Spinal Cord Series and Cases最新文献

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Surgical treatment for recurrent thoracic ventral intradural arachnoid cyst secondary to tuberculous meningitis: a case report. 继发于结核性脑膜炎的复发性胸腹腔硬膜内蛛网膜囊肿的手术治疗:病例报告。
IF 0.7
Spinal Cord Series and Cases Pub Date : 2024-05-23 DOI: 10.1038/s41394-024-00650-5
Yushi Sakamoto, Takayoshi Shimizu, Bungo Otsuki, Shuichi Matsuda
{"title":"Surgical treatment for recurrent thoracic ventral intradural arachnoid cyst secondary to tuberculous meningitis: a case report.","authors":"Yushi Sakamoto, Takayoshi Shimizu, Bungo Otsuki, Shuichi Matsuda","doi":"10.1038/s41394-024-00650-5","DOIUrl":"10.1038/s41394-024-00650-5","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal intradural arachnoid cysts (SIACs) are rare spinal entities that are categorized as primary or secondary pathologies. Secondary cysts can arise from various traumatic or inflammatory causes including subarachnoid hemorrhage, intrathecal injection or surgery, and infectious meningitis/arachnoiditis. Only a few cases of SIAC secondary to tuberculous meningitis have been previously reported, without details of the surgical treatment.</p><p><strong>Case presentation: </strong>A 27-year-old woman diagnosed with tuberculous meningitis developed myelopathy caused by thoracic ventral SIAC and intradural abscess. The patient underwent abscess evacuation and cyst fenestration; however, cyst recurrence occurred. The 2nd surgery consisted of cyst resection via a posterolateral approach with expansive duraplasty and spinal arthrodesis. Re-recurrence occurred, and at the 3rd surgery, cyst-subarachnoid bypass was performed. One year after the 3rd surgery, the myelopathic symptoms recovered, and MR images demonstrated a decreased cyst size.</p><p><strong>Discussion: </strong>Here, we report a rare case of recurrent thoracic SIAC secondary to tuberculous meningitis and arachnoiditis. Simple fenestration is associated with a high risk of recurrence in this pathology. Ventrally located thoracic cysts can be approached with posterolateral approach with pedicles resected followed by instrumented arthrodesis. Even in cases involving gross total resection of the cyst wall, there is a risk of recurrence. In such cases, cyst-subarachnoid bypass with a large-diameter tube can be effective.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"10 1","pages":"36"},"PeriodicalIF":0.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cauda equina syndrome with surgical intervention in pregnancy during the periviable period. 围产期妊娠手术治疗马尾综合征。
IF 0.7
Spinal Cord Series and Cases Pub Date : 2024-05-11 DOI: 10.1038/s41394-024-00646-1
Mary Taylor Winsten, Jessica Fine, Fatimah Fahimuddin, Diana Baxter, Tamika Auguste
{"title":"Cauda equina syndrome with surgical intervention in pregnancy during the periviable period.","authors":"Mary Taylor Winsten, Jessica Fine, Fatimah Fahimuddin, Diana Baxter, Tamika Auguste","doi":"10.1038/s41394-024-00646-1","DOIUrl":"10.1038/s41394-024-00646-1","url":null,"abstract":"<p><strong>Introduction: </strong>Cauda equina syndrome (CES) following lumbar disc herniation is exceedingly rare in pregnancy and there is limited literature outlining management of CES in pregnancy. There is further limited data addressing the management of periviable pregnancies complicated by CES.</p><p><strong>Case presentation: </strong>A 38-year-old female at 22 weeks gestation presented with worsening lower back pain radiating to the right posterior lower extremity. She was initially managed with conservative therapy, but re-presented with worsening neurologic symptoms, including fasciculations and perineal numbness. Magnetic resonance imaging showed a large herniated disc at L4-5, and given concern for CES, she underwent emergent decompression surgery, which was complicated by a superficial wound dehiscence. She ultimately carried her pregnancy to term and had a cesarean delivery. The patient's residual neurologic symptoms continued to improve with physical therapy throughout the postpartum period.</p><p><strong>Discussion: </strong>Cauda equina syndrome is a rare spinal condition with potentially devastating outcomes if not managed promptly. Diagnosis and management of CES in pregnancy is the same as in non-pregnant patients, however, standardization of patient positioning for surgery, surgical approach, anesthetic use, and fetal considerations is lacking. A multidisciplinary approach is critical, especially at periviable gestational ages of pregnancy. Our case and review of the literature demonstrates that patients in the second trimester can be managed surgically with prone positioning, intermittent fetal monitoring, and continued management of the pregnancy remains unchanged. Given the rarity of these cases, there is a need for a consensus on management and continued care in pregnant patients with CES.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"10 1","pages":"35"},"PeriodicalIF":0.7,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11088644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On Professor Robert Lipschitz, MB, ChB, PhD(Med), FRCS(Edin) and the Spinal Cord Injury Service, Chris Hani Baragwanath Hospital, Soweto, Johannesburg, South Africa. 关于南非约翰内斯堡索韦托克里斯-哈尼-巴拉夸那思医院的罗伯特-利普施茨教授(医学博士、医学博士、医学博士、爱丁堡皇家脊髓损伤研究中心)和脊髓损伤服务。
IF 0.7
Spinal Cord Series and Cases Pub Date : 2024-05-07 DOI: 10.1038/s41394-024-00645-2
Avi Ohry
{"title":"On Professor Robert Lipschitz, MB, ChB, PhD(Med), FRCS(Edin) and the Spinal Cord Injury Service, Chris Hani Baragwanath Hospital, Soweto, Johannesburg, South Africa.","authors":"Avi Ohry","doi":"10.1038/s41394-024-00645-2","DOIUrl":"10.1038/s41394-024-00645-2","url":null,"abstract":"<p><p>Professor Robert Lipschitz, MB, ChB, PhD(Med), FRCS(Edin) was a pioneer who established the Spinal Cord Injury Unit, at Chris Hani Baragwanath Hospital, Soweto, Johannesburg, South Africa. A brief description of his academic and clinical accomplishments is given.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"10 1","pages":"34"},"PeriodicalIF":0.7,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined rehabilitation therapy with botulinum toxin to the upper limbs for acute spinal cord injury: A case report 使用肉毒杆菌毒素对急性脊髓损伤的上肢进行联合康复治疗:病例报告
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-05-04 DOI: 10.1038/s41394-024-00647-0
Haruki Mori, Gosuke Satoh, Hideki Takashima, Takashi Masuda, Tomoo Mano
{"title":"Combined rehabilitation therapy with botulinum toxin to the upper limbs for acute spinal cord injury: A case report","authors":"Haruki Mori, Gosuke Satoh, Hideki Takashima, Takashi Masuda, Tomoo Mano","doi":"10.1038/s41394-024-00647-0","DOIUrl":"https://doi.org/10.1038/s41394-024-00647-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Patients with spinal cord injury (SCI) and incomplete paralysis may experience muscle immobilization due to functional impairment of agonist and antagonist muscles. This can induce spasticity and pain, with the risk of contracture increasing as the period of immobilization increases. This could be aggravated by pain, which interferes with rehabilitation. There is no established treatment for pain and joint contractures caused by acute SCI. Botulinum therapy plays a role in relieving muscle tension. Here, we report a case of acute SCI in which botulinum therapy was administered.</p><h3 data-test=\"abstract-sub-heading\">Case presentation</h3><p>The patient experienced a C5-cervical SCI due to a road traffic accident, with marked paralysis in the upper and lower limbs below the C5 level. The patient had persistent elbow flexion since the SCI and complained of excruciating pain, making adequate rehabilitation difficult. Botulinum toxin was administered to the biceps and brachialis muscles 15 days after the SCI. After administration, the patient experienced a reduction in pain with relaxation of the elbow flexor muscles, and rehabilitation treatment was resumed. This patient’s contracture did not worsen, his pain decreased, and he was able to initiate self-feeding training.</p><h3 data-test=\"abstract-sub-heading\">Discussion</h3><p>In this case, occupational and physical therapy was administered with botulinum therapy. Together, they successfully reduced pain. Botulinum therapy provides analgesia and muscle relaxation and may lead to functional recovery, and we believe that treatment can be considered even in the acute phase.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"9 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and psychometric properties of appraisals of post traumatic spinal cord injury health scale in Iran 伊朗脊髓损伤后健康评估量表的开发和心理测量学特性
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-04-23 DOI: 10.1038/s41394-024-00638-1
Maryam Shabany, Vafa Rahimi-Movaghar, Roya Habibi Arejan, Reza Tabrizi, Parastoo Saberi, Vali Baigi, Zahra Ghodsi, Fatemeh Rakhshani, Morteza Gholami, Alexander R. Vaccaro, Seyed Mohammad Ghodsi
{"title":"Development and psychometric properties of appraisals of post traumatic spinal cord injury health scale in Iran","authors":"Maryam Shabany, Vafa Rahimi-Movaghar, Roya Habibi Arejan, Reza Tabrizi, Parastoo Saberi, Vali Baigi, Zahra Ghodsi, Fatemeh Rakhshani, Morteza Gholami, Alexander R. Vaccaro, Seyed Mohammad Ghodsi","doi":"10.1038/s41394-024-00638-1","DOIUrl":"https://doi.org/10.1038/s41394-024-00638-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Development and psychometrics study</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To evaluate the reliability and validity of a new version of Appraisals of Post-Traumatic Spinal Cord Injury Health Scale (APTSCIHS) in the Persian language for persons with spinal cord injury (SCI).</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>The persons were selected from National Spinal Cord Injury Registry of Iran (NSCIR-IR) and Brain and Spinal Cord Injury Research center (BASIR).</p><h3 data-test=\"abstract-sub-heading\">Method</h3><p>This was a mixed sequential exploratory study that performed in two phases. In the qualitative phase, a systematic scoping review and 12 interviews with the participants were done. Finally, items were generated. In the quantitative phase, face, content, construct and convergent validity were assessed to evaluate validity. To evaluate construct validity, a cross-sectional study was conducted on 305 persons with TSCI along with internal consistency and stability assessments. All quantitative data analyses were conducted using SPSS 22 software.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The content validity and reliability were indicated by Scale’s Content Validity Ratio (S-CVR) = 0.73 and Scale’s Content Validity Index (S-CVI) = 0.86, Cronbach’s α = 0.9 and the Test re-test reliability using intra-class correlations were (ICC) = 0.97 to 0.98. Exploratory factor analysis determined eight factors which showed more than 52% of the variance. APTSCIHS had a significant and strong correlation with Appraisals of DisAbility Primary and Secondary Scale (ADAPSS) (r = 0.475, <i>P</i> &lt; 0.001).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Results showed the 36 items APTSCIHS tool had an acceptable validity and reliability in Iran, and it can help health care providers or even administrators improve the quality of the rehabilitation services and quality of life.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"147 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the challenges of air travel in the United States: a qualitative study of the lived experiences of wheelchair users with spinal cord injury or disorder 调查美国航空旅行的挑战:关于脊髓损伤或障碍的轮椅使用者生活经历的定性研究
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-04-20 DOI: 10.1038/s41394-024-00641-6
Julie L. Pfeiffer, Walt Bower, Phillip Rumrill
{"title":"Investigating the challenges of air travel in the United States: a qualitative study of the lived experiences of wheelchair users with spinal cord injury or disorder","authors":"Julie L. Pfeiffer, Walt Bower, Phillip Rumrill","doi":"10.1038/s41394-024-00641-6","DOIUrl":"https://doi.org/10.1038/s41394-024-00641-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Qualitative exploratory study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To understand the lived experiences of individuals with spinal cord injuries or disorders (SCI/D) who use wheelchairs during air travel in the United States (US), with a focus on the challenges and barriers to accessing this form of transportation.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Wheelchair users with SCI/D living in the community in the US.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Semi-structured interviews were used to collect data from six wheelchair users with SCI/D. Data were analyzed using a six-step thematic analysis.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Experiences of wheelchair users during air travel clustered into three themes; experiences interacting with the airport, experiences interacting with the airplane, and experiences across all stages of air travel. Barriers to airport accessibility were minimal. Physical barriers to airplane accessibility and damage to wheelchairs occurred when interacting with the airplane and airline staff. Undertrained staff and a shift in responsibility to the passenger with a disability impacted all stages of the experience.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Wheelchair users with SCI/D encounter challenges that can result in unsafe and inaccessible air travel within the US. Adverse consequences of air travel often impact the individual’s independence and quality of life during and after the flight. Participants provided recommendations to improve the air travel experience for wheelchair users, including the ability to remain in one’s wheelchair while onboard the airplane.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"19 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140635279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed paraparesis after posterior spinal fusion for congenital scoliosis: a case report 先天性脊柱侧凸后路脊柱融合术后延迟性截瘫:病例报告
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-04-17 DOI: 10.1038/s41394-024-00639-0
Shuhei Ohtsubo, Masayuki Ohashi, Toru Hirano, Hideki Tashi, Tatsuo Makino, Keitaro Minato, Yusuke Mitsuma, Hiroyuki Deguchi, Rintaro Hoshino, Nobuko Ohashi, Kenta Furutani, Hiroyuki Kawashima, Kei Watanabe
{"title":"Delayed paraparesis after posterior spinal fusion for congenital scoliosis: a case report","authors":"Shuhei Ohtsubo, Masayuki Ohashi, Toru Hirano, Hideki Tashi, Tatsuo Makino, Keitaro Minato, Yusuke Mitsuma, Hiroyuki Deguchi, Rintaro Hoshino, Nobuko Ohashi, Kenta Furutani, Hiroyuki Kawashima, Kei Watanabe","doi":"10.1038/s41394-024-00639-0","DOIUrl":"https://doi.org/10.1038/s41394-024-00639-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Although multimodal intraoperative neuromonitoring (IONM), which has high sensitivity and specificity, is typically performed during spinal deformity surgery, neurological status may deteriorate with delay after surgical maneuvers. Here, we report a rare case of delayed postoperative neurological deficit (DPND) that was not detected by IONM during posterior spinal fusion (PSF) for congenital scoliosis.</p><h3 data-test=\"abstract-sub-heading\">Case presentation</h3><p>A 14-year-old male presented with congenital scoliosis associated with T3 and T10 hemivertebrae. Preoperative Cobb angle of proximal thoracic (PT) and main thoracic (MT) curves were 50° and 41°, respectively. PSF (T1-L1) without hemivertebrectomy was performed, and the curves were corrected to 31° and 21° in the PT and MT curves, respectively, without any abnormal findings in IONM, blood pressure, or hemoglobin level. However, postoperative neurological examination revealed complete loss of motor function. A revision surgery, release of the curve correction by removing the rods, was immediately performed and muscle strength completely recovered on the first postoperative day. Five days postoperatively, PSF was achieved with less curve correction (36° in the PT curve and 26° in the MT curve), without postoperative neurological deficits.</p><h3 data-test=\"abstract-sub-heading\">Discussion</h3><p>Possible mechanisms of DPND in our patient are spinal cord ischemia due to spinal cord traction caused by scoliosis correction and spinal cord kinking by the pedicle at the concave side. Understanding the possible mechanisms of intra- and postoperative neural injury is essential for appropriate intervention in each situation. Additionally, IONM should be continued to at least skin closure to detect DPND observed in our patient.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"302 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral tibial fractures associated with powered exoskeleton use in complete spinal cord injury – a case report & literature review 完全性脊髓损伤患者使用动力外骨骼导致的双侧胫骨骨折--病例报告和文献综述
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-04-16 DOI: 10.1038/s41394-024-00635-4
John Mahon, Lily Nolan, David O’Sullivan, Mark Curtin, Aiden Devitt, Colin G. Murphy
{"title":"Bilateral tibial fractures associated with powered exoskeleton use in complete spinal cord injury – a case report & literature review","authors":"John Mahon, Lily Nolan, David O’Sullivan, Mark Curtin, Aiden Devitt, Colin G. Murphy","doi":"10.1038/s41394-024-00635-4","DOIUrl":"https://doi.org/10.1038/s41394-024-00635-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Powered robotic exoskeleton (PRE) physiotherapy programmes are a relatively novel frontier which allow patients with reduced mobility to engage in supported walking. Research is ongoing regarding their utility, risks, and benefits. This article describes the case of two fractures occurring in one patient using a PRE.</p><h3 data-test=\"abstract-sub-heading\">Case</h3><p>We report the case of a 54 year old man who sustained bilateral tibial fractures while using a PRE, on a background of T10 AIS A SCI. The initial session was discontinued due to acute severe bilateral knee swelling after approximately 15 min. The patient attended their local hospital the following day, where radiographs demonstrated bilateral proximal tibial fractures. The patient was treated with manipulation under anaesthetic and long-leg casting for five weeks, at which point he was stepped down to hinged knee braces which were weaned gradually while he remained non-weight bearing for 12 weeks. The patient was investigated with DEXA scan and was diagnosed with osteoporosis. He was liaised with rheumatology services and bone protection was initiated. Fracture healing was achieved and weight-bearing precautions were discontinued, however this period of immobilisation led to significant spasticity. The patient was discharged from orthopaedic services, with ongoing rehabilitation and physiotherapy follow-up.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>PRE assisted physiotherapy programmes are a promising concept in terms of rehabilitation and independence, however they are not without risk and it is important that both providers and patients are aware of this. Furthermore, SCI patients are at increased risk for osteoporosis and should be monitored and considered for bone protection.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"173 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140610296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute spinal cord injury serum biomarkers in human and rat: a scoping systematic review 人类和大鼠急性脊髓损伤血清生物标志物:范围界定系统综述
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-04-13 DOI: 10.1038/s41394-024-00636-3
Sina Shool, Saeed Rahmani, Mohammad Amin Habibi, Seyed Mohammad Piri, Mahmoud Lotfinia, Delara Jashnani, Sina Asaadi
{"title":"Acute spinal cord injury serum biomarkers in human and rat: a scoping systematic review","authors":"Sina Shool, Saeed Rahmani, Mohammad Amin Habibi, Seyed Mohammad Piri, Mahmoud Lotfinia, Delara Jashnani, Sina Asaadi","doi":"10.1038/s41394-024-00636-3","DOIUrl":"https://doi.org/10.1038/s41394-024-00636-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Scoping systematic review.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To summarize the available experimental clinical and animal studies for the identification of all CSF and serum-derived biochemical markers in human and rat SCI models.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Tehran, Iran.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this scoping article, we systematically reviewed the electronic databases of PubMed, Scopus, WOS, and CENTRAL to retrieve current literature assessing the levels of different biomarkers in human and rat SCI models.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 19,589 articles were retrieved and 6897 duplicated titles were removed. The remaining 12,692 studies were screened by their title/abstract and 12,636 were removed. The remaining 56 were considered for full-text assessment, and 11 papers did not meet the criteria, and finally, 45 studies were included. 26 studies were human observational studies comprising 1630 patients, and 19 articles studied SCI models in rats, including 832 rats. Upon reviewing the literature, we encountered a remarkable heterogeneity in terms of selected biomarkers, timing, and method of measurement, studied models, extent, and mechanism of injury as well as outcome assessment measures.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The specific expression and distribution patterns of biomarkers in relation to spinal cord injury (SCI) phases, and their varied concentrations over time, suggest that cerebrospinal fluid (CSF) and blood biomarkers are effective measures for assessing the severity of SCI.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"100 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140601644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trend differences in cervical spinal cord injuries before and after the coronavirus disease 2019 pandemic 2019 年冠状病毒病大流行前后颈椎脊髓损伤的趋势差异
IF 1.2
Spinal Cord Series and Cases Pub Date : 2024-04-10 DOI: 10.1038/s41394-024-00633-6
Hirotaka Fukushima, Chikara Ushiku, Shoshi Akiyama, Shinji Saito, Hiroki Wakiya, Kenji Okuno, Mitsuru Saito
{"title":"Trend differences in cervical spinal cord injuries before and after the coronavirus disease 2019 pandemic","authors":"Hirotaka Fukushima, Chikara Ushiku, Shoshi Akiyama, Shinji Saito, Hiroki Wakiya, Kenji Okuno, Mitsuru Saito","doi":"10.1038/s41394-024-00633-6","DOIUrl":"https://doi.org/10.1038/s41394-024-00633-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Study design</h3><p>Cross-Sectional Study.</p><h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To investigate the changes in the characteristics of cervical spinal cord injuries (CSCI) before and after the coronavirus disease 2019 (COVID-19) pandemic among patients transported to our hospital in Japan.</p><h3 data-test=\"abstract-sub-heading\">Setting</h3><p>Hospital with an emergency center in Chiba, Japan.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Patients eligible for the study were those transported within 24 h of injury and diagnosed with cervical spinal cord injury between January 2018 and December 2021 at our hospital. Medical records were retrospectively examined to investigate the number and characteristics of patients with CSCI. The clinical variables of patients with CSCI were compared according to the time of admission as related to the COVID-19 pandemic: 2018-19 (before) or 2020-21 (after).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The total number of patients with CSCI from 2018 to 2021 was 108, with 57 before the COVID-19 pandemic and 51 after the COVID-19 pandemic. The number of severe cases with an injury severity score (ISS) of &gt;16 decreased after COVID-19 (<i>p</i> &lt; 0.05). Falls on level surfaces were the most common cause of injury both before and after COVID-19. Although the ranking of traffic accidents decreased after COVID-19, among those, the number of bicycle injuries tended to increase.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The number of serious cases with an ISS &gt; 16 decreased, presumably because of the decline in high-energy trauma due to the background decrease in the number of traffic accidents.</p>","PeriodicalId":22079,"journal":{"name":"Spinal Cord Series and Cases","volume":"300 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140601639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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