Beatriz Santos-Pereira, Rafaela Nogueira, Yohannes Tafesse, Ariana Correia-Silva, Eduarda Leite-Gomes, Guillem Sanchez Sanchez, Xavier Luppens, Lyndsay E.A. Young, Bruno Cavadas, Carlos Vasconcelos, Daniela Oliveira, Ana Lé, Joana Torres, Ana Campar, João F. Serodio, António Marinho, José D. Alves, Tiago Torres, Richard R. Drake, David Vermijlen, Inês Alves, Salomé S. Pinho
{"title":"Glycome remodeling programs pathogenic γδ T17 cell responses in autoimmunity","authors":"Beatriz Santos-Pereira, Rafaela Nogueira, Yohannes Tafesse, Ariana Correia-Silva, Eduarda Leite-Gomes, Guillem Sanchez Sanchez, Xavier Luppens, Lyndsay E.A. Young, Bruno Cavadas, Carlos Vasconcelos, Daniela Oliveira, Ana Lé, Joana Torres, Ana Campar, João F. Serodio, António Marinho, José D. Alves, Tiago Torres, Richard R. Drake, David Vermijlen, Inês Alves, Salomé S. Pinho","doi":"10.1126/sciimmunol.aec9553","DOIUrl":"10.1126/sciimmunol.aec9553","url":null,"abstract":"<div >Glycans play fundamental roles in T cell biology; however, the glycome landscape of γδ T cells remains to be unlocked. Despite the growing importance of γδ T cells in host defense, tissue homeostasis, and diseases, the glycosylation mechanisms guiding their activation, commitment, and function remain poorly defined. By performing single-cell RNA sequencing, we revealed that type 3/γδ T17/interleukin-17A (IL-17A)–committed γδ T cells rely on (<i>N-acetylglucosaminyltransferase 1</i>) <i>MGAT1</i>–<i>MGAT5</i>–mediated branched N-glycosylation. We further demonstrated that the absence of branched <i>N</i>-glycans on γδ T cells acts as a peripheral signal, driving an IL-17A–pro-inflammatory phenotype, alongside a shift to a Vγ4<sup>+</sup> subset and the imprinting of innate-like properties. This altered glycoform of type 3 γδ T cells was shown to induce severe psoriasis. γδ T cells from patients with autoimmune and inflammatory diseases exhibited a deficiency in branched <i>N</i>-glycans. Glycan supplementation can reprogram γδ T cells toward a less-pathogenic state, highlighting <i>N</i>-glycans as a previously unrecognized immune checkpoint for γδ T cells.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Grassmann, Hyunu Kim, Timo Rückert, Christin Friedrich, Marine Pujol, Sherry X. Fan, Mark Owyong, Jennifer M. Zhang, Giorgi Beroshvili, Veit R. Buchholz, Georg Gasteiger, Joseph C. Sun
{"title":"STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells","authors":"Simon Grassmann, Hyunu Kim, Timo Rückert, Christin Friedrich, Marine Pujol, Sherry X. Fan, Mark Owyong, Jennifer M. Zhang, Giorgi Beroshvili, Veit R. Buchholz, Georg Gasteiger, Joseph C. Sun","doi":"10.1126/sciimmunol.aed4832","DOIUrl":"10.1126/sciimmunol.aed4832","url":null,"abstract":"<div >The immune system integrates signals to regulate immune responses, forming complex context-dependent networks where identical cues produce distinct outcomes. Signal transducer and activator of transcription (STAT) transcription factors convert cytokine receptor engagement into transcriptional responses, serving as central regulatory hubs. How concurrent STAT activation across different environments shapes immune cell function remains unclear. Here, we show that STAT3 plays a context-dependent role in antiviral natural killer (NK) cells, either promoting or impairing adaptive responses depending on the inflammatory milieu during mouse cytomegalovirus (MCMV) infection. STAT3 is recruited to distinct genomic loci depending on IL-15 or type I interferon availability, thus driving alternative transcriptional programs. Mechanistically, STAT3 differentially regulates downstream transcription factors MYB and B lymphocyte–induced maturation protein-1 (BLIMP-1) to shape NK cell differentiation during homeostasis and infection. STAT3 relocation is governed by epigenetic mechanisms and preferred relocation toward distinct STAT motifs. Thus, STAT3 functions as a cytokine-sensing transcriptional switch integrating IL-15 and type I interferon signals to control lymphocyte adaptation during viral infection.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ondrej Suchanek, Rory Fitzroy, Nathan Richoz, Krishnaa T. Mahbubani, Jack L. Martin, Benjamin J. Stewart, Elena Prigmore, Menna R. Clatworthy
{"title":"B1-like innate B cells are present in adult human organs in homeostasis","authors":"Ondrej Suchanek, Rory Fitzroy, Nathan Richoz, Krishnaa T. Mahbubani, Jack L. Martin, Benjamin J. Stewart, Elena Prigmore, Menna R. Clatworthy","doi":"10.1126/sciimmunol.adz3326","DOIUrl":"10.1126/sciimmunol.adz3326","url":null,"abstract":"<div >Innate-like B cells produce natural antibodies and include marginal zone (MZ) B cells and B1 cells. B1 cells are well characterized in mice, where they prenatally seed serous cavities and produce regulatory cytokines. Putative B1 cells have been identified in human prenatal organs, but whether they persist into adulthood remains unclear. Here, we identified B1-like cells in the IgM<sup>+</sup> and IgA<sup>+</sup> memory compartment across adult human organs. These cells transcriptionally resembled murine and human prenatal B1 cells but not MZ B cells. They expressed canonical murine B1 cell markers, including <i>AHNAK</i>, and spontaneously secreted IgM. B cell receptor sequencing of paired kidney-spleen samples revealed lower diversity and mutation rates in kidney IgM/IgA clones, suggesting spleen-independent seeding. Adult B1-like cells expressed the regulatory cytokine <i>TGFB</i> and had abundant inferred interactions with tissue myeloid cells, which reciprocally expressed B cell prosurvival cytokines. These findings support the presence of B1-like cells across adult human organs in homeostasis.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel M. Barrón, Radeesha D. Jayewickreme, Heather H. Tran, Thornton W. Thompson, Ramya Narasimhan, Ying Zhu, Leila B. DeSchepper, Dahlya Habashi, Katherine F. Nico, Miles D. Tyner, Flora M. Tierney, Tyler E. Billipp, Michael J. Rosen, Denise M. Monack, Jakob von Moltke, Michael R. Howitt
{"title":"Follicle-associated epithelial tuft cells amplify type 2 mucosal immunity and IgA production","authors":"Gabriel M. Barrón, Radeesha D. Jayewickreme, Heather H. Tran, Thornton W. Thompson, Ramya Narasimhan, Ying Zhu, Leila B. DeSchepper, Dahlya Habashi, Katherine F. Nico, Miles D. Tyner, Flora M. Tierney, Tyler E. Billipp, Michael J. Rosen, Denise M. Monack, Jakob von Moltke, Michael R. Howitt","doi":"10.1126/sciimmunol.aee1358","DOIUrl":"10.1126/sciimmunol.aee1358","url":null,"abstract":"<div >Peyer’s patches (PPs) in the intestinal mucosa coordinate antibody responses to luminal microbes and dietary antigens. The follicle-associated epithelium (FAE) is traditionally recognized by the presence of microfold cells (M cells) that mediate antigen sampling in PPs. By analyzing <i>Gfi1b</i>-eGFP reporter mice and human PP biopsies, we identified tuft cells as an additional, evolutionarily conserved FAE population that regulates mucosal immunity. Using mouse models and intestinal organoids, we demonstrate that M cells and tuft cells are distinct lineages arising from <i>Pou2f3<sup>+</sup></i> progenitors, whose differentiation is reciprocally regulated by RANKL and interleukin-13 (IL-13), respectively. Tuft cell–derived IL-25 activates type 2 innate lymphoid cells (ILC2s) in PPs. Furthermore, IL-13 production by ILC2 enhances immunoglobulin A class switching and antigen-specific immunity. These findings reveal a dual surveillance system in the FAE, where developmentally related epithelial lineages use distinct mechanisms to coordinate mucosal immunity.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Hvarregaard Christensen, Aneta J. Jurkiewicz, Cathrine Silberbauer Jensen, Katarzyna Kjøge, Weisheng Luo, Wenhao He, Yuqiang Chen, Jiyong Liu, Louise Dalskov, Andreas Bondrup Bagger, Kasper Grønbjerg Winther, Katrine Gårn Gulstad, Anna Lorentzen, Gabrielle Haas, Julia M. Kamper, Che Stafford, Mads Gyrd-Hansen, Jan J. Enghild, Veit Hornung, Hua Cai, Jean-Luc Imler, Hans Henrik Gad, Rune Hartmann
{"title":"The IKK complex and TBK1/IKKε are recruited to STING through distinct mechanisms to activate NF-κB signaling","authors":"Anna Hvarregaard Christensen, Aneta J. Jurkiewicz, Cathrine Silberbauer Jensen, Katarzyna Kjøge, Weisheng Luo, Wenhao He, Yuqiang Chen, Jiyong Liu, Louise Dalskov, Andreas Bondrup Bagger, Kasper Grønbjerg Winther, Katrine Gårn Gulstad, Anna Lorentzen, Gabrielle Haas, Julia M. Kamper, Che Stafford, Mads Gyrd-Hansen, Jan J. Enghild, Veit Hornung, Hua Cai, Jean-Luc Imler, Hans Henrik Gad, Rune Hartmann","doi":"10.1126/sciimmunol.aeh5148","DOIUrl":"10.1126/sciimmunol.aeh5148","url":null,"abstract":"<div >Stimulator of interferon genes (STING) is a highly conserved signaling molecule that coordinates an antiviral innate immune response through activation of the nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) signaling pathways. In addition to an antiviral response, STING-mediated NF-κB signaling also leads to an inflammatory response, which can cause substantial pathology. However, the molecular mechanism whereby STING drives inflammation is poorly understood, and this has hindered the development of anti-inflammatory strategies targeting this pathway. Here, we define an evolutionarily conserved mechanism whereby STING activates NF-κB signaling via recruitment of inhibitor of NF-κB kinase subunit γ (IKKγ) in an M1-linked ubiquitin-dependent manner. We also show that the more recently evolved carboxyl-terminal tail of STING cooperates with the IKKγ-IKK complex for NF-κB–dependent expression of pro-inflammatory genes in mammalian cells through the kinases TBK1 (TANK-binding kinase 1)/IKKε. Thus, the expression of the key inflammatory genes <i>CCL3</i> and <i>CCL4</i> requires the formation of M1-linked ubiquitin and the activation of NF-κB, but we do not detect a role for IRF3 in STING-driven NF-κB signaling.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149130271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro H. Papotto, James E. Parkinson, Brian H.K. Chan, I-Hsuan Lin, Georgia E. Baldwin, Faith Denny, Lili Zhang, Rebecca J. Dodd, Stella T. Pearson, Natalie Fischhaber, Joanne E. Konkel, David R. Withers, Matthew R. Hepworth, Judith E. Allen
{"title":"Migratory dermal γδ T cells determine the balance between lung immunity and tissue damage during helminth infection","authors":"Pedro H. Papotto, James E. Parkinson, Brian H.K. Chan, I-Hsuan Lin, Georgia E. Baldwin, Faith Denny, Lili Zhang, Rebecca J. Dodd, Stella T. Pearson, Natalie Fischhaber, Joanne E. Konkel, David R. Withers, Matthew R. Hepworth, Judith E. Allen","doi":"10.1126/sciimmunol.aec7574","DOIUrl":"10.1126/sciimmunol.aec7574","url":null,"abstract":"<div >Many helminth parasites migrate through multiple host organs during infection, but how immune responses are relayed across these tissues is still poorly understood. To investigate the immune aspects of intertissue communication during infection, we established a percutaneous infection model with the tissue-migrating nematode <i>Nippostrongylus brasiliensis</i>. Profiling of the initial cutaneous immune response revealed that dermal γδ T cells become activated via an interleukin 1 receptor (IL-1R)–dependent mechanism, engage cell motility–associated transcriptional pathways, and leave the skin after parasite invasion. Inhibition of leukocyte migration prevents the accumulation of IL-17–producing γδ T cells in the lungs. Bypassing the skin phase of infection, and thereby preventing dermal γδ T cell migration, dampens early IL-17 production in the lungs. This, instead, leads to an enhanced interferon-γ (IFN-γ) response together with increased lung damage. Collectively, our data highlight a critical skin-lung axis regulating host-parasite interactions and safeguarding lung health.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steven M. Blum, Thomas L. Chan, Neal P. Smith, Courtney Ambrose, Katherine H. Xu, Alice Tirard, Nandini Samanta, Sidney Martin, Roya Best, Elizabeth Tuttle, Christopher T. Stueber, Yuhui Song, Vaishnavi R. Yalala, Haley Barnes, Sean T. Bannon, Chloe Simms, Benjamin Y. Arnold, Mushriq Al-Jazrawe, Joseph J. Zhao, Kamil Slowikowski, Jessica Tantivit, Kasidet Manakongtreecheep, Lukas M. Altenburger, Simon Knott, Matthew R. Strickland, Michael G. Drage, Linda T. Nieman, Jesse S. Boehm, Raghav Sundar, Gary Reynolds, Samuel J. Klempner, Alexandra-Chloé Villani
{"title":"Multiomic analysis of malignant ascites defines RORC-expressing dendritic cells at sites of metastasis","authors":"Steven M. Blum, Thomas L. Chan, Neal P. Smith, Courtney Ambrose, Katherine H. Xu, Alice Tirard, Nandini Samanta, Sidney Martin, Roya Best, Elizabeth Tuttle, Christopher T. Stueber, Yuhui Song, Vaishnavi R. Yalala, Haley Barnes, Sean T. Bannon, Chloe Simms, Benjamin Y. Arnold, Mushriq Al-Jazrawe, Joseph J. Zhao, Kamil Slowikowski, Jessica Tantivit, Kasidet Manakongtreecheep, Lukas M. Altenburger, Simon Knott, Matthew R. Strickland, Michael G. Drage, Linda T. Nieman, Jesse S. Boehm, Raghav Sundar, Gary Reynolds, Samuel J. Klempner, Alexandra-Chloé Villani","doi":"10.1126/sciimmunol.aeb9068","DOIUrl":"10.1126/sciimmunol.aeb9068","url":null,"abstract":"<div >Malignant ascites is caused by the peritoneal dissemination of cancer and has a poor prognosis. Here, we performed multiomic analyses on ascites samples from patients with cancer and identified <i>RORC</i>-expressing dendritic cells (<i>RORC</i> DCs) enriched in malignant ascites. <i>RORC</i> DCs expressed <i>PIGR</i> and were transcriptionally similar to murine RORγt<sup>+</sup> DCs/Thetis cells implicated in immune tolerance. We devised a high-purity sorting strategy to enable in vitro experiments with patient-derived <i>RORC</i> DCs, which indicated that these cells were phenotypically stable and stimulated T cell proliferation while attenuating <i>IFNG</i> expression. Multiplexed immunofluorescence identified <i>RORC</i> DCs in primary tumors and demonstrated their enrichment in regional lymph node metastases. These results associate human <i>RORC</i> DCs with advanced malignancies and suggest a role for these cells in the tumor microenvironment.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Old dog, new tricks: Astrocytes use the CD40 pathway to propagate neuroinflammation","authors":"Jennifer L. Gommerman","doi":"10.1126/sciimmunol.aem6143","DOIUrl":"10.1126/sciimmunol.aem6143","url":null,"abstract":"<div >In addition to myeloid antigen-presenting cells (APCs), CD40 also induces APC potential in astrocytes during neuroinflammation.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pairing up to decode recognition","authors":"Jonathan S. Maltzman","doi":"10.1126/sciimmunol.aem6135","DOIUrl":"10.1126/sciimmunol.aem6135","url":null,"abstract":"<div >Fixing TCR chains decodes rules of epitope recognition.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 124","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149092131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hisham S. Hussain, Samuel J. Redmond, Wael Awad, Calvin Xu, Caroline Soliman, Huimeng Wang, Yuyang Zhang, Lisa Ciacchi, Alexis P. Gonzalez, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Alexandra J. Corbett, Adam P. Uldrich, Jamie Rossjohn, Dale I. Godfrey, Hui-Fern Koay, Nicholas A. Gherardin
{"title":"Specific targeting of MR1-antigen complexes using nanobodies","authors":"Hisham S. Hussain, Samuel J. Redmond, Wael Awad, Calvin Xu, Caroline Soliman, Huimeng Wang, Yuyang Zhang, Lisa Ciacchi, Alexis P. Gonzalez, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Alexandra J. Corbett, Adam P. Uldrich, Jamie Rossjohn, Dale I. Godfrey, Hui-Fern Koay, Nicholas A. Gherardin","doi":"10.1126/sciimmunol.aeb8726","DOIUrl":"10.1126/sciimmunol.aeb8726","url":null,"abstract":"<div >T cell receptor mimic (TCRm) antibodies that bind peptide–human leukocyte antigen complexes have great therapeutic potential. Major histocompatibility complex class I–related protein 1 (MR1) exhibits limited polymorphism and presents conserved metabolites, such as 5-OP-RU, derived from microbial riboflavin biosynthesis. Whether antibodies targeting such MR1–5-OP-RU complexes can be generated remains unclear. Using yeast display technology, nanobodies with high affinity toward the MR1–5-OP-RU complex were generated. These nanobodies can bind both mouse and human MR1–5-OP-RU and inhibit mucosal-associated invariant T (MAIT) cell responses to 5-OP-RU and bacterial challenge, demonstrating in vitro and in vivo bioactivity. We also solved the crystal structures of the lead nanobody in complex with MR1 antigens and demonstrated that the nanobody cobound MR1 and 5-OP-RU, akin to a TCRm antibody. Last, we engineered bispecific antibodies targeting both MR1–5-OP-RU and CD3 that drive broad T cell killing of bacterially infected cells as well as tumor cells treated with 5-OP-RU, providing evidence for immune redirection via MR1-targeting TCRm-based nanobodies.</div>","PeriodicalId":21734,"journal":{"name":"Science Immunology","volume":"11 123","pages":""},"PeriodicalIF":16.4,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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