Acute spinal cord injury serum biomarkers in human and rat: a scoping systematic review

IF 0.7 Q4 CLINICAL NEUROLOGY

Spinal Cord Series and Cases Pub Date : 2024-04-13 DOI:10.1038/s41394-024-00636-3

Sina Shool, Saeed Rahmani, Mohammad Amin Habibi, Seyed Mohammad Piri, Mahmoud Lotfinia, Delara Jashnani, Sina Asaadi

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Abstract

Study design

Scoping systematic review.

Objectives

To summarize the available experimental clinical and animal studies for the identification of all CSF and serum-derived biochemical markers in human and rat SCI models.

Setting

Tehran, Iran.

Methods

In this scoping article, we systematically reviewed the electronic databases of PubMed, Scopus, WOS, and CENTRAL to retrieve current literature assessing the levels of different biomarkers in human and rat SCI models.

Results

A total of 19,589 articles were retrieved and 6897 duplicated titles were removed. The remaining 12,692 studies were screened by their title/abstract and 12,636 were removed. The remaining 56 were considered for full-text assessment, and 11 papers did not meet the criteria, and finally, 45 studies were included. 26 studies were human observational studies comprising 1630 patients, and 19 articles studied SCI models in rats, including 832 rats. Upon reviewing the literature, we encountered a remarkable heterogeneity in terms of selected biomarkers, timing, and method of measurement, studied models, extent, and mechanism of injury as well as outcome assessment measures.

Conclusions

The specific expression and distribution patterns of biomarkers in relation to spinal cord injury (SCI) phases, and their varied concentrations over time, suggest that cerebrospinal fluid (CSF) and blood biomarkers are effective measures for assessing the severity of SCI.

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人类和大鼠急性脊髓损伤血清生物标志物：范围界定系统综述

研究设计范围界定的系统性综述。目的总结现有的临床和动物实验研究，以确定人类和大鼠 SCI 模型中所有 CSF 和血清衍生生化标志物。方法在这篇范围界定的文章中，我们系统性地查阅了 PubMed、Scopus、WOS 和 CENTRAL 等电子数据库，以检索评估人类和大鼠 SCI 模型中不同生物标志物水平的现有文献。结果共检索到 19589 篇文章，删除了 6897 个重复的标题。根据标题/摘要筛选了剩余的 12,692 篇研究，删除了 12,636 篇。对剩余的 56 篇文章进行了全文评估，有 11 篇文章不符合标准，最终有 45 项研究被纳入其中。其中 26 项研究为人类观察性研究，包括 1630 名患者；19 篇文章研究了大鼠 SCI 模型，包括 832 只大鼠。结论生物标志物在脊髓损伤（SCI）阶段的特异性表达和分布模式以及随时间变化的浓度表明，脑脊液（CSF）和血液中的生物标志物是评估 SCI 严重程度的有效指标。

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来源期刊

Spinal Cord Series and Cases Medicine-Neurology (clinical)

CiteScore

2.20

自引率

8.30%

发文量