Stroke最新文献

{"title":"Impact of Direct Transfer to Angiography Suite on Treatment Time Metrics in Patients With Acute Intracerebral Hemorrhage.","authors":"David Rodriguez-Luna, Olalla Pancorbo, Manuel Requena, Renato Simonetti, Marc Rodrigo-Gisbert, Federica Rizzo, Marta Olivé-Gadea, Álvaro García-Tornel, Noelia Rodriguez-Villatoro, Marián Muchada, Jorge Pagola, Marta Rubiera, Alejandro Tomasello, Carlos A Molina, Marc Ribo","doi":"10.1161/STROKEAHA.124.050209","DOIUrl":"10.1161/STROKEAHA.124.050209","url":null,"abstract":"<p><strong>Background: </strong>Shorter times to initiate antihypertensive and anticoagulation reversal treatments enhance their benefits in acute intracerebral hemorrhage (ICH). Improving workflows to optimize time performance metrics is strongly advocated. We aimed to evaluate the impact of direct transfer to angiography suite (DTAS) on time metrics for antihypertensive and anticoagulation reversal treatments in patients with stroke with suspected large vessel occlusion whose final diagnosis was ICH.</p><p><strong>Methods: </strong>We conducted a single-center, retrospective, observational cohort study using prospectively collected data from patients with ICH <6 hours directly arriving at a Comprehensive Stroke Center in Barcelona, Spain, from March 1, 2016, to August 31, 2023. Patients suspected of acute stroke from large vessel occlusion (prehospital Rapid Arterial Occlusion Evaluation scale score >4 and in-hospital National Institutes of Health Stroke Scale score >10) followed either direct transfer to computed tomography (DTCT) or DTAS protocol based on angiosuite availability. We compared door-to-needle times for initiating antihypertensive (primary outcome) and anticoagulation reversal treatments between both workflows.</p><p><strong>Results: </strong>Among 220 patients with ICH (mean age, 73.0±13.6 years; 131 [59.5%] male), 199 (90.5%) followed the DTCT protocol and 21 (9.5%) followed the DTAS protocol. Door-to-imaging time was shorter in the DTCT group than in the DTAS group (11 [7-17] versus 15 [12-20] minutes; <i>P</i>=0.013). Antihypertensive treatment was initiated in 168 (76.4%) patients, with the DTCT group having shorter door-to-needle times (20 [15-26] versus 30 [18-40] minutes; <i>P</i>=0.002). The anticoagulation reversal was administered to 34 (87.2%) of 39 anticoagulated patients, with the DTCT group achieving shorter door-to-needle times (28 [22-38] versus 58 [39-78] minutes; <i>P</i>=0.047). Time-to-event analysis showed that the DTCT group had a higher probability of initiating antihypertensive (<i>P</i>=0.001) and anticoagulation reversal (<i>P</i>=0.014) treatments sooner compared with the DTSA group.</p><p><strong>Conclusions: </strong>Patients with ICH following the DTAS workflow, without tailored actions, present longer door-to-needle times to initiate antihypertensive and anticoagulation reversal treatments compared with those following the DTCT workflow protocol.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"1581-1586"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Stroke Prediction by Applying a Stroke Polygenic Risk Score in the Japanese Population.","authors":"Naoki Kojima, Masaru Koido, Yunye He, Yuka Shimmori, Tsuyoshi Hachiya, Stéphanie Debette, Yoichiro Kamatani","doi":"10.1161/STROKEAHA.124.047786","DOIUrl":"10.1161/STROKEAHA.124.047786","url":null,"abstract":"<p><strong>Background: </strong>Recently, various polygenic risk score (PRS)-based methods were developed to improve stroke prediction. However, current PRSs (including cross-ancestry PRS) poorly predict recurrent stroke. Here, we aimed to determine whether the best PRS for Japanese individuals can also predict stroke recurrence in this population by extensively comparing the methods and maximizing the predictive performance for stroke onset.</p><p><strong>Methods: </strong>We used data from the disease-oriented BBJ1 (BioBank Japan first cohort; recruited between 2003 and 2007, n=179 938) to derive and optimize the PRSs using a 10-fold cross-validation. We integrated the optimized PRSs for multiple traits, such as vascular risk factors and stroke subtypes to generate a single PRS using the meta-scoring approach (metaGRS). We used an independent BBJ2 (BBJ second cohort; recruited between 2012 and 2017, n=41 929) as a test sample to evaluate the association of the metaGRS with stroke and recurrent stroke. In addition, we analyzed its association stratified by risk factors. We administered 3 distinct tests to consider the potential index event bias.</p><p><strong>Results: </strong>We analyzed recurrent stroke cases (n=174) and nonrecurrent stroke controls (n=1153) among subjects within the BBJ2. After adjusting for known risk factors, metaGRS was associated with stroke recurrence (adjusted odds ratio per SD, 1.18 [95% CI, 1.00-1.39]; <i>P</i>=0.044), although no significant correlation was observed with the published PRSs. The outcomes derived from these examinations did not provide any significant indication of the influence of index event bias. The high metaGRS group without a history of hypertension had a higher risk of stroke recurrence than that of the low metaGRS group (adjusted odds ratio, 2.24 [95% CI, 1.07-4.66]; <i>P</i>=0.032). There was no association at all in the hypertension group (adjusted odds ratio, 1.21 [95% CI, 0.69-2.13]; <i>P</i>=0.50).</p><p><strong>Conclusions: </strong>The metaGRS developed in a Japanese cohort predicted stroke recurrence in an independent cohort of patients. In particular, it predicted an increased risk of recurrence among stroke patients without hypertension. These findings provide clues for additional genetic risk stratification and help in developing personalized strategies for stroke recurrence prevention.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"1483-1491"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Modifiable Risk Factors in Young-Onset Cryptogenic Ischemic Stroke by High-Risk Patent Foramen Ovale.","authors":"Jukka Putaala, Nicolas Martinez-Majander, Michelle Leppert, Lauri Tulkki, Jani Pirinen, Heli Tolppanen, Tomi Sarkanen, Marko Virtanen, Nina Jaakonmäki, Pekka Jäkälä, Marja Hedman, Petra Redfors, Odd Bech-Hanssen, Ulla Junttola, Juha Huhtakangas, Pauli Ylikotila, Riikka Lautamäki, Ulf Schminke, Bettina von Sarnowski, Raila Busch, Nilüfer Yesilot, Mine Sezgin, Ulrike Waje-Andreassen, Sahrai Saeed, Ana Catarina Fonseca, André Paula, Laura Amaya Pascasio, Patricia Martínez-Sánchez, Janika Kõrv, Piibe Muda, Phillip Ferdinand, Cheryl Oxley, Diana Zakarkaitė, Kristina Ryliškienė, Alessandro Pezzini, Carlo Mario Lombardi, Radim Líčeník, Marialuisa Zedde, Teresa Grimaldi, Georgios Tsivgoulis, Juha Sinisalo, Eva Gerdts, Turgut Tatlisumak","doi":"10.1161/STROKEAHA.124.049855","DOIUrl":"10.1161/STROKEAHA.124.049855","url":null,"abstract":"<p><strong>Background: </strong>The incidence of young-onset ischemic stroke is rising, driven by cryptogenic ischemic stroke (CIS) and patients without vascular risk factors. This study examines the burden and associations of modifiable traditional, nontraditional, and female sex-specific risk factors with young-onset CIS, stratified by clinically relevant patent foramen ovale (PFO), defined by high-risk features of atrial septal aneurysm or large right-to-left shunt.</p><p><strong>Methods: </strong>We enrolled consecutive patients aged 18 to 49 years with recent CIS and frequency-matched stroke-free controls of the same age and sex from 19 European sites. Logistic regression assessed the association of risk factor counts (12 traditional, 10 nontraditional, 5 female sex-specific) and individual risk factors, stratified by PFO. Analyses were stratified by sex and age (18-39 and 40-49 years), with computation of population-attributable risk.</p><p><strong>Results: </strong>We included 523 patients (median age, 41 years; 47.3% women; 196 [37.5%] with PFO) and 523 controls. In patients with CIS without PFO, each additional traditional (odds ratio, 1.417 [95% CI, 1.282-1.568]), nontraditional (odds ratio, 1.702 [95% CI, 1.338-2.164]), and female sex-specific risk factor (odds ratio, 1.700 [95% CI, 1.107.1-2.611]) increased CIS risk. For patients with CIS with PFO, each traditional risk factor increased the risk (odds ratio, 1.185 [1.057-1.328]), but only nontraditional risk factors remained significant when fully adjusted (odds ratio, 2.656 [2.036-3.464]). Population-attributable risks for CIS without PFO were 64.7%, 26.5%, and 18.9% for traditional, nontraditional, and female sex-specific risk factors. For CIS with PFO, population-attributable risks were 33.8%, 49.4%, and 21.8%, respectively. Migraine with aura was the most significant contributor, with population-attributable risks of 45.8% for CIS with PFO and 22.7% for CIS without PFO, showing a stronger impact in women.</p><p><strong>Conclusions: </strong>Despite the initial cryptogenic label of these strokes, traditional risk factors significantly contribute to CIS without PFO, while nontraditional factors seem more critical for CIS with PFO. Migraine with aura plays a prominent role in young-onset CIS development, particularly in women.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT01934725.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"1428-1440"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Epidemiology, Outcomes, and Population Science in 2024.","authors":"Rebecca F Gottesman, Graeme J Hankey","doi":"10.1161/STROKEAHA.125.049886","DOIUrl":"https://doi.org/10.1161/STROKEAHA.125.049886","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":"56 6","pages":"1596-1599"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indirect Effects of Operating a Mobile Stroke Treatment Unit.","authors":"Nicolle W Davis, Teng J Peng, David Lykens, Andrea Corwine, Shelley Young, Rebekah Webb, Neha Saini, Christina A Wilson, Amita Singh, Anna Khanna","doi":"10.1161/STROKEAHA.125.051445","DOIUrl":"https://doi.org/10.1161/STROKEAHA.125.051445","url":null,"abstract":"<p><p>Mobile stroke units, also referred to as mobile stroke treatment units, have revolutionized acute stroke care by reducing thrombolysis and mechanical thrombectomy times, resulting in positive patient outcomes. These direct benefits of mobile stroke treatment units have been well documented in the literature. Yet, despite these demonstrated benefits, mobile stroke treatment unit programs are often perceived as a costly financial burden to establish. However, when implemented effectively, Mobile stroke programs can yield indirect societal and institutional benefits. We highlight the indirect effects and factors that are less commonly reported when operating a mobile stroke program, including aiding local emergency medical services, improving emergency department stroke care and throughput, optimizing hospital resource utilization, and extending community education and outreach initiatives.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":"56 6","pages":"1646-1649"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"June 2025 <i>Stroke</i> Highlights.","authors":"Nicole B Sur","doi":"10.1161/STROKEAHA.125.051914","DOIUrl":"https://doi.org/10.1161/STROKEAHA.125.051914","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":"56 6","pages":"1365"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Lp(a) With Stroke and Cerebral Injury on MRI: Insights From the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) and Investigation of Neurocognitive Aging MRI (SOL-INCA MRI).","authors":"Akhil Avunoori Chandra, Priscilla Duran Luciano, Katrina Swett, Robert Kaplan, Gregory A Talavera, Melissa Lamar, Wassim Tarraf, Freddie Marquez, Parag H Joshi, Linda Gallo, Daniela Sotres-Alvarez, Morgan Gianola, Martha L Daviglus, Daniel L Labovitz, Hector Gonzalez, Charles DeCarli, Carlos J Rodriguez","doi":"10.1161/STROKEAHA.124.048439","DOIUrl":"10.1161/STROKEAHA.124.048439","url":null,"abstract":"<p><strong>Background: </strong>Lp(a) (lipoprotein[a]) is a risk factor for cardiovascular disease; however, its association with cerebrovascular disease is not as well established.</p><p><strong>Methods: </strong>Data from a population-based cohort of Hispanics/Latinos included 16 333 individuals with baseline Lp(a) levels (nmol/L) and self-reported prevalent stroke or transient ischemic attack (TIA). A subset of 2642 individuals with brain magnetic resonance imaging was also included. Linear and multivariate logistic regression assessed the association of Lp(a) with (1) self-reported stroke or TIA, (2) cerebral injury defined as self-reported stroke or TIA or evidence of a stroke on brain magnetic resonance imaging, (3) white matter hyperintensity volume, and (4) silent brain infarcts. Sampling weights were utilized given the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) complex sample design.</p><p><strong>Results: </strong>Mean age±SE was 41.1±0.3 years, 52.0% women, and median interquartile range (Q₁, Q₃) Lp(a) level of 19.7 (7.3-60.6) nmol/L; brain magnetic resonance imaging subset mean age±SE was 49.9±0.4 years, 56.4% women, and median (interquartile range) Lp(a) level of 21.7 (8.1-62.9) nmol/L. Each unit increase in log-transformed Lp(a) was associated with higher odds of self-reported stroke or TIA (odds ratio, 1.13 [95% CI, 1.01-1.27]; <i>P</i>=0.03). Lp(a) levels in the highest quintile (>77 nmol/L) were significantly associated with higher odds of prevalent stroke or TIA compared with Lp(a) <6 nmol/L (first quintile: odds ratio, 1.74 [95% CI, 1.09-2.77]; <i>P</i>=0.02). The highest proportion of cerebral injury was noted in Q5, while the lowest proportion was noted in Q2. When comparing Lp(a) >77 nmol/L with Lp(a) of 6 to <13 nmol/L (second quintile), a significant association was found between Lp(a) and cerebral injury that persisted after fully adjusted models (odds ratio, 2.03 [95% CI, 1.05-3.93]; <i>P</i>=0.03). Each unit increase in log-Lp(a) was associated with a 0.10 increase in log-white matter hyperintensity (β, 0.10; <i>P</i>=0.005). No significant association was found between Lp(a) and silent brain infarcts.</p><p><strong>Conclusions: </strong>Lp(a) is independently and significantly associated with prevalent stroke/TIA, and white matter hyperintensity, in a large diverse population of Hispanics/Latinos.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"1492-1504"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke Prevention.","authors":"Iyas Daghlas, Ville Karhunen, Anthony S Kim, Dipender Gill","doi":"10.1161/STROKEAHA.124.049808","DOIUrl":"10.1161/STROKEAHA.124.049808","url":null,"abstract":"<p><strong>Background: </strong>While interindividual variations in concentration and function of coagulation cascade proteins are established risk factors for venous thromboembolism (VTE), their associations with arterial ischemic stroke are less well defined.</p><p><strong>Methods: </strong>We identified and validated genetic proxies for lifelong, randomized perturbations of coagulation cascade proteins in genome-wide association studies of circulating protein levels (deCODE, n=35 559; UK Biobank, n=46 218) and of VTE risk (81 190 cases and 1 419 671 controls). Study participants were all of European ancestry. We performed 2-sample Mendelian randomization and colocalization analyses to test associations of these genetic proxies with risk of ischemic stroke (62 100 cases and 1 234 808 controls from the GIGASTROKE consortium) and ischemic stroke subtypes, and further contextualized associations with VTE and secondary efficacy and safety outcomes.</p><p><strong>Results: </strong>We identified genetic proxies for 30 coagulation factors, with cross-trait associations recapitulating canonical coagulation biology. Mendelian randomization and colocalization analyses supported causal associations of genetically proxied levels of 5 proteins with risk of ischemic stroke, with all proteins associating with the cardioembolic stroke subtype: factor XI (odds ratio [OR] of cardioembolic stroke per 1-SD increase, 1.31 [95% CI, 1.19-1.44]; <i>P</i>=3.30×10^-8), high-molecular-weight kininogen (OR, 1.19 [95% CI, 1.09-1.30]; <i>P</i>=7.79×10^-5), prothrombin (OR, 1.83 [95% CI, 1.31-2.57]; <i>P</i>=4.20×10^-4), soluble PROCR (protein C receptor; OR, 0.88 [95% CI, 0.82-0.95]; <i>P</i>=6.19×10^-4), and γ' fibrinogen (OR per doubling in VTE risk due to lower γ' fibrinogen levels, 1.44 [95% CI, 1.25-1.66]; <i>P</i>=3.96×10^-7). γ' Fibrinogen and prothrombin also associated with large artery atherosclerotic stroke, and no proteins were associated with small vessel stroke risk. By contrast, genetic proxies for several coagulation factors (including proteins C and S and factors V and VII) showed selective associations with VTE.</p><p><strong>Conclusions: </strong>These data highlight specific coagulation cascade components implicated in ischemic stroke pathogenesis, while identifying proteins with distinct roles in VTE. These findings may inform development of novel anticoagulants and optimize their use in targeted populations with stroke.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"1542-1553"},"PeriodicalIF":7.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Feasibility of PETS-Stroke: A Patient-Reported Measure of Treatment Burden After Stroke.","authors":"Martin Taylor-Rowan, David T Eton, Hamish J McLeod, Jala Rizeq, Lisa Kidd, Grace Currie, Terry J Quinn, Frances S Mair, Katie I Gallacher","doi":"10.1161/STROKEAHA.125.051398","DOIUrl":"https://doi.org/10.1161/STROKEAHA.125.051398","url":null,"abstract":"<p><strong>Background: </strong>Treatment burden is the workload of health care for people with long-term conditions and the impact on wellbeing. A validated measure of treatment burden for use as an outcome measure in stroke trials is needed. We adapted a patient-reported measure of treatment burden in multimorbidity, Patient Experience With Treatment and Self-Management (PETS), version 2.0, to create a stroke-specific measure, PETS-stroke, and examined its psychometric properties.</p><p><strong>Methods: </strong>We conducted an observational cohort study. Stroke and transient ischemic attack survivors were recruited between February 2022 to June 2023 from 10 hospitals in the United Kingdom and through the Scottish Health Research Register. Participants completed the PETS-stroke questionnaire along with 3 other patient-reported measures (the Stroke Southampton Self-Management Questionnaire, the Satisfaction With Stroke Care Measure, and the Shortened Stroke Impact Scale). We performed confirmatory factor analysis to test the factor structure of the PETS-stroke. We assessed Spearman rank correlations between PETS-stroke and other patient-reported measures to determine convergent validity. An intraclass correlation coefficient was performed to assess test-retest reliability. Proportions of missing data along with feedback from qualitative interviews were used to determine feasibility. T-tests were conducted to examine variations in PETS-stroke scores based on multimorbidity and socioeconomic factors.</p><p><strong>Results: </strong>Three hundred eighty-one participants were included (mean age, 68.2 [SD, 11.2] years; female, 43.3%). The best fit was achieved with a 9-factor structure, and internal consistency was good (Omega values, 0.729-0.921). The factor loadings for the individual indicator items across 8 of the 9 domains were moderate to strong. All domains of PETS-stroke showed moderate to strong correlations with at least one other patient-reported measure. Test-retest reliability was good for all domains (intraclass correlation coefficient >0.7). Qualitative feedback on feasibility was positive: participants found the questionnaire to be easy and quick to complete, and missing data were within acceptable limits for 7 domains. PETS-stroke scores significantly differed based on multimorbidity in 3 domains and in 8 domains based on socioeconomic status.</p><p><strong>Conclusions: </strong>Psychometric performance suggests that PETS-stroke is a valid and feasible measure of treatment burden after stroke.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid Presence in Acute Ischemic Stroke Thrombi: Observational Evidence for Fibrinolytic Resistance.","authors":"Justine M Grixti, Arun Chandran, Jan-Hendrik Pretorius, Melanie Walker, Alakendu Sekhar, Etheresia Pretorius, Douglas B Kell","doi":"10.1161/STROKEAHA.124.050033","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.050033","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}