Scientifica最新文献

{"title":"Updates on SPOP Gene Mutations in Prostate Cancer and Computational Insights From TCGA cBioPortal Database.","authors":"Suleiman Zakari, Solomon O Rotimi, Chandra Tatsha Bholah, Olubanke O Ogunlana","doi":"10.1155/sci5/4084224","DOIUrl":"10.1155/sci5/4084224","url":null,"abstract":"<p><p>Speckle-type pox virus and zinc finger protein (SPOP) has emerged as a key focus in prostate cancer research due to its critical role in regulating the androgen receptor (AR) signaling pathway. This review aims to comprehensively summarize current knowledge on SPOP gene mutations in prostate cancer, emphasizing their importance in disease characterization and identification of therapeutic targets. A systematic literature search was conducted across multiple databases, including PubMed, Web of Science, Scopus, and Google Scholar. In addition, this study uses computational approaches and data from the TCGA cBioPortal database to explore the landscape of SPOP mutations in prostate cancer. After screening 682 articles and following systematic selection steps, 56 high-quality articles were included. Computational analysis of TCGA cBioPortal data revealed a SPOP mutation prevalence of 5%-6%, along with significant alterations in AR signaling and epigenetic regulation. SPOP mutations disrupt substrate recognition, leading to dysregulation of downstream pathways such as AR signaling and chromatin remodeling. Notably, SPOP-mutant prostate cancers are mutually exclusive with TMPRSS2-ERG fusions and enriched for Wnt pathway alterations. Patients with SPOP mutations demonstrate prolonged responses to androgen deprivation therapy (ADT), although concurrent mutations in TP53 or DNA repair genes negatively impact outcomes. While their prognostic significance continues to evolve, their impact on the AR pathway highlights their potential as therapeutic targets. The clinical implications of SPOP mutations are substantial, as they are linked to variations in treatment response and disease progression, thus serving as valuable biomarkers for risk stratification and prognosis.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"4084224"},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical Study of Medicinal Shrubs and Herbs Used by Forest-Fringe Communities of Ghana.","authors":"Michael Asigbaase, Linda Anaba, Daniel Adusu, Simon Abugre, Adisa Ayeley Musah, Collins Ayine Nsor, Daniel Akoto Sarfo","doi":"10.1155/sci5/1362301","DOIUrl":"10.1155/sci5/1362301","url":null,"abstract":"<p><p>Documenting and quantitatively assessing medicinal plants and indigenous knowledge in different social contexts is critical in providing nature-based solutions to contemporary issues. Therefore, our study quantitatively evaluated medicinal shrubs and herbs in forest-fringe communities of Ghana and tested the versatility, ecological apparency and sociodemographic traits and knowledge dynamics hypotheses. Structured questionnaires, interviews and field visits were used to conduct an ethnobotanical survey involving 78 respondents, selected based on random and snowball sampling techniques. The data were analysed using quantitative indices such as indigenous knowledge index (IKI), species use value (SUV), informant agreement ratio (IAR) and ethnobotanical importance value (EIV). To test the versatility and sociodemographic traits and knowledge dynamics hypotheses, linear mixed-effects regressions were conducted, while one-way ANOVA was used to test the ecological apparency hypothesis. The Jaccard dissimilarity index was used to assess the degree of uniqueness of diseases treated by plants. We found 69 medicinal shrubs and herbs, belonging to 35 plant families, used to treat 101 diseases in the study area. <i>Paullinia pinnata</i> L. recorded the highest SUV (18.2) values, whereas <i>Momordica charantia</i> L. recorded the highest EIV (22.326) values. We found support for the versatility and sociodemographic traits and knowledge dynamics hypotheses, but no support for the ecological apparency hypothesis. The IAR of the 16 disease categories evaluated in this study ranged from 0.50 to 0.77. The Jaccard index showed that diseases treated by using introduced or native plants were 65.6% dissimilar. Our findings have implications for the achievement of SDG 3 (good health and well-being). We concluded that sociodemographic traits influence ethnobotanical knowledge dynamics, while plants with multiple useful parts are the most versatile and recommend the conservation of biodiversity to enhance diversity of treatment options.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"1362301"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Perception of Forest Users Towards a Collaborative Forest Management in Terai Region of Nepal.","authors":"Anita Subedi, Gandhiv Kafle","doi":"10.1155/sci5/5512042","DOIUrl":"https://doi.org/10.1155/sci5/5512042","url":null,"abstract":"<p><p>The collaborative forest management (CFM) approach involves sustainable forest management in collaboration with local people to derive numerous benefits from government-managed forests, including maintenance of ecological balance, generation of economic returns, and improvement of livelihoods. This research aimed to analyze people's perception and knowledge regarding CFM at Sabaiya CFM in Parsa district, Nepal. Data were collected using household survey (<i>n</i> = 400), direct field observation, focus group discussions and key informant interview. Interviews. The results showed that both nearby and distant forest users had high expectations of receiving fuel wood and fodder from CFM. However, the inclusion of women and Disadvantaged and Vulnerable Groups (DAGs) in the management planning was found to be very low. Both distant users and nearby forest users demonstrated a lower level of awareness regarding forest management, resulting in a less positive attitude toward CFM and its associated benefits. It is recommended to encourage the participation of women and DAG members in management planning of CFM and engage them in income generation activities.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"5512042"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12088831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges in Fungal Coinfections Associated With Global COVID-19.","authors":"Ariyo Shahin Jafari, Amir Sasan Mozaffari Nejad, Hossein Faraji, Ahmed S Abdel-Moneim, Saeme Asgari, Hakime Karami, Ali Kamali, Ali Asghar Kheirkhah Vakilabad, Ali Habibi, Motahareh Faramarzpour","doi":"10.1155/sci5/6840605","DOIUrl":"https://doi.org/10.1155/sci5/6840605","url":null,"abstract":"<p><p>The early diagnosis of opportunistic infections is a critical concern for patient care worldwide, particularly in the context of the COVID-19 pandemic. This review examines the challenges and advancements in the management and early diagnosis of opportunistic fungal infections, which have become increasingly prominent during the pandemic. Using multiple sources, including curated databases such as PubMed and Scopus, as well as Google Scholar for broader literature searches, we systematically reviewed studies on COVID-19-associated fungal infections, with a focus on candidiasis, mucormycosis, and aspergillosis. The inclusion criteria encompassed peer-reviewed articles, clinical case reports, and cohort studies that discussed diagnostic methods, clinical outcomes, and treatment responses. Data were systematically extracted and analyzed to identify key trends and gaps in current diagnostic practices. Given the significance of opportunistic fungal infections-particularly the selected species-this review provides a comprehensive analysis of diagnostic challenges and advancements in the context of COVID-19 and beyond. Currently, there is no definitive strategy for effectively addressing these opportunistic pathogens, highlighting the need for continued research and innovation. Despite advancements in medical technology, opportunistic fungal infections continue to pose significant challenges to early and accurate diagnosis. The COVID-19 pandemic has exacerbated these challenges, with secondary fungal infections contributing to increased morbidity and mortality rates. This review highlights the complexities of diagnosing fungal coinfections and emphasizes the urgent need for improved diagnostic strategies. Enhancing the early and accurate detection of these infections is critical for effective patient management, particularly during viral pandemics. Addressing the challenges outlined in this review requires innovative diagnostic approaches to improve patient outcomes and reduce the burden of opportunistic infections on global healthcare systems.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"6840605"},"PeriodicalIF":2.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of Soil and Water Conservation Structures on Selected Soil Physicochemical Parameters in Wali Micro-Watershed Ambo District, Central Ethiopia.","authors":"Tesfaye Busa, Bayisa Duressa, Tena Regasa, Eve Bohnett, Siraj Mammo","doi":"10.1155/sci5/1465657","DOIUrl":"https://doi.org/10.1155/sci5/1465657","url":null,"abstract":"<p><p>Land degradation poses a significant environmental challenge, leading to reduced soil fertility, agricultural production, and overall land productivity. To combat this issue, the Ethiopian government has implemented various soil and water conservation (SWC) strategies in rural areas over the last few decades. This study assessed the impact of these SWC structures on selected soil physicochemical properties in Wali micro-watershed. A purposive sampling technique was used to select the study district and watershed, and a systematic randomized complete block design was used to collect soil samples. Samples were taken from both farmlands conserved with various SWC practices, like soil bund, stone bund, terraces, fanyajuu, and bench terrace, all from nonconserved lands along the lower, middle, slope classes using an \"X\" sampling design. Eighteen composite soil samples for all three slope classes were collected in triplicate from topsoil (0-30-cm depth) for analysis. These samples were processed and analyzed following standard laboratory procedures in the Ambo University Chemistry Department. The study assessed soil bulk density, moisture, pH, cation exchange capacity, electrical conductivity, organic matter, organic carbon, total nitrogen, available phosphorus, available potassium, and other basic cations (sodium, calcium, and magnesium). The results showed that conserved farmlands had mean values of 1.26 g/cm³ for bulk density, 6.72% for moisture, 6.29 for pH, 4.32% for organic matter, 2.24% for organic carbon, 0.30% for total nitrogen, 53.02 cmol/kg for CEC, 37.28 dS/cm for electrical conductivity, 25.80 mg/kg for available phosphorus, and 0.91 mg/kg for available potassium. In contrast, nonconserved farmlands exhibited 1.37 g/cm³ for bulk density, 6.07% for moisture, 5.86 for pH, 3.12% for organic matter, 1.84% for organic carbon, 0.21% for total nitrogen, 46.6 cmol/kg for CEC, 37.23 dS/cm for electrical conductivity, 21.06 mg/kg for available phosphorus, and 0.63 mg/kg for available potassium. The study concluded that SWC practices significantly improved soil bulk density, moisture content, pH, organic carbon, organic matter; cation exchange capacity, total nitrogen, sodium, available phosphorus, and potassium. However, electrical conductivity, calcium, and magnesium showed no significant improvement (<i>p</i> < 0.05). These findings highlight the positive effects of SWC structures on soil quality, underscoring the importance of maintaining these practices for sustainable land management and advocating for their expansion to other watersheds.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"1465657"},"PeriodicalIF":2.3,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility-Enhancing Potential of <i>P. amygdalas</i> and <i>J. regia</i> Oil Mixture in Wistar Rats: Male/Female Infertility Models Assessment.","authors":"Sadia Suri Kashif, Sadaf Naeem, Saira Saeed Khan, Shaheen Perveen, Nausheen Alam, Saba Zubair, Javeria Ameer","doi":"10.1155/sci5/3936227","DOIUrl":"https://doi.org/10.1155/sci5/3936227","url":null,"abstract":"<p><p>Polyunsaturated fatty acids-rich nuts are a group of natural sources that have served as a tonic in the treatment of many ailments for centuries. In this regard, <i>P. amygdalas</i> and <i>J. regia</i> nuts are traditionally used in infertility treatments. However, so far, the main mechanisms for the fertility-enhancing effects of these nuts in males/females are unknown. The present study was intended to evaluate the fertility-boosting effect of a mixture constituting <i>P. amygdalas</i> and <i>J. regia</i> oil on male/female infertility models and in two successive generations of rats; <i>F</i> ₀ (parents) and <i>F</i> ₁ (offspring). For the fertility assessment, male and female rats, 18 pairs (<i>n</i> = 36, 1:1, <i>F</i> ₀ generation), were separated into three groups and dosed with 2 and 4 mL/kg daily of oil mixture and saline, respectively, from precohabitation up to lactation. To determine the further protective role of the oil mixture in infertility, we designed ethanol-induced male and estradiol-induced female infertility models. Various parameters like hormonal, hematological, lipid profile, and antioxidant markers [superoxide dismutase (SOD), glutathione peroxidase (GPx)] were measured along with histopathology of sex organs. The continual exposure of <i>F</i> ₀ and <i>F</i> ₁ generations to the oil mixture did not affect the fertility index and survival index in females. However, in males, all sperm parameters were significantly improved in both generations. We have found pronounced fertility outcomes with oil mixture supplementation in both genders of <i>F</i> ₀ and <i>F</i> ₁ generations. Results showed that the oil mixture significantly restored (<i>p</i> < 0.05) luteinizing hormone (LH), follicular stimulating hormone, GPx, plasma testosterone, and SOD activities in both models. Histological findings endorsed enhanced folliculogenesis and spermatogenesis with enhanced architecture. Our results strongly suggest that <i>P. amygdalas</i> and <i>J. regia</i> oil mixture might be a promising option in future for male/female sterility treatment. This finding could pave the way in infertile men and women for clinical trials. This is the first study that has provided an experimental rationale for a walnut and almond oil mixture combination as an effective candidate for fertility recovery by improving sex hormones and managing oxidative stress.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"3936227"},"PeriodicalIF":2.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Analysis, Antibacterial, and Antitumor Potential of <i>Hibiscus rosa-sinensis</i> Linn.","authors":"Neelma Munir, Sheza Ayaz Khilji, Sajal Rasool, Anam Khalil, Zahoor Ahmad Sajid","doi":"10.1155/sci5/2722306","DOIUrl":"https://doi.org/10.1155/sci5/2722306","url":null,"abstract":"<p><p>This study aimed to investigate the phytochemical composition, antibacterial activity, and antitumor potential of <i>Hibiscus rosa-sinensis</i> Linn, a widely used medicinal plant. Qualitative systematic phytochemical analysis was conducted on flower of <i>Hibiscus rosa-sinensis</i> for determining their antimicrobial and antitumor potential by using disc diffusion method and potato disc bioassay, respectively. Phytochemicals found in chloroform extract of <i>H. rosa-sinensis</i> were alkaloids, betacyanin's, tannins, and quinones in nature while in ethanol extract only alkaloids and betacyanin's were present. The findings demonstrated potent inhibitory effects of the extracts against both Gram-positive and Gram-negative bacteria. Chloroform extract exhibited more significant antibacterial activity as compared to ethanolic extract against various drug resistant pathogens such as <i>Salmonella typhi</i>, <i>Escherichia coli, Staphylococcus aureus, Klebsiella</i> sp.<i>, Pseudomonas aeruginosa</i>, and <i>Bacillus subtilis.</i> Furthermore, the antitumor activity of the <i>H. rosa-sinensis</i> extract was evaluated using in vitro assays against selected cancer cell-lines. These extracts exhibited significant antiproliferative effects such as ethanolic extract had more significant antitumor activity as compared to chloroform. After 24 h zones of inhibition were analyzed and measured using ruler. The diameter of zones of inhibition of chloroform flower extract against <i>E. coli, S. aureus, Klebsiella</i> sp.<i>, Pseudomonas aeruginosa</i>, and <i>B. subtilis, S. typhi</i> was 11, 8, 13, 17, 10, and 23 mm, while ethanolic extract had 6, 0, 6, 10, 7, and 10 mm, zone of inhibition, respectively. Flower extracts by inhibiting the formation of crown gall tumors suggesting their potential as sources of natural anticancer compounds. These results provided valuable insights into the phytochemical composition and therapeutic potential of <i>H. rosa-sinensis</i>. Additional investigations into the bioactive components of <i>H. rosa-sinensis</i> might result in the creation of new antibacterial and anticancer medicines for use in a range of medical applications.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"2722306"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Tomato (<i>Solanum lycopersicum</i> L.) Traits to Microclimates: A Multilocation Evaluation of Yield and Quality Responses in Western Ethiopia.","authors":"Usman Mohammed Ali, Desalegn Negasa Soresa, Tilahun Wondimu Fufa","doi":"10.1155/sci5/6345142","DOIUrl":"https://doi.org/10.1155/sci5/6345142","url":null,"abstract":"<p><p>Tomato (<i>Solanum lycopersicum</i> L.) is a crucial crop for food security and income generation in Western Ethiopia. However, unsuitable cultivar choices and misalignment between genotype and microclimate conditions often constrain its productivity. This study aimed to evaluate the performance of eight national tomato cultivars and one local landrace across diverse microclimates in Western Ethiopia during the 2022/2023 off-season cropping period. A randomized complete block design with three replications was employed to assess growth, yield, and quality parameters at two locations: Bako Tibe and Gambella Tare. The results revealed significant genotype-environment interactions affecting various traits, underscoring the necessity for microclimatic adaptation in tomato cultivation. Cochoro emerged as a high-yielding cultivar, achieving marketable fruit yields of 91.5 t/ha at Bako and 84.28 t/ha at Gambella Tare, while Komto (43 t/ha at Bako Tibe) and Geli-Lema (42.2 t/ha at Gambella Tare) exhibited the lowest yields. Melka-Salsa demonstrated superior fruit quality, particularly in ascorbic acid content (26.30 mg/100 g), while Cochoro had the lowest (12.81 mg/100 g). A strong positive correlation (<i>r</i> = 0.998^∗∗) was identified between total marketable fruit yield and fruit weight per plant, suggesting potential targets for future breeding efforts. This study highlights the critical role of genotype-environment interactions in optimizing tomato production across microclimates in Western Ethiopia. These findings provide valuable information for farmers and stakeholders to select the most suitable cultivars, enhancing yields and improving farmer incomes. Future research should prioritize expanded genotype-environment interaction studies, breeding programs targeting yield components and stress resilience traits, and the development of location-specific agronomic packages integrating optimized irrigation, nutrient management, and climate-smart pest control strategies.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"6345142"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Analysis of Land Use and Cover Dynamics in Protected Areas of the Brazilian Cerrado.","authors":"Mariele R Torgeski, Emerson M de Carvalho, Alex M Dos Santos, Ana P Lemke, Claudemir A G Fioratti, Mauricio Stefanes, Sandro M Silva, Rosilda M Mussury","doi":"10.1155/sci5/7984448","DOIUrl":"https://doi.org/10.1155/sci5/7984448","url":null,"abstract":"<p><p>The Brazilian Cerrado, renowned as the most biodiverse savanna, is characterized by its pronounced climatic seasonality, diverse vegetation mosaic, and distinct topographic variations. Natural protected areas (NPA) within this biome play a pivotal role in safeguarding both biodiversity and natural resources. The objective of this study is to analyze the dynamic shifts in land use and land cover across seven NPA and their corresponding buffer zones (BZs) within a Cerrado region situated in Central-West Brazil. This research encompasses a comprehensive multitemporal analysis of satellite imagery spanning the period from 1985 to 2018 utilizing a geographic information system (GIS). The variability in land use and land cover classes is considerably more constrained within the NPA than BZs. The Templo dos Pilares Municipal Natural Park exhibits substantial expanses of preserved vegetation, while the Nascentes do Rio Taquari State Park demonstrates an extensive prevalence of pasturelands. The NPA exhibit coherent patterns of land cover transformation within their respective BZs. However, alterations in the landscape within the BZs offer insights into potential forthcoming challenges to the NPA. Escalated land use within the surrounding matrix of protected areas presents a formidable obstacle to biodiversity conservation, owing to extraneous pressures. A comprehensive understanding of the spatiotemporal distribution of land use and land cover within safeguarded Cerrado regions contributes substantively to the augmentation of management, preservation, and conservation endeavors over time.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"7984448"},"PeriodicalIF":2.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Management in Cancer Patients With Artificial Intelligence: Narrative Review.","authors":"Golnar Ghane, Raoofeh Karimi, Amir Mohammad Chekeni, Mahdi Darvishi, Reza Imani, Fatemeh Zahra Vafaeinezhad","doi":"10.1155/sci5/6888213","DOIUrl":"https://doi.org/10.1155/sci5/6888213","url":null,"abstract":"<p><p><b>Background:</b> Pain is a significant symptom in cancer patients that is frequently not effectively treated, and managing it is seen as a crucial aspect of caring for these patients. This severe pain frequently causes a significant disturbance in their quality of life. At present, there are different challenges in utilizing a range of pharmacological and nonpharmacological treatments for managing pain in cancer patients. Recent technological advancements, particularly in artificial intelligence, have improved the management of pain in cancer patients. Artificial intelligence and its algorithms offer potential solutions for pain relief in cancer patients with reduced side effects. <b>Study Design:</b> The current review aimed to assess the validity of studies on using artificial intelligence in pain management for cancer patients. Four databases have been used to review all published studies from the start of 2023: PubMed, Scopus, Web of Science, and Google Scholar. The search mechanism for articles was mainly using valid and mesh-based keywords, asking experts, and reviewing the literature and including \"Pain,\" \"Pain management,\" \"Cancer,\" and \"Artificial intelligence.\" During the initial search, a total of 450 articles were found, and after considering the inclusion and exclusion criteria and reviewing the abstract and content of the articles, 15 articles were finally included in the study. <b>Results:</b> AI-based solutions can provide individual pain relief plans. When AI analyzes large patient data such as physiological signals, responses to treatment, and symptoms of patients who have been diagnosed with pain, it is possible to accurately adjust therapeutic measures. <b>Conclusions:</b> AI enables healthcare providers to offer timely care and assistance to cancer patients through remote monitoring and telehealth services, even when they are not physically present. Despite the presence of hurdles such as ensuring ethical AI practices and protecting data privacy, the integration of AI in oncology pain management brings optimism for the future.</p>","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2025 ","pages":"6888213"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}