Science Immunology最新文献

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes 褐色脂肪组织中的调节性T细胞通过抑制产生干扰素γ的淋巴细胞来保护产热

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-25 DOI: 10.1126/sciimmunol.ads0478

Nathan W. Zammit, Ariana Vargas-Castillo, P. Kent Langston, Gang Wang, Yangzhong Zhou, Bruce M. Spiegelman, Christophe Benoist, Diane Mathis

{"title":"Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes","authors":"Nathan W. Zammit, Ariana Vargas-Castillo, P. Kent Langston, Gang Wang, Yangzhong Zhou, Bruce M. Spiegelman, Christophe Benoist, Diane Mathis","doi":"10.1126/sciimmunol.ads0478","DOIUrl":"10.1126/sciimmunol.ads0478","url":null,"abstract":"<div >Whereas visceral adipose tissue (VAT) primarily stores excess energy, brown adipose tissue (BAT) dissipates it in a process termed nonshivering thermogenesis. Several key VAT features, particularly murine epidydimal VAT, are regulated by a distinct population of regulatory T (T<sub>reg</sub>) cells, raising the question of whether BAT hosts an analogous population. Although T<sub>reg</sub> cells have been observed in BAT, their properties and mechanisms of action require elucidation. We found BAT T<sub>reg</sub> cells to be heterogeneous in subtissular localization and subtype composition. Punctual depletion of T<sub>reg</sub> cells unleashed interferon-γ (IFN-γ)–producing lymphocytes in BAT, but not in subcutaneous or visceral fat depots, leading to IFN-γ–dependent mitochondrial dysfunction and metabolic dysregulation, thereby impeding nonshivering thermogenesis. Cold challenge selectively expanded the IL-18R1<sup>+</sup> T<sub>reg</sub> subtype in BAT; stripping this receptor specifically from T<sub>reg</sub> cells unleashed IFN-γ–producing lymphocytes and compromised temperature control. Thus, control of local IFN-γ production is a core feature of T<sub>reg</sub> cell control of tissue homeostasis.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciimmunol.ads0478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity 组织来源和病毒特异性决定了人CD8+ T细胞的细胞毒性

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-18 DOI: 10.1126/sciimmunol.adq4881

Julia Niessl, Thomas R. Müller, Christian Constantz, Curtis Cai, Vera Nilsén, Olga Rivera Ballesteros, Sarah Adamo, Tobias Kammann, Elli Mouchtaridi, Yu Gao, Mily Akhirunnesa, Elisa J. M. Raineri, Whitney Weigel, Efthymia Kokkinou, Christopher Stamper, Anne Marchalot, John Bassett, Sabrina Ferreira, Inga Rodahl, Nicole Wild, Teresa Stellaccio, Demi Brownlie, Emma Ringqvist, Malin Flodström-Tullberg, Sian Llewellyn-Lacey, Chris Tibbitt, Quirin Hammer, Jakob Michaëlsson, David A. Price, Jenny Mjösberg, Nicole Marquardt, Johan K. Sandberg, Takuya Sekine, Carl Jorns, Marcus Buggert

{"title":"Tissue origin and virus specificity shape human CD8+ T cell cytotoxicity","authors":"Julia Niessl, Thomas R. Müller, Christian Constantz, Curtis Cai, Vera Nilsén, Olga Rivera Ballesteros, Sarah Adamo, Tobias Kammann, Elli Mouchtaridi, Yu Gao, Mily Akhirunnesa, Elisa J. M. Raineri, Whitney Weigel, Efthymia Kokkinou, Christopher Stamper, Anne Marchalot, John Bassett, Sabrina Ferreira, Inga Rodahl, Nicole Wild, Teresa Stellaccio, Demi Brownlie, Emma Ringqvist, Malin Flodström-Tullberg, Sian Llewellyn-Lacey, Chris Tibbitt, Quirin Hammer, Jakob Michaëlsson, David A. Price, Jenny Mjösberg, Nicole Marquardt, Johan K. Sandberg, Takuya Sekine, Carl Jorns, Marcus Buggert","doi":"10.1126/sciimmunol.adq4881","DOIUrl":"10.1126/sciimmunol.adq4881","url":null,"abstract":"<div >CD8<sup>+</sup> T cells are classically defined by cytotoxic activity, but it has remained unclear whether cytotoxic programs are compartmentalized across tissues and memory subsets. Here, we established a human organ donor cohort and found that expression of conventional cytotoxic molecules—granulysin, perforin, and granzyme B—was most prominent among circulating memory CD8<sup>+</sup> T cells and decreased progressively with tissue residency, inversely mirroring the expression of CD69 and CD103. Other cytotoxic molecules, including granzymes A, H, K, and M, were variably expressed across tissues, and memory CD8<sup>+</sup> T cells targeting persistent viruses expressed multiple granzymes coordinately. In an in vitro tonsil system, transforming growth factor–β induced discordant regulation of cytotoxic molecules and CD103. Combined with interleukin-15, this circuitry modulated proliferation and the acquisition of redirected killing activity via perforin and granzyme B. Our findings suggest that human memory CD8<sup>+</sup> T cell cytotoxicity is intricately regulated by environmental cues reflecting tissue location and antigen specificity.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation 胎盘霍夫鲍尔细胞与单核增生乳杆菌之间的相互作用在整个妊娠期发生变化

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-18 DOI: 10.1126/sciimmunol.adq3066

Nagisa Yoshida, Anna Appios, Qian Li, Joseph P. Hutton, George Wood, Martin Potts, Julia Aleksandrowicz, Enrico R. Barrozo, Freya Dover, Holly Anderson, Katie Stephens, Irving L. M. H. Aye, Jake R. Thomas, Hannah C. M. Schenk, Adam M. Bourke, Catherine E. Aiken, Ashley Moffett, Andrew Sharkey, Anna V. Protasio, Kjersti M. Aagaard, James R. Edgar, Betty Y. W. Chung, Naomi McGovern

{"title":"Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation","authors":"Nagisa Yoshida, Anna Appios, Qian Li, Joseph P. Hutton, George Wood, Martin Potts, Julia Aleksandrowicz, Enrico R. Barrozo, Freya Dover, Holly Anderson, Katie Stephens, Irving L. M. H. Aye, Jake R. Thomas, Hannah C. M. Schenk, Adam M. Bourke, Catherine E. Aiken, Ashley Moffett, Andrew Sharkey, Anna V. Protasio, Kjersti M. Aagaard, James R. Edgar, Betty Y. W. Chung, Naomi McGovern","doi":"10.1126/sciimmunol.adq3066","DOIUrl":"10.1126/sciimmunol.adq3066","url":null,"abstract":"<div >Hofbauer cells (HBCs) are extraembryonic macrophages generated de novo within the human placenta. In this study, we explored how the properties of HBCs change throughout gestation. Our analysis revealed transcriptomic differences between first-trimester and term HBCs, with many of the altered genes linked to immune responses. As pregnancy progresses, HBCs exhibit a marked decrease in phagosome maturation and acidification. We show that the differences between first-trimester and term HBCs are important in the context of infection with <i>Listeria monocytogenes</i>, a pathogen that crosses the placenta and replicates within macrophages. Specifically, we observed reduced colony-forming units and diminished actin recruitment by <i>L. monocytogenes</i> in first-trimester HBCs compared with term HBCs. Our findings indicate that the ability of <i>L. monocytogenes</i> to escape from vacuoles is impaired within first-trimester HBCs. Thus, the changes in HBC biology across pregnancy are important in shaping their interactions with <i>L. monocytogenes.</i></div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciimmunol.adq3066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation OTUD3通过抑制微生物介导的STING激活来预防溃疡性结肠炎

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-18 DOI: 10.1126/sciimmunol.adm6843

Bo Li, Taiki Sakaguchi, Haruka Tani, Takayoshi Ito, Mari Murakami, Ryu Okumura, Masao Kobayashi, Daisuke Okuzaki, Daisuke Motooka, Hiroki Ikeuchi, Takayuki Ogino, Tsunekazu Mizushima, Seiichi Hirota, Yuriko Otake-Kasamoto, Toshihiro Kishikawa, Shota Nakamura, Kouji Kobiyama, Ken J. Ishii, Takao Hashiguchi, Taro Kawai, Etsushi Kuroda, Shinichiro Shinzaki, Wataru Ise, Tomohiro Kurosaki, Akira Kikuchi, Yoshihiko Tomofuji, Yukinori Okada, Kiyoshi Takeda, Hisako Kayama

{"title":"OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation","authors":"Bo Li, Taiki Sakaguchi, Haruka Tani, Takayoshi Ito, Mari Murakami, Ryu Okumura, Masao Kobayashi, Daisuke Okuzaki, Daisuke Motooka, Hiroki Ikeuchi, Takayuki Ogino, Tsunekazu Mizushima, Seiichi Hirota, Yuriko Otake-Kasamoto, Toshihiro Kishikawa, Shota Nakamura, Kouji Kobiyama, Ken J. Ishii, Takao Hashiguchi, Taro Kawai, Etsushi Kuroda, Shinichiro Shinzaki, Wataru Ise, Tomohiro Kurosaki, Akira Kikuchi, Yoshihiko Tomofuji, Yukinori Okada, Kiyoshi Takeda, Hisako Kayama","doi":"10.1126/sciimmunol.adm6843","DOIUrl":"10.1126/sciimmunol.adm6843","url":null,"abstract":"<div >Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on the pathophysiology of intestinal fibroblasts remains poorly understood. Here, we demonstrate that OTU deubiquitinase 3 (OTUD3) suppresses pathologic activation of fibroblasts exposed to microbial cyclic GMP-AMP (3′3’-cGAMP) in the colon by deubiquitinating stimulator of interferon genes (STING). Mice harboring a UC risk missense variant in the <i>Otud3</i> gene showed pathological features of UC in the colon after transplantation of a fecal microbiota with the potential to produce excessive cGAMP from patients with UC. Collectively, these results highlight a mechanism of the interaction between OTUD3 in host fibroblasts and STING-activating microbiota in UC development.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncanonical Hedgehog signaling through Smoothened controls cytotoxic T cell migration in the tumor microenvironment 非规范Hedgehog信号通过Smoothened控制肿瘤微环境中细胞毒性T细胞的迁移

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-11 DOI: 10.1126/sciimmunol.adr3127

Chrysa Kapeni, Louise O’Brien, Dilyara Sabirova, Oliver Cast, Valentina Carbonaro, Stephen Clark-Leonard, Anne C. Machel, Flavio Beke, Sarah McDonald, Kate Fife, Maike de la Roche

{"title":"Noncanonical Hedgehog signaling through Smoothened controls cytotoxic T cell migration in the tumor microenvironment","authors":"Chrysa Kapeni, Louise O’Brien, Dilyara Sabirova, Oliver Cast, Valentina Carbonaro, Stephen Clark-Leonard, Anne C. Machel, Flavio Beke, Sarah McDonald, Kate Fife, Maike de la Roche","doi":"10.1126/sciimmunol.adr3127","DOIUrl":"10.1126/sciimmunol.adr3127","url":null,"abstract":"<div >The Hedgehog (Hh) signaling pathway is aberrantly regulated in cancer. Hh inhibitors are successful in treating basal cell carcinoma (BCC) and Sonic Hedgehog–driven medulloblastoma but have largely failed in clinical trials of other solid cancers. We show that Hh inhibitor treatment specifically diminishes CD8 T cell migration into the tumor microenvironment, both in murine cancer models and resected BCCs from patients treated with the Smoothened (Smo) inhibitor vismodegib. Using small-molecule antagonists and genetic knockout models of key Hh signaling components, we demonstrate that the migration defect is mediated exclusively by the signal transducer Smo and not Hh ligands or Gli transcription factors. Smo acts noncanonically as a G protein–coupled receptor to regulate the migration of murine and human CD8 T cells via RhoA. Our data establish a link between Hh inhibition in vivo and the antitumor immune response and provide the basis for improved Hh targeting approaches for patients with cancer.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate lymphoid cells originate from fetal liver–derived tissue-resident progenitors 先天淋巴样细胞起源于胎儿肝源性组织驻留祖细胞

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-11 DOI: 10.1126/sciimmunol.adu7962

Xianwei Wang, Jiarui Li, Lucas Rebuffet, Ming Cheng, Boqun Bao, Yawen Chen, Xiaodong Zheng, Yongyan Chen, Haoyu Sun, Rui Sun, Eric Vivier, Hui Peng, Zhigang Tian

{"title":"Innate lymphoid cells originate from fetal liver–derived tissue-resident progenitors","authors":"Xianwei Wang, Jiarui Li, Lucas Rebuffet, Ming Cheng, Boqun Bao, Yawen Chen, Xiaodong Zheng, Yongyan Chen, Haoyu Sun, Rui Sun, Eric Vivier, Hui Peng, Zhigang Tian","doi":"10.1126/sciimmunol.adu7962","DOIUrl":"10.1126/sciimmunol.adu7962","url":null,"abstract":"<div >Committed progenitors with innate lymphoid cell (ILC) developmental potential are present in the fetus and bone marrow (BM). However, how fetal and BM hematopoiesis temporally and spatially contribute to ILC pools remains unclear. Here, we elucidated the distinct origins and developmental pathways of extramedullary and intramedullary ILCs in mice during ontogeny. ILC-restricted hematopoiesis is initiated in the fetal liver (FL), and then FL-derived PD-1<sup>+</sup> ILC precursors (ILCPs) seed fetal lung and intestine. Organ niches determine the commitment of ILCPs to downstream precursors, including bipotent ILC1-ILC3 precursors (ILC1/3Ps), which preferentially reside in the liver and intestine, and ILC2 precursors (ILC2Ps), which are found predominantly in the lung. These precursors persist in adulthood and contribute to local ILC pools in a BM-independent manner. In contrast, intramedullary ILC2Ps and ILC2s rely on BM hematopoiesis. Thus, our study demonstrates that extramedullary and intramedullary ILCs have different origins and provides a comprehensive framework for ILC developmental dynamics.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors 肿瘤中耗尽的CD8 T细胞中效应功能层的多模态描述

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-11 DOI: 10.1126/sciimmunol.adt3537

Arja Ray, Molly Bassette, Kenneth H. Hu, Lomax F. Pass, Tristan Courau, Bushra Samad, Alexis J. Combes, Vrinda Johri, Brittany Davidson, Katherine Wai, Patrick Ha, Grace Hernandez, Itzia Zaleta-Linares, Matthew F. Krummel

{"title":"Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors","authors":"Arja Ray, Molly Bassette, Kenneth H. Hu, Lomax F. Pass, Tristan Courau, Bushra Samad, Alexis J. Combes, Vrinda Johri, Brittany Davidson, Katherine Wai, Patrick Ha, Grace Hernandez, Itzia Zaleta-Linares, Matthew F. Krummel","doi":"10.1126/sciimmunol.adt3537","DOIUrl":"10.1126/sciimmunol.adt3537","url":null,"abstract":"<div >Undescribed functional axes may intersect with the trajectory of T cell exhaustion (T<sub>EX</sub>) to contribute to the antitumoral functions of CD8 T cells. By leveraging fluorescent transcriptional reporting of the T cell activation marker <i>Cd69</i>, we defined a classifier for potent versus suboptimal CD69<sup>+</sup> activation states arising from T cell stimulation. In tumors, this delineation provided an additional functional readout among T<sub>EX</sub> subsets, marked by enhanced effector molecule production. The more potent <i>Cd69</i>-TFP<sup>hi</sup> state was the most prominent in a T cell–mediated tumor clearance model, displaying increased engagement and superior tumor cell killing. Simultaneous analysis of gene and protein expression in human head and neck tumors enabled a similar strategy to identify <i>Cd69</i>RNA<sup>hi</sup>CD69<sup>+</sup> cells with enhanced functional features compared with <i>Cd69</i>RNA<sup>lo</sup>CD69<sup>+</sup> cells among intratumoral CD8 T cell subsets. Thus, refining the T cell functional landscape in tumors potentiates the identification of rare, potent effectors that could be leveraged for improving cancer treatment.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 10 commandments of immunoregulation in lymphoma 淋巴瘤免疫调节的十诫

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-04 DOI: 10.1126/sciimmunol.aea0950

Maria de los Reyes Capilla Guerra, Gabriel K. Griffin

引用次数: 0

Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B 簇毛细胞通过转录因子Spi-B抑制肠道2型免疫

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-04 DOI: 10.1126/sciimmunol.ads5818

Jiali Wang, Ruoxi Shen, Kunpeng Yang, Xiaohuan Guo, Jingyou Yu, Chuan Wu, Xue-Kun Guo, Xiaoyu Hu

{"title":"Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B","authors":"Jiali Wang, Ruoxi Shen, Kunpeng Yang, Xiaohuan Guo, Jingyou Yu, Chuan Wu, Xue-Kun Guo, Xiaoyu Hu","doi":"10.1126/sciimmunol.ads5818","DOIUrl":"10.1126/sciimmunol.ads5818","url":null,"abstract":"<div >Excessive type 2 immunity underlies various disease conditions, including allergies, yet the homeostatic mechanisms that limit type 2 responses are not fully understood. Here, we revealed that intestinal tuft cells, specialized epithelial cells known for triggering type 2 immune activation, also have a molecular circuit that restrains type 2 responses. Ablation of the transcription factor Spi-B in tuft cells was sufficient to elicit spontaneous type 2 inflammation. Tuft cell–intrinsic deficiency of Spi-B rendered otherwise resistant C57BL/6J mice susceptible to food allergy models. Spi-B repressed c-Kit signaling–driven production of the type 2 alarmin TSLP by tuft cells. Disruption of this negative regulatory axis led to tuft cell hyperplasia and exacerbated type 2 inflammation, which could be pharmacologically targeted with a tyrosine kinase inhibitor. These findings pinpoint a crucial tuft cell–centric checkpoint of type 2 immunity and highlight the dual role of tuft cells in both promoting and restraining type 2 responses.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"10 109","pages":""},"PeriodicalIF":17.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciimmunol.ads5818","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB or not TB: That depends on the antibody Fc 结核病或非结核病：这取决于抗体Fc

IF 17.6 1区医学

Science Immunology Pub Date : 2025-07-04 DOI: 10.1126/sciimmunol.aea0953

Surabhi Kumar, Kevin C. O’Connor

引用次数: 0