Synthetic Communications最新文献_第6页

Synthesis of multifunctionalized allyl isothiocyanates via isomerization of Morita-Baylis-Hillman adduct-derived allylic thiocyanates 森田-贝利斯-希尔曼加合衍生烯丙基硫氰酸酯异构化合成多功能化异硫氰酸烯丙基

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-02-01 DOI: 10.1080/00397911.2024.2441336

Sang Gyu Shin , Hyun-Woo Oh , Byung Chang Kim , Jaeseung Ok , Seung In Lee , Sung Pyo Youn , Hyun Hee Bae , Ji Yoon Park , Jin Woo Han , Chang Hoon Lee

引用次数: 0

Electrochemical Fe-catalyzed deoxygenative alkoxycarbonylation of imidazoheterocycles with carbazates 电化学铁催化咪唑杂环与氨基甲酸酯的脱氧烷氧羰基化反应

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-02-01 DOI: 10.1080/00397911.2025.2458623

Jun-Qi Zhang , Hangfei Huang , Ying Fu

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Unlocking the imidazole ring: A comprehensive review of synthetic strategies 解锁咪唑环：合成策略的综合回顾

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-02-01 DOI: 10.1080/00397911.2024.2414201

Peter Solo , M. Arockia Doss

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Deprotection of nucleosides by lysine-assisted methanolysis of esters and amides 赖氨酸辅助酯和酰胺甲醇解对核苷的脱保护作用

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-31 DOI: 10.1080/00397911.2025.2456103

Jyothi Dhuguru , Brandon English , Ryan W. Dellinger , Marie E. Migaud

引用次数: 0

Selectfluor-mediated oxidative deamination: A scalable approach to aromatic aldehydes synthesis 选择性氟介导的氧化脱胺：芳香醛合成的可扩展方法

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-31 DOI: 10.1080/00397911.2025.2458625

Chengkan Gao , Lin Li , Xiangyang Lin , Renming Pan , Wenfang Zheng

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Design, synthesis, anticancer evaluation and molecular docking studies of different aryl derivatives of azaindole-pyrimidine-1,3,4-oxadiazoles 氮唑-嘧啶-1,3,4-恶二唑不同芳基衍生物的设计、合成、抗癌评价及分子对接研究

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-29 DOI: 10.1080/00397911.2025.2457440

Vankayala Ramesh Babu , V. D. N. Kumar Abbaraju , Reddymasu Sreenivasulu , Dasari Sravani , Singamsetty Rangaswamy , Ravi Kumar Kapavarapu , Deva H.Puranam , Farha Farahim

{"title":"Design, synthesis, anticancer evaluation and molecular docking studies of different aryl derivatives of azaindole-pyrimidine-1,3,4-oxadiazoles","authors":"Vankayala Ramesh Babu , V. D. N. Kumar Abbaraju , Reddymasu Sreenivasulu , Dasari Sravani , Singamsetty Rangaswamy , Ravi Kumar Kapavarapu , Deva H.Puranam , Farha Farahim","doi":"10.1080/00397911.2025.2457440","DOIUrl":"10.1080/00397911.2025.2457440","url":null,"abstract":"<div><div>The aryl-azaindole-pyrimidine-1,3,4-oxadiazole derivatives (<strong>12a–j</strong>) were synthesized by Suzuki coupling reaction between bromo-azaindole-1,3,4-oxadiaole intermediate <strong>10</strong> and various aryl boronic acids (<strong>11a–j</strong>) by using of Pd(dppf)Cl<sub>2</sub> and K<sub>2</sub>CO<sub>3</sub> in 1,4-dioxane/H<sub>2</sub>O. Here, the Suzuki coupling mechanism starts with the oxidative addition followed by transmetallation and ends with reductive elimination. These derivatives were screened in vitro anticancer applications against four human cancer cell lines including MCF-7, A549, Colo-205, and A2780 by employing of MTT method, the well-known chemotherapeutic agent as etoposide used as positive control. Among them, compound <strong>12a</strong> bearing 3,4,5-trimethoxy substituent on the aryl moiety displayed good activity as compared with positive control against MCF-7, A549, Colo-205, and A2780 cell lines with IC<sub>50</sub> values of 1.10 ± 0.84 µM, 1.07 ± 0.067 µM, 1.20 ± 0.95 µM, and 1.34 ± 0.66 µM respectively. Compounds <strong>12a</strong> and <strong>12b</strong> primarily engage in hydrophobic interactions such as pi-pi stacked, amide-pi stacked, pi-alkyl, and alkyl interactions. Specifically, nucleotides DG13, DA12, and arg503 display pi-pi stacked and amide-pi stacked interactions.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"55 5","pages":"Pages 405-421"},"PeriodicalIF":1.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile one-pot green synthesis, antioxidant and antimicrobial activities of 7-(substituted phenyl)-7,11-dihydro-6H,8H-chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidine-6,8,10(9H)-trione derivatives 7-（取代苯基）-7,11-二氢- 6h，8H-chromeno[3 ',4 ':5,6]吡喃[2,3-d]嘧啶-6,8,10(9H)-三酮衍生物的抗氧化和抗菌活性

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-25 DOI: 10.1080/00397911.2025.2455521

Omkar Reddy Vanukuri , Mohan Gundluru , Poojitha Bellala , Rama Sekhara Reddy Dachuru , Suresh Reddy Cirandur

{"title":"Facile one-pot green synthesis, antioxidant and antimicrobial activities of 7-(substituted phenyl)-7,11-dihydro-6H,8H-chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidine-6,8,10(9H)-trione derivatives","authors":"Omkar Reddy Vanukuri , Mohan Gundluru , Poojitha Bellala , Rama Sekhara Reddy Dachuru , Suresh Reddy Cirandur","doi":"10.1080/00397911.2025.2455521","DOIUrl":"10.1080/00397911.2025.2455521","url":null,"abstract":"<div><div>The work aims to develop a simple and efficient protocol for one-pot three-component synthesis to produce a series of poly functionalized 7-(substituted phenyl)-7,11-dihydro-6H,8H-chromeno[3′,4′:5,6]pyrano[2,3-d]pyrimidine-6,8,10(9H)-trione derivatives using Sulfonated reduced graphene oxide (rGO-SO<sub>3</sub>H) as an efficient catalyst <em>via</em> one-pot multicomponent reaction of 4-hydroxycoumarin, aromatic aldehydes and barbituric acid under microwave irradiation and solvent-free conditions in good to excellent yields. The reported protocol is metal-free, highly atom-economic, better yielding in quick reaction time, simple to operate and eco-friendly with reaction conditions comparatively milder. Use of low-cost acidic catalyst under neat conditions makes the reaction an environmentally benign protocol. Additionally, the compounds were screened for their free radical scavenging, antibacterial and antifungal activities which showed good activities when compared than that of standard drugs.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"55 4","pages":"Pages 325-337"},"PeriodicalIF":1.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A practical synthesis of functionalized pyrazoles promoted by a polyoxomolybdate-based iron catalyst 多氧钼酸盐基铁催化剂催化下功能化吡唑的合成

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-24 DOI: 10.1080/00397911.2025.2455529

Lianji Zhang , Yujuan Wu , Cuiping Wang , Wanguo Wei , Zhiqiang Zhang

引用次数: 0

Electrochemical regioselective methylthiolation of imidazo[2,1-b]thiazoles with DMSO 咪唑[2,1-b]噻唑与DMSO的电化学区域选择性甲基硫化

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-21 DOI: 10.1080/00397911.2025.2453872

Meng Xiao , Liyu Yi , Wenjie Liu , Gao Cao

引用次数: 0

Synthesis of Felbinac acid and Felbinac ester via PEPPSI palladium N-heterocyclic carbene catalytic system PEPPSI钯n杂环碳催化体系合成Felbinac酸和Felbinac酯

IF 1.8 3区化学

Synthetic Communications Pub Date : 2025-01-20 DOI: 10.1080/00397911.2025.2453977

Umar B. Suleiman , Mansur B. Ibrahim , Aminu Muhammad , Sani. A. Zarewa

{"title":"Synthesis of Felbinac acid and Felbinac ester via PEPPSI palladium N-heterocyclic carbene catalytic system","authors":"Umar B. Suleiman , Mansur B. Ibrahim , Aminu Muhammad , Sani. A. Zarewa","doi":"10.1080/00397911.2025.2453977","DOIUrl":"10.1080/00397911.2025.2453977","url":null,"abstract":"<div><div>Ethyl-4-biphenylacetate (Felbinac ester) and 4-biphenylacetic acid (Felbinac acid) are common active metabolites of non-steroidal anti-inflammatory drugs (NSAIDs) and are frequently used in the treatment of muscle inflammation and arthritis. The current studies synthesized Felbinacs via a Suzuki-Miyaura cross-coupling reaction mediated through PEPPSI-palladium N-heterocyclic carbene as a catalyst. The catalyst was synthesized through <em>N</em>-benzylation of benzimidazole followed by <em>N</em>-butylation of the resulting <em>N</em>-benzylbenzimidazole to yield the <em>N</em>-benzyl-<em>N</em>-butylbenzimidazolium bromide (the pre-carbene). The pre-carbene was then reacted with palladium bromide (PdBr<sub>2</sub>) in 3-methylpyridine, to produce the pre-catalyst (Pd-NHC-Py-Br<sub>2</sub>). The intermediates and the pre-catalyst were characterized using <sup>1</sup>H and <sup>13</sup>C NMR, FT-IR, and elemental analyses. The pre-catalyst was used to mediate the synthesis of 4-biphenylacetic acid (Felbinac acid) and 4-biphenylacetate (Felbinac ester) from the coupling reaction of Ethyl-4-bromophenyl acetate with phenylboronic acid. The Pd-NHC-Py-Br2 pre-catalyst demonstrated excellent air and moisture stability.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"55 4","pages":"Pages 315-324"},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0