Seminars in nephrology最新文献_第10页

The Importance of Improving Promotion of Kidney Health and Access to Kidney Care: Perspectives From Leaders of Patient Organizations in Honduras 改善促进肾脏健康和获得肾脏护理的重要性：洪都拉斯患者组织领导人的观点。

IF 2.8 3区医学

Seminars in nephrology Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1016/j.semnephrol.2025.151600

Marianella Canales Mejia , Daniela Alejandra Ordóñez Quezada , Cristina Valeria Sequeira Navarro , Jossel Ivan Meza Rodriguez , Andrea Nicole Izaguirre Baday

{"title":"The Importance of Improving Promotion of Kidney Health and Access to Kidney Care: Perspectives From Leaders of Patient Organizations in Honduras","authors":"Marianella Canales Mejia , Daniela Alejandra Ordóñez Quezada , Cristina Valeria Sequeira Navarro , Jossel Ivan Meza Rodriguez , Andrea Nicole Izaguirre Baday","doi":"10.1016/j.semnephrol.2025.151600","DOIUrl":"10.1016/j.semnephrol.2025.151600","url":null,"abstract":"<div><div>Accessibility to kidney care is an essential component to ensure that patients with chronic kidney disease receive the necessary treatment in a timely and equitable manner. From our perspective as patients and/or leaders of patient organizations, we have observed how geographic, economic, informational, and psychosocial barriers negatively affect timely access to kidney health services, especially in Latin America. Improving access to kidney care is a complex challenge that requires a comprehensive approach, with an inclusive and equitable assertiveness. This includes not only the elimination of inequalities in access to treatments such as dialysis or kidney transplant, which is a reality that affects many patients, especially those in remote rural or low-income areas, but also access to prevention, early detection, and early treatment to prevent kidney failure. Improvements in education and information can make significant gains that benefit all people at risk of, or who suffer from, kidney disease at all stages of advancement, regardless of their location or socioeconomic status. Therefore, policies are needed that focus not only on access to technology and its proper use but also on bringing these solutions to everyone, without forgetting the importance of emotional and psychosocial support, thus humanizing health care. This is a call to action for all actors involved, from health authorities to service providers, medical and scientific societies, and patient organizations, to work together to build a more accessible and equitable kidney health system for all kidney patients.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"45 1","pages":"Article 151600"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latin American Dialysis and Renal Transplantation Registry: Updates and Progress 拉丁美洲透析和肾移植登记处：更新和进展。

IF 2.8 3区医学

Seminars in nephrology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI: 10.1016/j.semnephrol.2025.151602

María Carlota González-Bedat MD, Guillermo Javier Rosa-Diez MD

引用次数: 0

Multi-Omics Integration in Nephrology: Advances, Challenges, and Future Directions 肾病学中的多组学整合：进展、挑战和未来方向。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-11 DOI: 10.1016/j.semnephrol.2025.151584

Afaf Saliba PhD , Yuheng Du MS , Tianqing Feng BS , Lana Garmire PhD

引用次数: 0

Multimodal Mass Spectrometry Imaging in Atlas Building: A Review 多模态质谱成像在地图集建设：综述。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-16 DOI: 10.1016/j.semnephrol.2025.151578

Kyle A. Vanderschoot BS, Kayle J. Bender BS, Christopher M. De Caro, Kelli A. Steineman, Elizabeth K. Neumann PhD

{"title":"Multimodal Mass Spectrometry Imaging in Atlas Building: A Review","authors":"Kyle A. Vanderschoot BS, Kayle J. Bender BS, Christopher M. De Caro, Kelli A. Steineman, Elizabeth K. Neumann PhD","doi":"10.1016/j.semnephrol.2025.151578","DOIUrl":"10.1016/j.semnephrol.2025.151578","url":null,"abstract":"<div><div>In the era of precision medicine, scientists are creating atlases of the human body to map cells at the molecular level, providing insight into what fundamentally makes each cell different. In these atlas efforts, multimodal imaging techniques that include mass spectrometry imaging (MSI) have revolutionized the way biomolecules, such as lipids, peptides, proteins, and small metabolites, are visualized in the native spatial context of biological tissue. As such, MSI has become a fundamental arm of major cell atlasing efforts, as it can analyze the spatial distribution of hundreds of molecules in diverse sample types. These rich molecular data are then correlated with orthogonal assays, including histologic staining, proteomics, and transcriptomics, to analyze molecular classes that are not traditionally detected by MSI. Additional computational methods enable further examination of the correlations between biomolecular classes and creation of visualizations that serve as a powerful resource for researchers and clinicians trying to understand human health and disease. In this review, we examine modern multimodal imaging methods and how they contribute to precision medicine and the understanding of fundamental disease mechanisms.</div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151578"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview: Spatial Metabolomics Review Series 综述：空间代谢组学综述系列。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-07 DOI: 10.1016/j.semnephrol.2025.151576

Kumar Sharma MD, Ravi Iyengar PhD

引用次数: 0

Pathology of Chronic Kidney Disease and Spatial Metabolomics 慢性肾脏疾病病理与空间代谢组学。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-05-06 DOI: 10.1016/j.semnephrol.2025.151579

Jeffrey B. Hodgin MD, PhD , Soumya Maity PhD , Matthias Kretzler MD , Kumar Sharma MD

引用次数: 0

Spatial Metabolomics in Acute Kidney Injury 急性肾损伤的空间代谢组学研究。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-12 DOI: 10.1016/j.semnephrol.2025.151580

Guanshi Zhang PhD , W. Brian Reeves MD

{"title":"Spatial Metabolomics in Acute Kidney Injury","authors":"Guanshi Zhang PhD , W. Brian Reeves MD","doi":"10.1016/j.semnephrol.2025.151580","DOIUrl":"10.1016/j.semnephrol.2025.151580","url":null,"abstract":"<div><div><span>Acute kidney injury (AKI) is a common condition linked to increased morbidity, mortality, and substantial health care costs both in the United States and globally. Early diagnosis, prompt intervention, and effective therapeutic management of AKI are vital for improving patient outcomes. Recent advancements in renal imaging and </span>omics<span><span><span><span><span> technologies have provided new perspectives and deeper insights into kidney injury while also presenting challenges in developing a comprehensive cellular and molecular atlas of the condition. This review focuses on the application of mass spectrometry imaging-based spatial </span>metabolomics in studying ischemia- and toxin-induced AKI in </span>animal models<span> and human patients. Spatial metabolomics offers a deeper understanding of the pathophysiological connections between various processes, such as dysregulated </span></span>lipid metabolism and the shift from the </span>tricarboxylic acid cycle<span><span> to glycolytic flux, which contribute to functional impairment and structural damage in AKI. Continued research in renal multimodal imaging and </span>omics is essential to further our understanding of kidney injury from diagnostic, mechanistic, and therapeutic perspectives.</span></span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151580"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Spatial Metabolomics and Proteomics for Functional Tissue Unit and Single-Cell Resolution 功能性组织单元和单细胞分辨率的空间代谢组学和蛋白质组学的挑战。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-21 DOI: 10.1016/j.semnephrol.2025.151583

Kevin J. Zemaitis PhD , Ljiljana Paša-Tolić PhD

{"title":"Challenges in Spatial Metabolomics and Proteomics for Functional Tissue Unit and Single-Cell Resolution","authors":"Kevin J. Zemaitis PhD , Ljiljana Paša-Tolić PhD","doi":"10.1016/j.semnephrol.2025.151583","DOIUrl":"10.1016/j.semnephrol.2025.151583","url":null,"abstract":"<div><div><span>In the last decade, advanced developments of mass spectrometry–based assays have made spatial measurements of hundreds of metabolites and thousands of proteins not only possible, but routine. The information obtained from such mass spectrometry imaging experiments traces metabolic events and helps decipher feedback loops across anatomical regions, connecting </span>genetic<span> and metabolic networks<span> that define phenotypes. Herein we overview developments in the field over the past decade, highlighting several case studies demonstrating direct measurement of metabolites, proteins, and proteoforms from thinly sliced tissues at the level of functional tissue units, approaching single-cell levels. Much of this work is feasible due to multidisciplinary team science, and we offer brief perspectives on paths forward and the challenges that persist with adoption and application of these spatial omics<span> techniques at the single-cell level on mammalian kidneys. Data analysis and reanalysis still pose issues that plague spatial omics, but many mass spectrometry imaging platforms are commercially available. With greater harmonization across platforms and rigorous quality control, greater adoption of these platforms will undoubtedly provide major insights in complex diseases.</span></span></span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151583"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Metabolomics and Lipidomics in Kidney Disease 肾脏疾病的空间代谢组学和脂质组学。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-15 DOI: 10.1016/j.semnephrol.2025.151582

Brittney L. Gorman PhD , Jessica K. Lukowski PhD

{"title":"Spatial Metabolomics and Lipidomics in Kidney Disease","authors":"Brittney L. Gorman PhD , Jessica K. Lukowski PhD","doi":"10.1016/j.semnephrol.2025.151582","DOIUrl":"10.1016/j.semnephrol.2025.151582","url":null,"abstract":"<div><div><span><span><span>Kidney disease is a global health issue that affects over 850 million people, and early detection is key to preventing severe disease and complications. Kidney diseases are associated with complex and dysregulation of </span>lipid metabolism<span>. Spatial metabolomics<span> through mass spectrometry imaging<span><span> (MSI) enables spatial mapping of the lipids<span> in tissue and includes a variety of techniques that can be used to image lipids. In the kidney, MSI studies often seek to resolve individual functional tissue units such as glomeruli and proximal tubules. Several different </span></span>MSI techniques, such as matrix-assisted laser desorption/ionization (MALDI) and </span></span></span></span>desorption electrospray ionization<span><span><span> (DESI), have been used to characterize lipids and small molecules in </span>chronic kidney disease, </span>acute kidney injury, </span></span>genetic<span><span><span> kidney disease, and cancer. In this review we provide several examples of how spatial metabolomics data can provide critical information concerning the localization of changes in various disease states. Additionally, when combined with pathology, </span>transcriptomics, or </span>proteomics, the metabolomic changes can illuminate underlying mechanisms and provide new clinical insights into disease mechanisms.</span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151582"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Glycomics and Kidney Disease 空间糖组学与肾脏疾病。

IF 3.5 3区医学

Seminars in nephrology Pub Date : 2024-11-01 Epub Date: 2025-04-09 DOI: 10.1016/j.semnephrol.2025.151581

Dušan Veličković PhD, Christopher R. Anderton PhD

{"title":"Spatial Glycomics and Kidney Disease","authors":"Dušan Veličković PhD, Christopher R. Anderton PhD","doi":"10.1016/j.semnephrol.2025.151581","DOIUrl":"10.1016/j.semnephrol.2025.151581","url":null,"abstract":"<div><div><span>Glycans<span> are critical for the kidney's physiological and pathological cellular functions, and our ability to see their spatial distributions within tissues has helped us reveal how these carbohydrate moieties are involved in many of these processes. This review discusses the role of different types of glycans in kidney biology and disease, common approaches used for glycan imaging, and how glycan imaging has helped us better understand kidney pathology. We mainly focus on emerging methods using mass spectrometry imaging<span> (MSI) because this technology is untargeted and provides complete information on glycan composition compared to the other methods, such as lectin and metabolite labeling, which are targeted and often inform only on the specific part of a glycan structure. We especially focus on protein </span></span></span><em>N</em>-glycosylation, as this is one of the most common post-translational modifications, and these moieties play a vital role in renal structure and function. The recent advancements in MSI of <em>N</em><span>-glycans we reviewed have provided new insights into the pathophysiology of the kidney and paved the way for clinical application.</span></div></div>","PeriodicalId":21756,"journal":{"name":"Seminars in nephrology","volume":"44 6","pages":"Article 151581"},"PeriodicalIF":3.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0