Seminars in arthritis and rheumatism最新文献

{"title":"Targeting the Wnt pathway for the treatment of Osteoarthritis of the knee.","authors":"Nancy E Lane","doi":"10.1016/j.semarthrit.2025.152680","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152680","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152680"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy in cancer.","authors":"Robert Zeiser","doi":"10.1016/j.semarthrit.2025.152666","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152666","url":null,"abstract":"<p><p>Immunotherapy has revolutionized the treatment of cancer. However, therapy resistance and immune mediated side effects reduce the overall success. Recent developments in these two areas were reported at the 2024 ATT conference. Here we discuss that immunotherapy resistance relies on immune escape mechanisms of cancer cells. Malignant conversion of a cell encompasses oncogene activation causing altered intracellular signal transduction termed \"oncogenic signaling\". A functional connection between oncogenic signaling and immune evasion mechanisms was shown for different haematological malignancies such as the FLT3-ITD/ATF6/IL-15 inhibition axis in acute myeloid leukemia. A second clinical problem are Immune mediated side effects after cancer immunotherapy because they lead to treatment interruption and potentially loss of activity by introduction of immunosuppressive medication. Anti-PD-1 immunotherapy induced inflammation of the central nervous system is rare but has a high morbidity and mortality. Recent data show that spleen tyrosine kinase (Syk) activation and downstream signaling in microglia mediates anti-PD-1 immunotherapy induced inflammation of the central nervous system.</p>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152666"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to analyze and understand the human immune system.","authors":"Kazuhiko Yamamoto","doi":"10.1016/j.semarthrit.2025.152696","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152696","url":null,"abstract":"<p><p>To enhance our understanding of the pathogenesis of diseases, including rheumatic diseases, and to improve disease control, it is essential to attain a thorough understanding of the human immune system, alongside mouse immunology. Historically, the investigation of the human immune system has posed significant challenges due to methodological limitations. Nonetheless, recent advancements in genomic studies of multifactorial diseases have elucidated that numerous risk-associated genetic variants affecting quantitative differences in cell-specific gene expression. In light of these findings, we are currently examining individual genetic variations in both healthy individuals and patients, as well as categorizing cells into distinct subsets in order to construct a comprehensive dataset concerning the human immune system. This is accomplished by combining data on gene expression, factors influencing the expression mechanisms, protein expression, metabolomics, and environmental variables pertinent to immune functionality-such as gut microbiota. These datasets will facilitate the comprehensive characterization of the human immune system. Using these datasets and through the integrative analyses of data related to risk genetic variations and gene expression profiles of each disease and individual, we anticipate uncovering novel insights into the human immune system, the heterogeneity of diseases, immune function mechanisms, and their regulatory strategies that may not be achievable through murine models.</p>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152696"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the polymyalgia rheumatica-activity score: A prospective cohort study","authors":"Lien Moreel ,&nbsp;Michaël Doumen ,&nbsp;Albrecht Betrains ,&nbsp;Ellen De Langhe ,&nbsp;Daniel Blockmans ,&nbsp;Steven Vanderschueren","doi":"10.1016/j.semarthrit.2025.152695","DOIUrl":"10.1016/j.semarthrit.2025.152695","url":null,"abstract":"<div><h3>Objective</h3><div>To validate the polymyalgia rheumatica-activity score (PMR-AS).</div></div><div><h3>Methods</h3><div>Prospective cohort study at the University Hospitals Leuven (Belgium) between July 2022 and December 2023. We created a new alternative PMR-AS in which ability to elevate the upper limbs (EUL) was replaced by visual analogue scale (VAS) of functionality and both the severity and the duration of stiffness were evaluated. The discriminatory capacity for detecting active disease of the PMR-AS, the change in PMR-AS and several alternative scores were assessed using area under the receiver operating characteristic curves (AUC) and compared using Delong's tests. GEE-logistic prediction models were used to correct for repeated measures.</div></div><div><h3>Results</h3><div>We included 133 PMR patients (419 visits). PMR-AS had a good discriminatory power with an AUC of 0.938 and an optimal cut-off point of 11.0 with corresponding sensitivity of 87 % and specificity of 87 %. The change in PMR-AS (AUC 0.862), clinical-PMR-AS (AUC 0.928) and imputed-PMR-AS (AUC 0.928) significantly performed worse in detecting active disease (all p≤0.010). The ESR-PMR-AS also tended to have a lower discriminatory capacity (AUC 0.932, p=0.050). Our alternative PMR-AS had a higher AUC (AUC 0.948, p=0.010) with an optimal cut-off point of 13.5 and corresponding sensitivity of 87 % and specificity of 88 %.</div></div><div><h3>Conclusion</h3><div>PMR-AS had a good discriminatory capacity for detecting active disease, but the alternative PMR-AS performed slightly better. Alternative activity scores which do not require the use of CRP performed slightly worse but can be used in case of treatment with glucocorticoid-sparing agents affecting the CRP level.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"72 ","pages":"Article 152695"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update on IgG4-related periaortitis/retroperitoneal fibrosis and periarteritis -recent clinical, diagnostic and therapeutic advances.","authors":"Mitsuhiro Kawano","doi":"10.1016/j.semarthrit.2025.152691","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152691","url":null,"abstract":"<p><strong>Background: </strong>IgG4-related disease (IgG4-RD) is a systemic, chronic immune-mediated inflammatory disorder that, similar to sarcoidosis, can affect various organs and tissues. IgG4-related periaortitis (PAo)/retroperitoneal fibrosis (RPF) is among the five major manifestations of IgG4-RD. Despite introduction of the ACR and EULAR classification criteria for IgG4-RD in 2019, diagnosing IgG4-related PAo/RPF and periarteritis (PA) remains challenging because obtaining biopsies from these lesions is difficult. Additionally, while glucocorticoids are highly effective in treating IgG4-RD, managing aortic or arterial lesions poses unique challenges.</p><p><strong>Objectives: </strong>This brief review discusses the utility of Japanese organ-specific diagnostic criteria for IgG4-related PAo/RPF and PA, along with recent advances in treatment strategies including management of organ-specific issues related to these lesions.</p><p><strong>Methods: </strong>First, we analyzed 99 patients with IgG4-related PAo/RPF and PA based on expert diagnoses to propose organ-specific diagnostic criteria. Next, we retrospectively analyzed an additional 110 patients with IgG4-related PAo/RPF and PA, as well as 73 mimickers with clinical features requiring differentiation from true IgG4-RD to validate the proposed criteria.</p><p><strong>Results: </strong>Histopathological specimens were obtained from only 33 patients (20 periaortic, 5 coronary arteries, 4 iliac arteries, 1 mesenteric artery, and 5 retroperitoneal lesions not involving arteries). Among these, 71.4 % showed storiform fibrosis, and 71.4 % displayed obliterative phlebitis. The mean number of IgG4-positive plasma cells exceeded 10 per high-power field in all specimens, and the IgG4/IgG-positive cell ratio exceeded 40 % in 32 specimens (91.4 %). Radiographic findings were essential for diagnosing IgG4-related PAo/RPF and PA, supported by elevated serum IgG4 levels and the presence of characteristic involvement of other organs affected by IgG4-RD. Validation analysis confirmed that incorporating \"imaging findings of pericarditis\", \"eosinophilic infiltration or lymphoid follicles\", and \"probable diagnosis of extra-Pao/PA/RPF lesions\" improved sensitivity from 68.4 % to 77.2 %, with only a minimal reduction in specificity (from 97.4 % to 94.7 %).</p><p><strong>Conclusions: </strong>Diagnosing IgG4-related PAo/RPF and PA remains challenging even when using the latest diagnostic or classification criteria, compared to diagnosing IgG4-RD involving other major organs, such as lacrimal and salivary glands, pancreas, and kidneys. In addition, when treating patients with IgG4-related PAo/RPF and PA, organ-specific factors must be considered when developing treatment strategies.</p>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152691"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of joint pain: Five short lessons from osteoarthritis.","authors":"Anne-Marie Malfait","doi":"10.1016/j.semarthrit.2025.152690","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152690","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152690"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging findings of scleroderma-associated myopathy: A systematic literature review","authors":"Elvina Ingrid ,&nbsp;Mathuja Bavanendrakumar ,&nbsp;Shereen Oon ,&nbsp;Warren Perera ,&nbsp;Jessica Day ,&nbsp;Laura Ross","doi":"10.1016/j.semarthrit.2025.152672","DOIUrl":"10.1016/j.semarthrit.2025.152672","url":null,"abstract":"<div><h3>Aims</h3><div>Systemic sclerosis (SSc) affects skeletal muscle directly, with SSc-associated myopathy (SSc-myopathy) increasingly recognised as a distinct immune-mediated myopathy. Manual muscle testing and creatine kinase (CK) are insensitive diagnostic tools for SSc-myopathy. We aimed to evaluate the role of imaging in SSc-myopathy diagnosis.</div></div><div><h3>Methods</h3><div>A systematic search of MEDLINE(Ovid), Pubmed, and EMBASE databases was performed to identify studies of ≥10 SSc patients that reported skeletal muscle imaging results. Eligibility criteria were defined a priori. Risk of bias assessment was performed using the National Heart, Lung and Blood Institute (NHLBI) quality assessment tool. Descriptive summaries were used to present data owing to inter-study heterogeneity.</div></div><div><h3>Results</h3><div>Of 2426 studies identified, 17 articles met the inclusion criteria. Imaging modalities varied, but magnetic resonance imaging (MRI) was the most commonly applied imaging technique (<em>n</em> = 9 studies). Abnormalities on MRI were reported in 38–100 % of patients and included muscle oedema, atrophy, and fatty infiltration. Changes were observed in skeletal muscles (<em>n</em> = 14 studies), axial muscles (<em>n</em> = 1), masseter muscle (<em>n</em> = 1), and accessory respiratory muscles (<em>n</em> = 2). Blood oxygenation level-dependent MRI, dynamic contrast-enhanced ultrasound, and scintigraphic evaluation have each been used to assess skeletal muscle perfusion. A lack of correlation between creatine kinase, clinical weakness, and imaging findings was consistently reported. We were unable to identify any distinct imaging patterns or relationship between imaging and histopathological skeletal muscle abnormalities owing to limited data available.</div></div><div><h3>Conclusion</h3><div>Imaging detects inflammatory, atrophic, and vasculopathic changes in the skeletal musculature of SSc patients. The discordance between clinical assessment and imaging findings underscores the potential role for muscle imaging to both screen and diagnose SSc-myopathy.</div></div>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":"72 ","pages":"Article 152672"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic disease in giant cell arteritis.","authors":"Kenneth J Warrington","doi":"10.1016/j.semarthrit.2025.152677","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152677","url":null,"abstract":"<p><p>The increasing use of non-invasive vascular imaging has allowed for improved detection of aortic disease in patients with vasculitis. Indeed, up to 70 % of patients have radiographic evidence of aortitis at GCA onset and aortic dilatation is already identified in about 15 %. Aortic inflammation is generally diagnosed by imaging studies such as CT angiography, MR angiography or FDG-PET, and occasionally by histopathology following resection of the aorta for aneurysm repair. Aortic inflammation may be clinically silent but is a risk factor for progressive aortic dilatation and aneurysm formation in GCA. By comparison, aortitis in Takayasu arteritis may lead to aortic dilatation or stenosis, particularly in the descending thoracic and abdominal aorta. The risk of thoracic aortic aneurysm in patients with GCA has been estimated to be up to 17-fold higher than that of the general population, with up to 1/3 of patients developing aortic aneurysm at 10 years of follow-up. Moreover, chronic smoldering aortitis may be refractory to current therapy, lasts for several years and contributes to progressive aortic dilatation. A rare but life-threatening complication of GCA-associated aortic disease is dissection or rupture. Observational studies are informing outcomes and management of inflammatory aortic aneurysms, while transcriptomic and molecular studies on aortic tissue are yielding important information regarding disease pathogenesis. These endeavors are critical to reducing the excess mortality related to aortic disease in GCA. Also, improved understanding of the pathophysiology of the disease is allowing the development of non-glucocorticoid targeted therapies.</p>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152677"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic regulators of crystal-induced arthritis.","authors":"Chinh Nghia Pham, Charles Leroy, Hang Korng Ea","doi":"10.1016/j.semarthrit.2025.152688","DOIUrl":"https://doi.org/10.1016/j.semarthrit.2025.152688","url":null,"abstract":"","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152688"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The joint accumulation model of arthritis.","authors":"Peter A Nigrovic","doi":"10.1016/j.semarthrit.2025.152685","DOIUrl":"10.1016/j.semarthrit.2025.152685","url":null,"abstract":"<p><p>Most inflammatory arthritides are systemic diseases. In an individual patient, however, disease flares are more common in joints affected previously, a phenomenon termed joint-specific memory. A key driver of localized recurrence is the accumulation of CD8+ T resident memory (T_RM) cells in inflamed synovial tissues. These cells remain during remission and initiate recurrent disease when activated by arthritogenic antigens. The joint accumulation model is a paradigm that recognizes the contribution of local as well as systemic immune mechanisms to arthritis chronicity, highlighting new targets for disease intervention, including but not limited to T_RM cells. The joint accumulation model underscores the importance of preventing extension of arthritis to new joints, even in established disease, translating into a rolling window of opportunity for optimal long-term arthritis management.</p>","PeriodicalId":21715,"journal":{"name":"Seminars in arthritis and rheumatism","volume":" ","pages":"152685"},"PeriodicalIF":4.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}