使用电子调谐亚硝基自由基作为催化剂氧化形成异色氨酸的 C-N 键

IF 2 Q2 CHEMISTRY, ORGANIC

SynOpen Pub Date : 2024-05-13 DOI:10.1055/s-0040-1720118

Kyoko Yano, Ayano Ohshimo, Elghareeb E. Elboray, Yusuke Kobayashi, Takumi Furuta, Shohei Hamada

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引用次数: 0

摘要

研究人员使用一种电子调谐的硝基自由基催化剂研究了异色胺与亲核物之间的交叉脱氢偶联，该催化剂可有效促进苄基醚的氧化。利用磺酰胺作为亲核体，在常温下通过氧化形成 C-N 键实现了对异色氨酸的修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Oxidative C–N Bond Formation of Isochromans Using an Electronically Tuned Nitroxyl Radical as Catalyst

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Oxidative C–N Bond Formation of Isochromans Using an Electronically Tuned Nitroxyl Radical as Catalyst

The cross-dehydrogenative coupling between isochromans and nucleophiles using an electronically tuned nitroxyl radical catalyst, which effectively promotes the oxidation of benzylic ethers, has been investigated. Using sulfonamides as a nucleophile, modification of isochromans via oxidative C–N bond formation has been achieved at ambient temperature.

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来源期刊

SynOpen CHEMISTRY, ORGANIC-

CiteScore

2.30

自引率

4.00%

发文量

审稿时长

6 weeks