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Diagnosing Monkeypox: The "Doughnut Pustule" Debunked. 诊断猴痘：被揭穿的 "甜甜圈脓疱"。
Skinmed Pub Date : 2023-08-28 eCollection Date: 2023-01-01
Madison Hackley, Nicholas D Brownstone, Sylvia Hsu
{"title":"Diagnosing Monkeypox: The \"Doughnut Pustule\" Debunked.","authors":"Madison Hackley, Nicholas D Brownstone, Sylvia Hsu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psori Silk in Mild to Moderate Psoriasis: A Randomized Phase I-II Trial Study. 治疗轻度至中度银屑病的 Psori Silk：随机 I-II 期试验研究。
Skinmed Pub Date : 2023-08-28 eCollection Date: 2023-01-01
Felix Pavlotsky, Meir Babaev, Aviv Barzilai
{"title":"Psori Silk in Mild to Moderate Psoriasis: A Randomized Phase I-II Trial Study.","authors":"Felix Pavlotsky, Meir Babaev, Aviv Barzilai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In patients with mild to moderate psoriasis, topical corticosteroids are usually the first-line of treatment; however, they are not suitable for long-term use. The purpose of this study was to assess the efficacy and safety of a multi-fruit-and-vegetable compound, Psori Silk, in the treatment of patients with psoriasis. This was a randomized double-blind trial comprising 12 weeks of treatment with Psori Silk versus a vehicle, and a 4-week follow-up. The primary endpoint was 50% reduction in the modified Psoriasis Area and Severity Index (MPASI 50) score at week 12, while the secondary endpoint was quality of life assessment using the Dermatology Life Quality Index (DLQI). The Psori Silk group consisted of 23 patients with 34 lesions to be treated versus 22 patients in the vehicle group with 36 lesions. The MPASI 50 score was observed in 59% patients in the active group versus 22.7% patients in the vehicle group (<i>P</i> < 0.001). A mean 33% DLQI improvement was observed in 65.2% patients in the active group versus 27.2% patients in the vehicle group (<i>P</i> < 0.001). Mild and temporary discomfort at the site of application was reported in 39% patients in the active group versus 23% patients in the vehicle group. Psori silk appears to be an effective and safe treatment option for mild to moderate plaque psoriasis.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10107779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Omalizumab Updosing in Chronic Urticaria: A Retrospective Study. Omalizumab升级治疗慢性荨麻疹的有效性和安全性:一项回顾性研究
Skinmed Pub Date : 2023-01-01
Fatma Asli Hapa, Fatma Elif Yıldırım
{"title":"Efficacy and Safety of Omalizumab Updosing in Chronic Urticaria: A Retrospective Study.","authors":"Fatma Asli Hapa,&nbsp;Fatma Elif Yıldırım","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Omalizumab is an effective and safe treatment option with licensed doses in patients with chronic spontaneous urticaria (CSU); however, some patients are not responsive to licensed doses and require updosing. As studies concerning updosing were insufficient, the present study evaluated the effectiveness and safety of omalizumab updosing (300 mg every 2 weeks) in CSU patients. Data of CSU patients treated with omalizumab were analyzed retrospectively. As an outcome measure, physician assessment of treatment response (complete response [CR], partial response, and unresponsiveness) was used. In all, 49 patients depicting CR to omalizumab 300 mg every 4 weeks and 54 patients treated with omalizumab 300 mg every 2 weeks were included in the study. Mean duration of the disease in updosing group was significantly lengthier than the CR group. The mean percentage level of eosinophils and basophils was significantly higher in the CR group. The history of systemic corticosteroid and oral cyclosporine treatment was significantly more frequent in the updosing group. Treatment with omalizumab 300 mg every 2 weeks for 12 weeks led to CR in 41 patients (75.9%). Our results confirmed the efficacy and safety of omalizumab updosing. Low baso-phil and eosinophil levels could also be important factors in defining the need for updosing.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10458680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ring Warts. 环疣。
Skinmed Pub Date : 2023-01-01
Annie Jin, Elizabeth K Jones
{"title":"Ring Warts.","authors":"Annie Jin,&nbsp;Elizabeth K Jones","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed Diagnosis of Retronychia: How Ultrasound Can Nail the Diagnosis in Clinically Subtle Patients. 迟发性甲后的诊断:超声如何在临床不易发现的病人中明确诊断。
Skinmed Pub Date : 2023-01-01
Yong-Hun Kim, Elizabeth Sutton, Nora S Ali, Nahid Y Vidal
{"title":"Delayed Diagnosis of Retronychia: How Ultrasound Can Nail the Diagnosis in Clinically Subtle Patients.","authors":"Yong-Hun Kim,&nbsp;Elizabeth Sutton,&nbsp;Nora S Ali,&nbsp;Nahid Y Vidal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 47-year-old man presented to the dermatologic surgery clinic with a 7-month history of a painful, swollen left great toe after minor trauma. Intermittently, the toe became exquisitely tender such that even weight of a blanket exacerbated pain. The patient initially presented to primary care with purulence and pain, but the culture of expressed purulence revealed normal flora. Condition of the patient did not improve despite evaluation by several medical specialists and multiple rounds of topical antifungal and steroid creams, vinegar soaks, and oral antibiotics.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9791474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Skin Cancer among Beachgoers in Israel. 以色列海滩游客皮肤癌患病率
Skinmed Pub Date : 2023-01-01
Ariel Berl, Ofir Shir-Az, Sharon Sandbank, Assaf Persitz, Avshalom Shalom
{"title":"Prevalence of Skin Cancer among Beachgoers in Israel.","authors":"Ariel Berl,&nbsp;Ofir Shir-Az,&nbsp;Sharon Sandbank,&nbsp;Assaf Persitz,&nbsp;Avshalom Shalom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We assessed the prevalence of suspected skin lesions among beachgoers with dermatoscopy and evaluated their compliance with recommendations. This was conducted as a screening activity at a beach in central Israel. A dermatoscopy specialist evaluated beachgoers and maintained follow-up with them to ascertain compliance with recommendations. In all, 296 participants were screened. Normal examination was observed in 251 (85%), while a malignant finding was suspected in 12 (4%). Compliance with recommendations for excision was moderately low, with 8 of the 14 patients complying with recommendations. Skin malignancy is prevalent in local beachgoing population. Voluntary projects increase awareness in youngsters and deliver accessible screening to the older population. We believe that screening activities must be increased due to high attendance, yet close follow-up must be maintained due to intermediate compliance with medical recommendations.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulomatous Panniculitis as a Complication of Subcutaneous Testosterone Pellet Therapy. 皮下睾酮颗粒治疗并发肉芽肿性泛膜炎。
Skinmed Pub Date : 2023-01-01
Meera H Patel, Caitlin M Brumfiel, Ilana Breen, David Glembocki, Adam Luber
{"title":"Granulomatous Panniculitis as a Complication of Subcutaneous Testosterone Pellet Therapy.","authors":"Meera H Patel,&nbsp;Caitlin M Brumfiel,&nbsp;Ilana Breen,&nbsp;David Glembocki,&nbsp;Adam Luber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 51-year-old man with a 3-year history of exogenous testosterone pellet injections to the left buttock presented for routine skin examination. While the patient reported recurrent drainage from the site of testosterone replacement therapy (TRT) injections, he continued to receive repeated implantations every 6 months. On physical examination, a 12-mm irregular, brown macule was identified within a poorly demarcated, ecchymotic, and fluctuant subcutaneous plaque on the left buttock with a sinus tract draining serosanguinous fluid. The pigmented lesion was biopsied, revealing malignant melanoma <i>in situ</i>; hence, a wide local excision was scheduled. During the procedure, necrotic subcutaneous fat was observed surrounding the site of biopsy, and a region measuring 18 cm<sup>2</sup> approximately was debrided and submitted for pathologic evaluation. Histopathologic examination revealed a diffused subcutaneous granulomatous infiltrate with septal and lobular panniculitis and fat necrosis as well as peripherally palisading histiocytes and hemosiderin deposition (Figures 1A and B). Similar findings were observed in another specimen from the same segment of debrided tissue, compatible with granulomatous panniculitis. Periodic acid-Schiff (PAS), Gram's, and acid-fast bacilli (AFB) stains revealed no microorganisms. During surgical exploration, six foreign bodies were discovered and identified as undissolved testosterone pellets. The patient was referred to a wound care center, but ultimately lost to follow-up.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycobacterium chelonae Cutaneous Infection: An Important Differential Diagnosis in the Immunosuppressed Patient with Chronic Ulcers. 龟分枝杆菌皮肤感染:慢性溃疡免疫抑制患者的重要鉴别诊断。
Skinmed Pub Date : 2023-01-01
Eugenio Del Valle-Espinosa, Sofia Lopez-Cordero, Amelia Peniche-Castellanos, Patricia Mercadillo-Perez, Ivonne Arellano-Mendoza
{"title":"<i>Mycobacterium chelonae</i> Cutaneous Infection: An Important Differential Diagnosis in the Immunosuppressed Patient with Chronic Ulcers.","authors":"Eugenio Del Valle-Espinosa,&nbsp;Sofia Lopez-Cordero,&nbsp;Amelia Peniche-Castellanos,&nbsp;Patricia Mercadillo-Perez,&nbsp;Ivonne Arellano-Mendoza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 2018, a 38-year-old woman was referred to our hospital with some nodules and nonhealing ulcers on her left thigh that had been present for 18 months. Her medical history included rheumatoid arthritis (RA) being treated with 20-mg prednisone for the last 8 years. There was no history of trauma, surgery, or cosmetic procedure on the leg. Physical examination revealed multiple lesions on her left thigh, including nodules, surrounded by erythema, some of them being covered with a fine white-yellowish scale and hyperpigmented macules. Central atrophy was evident in some lesions. She also had one ulcer with purulent discharge (Figure 1). An infectious disease and vasculitis were considered in the differential diagnoses. Biopsy and culture were conducted from the lesion. A Ziehl-Neelsen stain was obtained from the ulcer's discharge with visible acid-fast bacilli (Figure 2). Light microscopy examination revealed a mixed granuloma with lymphocytes, neutrophils, and giant cells in the dermis (Figure 3). The culture was positive for <i>M. chelonae</i> sensitive to clarithromycin. Treatment with clarithromycin was initiated (500 mg, twice a day) for 8 weeks, with healing of some of the lesions. She was advised to continue antibiotic treatment for 4 more weeks and to report to our hospital after its completion, but she never returned and was lost on follow-up.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Flesh-Colored Nodules: A Patient with Multiple BAP 1-Inactivated Melanocytic Tumors. 多发性肉色结节:一例多发性BAP - 1失活黑色素细胞肿瘤。
Skinmed Pub Date : 2023-01-01
Sujitha Yadlapati, Subuhi Kaul, Leah Shama-Brown, Faraz Yousefian, Thomas Davis
{"title":"Multiple Flesh-Colored Nodules: A Patient with Multiple <i>BAP 1-</i>Inactivated Melanocytic Tumors.","authors":"Sujitha Yadlapati,&nbsp;Subuhi Kaul,&nbsp;Leah Shama-Brown,&nbsp;Faraz Yousefian,&nbsp;Thomas Davis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 22-year-old man without previously known skin disease presented with multiple asymptomatic, skin-brown to red-brown papules on the head and neck for 1 year (Figure 1). The diagnoses considered included benign intradermal or compound nevi, atypical nevi, and neurofibromas. Shave biopsies of three lesions revealed intradermal melanocytic lesions comprising large epithelioid melanocytes flanked by small banal melanocytes (Figure 2). All nevi had a low proliferation index, absent junctional component as demonstrated by a dual Ki-67/Mart-1 immunostain, and no dermal mitotic figures. Immunostaining demonstrated lesional melanocytes positive for p16, but the larger epithelioid melanocytes in these lesions lacked nuclear expression of ubiquitin carboxyl-terminal hydrolase protein (<i>BAP-1</i>; Figure 3). The diagnosis of a <i>BAP-1</i>-inactivated nevus was made, and the patient was referred for genetic counseling and screening for associated malignancies. Given that the lesions involved deep margins, the same were completely excised.</p>","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9816537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmetic Dermatologic Surgery. 皮肤美容外科。
Skinmed Pub Date : 2023-01-01
Nkemjika Ugonabo, Jordan V Wang
{"title":"Cosmetic Dermatologic Surgery.","authors":"Nkemjika Ugonabo,&nbsp;Jordan V Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21891,"journal":{"name":"Skinmed","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9479023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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