Interstitial Lung Disease with Autoimmune Features Successfully Treated with Mycophenolate Mofetil: Case Report

Abstract

of 30 (normal > 70%), forced vital capacity (FVC) of 67% of age predicted, and forced expiratory volume (FEV1) of 66% (normal between 70-80%). Initial CT scan performed demonstrated mediastinal lymph nodes with upper lobe fibrotic changes. His lung biopsy showed inflammation and evidence of non-specific ILD (NSIP). Laboratory results were positive for anti-nuclear antibodies (ANA) and elevated erythrocyte sedimentation rate (ESR) while negative for other immunological markers. The patient did not have any known occupational exposure. On physical exam, he had evidence of nail clubbing. The patient met criteria for diagnosis of interstitial lung disease with autoimmunity. He was started on treatment with 1000 mg of MMF twice daily as well as oral prednisone 2.5 mg daily. The patient was found at follow up appointments to be responding well to treatment.