发布求助
文献互助 智能选刊 最新文献

SynOpen最新文献

筛选
英文 中文
Synthesis of 5-(4-Formylphenyl)barbituric Acid to Access Enolizable Chromophoric Barbituric Acids 合成 5-(4-甲酰基苯基)巴比妥酸以获得可烯醇化的铬代巴比妥酸
IF 2.5
SynOpen Pub Date : 2024-09-02 DOI: 10.1055/s-0043-1775398
Alexander Schade
{"title":"Synthesis of 5-(4-Formylphenyl)barbituric Acid to Access Enolizable Chromophoric Barbituric Acids","authors":"Alexander Schade","doi":"10.1055/s-0043-1775398","DOIUrl":"https://doi.org/10.1055/s-0043-1775398","url":null,"abstract":"<p>Barbituric acids mono-substituted at the 5-position show keto–enol tautomerism. In the keto form, conjugation to an aryl substituent is interrupted due to the sp³-hybridized carbon atom at the 5-position of barbituric acid. The enol form generates a conjugated π-system to the aryl substituent and acts as an electron-donating group. If the aryl substituent is electron-deficient, a push-pull system is generated that shows typical UV/Vis absorption. These types of compounds are difficult to access synthetically due to their intrinsic convertibility. The synthesis of barbituric acids with a 4-formylphenyl functionality at the 5-position is reported. This compound, 5-(4-formylphenyl)barbituric acid, could be used to introduce extended π-systems with electron-withdrawing groups in great variety by simple condensation reactions. We demonstrate this by a Horner–Wadsworth–Emmons reaction that forms the enolizable dye (<i>E</i>)-5-(4-(4-nitrostyryl)phenyl)barbituric acid.</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Recent Progress on the Anticancer Activity of Heterocyclic Compounds 杂环化合物抗癌活性最新进展综述
IF 2.5
SynOpen Pub Date : 2024-08-26 DOI: 10.1055/s-0040-1720125
Beena Negi, Aarshiya Kwatra
{"title":"A Review of Recent Progress on the Anticancer Activity of Heterocyclic Compounds","authors":"Beena Negi, Aarshiya Kwatra","doi":"10.1055/s-0040-1720125","DOIUrl":"https://doi.org/10.1055/s-0040-1720125","url":null,"abstract":"<p>Cancer is one of the most daunting illnesses in the world as compared to many other human diseases. This review article aims to summarize the literature that is already published based on heterocyclic anticancer compounds. Under this broad topic we try to shed a light on anticancer potentiality of oxygen-, sulfur-, and nitrogen-containing heterocyclic compounds, such as quinolines, pyrroles, pyrimidines, pyridines, indoles, also sulfonamides linked heterocycles, benzimidazoles and oxadiazoles.</p> <p>1 Introduction</p> <p>1.1 Drugs in Use for Cancer Treatment</p> <p>1.2 Recently Discovered Anticancer Drugs</p> <p>2 Various Classes of Compounds as Anticancer Agents</p> <p>2.1 Quinoline Derivatives as Anticancer Agents</p> <p>2.2 Benzimidazoles as Anticancer Agents</p> <p>2.3 Indole: A Privileged Scaffold for the Design of Anticancer Agents</p> <p>2.4 Pyrimidine Derivatives as Anticancer Agents</p> <p>2.5 Pyridine Derivatives as Anticancer Agents</p> <p>2.6 Pyrrole Derivatives as Anticancer Agents</p> <p>2.7 Sulfonamides linked with heterocycles as Anticancer Agents</p> <p>2.8 Oxadiazole and Its Derivatives as Anticancer Compounds</p> <p>2.9 Benzothiazole-Triazole Hybrids as Anticancer Compounds</p> <p>3 Conclusion</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Porphyrins, Phthalocyanines and Corroles as Photocatalysts for Organic Transformations 探索将卟啉、酞菁和络合物用作有机物转化的光催化剂
IF 2.5
SynOpen Pub Date : 2024-08-13 DOI: 10.1055/s-0040-1720126
Ashmita Jain, Iti Gupta
{"title":"Exploring Porphyrins, Phthalocyanines and Corroles as Photocatalysts for Organic Transformations","authors":"Ashmita Jain, Iti Gupta","doi":"10.1055/s-0040-1720126","DOIUrl":"https://doi.org/10.1055/s-0040-1720126","url":null,"abstract":"<p>In recent years, macrocycles have emerged as efficient and sustainable photosensitizers for the catalysis of organic transformations. This graphical review provides a concise overview of photocatalysis and photoredox catalysis utilizing three common macrocycles: porphyrins, phthalocyanines and corroles. They exhibit strong absorption in the visible region and can be easily oxidized or reduced, making them good candidates for photocatalysis.</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thiourea/NCBSI/HCl System: Telescoping alkyl halide to alkyl sulfonyl chloride by recyclable N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) 硫脲/NCBSI/HCl 系统：通过可回收的 N-氯-N-(苯磺酰基)苯磺酰胺 (NCBSI) 将烷基卤伸缩为烷基磺酰氯
IF 2
SynOpen Pub Date : 2024-07-16 DOI: 10.1055/a-2360-9229
Shweta Gaikwad, G. Chaturbhuj
{"title":"Thiourea/NCBSI/HCl System: Telescoping alkyl halide to alkyl sulfonyl chloride by recyclable N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)","authors":"Shweta Gaikwad, G. Chaturbhuj","doi":"10.1055/a-2360-9229","DOIUrl":"https://doi.org/10.1055/a-2360-9229","url":null,"abstract":"A convenient and efficient method to synthesize diverse alkyl sulfonyl chlorides through N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)-mediated oxidative chlorosulfonation of S-alkyl isothiouronium salts obtained from alkyl chlorides is presented. Synthesizing structurally diverse alkyl sulfonyl chloride in moderate to excellent yields up to 98% from alkyl halide via easy formation of S-alkyl isothiouronium salts using inexpensive thiourea. The mild reaction conditions and broad substrate scope make this method beneficial and advantageous to alkylsulfonyl chloride syntheses.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrazide–hydrazones as potential antitubercular agents: overview of the literature (1999-2023) 作为潜在抗结核药物的肼基甲酰肼：文献综述（1999-2023 年）
IF 2
SynOpen Pub Date : 2024-07-16 DOI: 10.1055/a-2367-6993
Suraj N. Mali, Anima Pandey, Umang Shah, Rahul D. Jawarkar, Rakesh Somani
{"title":"Hydrazide–hydrazones as potential antitubercular agents: overview of the literature (1999-2023)","authors":"Suraj N. Mali, Anima Pandey, Umang Shah, Rahul D. Jawarkar, Rakesh Somani","doi":"10.1055/a-2367-6993","DOIUrl":"https://doi.org/10.1055/a-2367-6993","url":null,"abstract":"Hydrazide-hydrazone derivatives are prevalent in numerous bioactive compounds, showcasing a diverse array of biological effects including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antiviral, and antiprotozoal properties. Consequently, numerous medicinal chemists undertake the synthesis of various hydrazide-hydrazones, subjecting them to evaluation for their biological activities. Among these, antituberculosis activity stands out as a recurring focus in scientific literature. This paper provides a comprehensive overview of research spanning the last twenty-four years (1999-2023), concentrating on the antituberculosis properties of hydrazide-hydrazone derivatives. The insights presented herein could serve as a valuable roadmap for the development of novel hydrazide-hydrazones with potential antimicrobial efficacy.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141640462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pd-Catalyzed Transfer Hydrogenation of Alkenes Using Tetrahydroxydiboron as the Sole Hydrogen Donor 以四羟基二硼作为唯一的氢供体，Pd 催化烯烃的转移加氢反应
IF 2
SynOpen Pub Date : 2024-07-16 DOI: 10.1055/a-2367-6943
Mahshid Yaghoubi, Isabella Reyes, Ben Stokes
{"title":"Pd-Catalyzed Transfer Hydrogenation of Alkenes Using Tetrahydroxydiboron as the Sole Hydrogen Donor","authors":"Mahshid Yaghoubi, Isabella Reyes, Ben Stokes","doi":"10.1055/a-2367-6943","DOIUrl":"https://doi.org/10.1055/a-2367-6943","url":null,"abstract":"Tetrahydroxydiboron-mediated catalytic transfer hydrogenations have typically involved co-additives that, like tetrahydroxydiboron itself, are H atom donors. Herein we report an alkene transfer hydrogenation method with tetrahydroxydiboron as the sole source of H atoms. The reaction uses Pd(OAc)2 as a convenient putative colloid pre-catalyst, and cyclic monoethers are competent solvents. Highly efficient alkene deuteration is demonstrated using tetradeuteroxydiboron.","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave-Assisted Synthesis of Heterocyclic Scaffolds 微波辅助合成杂环支架
IF 2.5
SynOpen Pub Date : 2024-07-03 DOI: 10.1055/s-0043-1775379
Sanjeev Kumar, Anand Maurya, Alka Agarwal
{"title":"Microwave-Assisted Synthesis of Heterocyclic Scaffolds","authors":"Sanjeev Kumar, Anand Maurya, Alka Agarwal","doi":"10.1055/s-0043-1775379","DOIUrl":"https://doi.org/10.1055/s-0043-1775379","url":null,"abstract":"<p>In recent years, there has been a notable surge in the utilization of microwave energy, leading to the emergence of innovative and groundbreaking methods across various branches of chemistry, including organic synthesis, materials science, heterocyclic chemistry, and medicinal chemistry. This comprehensive literature review delves into the microwave-assisted organic synthesis of specific heterocycles, illuminating its effectiveness in producing diverse molecules with heightened efficiency and selectivity. The review highlights the significant role of microwave irradiation as a potent method for constructing a wide range of compounds. Particular emphasis is placed on the impact of the technique on synthesizing various hybrids such as 1,2,3-triazole hybrids, coumarin hybrids, imidazopyridine hybrids, phenanthridines hybrids, carbene hybrids, and oxazole hybrids. This article is valuable as it offers insights into current synthetic procedures and trends in developing innovative medications utilizing heterocyclic compounds.</p> <p>1 Introduction</p> <p>2 Synthesis of 1,2,3-Triazole Hybrids</p> <p>3 Coumarin Hybrids</p> <p>4 Imidazo Pyridine Hybrids</p> <p>5 Phenanthridine Hybrids</p> <p>6 Carbene Hybrids</p> <p>7 Oxazole Hybrids</p> <p>8 Conclusion</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141550491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalization of Position 7 of Pyrazolo[1,5-a]pyrazines 吡唑并[1,5-a]吡嗪的第 7 位官能化
IF 2.5
SynOpen Pub Date : 2024-07-01 DOI: 10.1055/s-0043-1775378
Georgyi Koidan, Nazar Tsyzoryk, Eduard B. Rusanov, Svitlana V. Shishkina, Mykhailo Vovk, Aleksandr Kostyuk
{"title":"Functionalization of Position 7 of Pyrazolo[1,5-a]pyrazines","authors":"Georgyi Koidan, Nazar Tsyzoryk, Eduard B. Rusanov, Svitlana V. Shishkina, Mykhailo Vovk, Aleksandr Kostyuk","doi":"10.1055/s-0043-1775378","DOIUrl":"https://doi.org/10.1055/s-0043-1775378","url":null,"abstract":"<p>We report a straightforward formylation at position 7 of pyrazolo[1,5-<i>a</i>]pyrazine derivatives featuring substituents at the 2,3,4 positions. <i>N</i>,<i>N</i>,<i>N</i>′,1,1,1-Hexamethylsilanecarboximidamide exists in equilibrium with its carbene form due to 1,2-migration of the silyl group. The ensuing carbene can be inserted into the most acidic C–H group of the pyrazolo[1,5-<i>a</i>]pyrazines. The most acidic calculated p<i>K</i>\u0000<sub>a</sub> (DMSO) C–H group is at position 7 and does not depend significantly on the substituents. The reactions proceed in high yields affording aminals that can be hydrolyzed to the corresponding aldehydes. Methanolysis of the aminals affords the corresponding methylimines. The constitution of the aminals was unambiguously proved by X-ray crystal structure analysis of a set of derivatives. The method is simple, often does not require even solvents, and can be extended to other heterocyclic compounds.</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative C–N Bond Formation of Isochromans Using an Electronically Tuned Nitroxyl Radical as Catalyst 使用电子调谐亚硝基自由基作为催化剂氧化形成异色氨酸的 C-N 键
IF 2.5
SynOpen Pub Date : 2024-05-13 DOI: 10.1055/s-0040-1720118
Kyoko Yano, Ayano Ohshimo, Elghareeb E. Elboray, Yusuke Kobayashi, Takumi Furuta, Shohei Hamada
{"title":"Oxidative C–N Bond Formation of Isochromans Using an Electronically Tuned Nitroxyl Radical as Catalyst","authors":"Kyoko Yano, Ayano Ohshimo, Elghareeb E. Elboray, Yusuke Kobayashi, Takumi Furuta, Shohei Hamada","doi":"10.1055/s-0040-1720118","DOIUrl":"https://doi.org/10.1055/s-0040-1720118","url":null,"abstract":"<p>The cross-dehydrogenative coupling between isochromans and nucleophiles using an electronically tuned nitroxyl radical catalyst, which effectively promotes the oxidation of benzylic ethers, has been investigated. Using sulfonamides as a nucleophile, modification of isochromans via oxidative C–N bond formation has been achieved at ambient temperature.</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140934495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances and Challenges in Electrocatalytic Carboxylation of CO2 二氧化碳电催化羧化的最新进展和挑战
IF 2.5
SynOpen Pub Date : 2024-04-22 DOI: 10.1055/s-0043-1763748
Jie Wang, Zhen-Feng Wei, Yun-Xia Luo, Chang-Hai Lu, Ren-Jie Song
{"title":"Recent Advances and Challenges in Electrocatalytic Carboxylation of CO2","authors":"Jie Wang, Zhen-Feng Wei, Yun-Xia Luo, Chang-Hai Lu, Ren-Jie Song","doi":"10.1055/s-0043-1763748","DOIUrl":"https://doi.org/10.1055/s-0043-1763748","url":null,"abstract":"<p>The electrochemical fixation of carbon dioxide onto organic matter has emerged as a promising approach in recent years. By combining the unique features of electrochemistry with the goal of carbon dioxide fixation, researchers aim to develop new strategies that can contribute to a more sustainable and environmentally friendly synthesis of organic compounds. One advantage of electrochemical methods is their ability to provide both electrons and energy for chemical transformations. This allows for the direct conversion of carbon dioxide into valuable organic products, without the need for transition metal catalysts or harsh reaction conditions. As a result, electrochemical carbon dioxide fixation offers the potential for milder and more efficient processes compared to traditional methods. Scientists have made noteworthy progress in exploring different strategies for the fixation of carbon dioxide under electrochemical conditions. These strategies involve the activation of various types of chemical bonds, including C(sp<sup>2</sup>)–C(sp<sup>2</sup>), C(sp<sup>2</sup>)–H, C–X (X = halogen), and C(sp<sup>3</sup>)–X (X = S, C, O, N). This review aims to provide an overview of the current state of research on electrochemical carbon dioxide fixation into organic matter. It will discuss the different strategies employed, the key findings, and the challenges that remain to be addressed. By highlighting the recent advancements in this field, this review hopes to inspire further exploration and innovation in the area of electrochemical synthesis for carbon dioxide fixation.</p> <p>1 Introduction</p> <p>2 Electrocatalytic Monocarboxylation of CO<sub>2</sub>\u0000</p> <p>2.1 Monocarboxylation of C(sp<sup>2</sup>)–C(sp<sup>2</sup>)</p> <p>2.2 Monocarboxylation of C(sp<sup>2</sup>)–H</p> <p>2.3 Monocarboxylation of C–X (X = Cl, Br, I)</p> <p>2.4 Monocarboxylation of C(sp<sup>3</sup>)–X (X = S, C, O, N)</p> <p>3 Electrocatalytic Dicarboxylation of CO<sub>2</sub>\u0000</p> <p>4 Electrocatalytic Esterification of CO<sub>2</sub>\u0000</p> <p>5 Conclusions</p> ","PeriodicalId":22135,"journal":{"name":"SynOpen","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信