Seminars in cutaneous medicine and surgery最新文献_第6页

Cutaneous Lymphoma, Introduction. 皮肤淋巴瘤，简介。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2019.017

Laura B Pincus

引用次数: 1

Cutaneous CD30-positive T-cell lymphoproliferative disorders-clinical and histopathologic features, differential diagnosis, and treatment. 皮肤cd30阳性t细胞增生性疾病的临床和组织病理学特征、鉴别诊断和治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.001

Werner Kempf, Katrin Kerl, Christina Mitteldorf

引用次数: 32

NK/T-cell lymphoma, nasal type, γδ T-cell lymphoma, and CD8-positive epidermotropic T-cell lymphoma-clinical and histopathologic features, differential diagnosis, and treatment. NK/ t细胞淋巴瘤，鼻型，γδ t细胞淋巴瘤和cd8阳性表皮性t细胞淋巴瘤的临床和组织病理学特征，鉴别诊断和治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.020

Shamir Geller, Patricia L Myskowski, Melissa Pulitzer

引用次数: 17

Primary cutaneous B-cell lymphomas- clinical and histopathologic features, differential diagnosis, and treatment. 原发性皮肤b细胞淋巴瘤-临床和组织病理学特征，鉴别诊断和治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.014

Steven T Chen, Jeffrey Barnes, Lyn Duncan

{"title":"Primary cutaneous B-cell lymphomas- clinical and histopathologic features, differential diagnosis, and treatment.","authors":"Steven T Chen, Jeffrey Barnes, Lyn Duncan","doi":"10.12788/j.sder.2018.014","DOIUrl":"https://doi.org/10.12788/j.sder.2018.014","url":null,"abstract":"Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are rare. Given the variable natural history of the CBCL, proper classification is critical so that patients are treated appropriately. CBCLs can be divided into 2 main groups: indolent and aggressive. Indolent CBCLs include primary cutaneous follicle center lymphoma and primary cutaneous marginal zone lymphoma. These subtypes usually do not affect a patient's lifespan but can lead to substantial symptomatology, prompting the need for treatment. The aggressive subtypes of CBCL include diffuse large B-cell lymphoma leg type and intravascular large B-cell lymphoma. These are treated as systemic lymphomas, and their prognoses are not as good. In this article, we discuss the clinical features, differential diagnoses, histopathologic features, and treatment options for each of the 4 types of CBCL. The proper categorization of these diseases can allow physicians to properly treat a patient with CBCL, including the avoidance of unnecessary therapy.","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36063355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Histopathologic approach to epidermotropic lymphocytic infiltrates. 表皮性淋巴细胞浸润的组织病理学检查。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.003

Shyam S Raghavan, Jinah Kim

引用次数: 3

Approach to dermal-based lymphoid infiltrates and proliferations. 皮肤淋巴浸润和增生的检查方法。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.015

Yann Charli-Joseph, Sonia Toussaint-Claire, Carmen Lome-Maldonado, Daniel Montante-Montes de Oca, Carlos Ortiz-Hidalgo

{"title":"Approach to dermal-based lymphoid infiltrates and proliferations.","authors":"Yann Charli-Joseph, Sonia Toussaint-Claire, Carmen Lome-Maldonado, Daniel Montante-Montes de Oca, Carlos Ortiz-Hidalgo","doi":"10.12788/j.sder.2018.015","DOIUrl":"https://doi.org/10.12788/j.sder.2018.015","url":null,"abstract":"The histopathological diagnosis of dermal-based lymphoid infiltrates and proliferations is often challenging due to the vast list of biologically diverse entities that archetypally or occasionally center in the mid-dermis, especially because significant overlap exists in their clinical, histopathologic, and immunophenotypic features. The differential diagnosis includes reactive infiltrates in common and rare inflammatory dermatoses, benign conditions that may mimic lymphoid neoplasms (pseudolymphomas), and true clonal proliferations arising either primarily in the skin or rarely in extracutaneous tissues with secondary cutaneous dissemination. While numerous histopathological and immunophenotypic features have been reported to support a definitive diagnosis, no single ancillary test is sufficient for their distinction. Therefore, in this review we advocate a stepped histopathological approach for dermalbased lymphoid infiltrations, employing as key elements the general lymphocytic composition (relative B- versus T-cell ratio), coupled with the predominant cytomorphology (cell size) present. Following this strategy, the relative incidence of cutaneous involvement by each disease should always be considered, as well as the notion that a definitive diagnosis must be founded on a multiparameter approach integrating all clinical, histopathologic, immunophenotypic, and-in selected cases-molecular features.","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 1","pages":"61-74"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36063358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Mycosis fungoides variants-clinicopathologic features, differential diagnosis, and treatment. 蕈样真菌病的临床病理特征、鉴别诊断和治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.004

Rein Willemze

引用次数: 23

Sézary syndrome-clinical and histopathologic features, differential diagnosis, and treatment. ssamzary综合征-临床和组织病理学特征，鉴别诊断和治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.005

Kerith E Spicknall

引用次数: 22

Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder-clinical and histopathologic features, differential diagnosis, and treatment. 原发性皮肤CD4+小/中t细胞增生性疾病-临床和组织病理学特征、鉴别诊断和治疗

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.006

Alejandro A Gru, Mark R Wick, Mary Eid

{"title":"Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder-clinical and histopathologic features, differential diagnosis, and treatment.","authors":"Alejandro A Gru, Mark R Wick, Mary Eid","doi":"10.12788/j.sder.2018.006","DOIUrl":"https://doi.org/10.12788/j.sder.2018.006","url":null,"abstract":"Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder usually presents as a slow-growing and asymptomatic solitary lesion in the form of a nodule or tumor in the head and neck region. By definition, it is histologically characterized by small- to medium-sized CD4+ lymphocytes involving the dermis in a dense and either nodular or diffuse pattern. Epidermotropism should be absent or minimal. Tumor cells are accompanied by numerous reactive B cells, plasma cells, histiocytes, and eosinophils. This lymphoproliferative disorder is characterized by the expression of follicular helper T-cell markers, particularly B-cell lymphoma 6 (BCL-6), programmed cell death protein 1 (PD-1), and C-X-C motif chemokine ligand 13 (CXCL-13), while CD10 is usually negative. Molecular studies show a clonal rearrangement of T-cell receptor genes in more than 60% of cases. Management of disease includes surgical excision, radiation therapy, and steroids (topical or intralesional). Patients with this diagnosis have an excellent prognosis, with a clinical course that is invariably indolent.","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36063354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment. 蕈样真菌病的临床和组织病理学特征、鉴别诊断和治疗。

Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.002

Lorenzo Cerroni

{"title":"Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment.","authors":"Lorenzo Cerroni","doi":"10.12788/j.sder.2018.002","DOIUrl":"https://doi.org/10.12788/j.sder.2018.002","url":null,"abstract":"Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The term MF should be used only for the classical presentation of the disease characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. MF is divided into 3 clinical phases: patch, plaque, and tumor stage, and the clinical course is usually protracted over years or decades. Histopathologically, MF is characterized by an epidermotropic infiltrate of T lymphocytes that displays in most cases a helper phenotype. Cytotoxic variants are well described and do not have specific clinical, histopathological, or prognostic features. MF should be differentiated from other cutaneous epidermotropic lymphomas and from many inflammatory dermatoses with some similar clinicopathological features. The therapy of MF is planned mainly according to the stage and extent of the disease. In early phases, nonaggressive options represent the first-line strategy (eg, local corticosteroids, psoralen, and ultraviolet A [UV-A] irradiation, etc.). In patients with advanced disease, good results with potential for cure have been obtained with allogeneic stem cell transplantation, but toxicity is a serious limiting factor for this treatment. Conventional systemic chemotherapy and single-agent chemotherapy (eg, gemcitabine) give usually good results in advanced MF, but recurrences are the rule. Monoclonal antibodies directed against cluster of differentiation (CD)52 (alemtuzumab), CD30 (brentuximab vedotin), and chemokine receptor 4 (CCR4; mogamulizumab), as well as several other experimental therapies, have shown promising results and represent a valid alternative.","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 1","pages":"2-10"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36062406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58