Translation: The University of Toledo Journal of Medical Sciences最新文献

{"title":"A prolonged presentation of cyclic vomiting syndrome in an adult","authors":"Audrey Ballard, MD Andrew Campbell","doi":"10.46570/utjms.vol11-2023-911","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-911","url":null,"abstract":". Cyclic","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"impact of libman-sacks endocarditis on inpatient outcomes of patients with systemic lupus erythematosus: A retrospective study","authors":"Halah Alfatlawi","doi":"10.46570/utjms.vol11-2023-948","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-948","url":null,"abstract":"","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"126 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treprostinil inhibits functional activation of scleroderma (SSc) vascular smooth muscle cells (vSMCs) by inhibiting Yap and activating PPARG signaling.","authors":"Yongqing Wang, B. Kahaleh","doi":"10.46570/utjms.vol11-2023-908","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-908","url":null,"abstract":"Background: \u0000Progressive vascular wall thickness and fibrosis are the hallmarks of SSc vasculopathy. Overexpression of TGFB1 in SSc and activation of vSMCs are important steps in the pathogenesis of SSc vascular disease. \u0000Objectives: \u0000 In this study, we examined the expression levels of COL1, PCNA, PFKP, IP, EP2, IP, and PTGIS in SSc skin, the effects of Treprostinil (prostacyclin analog) on cell proliferation, TGFB1-induced collagen expression in SSc-vSMCs, PPARG expression and Yap nuclear translocation. \u0000Methods: \u0000SSc and control skin biopsies were fixed and 10uM serial sections were cut for histological examination.  vSMCs were isolated from involved skin and matched healthy subjects. The expression and distribution of collagen, PCNA, PFKP, IP, EP2, PTGIS, PPARG, and Yap were measured by immunohistochemical staining or immunofluorescent staining. Cell proliferation was measured by MTT assay.  The mRNA expression levels were detected by qPCR. \u0000Results: \u0000The protein expression levels of collagen, PCNA, PFKP, and EP2 were increased, while the expression levels of PTGIS and IP were decreased in vSMCs of SSc-skin, compared to the control. These results suggested that defective PGI2-IP signaling in SSc-vSMCs may contribute to vessel wall thickness and vascular fibrosis in SSc. Treprostinil inhibited vSMCs proliferation, COL1A1, and PFKP mRNA expression in SSc-vSMCs in a dose-dependent fashion. Treprostinil also inhibited TGFB1-induced COL1A1 mRNA expression in SSc-vSMCs via engagement of EP2. The PPARG expression was significantly increased in treprostinil-treated SSc-vSMCs. Treprostinil decreased the nuclear location of YAP which is induced by 10%FBS and TGFB1. \u0000Conclusion: \u0000Defective PGI2-IP signaling in SSc-vSMCs is associated with enhanced expression of collagen, PCNA, and PFKP in SSc vessel walls. The antiproliferative and antifibrotic activity of treprostinil is mediated through the inhibition of YAP nuclear translocation and enhanced PPARG expression. YAP and PPARG might be promising therapeutic targets for the treatment of SSc-related vasculopathy.  ","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial Lung Disease with Autoimmune Features Successfully Treated with Mycophenolate Mofetil: Case Report","authors":"Sabrina Khuder, Samantha Davis, Nathan Gilbert, Nezam Altorok","doi":"10.46570/utjms.vol11-2023-934","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-934","url":null,"abstract":"of 30 (normal > 70%), forced vital capacity (FVC) of 67% of age predicted, and forced expiratory volume (FEV1) of 66% (normal between 70-80%). Initial CT scan performed demonstrated mediastinal lymph nodes with upper lobe fibrotic changes. His lung biopsy showed inflammation and evidence of non-specific ILD (NSIP). Laboratory results were positive for anti-nuclear antibodies (ANA) and elevated erythrocyte sedimentation rate (ESR) while negative for other immunological markers. The patient did not have any known occupational exposure. On physical exam, he had evidence of nail clubbing. The patient met criteria for diagnosis of interstitial lung disease with autoimmunity. He was started on treatment with 1000 mg of MMF twice daily as well as oral prednisone 2.5 mg daily. The patient was found at follow up appointments to be responding well to treatment.","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138997458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Bullous Systemic Lupus Erythematosus","authors":"Matthew Niedoba, S. Chinnam, Alborz Sherafati, Andrew Teletnick, Natalie Tuttle, Anu Garg","doi":"10.46570/utjms.vol11-2023-883","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-883","url":null,"abstract":"","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"151 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal microbiota transplant is associated with lower risk of mortality, hepatic encephalopathy, ascites, and infection patients with severe alcohol-associated hepatitis: A systematic review and meta-analysis","authors":"Zohaib Ahmed, Andrew Kelly, Joyce Badal, Wade Lee-Smith, M. Gangwani, Yaseen Alastal, Mona Hassan","doi":"10.46570/utjms.vol11-2023-922","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-922","url":null,"abstract":"","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"113 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138998470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficiency of melanocortin 5 receptor exacerbates proteinuria and podocytopathy after glomerular injury","authors":"Bohan Chen, Y. Ge, Lance Dworkin, R. Gong","doi":"10.46570/utjms.vol11-2023-842","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-842","url":null,"abstract":"Background: Converging evidence suggests that therapeutic targeting of nonsteroidogenic melanocortinergic pathways represents a novel strategy for treating proteinuric glomerulopathies. However, the type of melanocortin receptor (MCR) mediating this beneficial effect remains controversial and uncertain. MC5R is one such receptor that is expressed in glomerular cells. This study examined the possible effect of MC5R knockout (KO) in nephrotoxic serum (NTS)-elicited podocytopathy. Methods: NTS nephritis was induced in MC5R KO mice and wild-type (WT) littermates. Additional WT mice received treatment with a highly selective MC5R agonist or vehicle before NTS injury. Proteinuria, podocyte injury and glomerular damage were evaluated. Results: Despite no discernible phenotype under physiological conditions, KO mice sustained exacerbated glomerulopathy early in the heterologous phase of NTS nephritis, as shown by heavier albuminuria. This was associated with worsened glomerular pathology, which was characterized by glomerular hypercellularity, swelling of glomerular endothelial cells, and fibrinoid necrosis","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"49 217","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perihepatic abscess secondary to Sphingobacterium spiritivorum","authors":"Victoria Soewarna, Kada Williams, Salman Arif, Hend Elsaghir","doi":"10.46570/utjms.vol11-2023-875","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-875","url":null,"abstract":"","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"95 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Silent Constrictor: A Case Report of Takayasu Arteritis Manifesting as a Vascular Enigma","authors":"Vanessa Pasadyn, BA, Samantha Davis, MD, Rawish Fatima, MD, Nezam Altorok, MD","doi":"10.46570/utjms.vol11-2023-889","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-889","url":null,"abstract":"Introduction \u0000Takayasu arteritis (TKA) is a rare large vessel vasculitis, most prevalent in Asia and affecting females ages 10-40 years. Through unclear etiology, it triggers chronic granulomatous inflammation leading to vessel wall thickening, stenosis, and occlusion. Manifestations vary from mild malaise to severe ischemic complications. Diagnosis hinges on clinical criteria, including angiography, and exclusion of mimicking conditions like giant cell arteritis, fibromuscular dysplasia, or atherosclerosis. Treatment necessitates immunosuppression and anti-inflammatories to curb disease progression and limit complications. \u0000Case Presentation \u0000A 61-year-old Caucasian female presented with claudication of the upper extremities upon using the shower. She reported episodes of headache, myalgia, fever and chills of several months. She reported fatigue with overhead reaching and difficulty finding her pulse on her upper extremities. Labs were notable for elevated ESR and CRP. MRA chest showed smoky thickened appearance of the descending aorta wall, some missing wall thickening in origins of the left common carotid and left subclavian arteries. PET scan revealed diffuse hypermetabolic activity involving the bilateral common carotid arteries, peripheral aortic arch and descending thoracic aorta (Figure 1). With these ongoing symptoms and characteristic features on imaging, we established the diagnosis of TKA. She was started on 5mg oral prednisone daily and methotrexate 10mg weekly with daily folic acid. \u0000Conclusion \u0000This case highlights the diagnosis and treatment of a rare condition, Takayasu arteritis, the pulseless disease. TKA is a challenging condition to study and understand fully, but advancements in medical knowledge, imaging, and management are gradually improving our understanding and ability to diagnose and treat this condition. With increased awareness of this condition, earlier detection and monitoring will serve to benefit future patient populations.","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"113 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138999536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"effects of MC4R activation on behavioral activity in mice","authors":"Joseph Dale, Mitchell Haberson, Jennifer W. Hill","doi":"10.46570/utjms.vol11-2023-1152","DOIUrl":"https://doi.org/10.46570/utjms.vol11-2023-1152","url":null,"abstract":" \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 ","PeriodicalId":220681,"journal":{"name":"Translation: The University of Toledo Journal of Medical Sciences","volume":"36 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139000114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}