal approaches. The authors report a case of idiopathic RM occurring after transnasal resection of a sincipital encephalocele.</p></div><div><h3>Case Description</h3><p>A 32-year-old woman underwent a transnasal resection of a sincipital encephalocele after 6 years of intermittent clear nasal drainage. Postoperatively, she experienced severe back pain, peripheral neuropathy, associated with a markedly elevated creatinine kinase, and severe RM. The patient was treated with hydration and forced urine alkalization and treated symptomatically for her pain and neuropathy. She ultimately made a full recovery without complication.</p></div><div><h3>Conclusion</h3><p>Rhabdomyolysis is a rare but known complication of neurosurgical procedures. We report the first known case report of RM after a transnasal procedure. Furthermore, a review of documented postneurosurgical cases of RM is presented and reveals that the causes and risk factors for this complication after neurosurgery are similar to those in other surgical subspecialties.</p></div>","PeriodicalId":22153,"journal":{"name":"Surgical Neurology","volume":"72 6","pages":"Pages 757-760"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.surneu.2009.05.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28309240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rabbit model for efficacy evaluation of endovascular coil materials","authors":"Masaki Ebara MD , Ichiro Yuki MD , Yuichi Murayama MD , Takayuki Saguchi MD , Yih-Lin Nien MD , Harry V. Vinters MD , Fernando Vinuela MD , Toshiaki Abe MD","doi":"10.1016/j.surneu.2009.04.017","DOIUrl":"10.1016/j.surneu.2009.04.017","url":null,"abstract":"<div><h3>Background</h3><p>To investigate biomaterials seeking for their possible use for aneurysm treatment, in vivo screening tests using a number of potential materials are required. However, there is no established animal model that is suitable for such purpose. Some models require special preparation of tested materials for transcatheter delivery and others are inappropriate in view of their cost-effectiveness. The purpose of this study is to establish an animal model that overcomes these limitations and help us select potential materials before the preclinical evaluation.</p></div><div><h3>Methods</h3><p>Bilateral CCAs in a rabbit were surgically ligated, and a 2-cm segment of either a bare platinum coil or a polymeric coil (a platinum coil coated with PLGA 10/90) was implanted into each blind-ended arterial segment (n = 26). They were harvested at day 1, 7, 10, 14, or 30, respectively. Angiographic and histologic evaluations as well as quantitative analysis on the development of the organized thrombus were performed.</p></div><div><h3>Results</h3><p>One day after the implantation, both platinum and PLGA coils were surrounded by immature thrombus that was induced by blood flow stagnation in the arterial segment. At day 7, minimal thrombus organization was observed around both types of materials. At postimplantation days 10 and 14, fibrocellular responses, the early findings of the thrombus organization process, were observed in both material groups. Such histologic findings were more prominent in the PLGA coil group as compared to the platinum coil group (day 10, <em>P</em> = .051; day 14, <em>P</em> = .011). Well-organized thrombus was observed in both material groups at day 30 without showing statistical difference (<em>P</em> = .12).</p></div><div><h3>Conclusion</h3><p>Given the cost-effectiveness, the simple material preparation process, and its feasible histologic evaluation methods, this new animal model can be useful in screening other potential biomaterials for the development of new coil devices.</p></div>","PeriodicalId":22153,"journal":{"name":"Surgical Neurology","volume":"72 6","pages":"Pages 620-627"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.surneu.2009.04.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28654349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surgical NeurologyPub Date : 2009-12-01DOI: 10.1016/j.surneu.2009.07.010
Ibrahim Sbeih MBCHB, FRCS, FRCSSN
{"title":"Do we need a neurosurgical Interpol?","authors":"Ibrahim Sbeih MBCHB, FRCS, FRCSSN","doi":"10.1016/j.surneu.2009.07.010","DOIUrl":"10.1016/j.surneu.2009.07.010","url":null,"abstract":"","PeriodicalId":22153,"journal":{"name":"Surgical Neurology","volume":"72 6","pages":"Pages 628-629"},"PeriodicalIF":0.0,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.surneu.2009.07.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28428926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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