Seminars in nephrology最新文献_第5页

Lessons Learned From Large Animal Models of Trauma-Induced AKI 创伤性AKI大型动物模型的经验教训。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2026-01-01 Epub Date: 2025-10-01 DOI: 10.1016/j.semnephrol.2025.151670

David M. Burmeister PhD , Julia N. Nguyen MD , Ian J. Stewart MD

引用次数: 0

Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury 涉及线粒体的急性肾损伤治疗方法。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2026-01-01 Epub Date: 2025-09-29 DOI: 10.1016/j.semnephrol.2025.151676

Prisha S. Patel MD , Navjot S. Pabla PhD , Amandeep Bajwa PhD

{"title":"Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury","authors":"Prisha S. Patel MD , Navjot S. Pabla PhD , Amandeep Bajwa PhD","doi":"10.1016/j.semnephrol.2025.151676","DOIUrl":"10.1016/j.semnephrol.2025.151676","url":null,"abstract":"<div><div>Acute kidney injury (AKI) continues to pose a significant clinical burden, characterized by high morbidity and mortality rates. Emerging evidence has established mitochondrial dysfunction as a central driver in the pathogenesis of AKI, encompassing deficits in bioenergetics, excessive production of reactive oxygen species, and disruption of mitochondrial dynamics. Therapeutic interventions targeting mitochondrial pathways—most notably peptide-based agents such as SS-31—have demonstrated promising results in preclinical models. Recent discoveries have identified phospholipid scramblase 3 (PLSCR3) as an essential mediator of SS-31′s mitochondrial protective effects, positioning it as a novel therapeutic target. This review synthesizes current mitochondrial-directed approaches for AKI, with a particular emphasis on the mechanistic role of PLSCR3 in maintaining mitochondrial homeostasis and injury responses. Despite encouraging data, mitochondrial therapies face several translational hurdles, including limited bioavailability, challenges in establishing effective dosing regimens, incomplete mechanistic understanding, and variability in efficacy across different experimental models. Moreover, concerns regarding cost, accessibility, and long-term safety remain unresolved, contributing to inconsistent outcomes in clinical trials. Herein we evaluate the emerging role of PLSCR3 as a potentially druggable mitochondrial target, supported by recent genetic, biochemical, and <em>in vivo</em> evidence, and discuss translational strategies that may bridge the gap between experimental promise and clinical application.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"46 1","pages":"Article 151676"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using Predictive Models and AI for AKI Research 利用预测模型和人工智能进行AKI研究。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2026-01-01 Epub Date: 2025-10-08 DOI: 10.1016/j.semnephrol.2025.151673

Madhumitha Rajagopal MD, PhD , Lili Chan MD, MSCR , Girish N. Nadkarni MD, MPH

引用次数: 0

Macrophage Plasticity and Functional Dynamics in Acute Kidney Injury and Its Progression to Chronic Kidney Disease 急性肾损伤及其向慢性肾脏疾病发展的巨噬细胞可塑性和功能动力学。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI: 10.1016/j.semnephrol.2025.151672

Dana Hammouri PhD , Theresa Weis BS , Leah J. Siskind PhD

{"title":"Macrophage Plasticity and Functional Dynamics in Acute Kidney Injury and Its Progression to Chronic Kidney Disease","authors":"Dana Hammouri PhD , Theresa Weis BS , Leah J. Siskind PhD","doi":"10.1016/j.semnephrol.2025.151672","DOIUrl":"10.1016/j.semnephrol.2025.151672","url":null,"abstract":"<div><div>Acute kidney injury (AKI) and chronic kidney disease (CKD) are increasingly recognized as interconnected syndromes with overlapping pathophysiological mechanisms. A growing body of evidence suggests that macrophages are central regulators of the AKI-to-CKD transition, influencing both injury and repair through dynamic, microenvironment-dependent phenotypic shifts. M1-like macrophages dominate early injury responses in AKI, while M2-like macrophages can adopt a pro-fibrotic phenotype potentially contributing to the progression of CKD. Beyond this classical dichotomy, single-cell and spatial transcriptomic studies reveal a complex spectrum of macrophage states shaped by origin, tissue niche, temporal dynamics, and intercellular signaling. This review summarizes the current understanding of macrophage ontogeny, heterogeneity, and functional specialization in AKI and progression to CKD. We highlight how macrophages respond to local cues, engage in crosstalk with other cell types, and mediate phase-specific effects on inflammation and tissue remodeling. We also evaluate the consequences of macrophage depletion in AKI and the progression of AKI to CKD, highlighting divergent outcomes. Advancing our understanding of macrophage complexity is essential for developing precise immunomodulatory strategies for treating AKI and preventing CKD progression. By disentangling the context-specific roles of macrophages, future therapies can be tailored to attenuate pathogenic responses without compromising essential reparative functions, ultimately improving long-term renal outcomes.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"46 1","pages":"Article 151672"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward Combinatorial Strategies to Improve Proximal Tubule Recovery Following Acute Kidney Injury 改善急性肾损伤后近端小管恢复的组合策略探讨。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2026-01-01 Epub Date: 2025-10-10 DOI: 10.1016/j.semnephrol.2025.151675

David A. Bastos BS , Lisa O. Oti BS , Carla L. Ellis MD , Shayna T.J. Bradford PhD

{"title":"Toward Combinatorial Strategies to Improve Proximal Tubule Recovery Following Acute Kidney Injury","authors":"David A. Bastos BS , Lisa O. Oti BS , Carla L. Ellis MD , Shayna T.J. Bradford PhD","doi":"10.1016/j.semnephrol.2025.151675","DOIUrl":"10.1016/j.semnephrol.2025.151675","url":null,"abstract":"<div><div>Maintaining kidney health throughout the human lifespan remains a significant global challenge. Worldwide, an estimated 850 million people have some level of kidney disease, with many unaware because of asymptomatic progression. Whether initiated by acute or chronic insults, renal injury and disease can have life-threatening consequences requiring interventions spanning the gamut of supportive care to kidney replacement therapies. Design of precision therapeutics is likely to benefit from understanding the heterogenous cell types and states that arise in the context of kidney injury and disease. Here we review an array of cellular states that have been detected following acute ischemic kidney injury, hypothesized to promote transition to chronic kidney disease. We focused on studies describing the cellular states of the proximal tubule (PT), a segment of the nephron most vulnerable to ischemic injury. PT cells have been shown in preclinical animal studies to have a heterogeneous response to ischemic injury, including repaired and failed-repair cellular states, inter alia. We end by discussing targeting these cellular states and/or pathological processes.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"46 1","pages":"Article 151675"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Technologies for Kidney Research: Three-Dimensional Imaging and Quantification 肾脏研究的创新技术：三维成像和量化。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2026-01-01 Epub Date: 2025-10-01 DOI: 10.1016/j.semnephrol.2025.151671

Sarah R. McLarnon PhD, Pierre-Emmanuel Y. N’Guetta BS, Lori L. O’Brien PhD

引用次数: 0

Introduction: The 2025 American Society of Nephrology Third Acute Kidney Injury: Bench to Bedside Conference 简介：2025年美国肾脏病学会第三届急性肾损伤：从实验室到床边会议。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2025-11-01 Epub Date: 2025-08-30 DOI: 10.1016/j.semnephrol.2025.151662

Kelly A. Hyndman PhD, Leah J. Siskind PhD, Mark de Caestecker MB BS, PhD

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Regenerative Versus Nonregenerative Repair of the Renal Medulla After Reversal of Ureteral Obstruction 输尿管梗阻逆转后肾髓质的再生与非再生修复。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2025-11-01 Epub Date: 2025-08-24 DOI: 10.1016/j.semnephrol.2025.151669

Alex Gonzalez BS, Rachel Delgado BS, Mark P. de Caestecker MB, BS, PhD

{"title":"Regenerative Versus Nonregenerative Repair of the Renal Medulla After Reversal of Ureteral Obstruction","authors":"Alex Gonzalez BS, Rachel Delgado BS, Mark P. de Caestecker MB, BS, PhD","doi":"10.1016/j.semnephrol.2025.151669","DOIUrl":"10.1016/j.semnephrol.2025.151669","url":null,"abstract":"<div><div>Many patients with urinary obstruction have an accelerated decline in renal function despite early urologic interventions. They also have defects in urinary concentrating capacity that may predispose them to acute kidney injury and chronic kidney disease. Because urinary concentrating capacity depends on having intact solute concentrating mechanisms in the renal medulla, it is likely that this results from obstruction-induced abnormalities in renal medullary structure, function, or both. This review focuses on findings from a recent study characterizing the long-term effects of reversible unilateral ureteral obstruction in mice that address these questions. These findings show that there is delayed long-term growth of the inner medulla, which is initially shrunken, that results in complete restoration of inner medullary size and gross tissue architecture 3 months after reversal of the obstruction. More detailed analysis shows that despite relatively normal histologic appearances, there are permanent defects in the cellular organization and function of the medulla that account for the loss of urinary concentrating capacity. We discuss the extent to which regenerative versus nonregenerative repair mechanisms may contribute to the growth and functional recovery of the renal medulla and consider how these findings shed light on the mechanisms of tissue repair and dysfunction after reversal of urinary obstruction.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"45 6","pages":"Article 151669"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Clinical View of Sepsis-Associated AKI: How Basic Science Can Help Solve This Problem 败血症相关AKI的临床观点：基础科学如何帮助解决这一问题。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2025-11-01 Epub Date: 2025-09-10 DOI: 10.1016/j.semnephrol.2025.151665

James D. Odum MD, MEd , Denise C. Hasson MD , Natalja L. Stanski MD, MS , Hernando Gómez MD, MPH , Danielle E. Soranno MD

引用次数: 0

When the Heart Hurts the Kidneys: From Flow to Translational Future 当心脏伤害肾脏：从流动到翻译的未来。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2025-11-01 Epub Date: 2025-09-11 DOI: 10.1016/j.semnephrol.2025.151667

Kevin G. Burfeind MD, PhD , Daiki Aomura MD, PhD , Jessica F. Hebert PhD , Michael P. Hutchens MD, MA

引用次数: 0