Seminars in liver disease最新文献

Neutrophils in Liver Diseases: Functions and Challenging Therapies. 中性粒细胞在肝脏疾病中的作用和挑战性治疗。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-04-07 DOI: 10.1055/a-2847-3228

Rui Ma, Haoran Meng, Xiutong Chen, Haiyuan Shen, Li Zuo, Hua Wang

{"title":"Neutrophils in Liver Diseases: Functions and Challenging Therapies.","authors":"Rui Ma, Haoran Meng, Xiutong Chen, Haiyuan Shen, Li Zuo, Hua Wang","doi":"10.1055/a-2847-3228","DOIUrl":"https://doi.org/10.1055/a-2847-3228","url":null,"abstract":"This review explores the pivotal and multifaceted roles of neutrophils in the context of liver pathophysiology. While traditionally recognized as primary effectors of antibacterial immunity, recent evidence reveals that these abundant leukocytes function as complex regulators in the development and progression of various hepatic conditions. Neutrophils act as double-edged swords: they serve as critical instigators of inflammatory cascades and fibrogenesis, yet simultaneously provide essential contributions to immune defense and the orchestration of tissue repair. This paper synthesizes current research regarding neutrophil behavior within diverse hepatic microenvironments and evaluates their specific contributions to disease resolution versus exacerbation. Furthermore, we deliberate on the emerging potential of targeting neutrophil-specific pathways as a novel therapeutic strategy for liver diseases. Understanding these intricate balances is essential for transitioning from broad anti-inflammatory approaches to precise, neutrophil-modulated interventions. In conclusion, given their status as a dynamic research hotspot, a deeper mechanical understanding of neutrophil functions is imperative for the development of targeted clinical treatments for liver disorders.","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical Guide to Best Practices in Alcohol-Associated Liver Disease. 酒精相关肝病最佳实践指南

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1055/a-2772-7248

Vinay Jahagirdar, Elina Stoffel, Kaanthi Rama, Alexandre Louvet, Gene Im, Juan P Arab

引用次数: 0

Expert Practical Recommendations for Hepatocellular Carcinoma. 肝细胞癌专家实用建议。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2026-03-25 DOI: 10.1055/a-2832-4720

Feng Su, Alejandro Torres-Hernandez, Ryan Hickey, Krishna Shanbhogue, Kristen Spencer, Karim Halazun, Augusto Villanueva

引用次数: 0

Endothelial Cell Therapy for the Acute and Chronic Liver Disease. 急性和慢性肝病的内皮细胞治疗

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2026-04-09 DOI: 10.1055/a-2841-9824

Dilnar Mahmut, Valerie Gouon-Evans

{"title":"Endothelial Cell Therapy for the Acute and Chronic Liver Disease.","authors":"Dilnar Mahmut, Valerie Gouon-Evans","doi":"10.1055/a-2841-9824","DOIUrl":"10.1055/a-2841-9824","url":null,"abstract":"Endothelial cell dysfunction and loss are key drivers of acute and chronic liver disease, underscoring a critical unmet need for liver vascular-targeted therapies. Liver sinusoidal endothelial cells are specialized endothelial cells that form a fenestrated microvascular niche regulating hepatocyte metabolism, immune homeostasis, and hepatic stellate cell activation. Repopulating this niche through transplantation of primary liver sinusoidal endothelial cells, endothelial progenitor cells, induced-pluripotent stem cell-derived liver sinusoidal endothelial cells, or engineered endothelial cells delivered within biomaterial aims to restore microvascular architecture, reestablish supportive angiocrine signaling, attenuate fibrosis, and promote liver regeneration. This review summarizes the biological rationale for endothelial cell-based therapy, compares cell sources and engineering strategies, evaluates cell delivery and engraftment approaches, and synthesizes preclinical evidence demonstrating therapeutic benefits across diverse animal models of liver injury. Finally, we highlight key translational challenges and propose future directions to accelerate the clinical development of endothelial cell-based therapies for liver disease.","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":"77-88"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Liver Cancer Care Through BCLC Principles. 通过BCLC原则优化肝癌治疗。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2026-02-27 DOI: 10.1055/a-2769-7224

Gemma Iserte, Neus Llarch, Andrew M Moon, María Reig

{"title":"Optimizing Liver Cancer Care Through BCLC Principles.","authors":"Gemma Iserte, Neus Llarch, Andrew M Moon, María Reig","doi":"10.1055/a-2769-7224","DOIUrl":"10.1055/a-2769-7224","url":null,"abstract":"Hepatocellular carcinoma (HCC) care is rapidly evolving, driven by a relentless pursuit of improved patient outcomes, enhanced quality of life, and increased patient empowerment. This transformation draws inspiration from innovative concepts originating in the corporate world, notably the insights of Rita McGrath, and their application to medicine, particularly within the Barcelona Clinic Liver Cancer (BCLC) system. This review explores pivotal advancements in shared decision-making, cross-disease insights, remote monitoring and telehealth, dynamics of multidisciplinary teamwork, and patient empowerment. These innovations signify a fundamental shift in our commitment to alleviating patient distress, fostering treatment adherence, and elevating the overall patient experience. This approach not only optimizes established practices but also broadens the horizons of HCC care by transferring expertise to new domains. Advanced practice nurses (APNs) play an essential role in spearheading this transformation through patient-centered care coordination and educational initiatives, fundamentally improving the management and outcomes of HCC care within the BCLC framework. · Value-based Coordination: Dynamic scheduling, team coordination, and personalized care reduce inefficiencies, ensuring timely, patient-centered interventions.. · Empowering Nurses and Patients: Advanced practice nurses (APNs) play a central role in educating and guiding patients, boosting adherence and autonomy.. · Leveraging Technology: Tools like telemedicine and real-time alerts streamline communication, reduce hospitalizations, and optimize resource allocation.. · Scalable Solutions: The Barcelona Clinic Liver Cancer (BCLC) model offers replicable practices adaptable to broader healthcare systems..","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":"23-30"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition and Liver Disease. 营养与肝脏疾病。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2025-11-28 DOI: 10.1055/a-2725-5313

Allison Franz, Henry Shay, Irina Kirpich, Craig J McClain

引用次数: 0

Hepatic Fibrosis and Liver Cancer. 肝纤维化和肝癌。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2025-12-30 DOI: 10.1055/a-2779-4937

Aina Anton, Scott L Friedman, Bruno Cogliati

{"title":"Hepatic Fibrosis and Liver Cancer.","authors":"Aina Anton, Scott L Friedman, Bruno Cogliati","doi":"10.1055/a-2779-4937","DOIUrl":"10.1055/a-2779-4937","url":null,"abstract":"Primary liver cancer, or hepatocellular carcinoma (HCC), typically emerges in fibrotic livers where persistent inflammation and extracellular matrix (ECM) remodeling create a permissive niche for malignant transformation. Although cirrhosis remains a major risk factor, mounting data show that fibrosis itself, often in the context of metabolic dysfunction-associated steatotic liver disease (MASLD), can promote hepatocarcinogenesis even before cirrhosis develops. This review synthesizes mechanistic insights from hepatic stellate cell (HSC) biology and tumor immunology that position fibrosis as an instigator of HCC. Fibrotic remodeling increases ECM stiffness, distorts sinusoidal architecture, and promotes abnormal angiogenesis, while HSCs reprogram immune surveillance toward immune cell exclusion and immunosuppression. Aging and cellular senescence amplify these effects through a senescence-associated secretory phenotype in HSCs and hepatocytes, which fuels chronic inflammation and immune dysfunction. Metabolic crosstalk and extracellular vesicle exchange further couple stromal and epithelial programs, reinforcing stemness, therapy resistance, and metastatic fitness. In conclusion, the convergence of fibrogenic and oncogenic signaling drives HCC, uncovering actionable targets for its prevention and treatment.","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":"31-50"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-Derived Models of Liver Cancer to Inform Clinical Treatment Paradigms: Recent Updates. 患者衍生的肝癌模型为治疗决策提供信息：最近的更新。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2026-03-01 Epub Date: 2026-01-14 DOI: 10.1055/a-2779-4984

Kelley Weinfurtner, Rudra Amin, Nicolas Skuli, Terence P Gade, David E Kaplan

{"title":"Patient-Derived Models of Liver Cancer to Inform Clinical Treatment Paradigms: Recent Updates.","authors":"Kelley Weinfurtner, Rudra Amin, Nicolas Skuli, Terence P Gade, David E Kaplan","doi":"10.1055/a-2779-4984","DOIUrl":"10.1055/a-2779-4984","url":null,"abstract":"Primary liver cancer remains a global health challenge due to rising incidence, limited curative options, and poor overall survival. Poor outcomes stem from tumor heterogeneity, limited efficacy of current therapies, and comorbid chronic liver disease. Despite recent advances in immunotherapy and combination treatments, response rates remain low, and predictive biomarkers are lacking. As a result, there is an urgent need for preclinical models that capture the molecular, cellular, and immune landscape of primary liver cancer. This review discusses the strengths and limitations of patient-derived models of liver cancer, including two-dimensional patient-derived cell lines (PDCL), three-dimensional (3D) patient-derived tumor organoids (PDTOs), and patient-derived xenografts (PDXs). While PDCLs and PDTOs enable high throughput studies, they lack a representative tumor microenvironment. PDXs, including PDXs in animals with humanized immune systems, may more effectively mimic tumor-environment interactions but are costly, complex, and still contain mouse stromal cells. Ex vivo tissue culture preserves tissue structure and cell-cell interactions in an immunocompetent environment; however, short duration of viable culture limits broader application. Continued innovation in the development of multicellular three-dimensional culture systems and in vivo humanization strategies will play a critical role in enabling the development of more personalized and effective therapies for primary liver cancer.","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":"51-62"},"PeriodicalIF":3.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-Centered Treatment of Cirrhosis. 以患者为中心的肝硬化治疗。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2025-12-01 Epub Date: 2025-08-18 DOI: 10.1055/a-2684-6289

Ammar Hassan, Elliot B Tapper

引用次数: 0

Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective. 精准医学中整合病人数字和仿生双胞胎：一个视角。

IF 3.7 3区医学

Seminars in liver disease Pub Date : 2025-12-01 Epub Date: 2025-07-04 DOI: 10.1055/a-2649-1560

Mark T Miedel, Mark E Schurdak, Andrew M Stern, Alejandro Soto-Gutierrez, Eric von Strobl, Jaideep Behari, D Lansing Taylor

{"title":"Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective.","authors":"Mark T Miedel, Mark E Schurdak, Andrew M Stern, Alejandro Soto-Gutierrez, Eric von Strobl, Jaideep Behari, D Lansing Taylor","doi":"10.1055/a-2649-1560","DOIUrl":"10.1055/a-2649-1560","url":null,"abstract":"A new paradigm for drug development and patient therapeutic strategies is required, especially for complex, heterogeneous diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). Heterogeneity in MASLD patients is driven by genetics, various comorbidities, gut microbiota composition, lifestyle, environment, and demographics that produce multiple patient disease presentations and outcomes. Existing drug development methods have had limited success for complex, heterogeneous diseases like MASLD where only a fraction of patients respond to specific treatments, prediction of a therapeutic response is not presently possible, and the cost of the new classes of drugs is high. However, it is now possible to generate patient digital twins (PDTs) that are computational models of patients using clinomics and other \"omics\" data collected from patients to make various predictions, including responses to therapeutics. PDTs are then integrated with patient biomimetic twins (PBTs) that are patient-derived organoids or induced pluripotent stem cells that are then differentiated into the optimal number of organ-specific cells to produce organ experimental models. The PBTs mimic key aspects of the patient's pathophysiology, enabling predictions to be tested. In conclusion, integration of PTDs and PBTs has the potential to create a powerful precision medicine platform, yet there are challenges.","PeriodicalId":21724,"journal":{"name":"Seminars in liver disease","volume":" ","pages":"458-475"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0