Synthetic Communications最新文献_第6页

Imine–linked covalent organic framework synthesis 亚胺连接共价有机框架合成

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-17 DOI: 10.1080/00397911.2024.2386093

Kajal Kaliya , Deepak Dabur , Sushil K. Maurya

引用次数: 0

Study on the development of radical building block: Mn(III)-based reaction of 1,3-indanedione 关于开发自由基构筑模块的研究：基于锰（III）的 1,3-茚二酮反应

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-17 DOI: 10.1080/00397911.2024.2385542

Kazuki Hisano , Hiroshi Nishino

引用次数: 0

Synthesis of thiazolidinone and methylthiazole derivatives incorporating benzodioxole moiety and evaluation of their antimicrobial activity 合成含有苯并二恶茂分子的噻唑烷酮和甲基噻唑衍生物并评估其抗菌活性

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-17 DOI: 10.1080/00397911.2024.2387118

Reem A. K Al-Harbi

{"title":"Synthesis of thiazolidinone and methylthiazole derivatives incorporating benzodioxole moiety and evaluation of their antimicrobial activity","authors":"Reem A. K Al-Harbi","doi":"10.1080/00397911.2024.2387118","DOIUrl":"10.1080/00397911.2024.2387118","url":null,"abstract":"<div>One of the most serious future challenges to health care professionals is the emergence of multi-drug resistance pathogenic microbes that rapidly develop resistance to currently used antibiotics. So, as a way to overcome the antimicrobial drug-resistance problems, it is urgent need to synthesize several new lead molecules that are expected to have antibacterial and antifungal activities. So, some new thiazolidinone and methylthiazole derivatives incorporating benzodioxole nucleolus were constructed. Two different series of N-substituted thiosemicarbazones carrying a benzodioxole nucleus were synthesized through mutation reaction of the different aromatic and heterocyclic aldehydes with benzodioxolyl thiosemicarbazide. Cycloalkylation reaction of the latter thiosemicarbazones through with both of the ethyl chloroacetate or chloroacetone gave the thiazolidin-4-ones or 4-methylthiazoles, respectively. The antimicrobial activity of the thiazolidin-4-one and 4-methylthiazole derivatives was investigated. All of compounds showed from weak to moderate effects toward all tested bacteria.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 16","pages":"Pages 1366-1375"},"PeriodicalIF":1.8,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of novel chromenyl phosphonates via nano-ZnO-catalyzed microwave method: Exploring potential anti-diabetic agents through molecular docking, ADMET analysis, and α-amylase inhibition 通过纳米氧化锌催化微波法合成新型铬烯基膦酸盐：通过分子对接、ADMET 分析和 α 淀粉酶抑制作用探索潜在的抗糖尿病药物

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-14 DOI: 10.1080/00397911.2024.2388799

Manjula Kavala , Raja Rajeswari Tiruveedula , Subramanyam Chennamsetty

{"title":"Synthesis of novel chromenyl phosphonates via nano-ZnO-catalyzed microwave method: Exploring potential anti-diabetic agents through molecular docking, ADMET analysis, and α-amylase inhibition","authors":"Manjula Kavala , Raja Rajeswari Tiruveedula , Subramanyam Chennamsetty","doi":"10.1080/00397911.2024.2388799","DOIUrl":"10.1080/00397911.2024.2388799","url":null,"abstract":"<div>A more efficient and environmentally friendly approach has been developed for synthesizing phosphonates through the Michaelis-Arbuzov reaction, catalyzed by nano-ZnO in a solvent-free environment, utilizing microwave irradiation. Before synthesis, each compound underwent in silico ADMET analysis and molecular docking to assess drug-like characteristics and their potential to inhibit α-amylase. The structure of the newly synthesized compounds was validated using spectroscopic analysis, and their in vitro inhibitory effects on α-amylase were assessed. Among the compounds, dimethyl 2-(anthracen-10-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6j), dimethyl 2-(naphthalen-1-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6h), and dimethyl 2-(1-methyl-1H-indol-3-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6e) displayed the highest inhibitory activity compared to the reference substance, acarbose. Additionally, compounds dimethyl 2-(benzo[d][1,3]dioxol-4-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6i), dimethyl 4-oxo-2-phenyl-4H-chromen-6-yl-6-phosphonate (6a), and dimethyl 2-(1H-indol-5-yl)-4-oxo-4H-chromen-6-yl-6-phosphonate (6g) exhibited nearly equivalent effective inhibitory activity when compared to the standard. The remaining compounds demonstrated moderate to good enzyme inhibition.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 17","pages":"Pages 1433-1449"},"PeriodicalIF":1.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic approaches for quinoline heterocycles fused at face b: A review 面 b 融合的喹啉杂环的合成方法：综述

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-14 DOI: 10.1080/00397911.2024.2390172

Nada Mohamed , Najla A. Alshaye , Mai A. Mostafa , Al-Shimaa Badran , Zeinab Hussain , Magdy A. Ibrahim

引用次数: 0

Synthesis of N-(1-((1H-perimidin-2-yl)amino)-2,2,2-trichloroethyl)carboxamides based on N-(2,2,2-trichloro-1-isothiocyanatoethyl)carboxamides 以 N-(2,2,2-三氯-1-异硫氰乙基)羧酰胺为基础合成 N-(1-((1H-哌啶-2-基)氨基)-2,2,2-三氯乙基)羧酰胺

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-12 DOI: 10.1080/00397911.2024.2390178

Yelyzaveta R. Lomynoha , Pavlo V. Zadorozhnii , Aleksey B. Ryabitsky , Vadym V. Kiselev , Aleksandr V. Kharchenko

{"title":"Synthesis of N-(1-((1H-perimidin-2-yl)amino)-2,2,2-trichloroethyl)carboxamides based on N-(2,2,2-trichloro-1-isothiocyanatoethyl)carboxamides","authors":"Yelyzaveta R. Lomynoha , Pavlo V. Zadorozhnii , Aleksey B. Ryabitsky , Vadym V. Kiselev , Aleksandr V. Kharchenko","doi":"10.1080/00397911.2024.2390178","DOIUrl":"10.1080/00397911.2024.2390178","url":null,"abstract":"<div>Here we report the development of a concise and efficient synthetic protocol for the preparation of 1H-perimidin-2-amine derivatives that contain an N-(2,2,2-trichloroethyl)carboxamide substituent near the amino group. These compounds’ synthesis method is based on the interaction of naphthalene-1,8-diamine with N-(2,2,2-trichloro-1-isothiocyanatoethyl)carboxamides under reflux in acetonitrile medium for 15 minutes. This transformation is likely to pass through the stage of formation of the intermediate thiourea, which further eliminates hydrogen sulfide, which is accompanied by the closure of the perimidine cycle. Using the developed protocol, we synthesized nine new 1H-perimidin-2-amine derivatives. The yield of synthesized compounds was 67-82%. IR,1H NMR,13C NMR, 1H-1H COSY, 1H-13C HSQC, and 1H-13C HMBC spectroscopy data proved their structures.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 17","pages":"Pages 1470-1481"},"PeriodicalIF":1.8,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One pot synthesis of 4-iodo-3-phenylbenzo[b][1,6]naphthyridine via imino iodization-cyclization of alkynylquinoline-3-carbaldehydes 通过炔基喹啉-3-羰基醛的亚氨基碘化-环化一次性合成 4-碘-3-苯基苯并[b][1,6]萘啶

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-12 DOI: 10.1080/00397911.2024.2389542

Rashmi Singh , Vishal Prasad Sharma , Rajesh Kumar , Manish Raj , Tanu Gupta

引用次数: 0

Synthesis of trifluoromethyl substituted heterocyclic compounds with β-trifluoromethylated acrylates 用 β-三氟甲基丙烯酸酯合成三氟甲基取代的杂环化合物

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-10 DOI: 10.1080/00397911.2024.2390696

Cai Zhang

引用次数: 0

Synthesis, antiproliferative activity and insilco studies of substituted 2-((N-benzyl-5-bromo-2-methoxyphenyl) sulfonamide) glycinamide derivatives 取代的 2-((N-苄基-5-溴-2-甲氧基苯基)磺酰胺)甘氨酰胺衍生物的合成、抗增殖活性和绝缘研究

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-06 DOI: 10.1080/00397911.2024.2387810

Dattatray D. Gaikwad , Sachin A. Dhawale , Chandrakant D. Pawar , Dattatraya N. Pansare , Umakant D. Pawar , Ashok M. Zine

{"title":"Synthesis, antiproliferative activity and insilco studies of substituted 2-((N-benzyl-5-bromo-2-methoxyphenyl) sulfonamide) glycinamide derivatives","authors":"Dattatray D. Gaikwad , Sachin A. Dhawale , Chandrakant D. Pawar , Dattatraya N. Pansare , Umakant D. Pawar , Ashok M. Zine","doi":"10.1080/00397911.2024.2387810","DOIUrl":"10.1080/00397911.2024.2387810","url":null,"abstract":"<div>The present work aimed to synthesize different substituted glycinamide derivatives. A series of novel substituted 2-((N-benzyl-5-bromo-2-methoxyphenyl) sulfonamide) and their glycinamide derivatives (5a–5p) were synthesized. We developed a simple strategy for synthesizing functionally diverse sulfonamide and glycinamide derivatives through a series of steps. A series of molecules containing amide derivatives were designed and synthesized, and their structures were elucidated and confirmed by1H NMR, 13 C NMR, LCMS, and their purity was checked using HPLC. The synthesized compounds were screened for anticancer activity against A-549 and A431 cancer cell lines by MTT assay and then docking studies were carried out to understand the molecular interactions. The preliminary bioassay suggests that most compounds showed remarkable anti-proliferation activity. Gefitinib was used as a positive control. The compounds 5g and 5f were active compared with Gefitinib in both the cell lines.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 17","pages":"Pages 1423-1432"},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleophilic reactions with 3-formylchromones: A decade update 与 3-甲酰基色素的亲核反应：十年更新

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-08-05 DOI: 10.1080/00397911.2024.2387134

Magdy A Ibrahim , Mohamed Abdel-Megid , Osama Farouk , Nasser M. El-Gohary , Asmaa I Nabeel , Marwa M. A. Attai , Al-Shimaa Badran

引用次数: 0