Stroke最新文献

{"title":"Anti-Inflammatory Thrombolytic JX10 (TMS-007) in Late Presentation of Acute Ischemic Stroke.","authors":"Kuniyasu Niizuma, Naoko Nishimura, Keiko Hasegawa, Takashi Moritoyo, Kohsuke Kudo, Josh Bell, Michael Wald, Yoshifumi Umeda, Kazuhiko Kuribayashi, Yasuo Toda, Teiji Tominaga, Keiji Hasumi","doi":"10.1161/STROKEAHA.124.048464","DOIUrl":"10.1161/STROKEAHA.124.048464","url":null,"abstract":"<p><strong>Background: </strong>Contemporary thrombolytics in acute ischemic stroke are limited to administration within 4.5 hours of last known normal. JX10 (formerly TMS-007), a <i>Stachybotrys microspora</i> triprenyl phenol family member, may extend this therapeutic window.</p><p><strong>Methods: </strong>In this multicenter, randomized, double-blind, placebo-controlled, dose-escalation phase 2a study, JX10 or placebo was administered as a single intravenous infusion to Japanese patients with acute ischemic stroke who were unable to receive tissue-type plasminogen activator or thrombectomy within 12 hours of last known normal. Primary end point was incidence of symptomatic intracranial hemorrhage with a worsening National Institutes of Health Stroke Scale score of ≥4 points within 24 hours of drug administration (symptomatic intracranial hemorrhage incidence).</p><p><strong>Results: </strong>Ninety patients received either placebo (n=38; female 26.3%) or JX10 at 1, 3, or 6 mg/kg (n=6, 18, 28; female 0%, 33.3%, and 42.9%, respectively). Median age (range) and baseline median (range) National Institutes of Health Stroke Scale scores were respectively 76.5 (42-87) and 8 (6-21) for the combined JX10 cohort (JX10 Cohorts) and 75.0 (34-85) and 8 (6-22) for placebo. Median (range) dosing time since last known normal was 9.5 (5.0-12.1) and 10.0 (3.7-12.0) hours for JX10 Cohorts and placebo, respectively. Symptomatic intracranial hemorrhage incidence was 0% (0/52 [95% CI, 0.0-5.6]) for JX10 Cohorts versus 2.6% (1/38 [95% CI, 0.1-13.8]) for placebo (<i>P</i>=0.42). Vessel patency at 24 hours (secondary end point) in patients with baseline arterial occlusive lesion score <3 (39/90) improved in 58.3% (14/24) of patients in JX10 Cohorts versus 26.7% (4/15) for placebo (odds ratio, 4.23 [95% CI, 0.99-18.07]). In JX10 Cohorts, a significantly higher proportion of patients had modified Rankin Scale scores of 0 to 1 on day 90 (secondary end point) versus placebo (JX10: 21/52, 40.4% versus placebo: 7/38, 18.4%; <i>P</i>=0.03).</p><p><strong>Conclusions: </strong>JX10 was well tolerated and may expand the acute ischemic stroke therapeutic window as a novel thrombolytic agent.</p><p><strong>Registration: </strong>URL: https://rctportal.niph.go.jp/en; Unique identifier: jRCT2080223786.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"2786-2794"},"PeriodicalIF":7.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11593998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"December 2024 <i>Stroke</i> Highlights.","authors":"Nicole B Sur","doi":"10.1161/STROKEAHA.124.049782","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.049782","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":"55 12","pages":"2773"},"PeriodicalIF":7.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Testing for Monogenic Stroke.","authors":"S Pamela Herrada, N Abimbola Sunmonu, James F Meschia, Bradford B Worrall, Carol L Greene, Steven J Kittner","doi":"10.1161/STROKEAHA.124.047435","DOIUrl":"10.1161/STROKEAHA.124.047435","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"2946-2955"},"PeriodicalIF":7.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Localization Microscopy for the Assessment of Microvascular Circulation in Ischemic Perinatal Stroke.","authors":"Adrian P Regensburger, Felix Wachter, Louise Denis, Henriette Mandelbaum, Frauke Schey, Adrian Buehler, Gregor Siebenlist, Simone Schwarz, Susanne Schulz-Heise, Oliver Rompel, Regina Trollmann, Joachim Woelfle, Jörg Jüngert, Olivier Couture, Heiko Reutter, Gregor Hanslik, Ferdinand Knieling","doi":"10.1161/STROKEAHA.124.048390","DOIUrl":"10.1161/STROKEAHA.124.048390","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"e323-e325"},"PeriodicalIF":7.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11593985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic Risk of Epilepsy and Poststroke Epilepsy.","authors":"Santiago Clocchiatti-Tuozzo, Cyprien A Rivier, Shubham Misra, Johan Zelano, Rajarshi Mazumder, Lauren H Sansing, Adam de Havenon, Lawrence J Hirsch, David S Liebeskind, Emily J Gilmore, Kevin N Sheth, Jennifer A Kim, Bradford B Worrall, Guido J Falcone, Nishant K Mishra","doi":"10.1161/STROKEAHA.124.047459","DOIUrl":"10.1161/STROKEAHA.124.047459","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is highly heritable, with numerous known genetic risk loci. However, the genetic predisposition's role in poststroke epilepsy (PSE) remains understudied. This study assesses whether a higher genetic predisposition to epilepsy raises poststroke survivor's risk of PSE.</p><p><strong>Methods: </strong>We conducted a case-control genetic association study nested within the UK Biobank, a large UK-based prospective cohort. Our exposures of interest were 2 distinct polygenic risk scores-generalized and focal epilepsy-modeled as deciles and constructed using genetic variants identified in the latest International League Against Epilepsy genome-wide association study meta-analysis. We aimed to evaluate the association between these polygenic risk scores and their corresponding subtype of PSE-generalized and focal. In sensitivity analyses, we evaluated participants of European ancestry separately and considered focal and generalized epilepsy outcomes in participants without a history of stroke. In secondary analyses, we evaluated the polygenic risk of PSE by stroke subtype (ischemic, hemorrhagic, or any stroke). Multivariable logistic regression models were fitted, adjusting for age, sex, genetic ancestry, and the first 5 principal genetic components.</p><p><strong>Results: </strong>Among 17 549 UK Biobank stroke survivors with available genetic information (mean age, 61; 43% female), 185 (1%) developed generalized PSE, while 124 (0.7%) developed focal PSE. Multivariable logistic regression results showed that, when compared against the lowest decile, participants within the highest PRS decile for generalized PSE had 5-fold higher odds of developing generalized PSE (OR, 5.05 [95% CI, 2.37-12.5]; <i>P</i> trend<0.001). Similarly, when compared against the lowest decile, participants within the highest polygenic risk score decile for focal PSE had 3-fold higher odds of developing focal PSE (OR, 3.20; [5% CI, 1.25-9.82]; <i>P</i> trend=0.024). Sensitivity analyses among participants of European ancestry yielded similar results.</p><p><strong>Conclusions: </strong>Our findings suggest that, like other forms of epilepsy, genetic predisposition plays an essential role in PSE. These results underscore the need for future studies to elucidate the mechanisms underlying PSE development and to identify novel therapeutic avenues.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":"2835-2843"},"PeriodicalIF":7.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bedside Neuroimaging Using High-Density Diffuse Optical Tomography in a Pediatric Patient on Extracorporeal Support.","authors":"Sophia R McMorrow, Sung Min Park, Tessa G George, Chloe M Sobolewski, Dalin Yang, Kelsey T King, Jeanette Kenley, Christopher D Smyser, Joseph P Culver, Kristin P Guilliams, Ahmed S Said, Adam T Eggebrecht","doi":"10.1161/STROKEAHA.124.049116","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.049116","url":null,"abstract":"","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of a Dedicated Device for Cerebral Venous Thrombectomy: A Pilot Randomized Clinical Trial.","authors":"Yi Xu, Yan Wu, Miaowen Jiang, Baoying Song, Chuanhui Li, Chuanjie Wu, Jiangang Duan, Ran Meng, Chen Zhou, Sijie Li, Feng Yan, Jian Chen, Ming Li, Xunming Ji","doi":"10.1161/STROKEAHA.124.045607","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.045607","url":null,"abstract":"<p><strong>Background: </strong>Lack of a dedicated thrombectomy device for cerebral venous thrombosis hinders the recanalization ability of endovascular treatment (EVT). Novel NiTi-braided stent retriever (Venous-TD) is a dedicated venous sinus thrombectomy device. This study aims to demonstrate the safety and efficacy of Venous-TD.</p><p><strong>Methods: </strong>In this pilot, prospective, randomized, single-blind, parallel-group control, single-center clinical study, patients with cerebral venous thrombosis from Beijing Xuanwu Hospital were included. Randomization was performed to EVT with either the Venous-TD or Angioguard with Sterling balloon (control group). The primary efficacy outcome was the proportion of immediate complete recanalization during EVT. Secondary outcomes included the proportion of functional independence and moderate to severe residential headache at 180 days after EVT. Safety outcomes included peri-procedural complications, all-cause mortality, and symptomatic intracranial hemorrhage after EVT.</p><p><strong>Results: </strong>A total of 61 patients were enrolled and randomized. Thirty-one patients were randomized to the Venous-TD group, and 30 were randomized to the control group. The median (interquartile range) age was 28 (21-45) in the Venous-TD group and 34 (24-43) in the control group. The proportion of patients with a National Institutes of Health Stroke Scale score >8 on admission was 8 (25.8%) in the Venous-TD group and 11 (36.7%) in the control group. During EVT, Venous-TD significantly improved the proportion of complete recanalization compared with Angioguard (23 [76.7%] versus 6 [20.0%]; relative risk, 3.833 [95% CI, 1.825-8.054]). The proportions of long-term functional independence at 180 days in the Venous-TD group and the control group were not significantly different. The proportion of patients with severe residual headache at 180 days in the Venous-TD group was significantly lower than that in the control group (3 [9.7%] versus 10 [35.7%]; relative risk, 0.271 [95% CI, 0.083-0.886]). Safety outcomes showed no statistically significant difference between the 2 groups.</p><p><strong>Conclusions: </strong>This trial indicated that Venous-TD did not increase complications in EVT of cerebral venous thrombosis and can significantly increase the proportion of complete recanalization. A multicenter phase III randomized control trial assessing efficacy and safety of Venous-TD is warranted.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT05291585.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Insights on Truthfully Reporting \"Success Rates\" in Modern Stroke Research: A Cautionary Tale.","authors":"Santiago Ortega-Gutierrez, Marc Ribo","doi":"10.1161/STROKEAHA.124.048972","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.048972","url":null,"abstract":"<p><p>In 2015, several trials confirmed the safety and efficacy of mechanical thrombectomy for acute ischemic stroke. These findings revolutionized acute ischemic stroke treatment and established mechanical thrombectomy as a standard of care. Subsequent studies have further validated that optimal clinical outcomes are closely associated with achieving higher grades of complete reperfusion and minimizing the number of retrieval attempts. As a result, in recent years, the field has seen a growing trend of publications aggressively pursuing the highest rates of angiographic success. This trend is further exacerbated by the proliferation of impressive individual case reports shared on social media platforms, often devoid of significant scientific merit or educational value. We aim to review the potential biases in authors, which may incur when reporting recanalization rates, and underscore the importance of truthfully reporting success rates.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic Events May Trigger Acute Ischemic Stroke Within 30 Days in Those With Diabetes: A Case-Crossover Study.","authors":"Supriya Makam, Laura K Stein, Mandip S Dhamoon","doi":"10.1161/STROKEAHA.124.049178","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.049178","url":null,"abstract":"<p><strong>Background: </strong>Stroke triggers are factors that may precipitate a stroke within a given time interval and can predict the timing of a stroke. While hypoglycemia has been established as a risk factor for cardiovascular events such as acute ischemic stroke (AIS), there is limited research demonstrating hypoglycemic events as stroke triggers. We hypothesize an association between hypoglycemic events and the occurrence of stroke among patients with diabetes.</p><p><strong>Methods: </strong>We used Medicare inpatient, outpatient, emergency department, and subacute nursing facility data sets from January 1, 2016, to December 31, 2019, and validated using <i>International Classification of Diseases</i>, <i>Tenth Revision</i>, Clinical Modification codes to identify conditions. We used a case-crossover study design, testing whether exposure to a hypoglycemia encounter within progressively longer case periods (up to 30 days before index AIS) was associated with the subsequent occurrence of AIS, compared with control periods of equal length exactly 1 year before the case period. We used conditional logistical regression models to estimate odds ratios and 95% CIs.</p><p><strong>Results: </strong>There were 237 667 index admissions with AIS and diabetes during the study period. There were increased odds of AIS following an encounter with hypoglycemia. The risk was the highest immediately on the first day following the hypoglycemia encounter (odds ratio, 3.694 [95% CI, 2.694-5.065]; <i>P</i><0.0001) and gradually became lower as the case-control period lengthened. At a 30-day case-control interval, the risk was lowest but still significant (odds ratio, 2.345 [95% CI, 2.179-2.523]; <i>P</i><0.0001).</p><p><strong>Conclusions: </strong>We found that hypoglycemic events in patients with diabetes are associated with a more than 3-fold greater risk of AIS in the first day but can trigger AIS in the 30 days following the event. More research is needed to assess the link between the severity of hypoglycemia and stroke occurrence, as well as the severity of the stroke. These results, if confirmed in other studies, emphasize the importance of avoiding hypoglycemic events in patients with diabetes.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Adjunct Emergent Stenting Versus Mechanical Thrombectomy Alone: The RESCUE-ICAS Registry.","authors":"Sami Al Kasab, Eyad Almallouhi, Mouhammad A Jumaa, Violiza Inoa, Francesco Capasso, Michael I Nahhas, Robert M Starke, Isabel R Fragata, Matthew T Bender, Krisztina Moldovan, Shadi Yaghi, Ilko L Maier, Jonathan A Grossberg, Pascal M Jabbour, Marios-Nikos Psychogios, Edgar A Samaniego, Jan-Karl Burkhardt, Brian T Jankowitz, Mohamad Abdalkader, Ameer E Hassan, David J Altschul, Justin Mascitelli, Robert W Regenhardt, Stacey Q Wolfe, Mohamad Ezzeldin, Kaustubh Limaye, Ramesh Grandhi, Hossam Al-Jehani, Muhammad Niazi, Nitin Goyal, Stavropoula I Tjoumakaris, Ali M Alawieh, Ahmed Abdelsalam, Luis Guada, Nikolaos Ntoulias, Reem El-Ghawanmeh, Vivek Batra, Ashley Choi, Youssef M Zohdy, Sarah Nguyen, Muhammed Amir Essibayi, Kareem El Naamani, Andrew B Koo, Mohammed A Almekhlafi, Eytan Raz, Samantha Miller, Adam Mierzwa, Syed F Zaidi, Andres S Gudino, Ali Alsarah, Hussain Azeem, Thomas K Mattingly, Derrek Schartz, Ashley M Nelson, Carolina Pinheiro, Alejandro M Spiotta, Kimberly P Kicielinski, Jonathan Lena, Orgest Lajthia, Zachary Hubbard, Osama O Zaidat, Colin P Derdeyn, Piers Klein, Thanh N Nguyen, Adam de Havenon","doi":"10.1161/STROKEAHA.124.049038","DOIUrl":"https://doi.org/10.1161/STROKEAHA.124.049038","url":null,"abstract":"<p><strong>Background: </strong>Underlying intracranial stenosis is the most common cause of failed mechanical thrombectomy in acute ischemic stroke patients with large vessel occlusion. Adjunct emergent stenting is sometimes performed to improve or maintain reperfusion, despite limited data regarding its safety or efficacy.</p><p><strong>Methods: </strong>We conducted a prospective multicenter observational international cohort study. Patients were enrolled between January 2022 and December 2023 at 25 thrombectomy capable centers in North America, Europe, and Asia. Consecutive patients treated with mechanical thrombectomy were included if they were identified as having underlying intracranial stenosis, defined as 50-99% residual stenosis of the target vessel or intra-procedural re-occlusion. The primary outcome was functional independence, defined as modified Rankin Scale of 0-2 at 90 days. After applying inverse probability of treatment weighting (IPTW) based on propensity scores, we compared outcomes among patients who underwent adjunct emergent intracranial stenting (stenting) versus those who received mechanical thrombectomy alone.</p><p><strong>Results: </strong>A total of 417 patients were included; 218 patients treated with mechanical thrombectomy alone (168 anterior circulation) and 199 with mechanical thrombectomy plus stenting (144 anterior circulation). Patients in the stenting group were less likely to be non-Hispanic White (51.8% vs 62.4%, p=0.03), and less likely to have diabetes (33.2% vs 43.1%, p=0.037) or hyperlipidemia (43.2% vs 56%, p= 0.009). In addition, there was a lower rate of IV thrombolysis use in the stenting group (18.6% vs 27.5%, p=0.03). There was a higher rate of successful reperfusion (modified Treatment In Cerebral Infarction score ≥ 2B) in the stenting versus mechanical thrombectomy alone group (90.9% vs 77.9%, p<0.001) and a higher rate of a 24-hour infarct volume of <30 mL (n=260, 67.9% vs 50.3%, p=0.005). The overall complication rate was higher in the stenting group (12.6% vs 5%, p=0.006), but there was not a significant difference in the rate of symptomatic hemorrhage (9% vs 5.5%, p=0.162). Functional independence at 90 days was significantly higher in the stenting group (42.2% vs. 28.4%, adjusted odds ratio 2.67; 95% CI, 1.66-4.32).</p><p><strong>Conclusions: </strong>In patients with underlying stenosis who achieved reperfusion with mechanical thrombectomy, adjunct emergent stenting was associated with better functional outcome without a significantly increased risk of symptomatic hemorrhage.</p><p><strong>Registration: </strong>https://clinicaltrials.gov/study/NCT05403593.</p>","PeriodicalId":21989,"journal":{"name":"Stroke","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}