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Talimogene Laherparepvec for Advanced Stage Merkel Cell Carcinoma: Therapeutic Role and Immunologic Mechanisms. 塔利莫gene Laherparepvec治疗晚期默克尔细胞癌:治疗作用和免疫机制。
Skinmed Pub Date : 2023-01-01
Morgan A Farr, Tejas P Joshi, Ramie A Fathy, Daniel J Lewis
{"title":"Talimogene Laherparepvec for Advanced Stage Merkel Cell Carcinoma: Therapeutic Role and Immunologic Mechanisms.","authors":"Morgan A Farr, Tejas P Joshi, Ramie A Fathy, Daniel J Lewis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 3","pages":"153-155"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angina Bullosa Hemorrhagica. 出血性大疱性心绞痛。
Skinmed Pub Date : 2023-01-01
Sheetanshu Kumar, Dipankar De
{"title":"Angina Bullosa Hemorrhagica.","authors":"Sheetanshu Kumar, Dipankar De","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 3","pages":"185"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Dermatoscopy in Diagnosing Vestibular Papillomatosis in Pregnancy: An Uncommon Differential of Genital Warts. 使用皮肤镜诊断妊娠前庭乳头状瘤病:一种罕见的生殖器疣鉴别。
Skinmed Pub Date : 2023-01-01
Niharika Dhattarwal, Neha Chauhan, Poonam Puri
{"title":"Use of Dermatoscopy in Diagnosing Vestibular Papillomatosis in Pregnancy: An Uncommon Differential of Genital Warts.","authors":"Niharika Dhattarwal, Neha Chauhan, Poonam Puri","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 3","pages":"212-213"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conjunctival "Melanoma-In-Situ''-A Rare Neoplasia of Xeroderma Pigmentosum in Indian Scenario. 结膜“原位黑色素瘤”-印度地区罕见的色素性干皮病的肿瘤。
Skinmed Pub Date : 2023-01-01
Sanjiv Choudhary, Ankita Srivastava, Saroj Gupta, Deepti Joshi
{"title":"Conjunctival \"Melanoma-<i>In-Situ</i>''-A Rare Neoplasia of Xeroderma Pigmentosum in Indian Scenario.","authors":"Sanjiv Choudhary,&nbsp;Ankita Srivastava,&nbsp;Saroj Gupta,&nbsp;Deepti Joshi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 16-year-old girl born from a nonconsanguineous marriage presented to the dermatology out-patient department with innumerable hyperpigmented macules predominantly over the photoexposed parts of her body involving the face, neck, chest, back, of forearms, hands, and legs with a history of photosensitivity and photophobia (Figure 1). These were interspersed with multiple depigmented macules over her arms and legs since, she was three years old. She also had a small pigmented mass involving the left eye present for the last 3 months. She had a family history of similar cutaneous lesions in her elder sister. There was no history of hearing loss, seizures, spasticity, or cognitive impairment.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 2","pages":"114-115"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9791471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Non-Steroidal Topical Therapies for Inflammatory Dermatoses-Part 1: Ruxolitinib. 新的非甾体局部治疗炎症性皮肤病-第一部分:鲁索利替尼。
Skinmed Pub Date : 2023-01-01
Elizabeth Mancuso-Stewart, Margaret DiRuggiero, Douglas DiRuggiero, Matt Zirwas
{"title":"New Non-Steroidal Topical Therapies for Inflammatory Dermatoses-Part 1: Ruxolitinib.","authors":"Elizabeth Mancuso-Stewart,&nbsp;Margaret DiRuggiero,&nbsp;Douglas DiRuggiero,&nbsp;Matt Zirwas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For the twenty-year period from 2001 to 2021, only one new topical molecular entity for an inflammatory skin disease was approved in the United States. This situation has shifted dramatically, with three non-steroidal new molecular entities, each with completely different mechanisms of action, receiving FDA approval in the past year. As a three-part series, each non-steroidal molecule will be reviewed. We focus first on topical ruxolitinib, which received FDA approval in September of 2021 as the first Janus Kinase Inhibitor (JAK) for the treatment of atopic dermatitis. Other topical therapies covered in this review series include tapinarof, an aryl hydrocarbon receptor modulating agent, which was approved for the treatment of psoriasis in May 2022 and topical roflumilast, a highly potent phosphodiesterase-4 inhibitor, which was recently approved in July 2022 for treatment of plaque psoriasis. In addition to their unique mechanisms of action and spectra of activity, each of these agents have unique clinical characteristics - including degree of efficacy, rapidity of onset of efficacy, potential remittive effects, and safety and tolerability profiles. In this review series, we review and summarize the data surrounding each agent, providing a comprehensive overview which will allow dermatology providers to confidently and appropriately integrate them into treatment paradigms. As stated, this contribution focuses on topical ruxolitinib, the only topical JAK therapy FDA approved for treatment atopic dermatitis, and most recently, the first ever approved therapy for nonsegmental vitiligo.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 2","pages":"93-98"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9791473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of a Novel PLCD1 Variant in a Danish Family with Hereditary Leukonychia. 一个丹麦家族遗传性白甲病PLCD1新变异的鉴定。
Skinmed Pub Date : 2023-01-01
Sofie Lieberoth, Sheetal Kumar, Klaus Brusgaard, Lillian B Ousager, Regina C Betz, Anette Bygum
{"title":"Identification of a Novel <i>PLCD1</i> Variant in a Danish Family with Hereditary Leukonychia.","authors":"Sofie Lieberoth,&nbsp;Sheetal Kumar,&nbsp;Klaus Brusgaard,&nbsp;Lillian B Ousager,&nbsp;Regina C Betz,&nbsp;Anette Bygum","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 1-year-old girl presented with porcelain white fingernails, accidentally discovered when she was referred for an infantile hemangioma consultation. The family reported that the nails had been milky white since birth and her father had similar white finger and toenails. The father remembered that additional family members on his side of the family presented with white nails; however, he could not provide exact information about the number of other relatives affected by this nail abnormality. The girl and her father were the only available family members with white nails presented for this study (Figure 1). The girl presented with leukonychia totalis on all fingernails only, while the father had this abnormality on all finger and toenails (Figure 2). We were not aware of any association with other diseases or features in this family, except hemangioma in the girl. (<i>SKINmed</i>. 2023;21:44-46).</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 1","pages":"44-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9202994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Need for Unified Consensus on Wound Care Management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. 史蒂文斯-约翰逊综合征和中毒性表皮坏死松解的伤口护理管理需要统一共识。
Skinmed Pub Date : 2023-01-01
Theresa N Tran, Simo Huang, Sylvia Hsu
{"title":"The Need for Unified Consensus on Wound Care Management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.","authors":"Theresa N Tran,&nbsp;Simo Huang,&nbsp;Sylvia Hsu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical, Radiologic, and Histopathologic Features that Distinguish a Pigmented Plexiform Neurofibroma from a Congenital Melanocytic Nevus. 区分色素丛状神经纤维瘤与先天性黑素细胞痣的临床、放射学和组织病理学特征。
Skinmed Pub Date : 2023-01-01
Larissa M Pastore, Steven M Manders, L David Hall, Emily D Scattergood, R Matthew McLarney
{"title":"Clinical, Radiologic, and Histopathologic Features that Distinguish a Pigmented Plexiform Neurofibroma from a Congenital Melanocytic Nevus.","authors":"Larissa M Pastore,&nbsp;Steven M Manders,&nbsp;L David Hall,&nbsp;Emily D Scattergood,&nbsp;R Matthew McLarney","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 13-year-old Hispanic boy with no significant medical etymology presented with a chief complaint of widespread brown macules and patches. He had a large and evenly pigmented brown patch, with a centrally located 2.2 cm × 1.2 cm soft and darkly pigmented plaque, which became more apparent with tension applied to the surrounding skin (Figure 1). The patient's mother stated that the plaque was present since birth and had increased in size over time. The clinical differential diagnoses included a congenital melanocytic nevus (CMN), a large café au lait macule (CALM), and a Becker's nevus with a congenital smooth muscle hamartoma.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 3","pages":"187-189"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Voice of the Lost Toe: Pseudo-Ainhum Beyond Skin. 失去脚趾的声音:皮肤之外的伪ainhum。
Skinmed Pub Date : 2023-01-01
Chandrasekaran Divyalakshmi, Aditi Dhanta, Riti Bhatia, Neirita Hazarika, Venkata Subbaih
{"title":"The Voice of the Lost Toe: Pseudo-Ainhum Beyond Skin.","authors":"Chandrasekaran Divyalakshmi,&nbsp;Aditi Dhanta,&nbsp;Riti Bhatia,&nbsp;Neirita Hazarika,&nbsp;Venkata Subbaih","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An 11-year-old boy presented with serial autoamputations of the right 4th and 5th toes during the past 6 years. This was associated with sensory loss on the right leg and development of constriction bands around the right 2nd and 3rd digits for the past 5 months. For a year, the patient had been treated with paucibacillary, multi-drug therapy (PB-MDT) with a presumptive diagnosis of leprosy. He was born from a nonconsanguinous marriage and the birth was uneventful. The developmental milestones were normal, and no family history of any congenital anomalies was reported.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 3","pages":"208-210"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pride, Prejudice, and Politics: The Pellagra Story-Part I. 傲慢、偏见与政治:糙皮病的故事(一)。
Skinmed Pub Date : 2023-01-01
Amiya Kumar Mukhopadhyay, Lawrence Charles Parish
{"title":"Pride, Prejudice, and Politics: The Pellagra Story-Part I.","authors":"Amiya Kumar Mukhopadhyay,&nbsp;Lawrence Charles Parish","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":"21 2","pages":"66-68"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9472287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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