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Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment. 蕈样真菌病的临床和组织病理学特征、鉴别诊断和治疗。
Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.002
Lorenzo Cerroni
{"title":"Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment.","authors":"Lorenzo Cerroni","doi":"10.12788/j.sder.2018.002","DOIUrl":"https://doi.org/10.12788/j.sder.2018.002","url":null,"abstract":"<p><p>Mycosis fungoides (MF) is the most common type of cutaneous lymphoma. The term MF should be used only for the classical presentation of the disease characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. MF is divided into 3 clinical phases: patch, plaque, and tumor stage, and the clinical course is usually protracted over years or decades. Histopathologically, MF is characterized by an epidermotropic infiltrate of T lymphocytes that displays in most cases a helper phenotype. Cytotoxic variants are well described and do not have specific clinical, histopathological, or prognostic features. MF should be differentiated from other cutaneous epidermotropic lymphomas and from many inflammatory dermatoses with some similar clinicopathological features. The therapy of MF is planned mainly according to the stage and extent of the disease. In early phases, nonaggressive options represent the first-line strategy (eg, local corticosteroids, psoralen, and ultraviolet A [UV-A] irradiation, etc.). In patients with advanced disease, good results with potential for cure have been obtained with allogeneic stem cell transplantation, but toxicity is a serious limiting factor for this treatment. Conventional systemic chemotherapy and single-agent chemotherapy (eg, gemcitabine) give usually good results in advanced MF, but recurrences are the rule. Monoclonal antibodies directed against cluster of differentiation (CD)52 (alemtuzumab), CD30 (brentuximab vedotin), and chemokine receptor 4 (CCR4; mogamulizumab), as well as several other experimental therapies, have shown promising results and represent a valid alternative.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 1","pages":"2-10"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36062406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
The Evolving Landscape of Psoriasis Treatment. 银屑病治疗的发展前景。
Seminars in cutaneous medicine and surgery Pub Date : 2018-02-01 DOI: 10.12788/j.sder.2018.009
April W Armstrong, Kenneth B Gordon, M Alan Menter, Jashin J Wu
{"title":"The Evolving Landscape of Psoriasis Treatment.","authors":"April W Armstrong,&nbsp;Kenneth B Gordon,&nbsp;M Alan Menter,&nbsp;Jashin J Wu","doi":"10.12788/j.sder.2018.009","DOIUrl":"https://doi.org/10.12788/j.sder.2018.009","url":null,"abstract":"<p><p>The process of discovering new drugs for plaque psoriasis has revealed much about the multisystemic nature of the disease. Current and emerging biologic agents may reliably achieve a Psoriasis Area and Severity Index (PASI 75) up to 90. Initially, clinicians select therapies based on the severity of the psoriasis. Although mild disease can be treated with topical agents, for patients with moderate to severe disease, concurrent therapy with oral systemic agents, biologics, and/ or phototherapy needs to be considered. In some instances, clinicians may need to combine medications to provide patients with rapid relief of symptoms. Semin Cutan Med Surg 37(supp2):S39-S43.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 2S","pages":"S39-S43"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35973591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Practical Strategies for Optimizing Management of Psoriasis. 优化银屑病治疗的实用策略。
Seminars in cutaneous medicine and surgery Pub Date : 2018-02-01 DOI: 10.12788/j.sder.2018.012
Jashin J Wu, April W Armstrong, Kenneth B Gordon, M Alan Menter
{"title":"Practical Strategies for Optimizing Management of Psoriasis.","authors":"Jashin J Wu,&nbsp;April W Armstrong,&nbsp;Kenneth B Gordon,&nbsp;M Alan Menter","doi":"10.12788/j.sder.2018.012","DOIUrl":"https://doi.org/10.12788/j.sder.2018.012","url":null,"abstract":"<p><p>Approximately 30% of patients with moderate plaque psoriasis and 20% of those with severe psoriasis have inadequate disease control with their current therapeutic regimens. Among the factors that affect treatment efficacy are drug selection and lack of patient adherence to treatment, which is often due to patient frustration that psoriasis is a chronic, multisystemic, and incurable disease. By forming a strong therapeutic alliance with patients and by asking them about their expectations for treatment, clinicians have a better chance of providing patients with more effective and durable relief from their psoriasis symptoms. Semin Cutan Med Surg 37(supp2):S52-S55.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 2S","pages":"S52-S55"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35973598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Treating to Target-A Realistic Goal in Psoriasis? 治疗目标-银屑病的现实目标?
Seminars in cutaneous medicine and surgery Pub Date : 2018-02-01 DOI: 10.12788/j.sder.2018.010
Kenneth B Gordon, April W Armstrong, M Alan Menter, Jashin J Wu
{"title":"Treating to Target-A Realistic Goal in Psoriasis?","authors":"Kenneth B Gordon,&nbsp;April W Armstrong,&nbsp;M Alan Menter,&nbsp;Jashin J Wu","doi":"10.12788/j.sder.2018.010","DOIUrl":"https://doi.org/10.12788/j.sder.2018.010","url":null,"abstract":"<p><p>For many patients, the new biologic therapies for psoriasis can improve Psoriasis Area and Severity Index (PASI) scores in a relatively short time. But when results are less than optimal, patients often become frustrated. By providing effective medical treatment using a treat-to-target strategy, clinicians can relieve symptoms and halt disease progression. Although body surface area (BSA) and PASI scores are appropriate for analyzing results of clinical trials, clinicians need to use more patient-centered assessments of patients' progress such as the Dermatology Life Quality Index (DLQI) and Psoriasis Symptom Inventory (PSI), as well as other validated patientreported outcomes, which can enable them to set realistic and achievable goals for individual patients. Semin Cutan Med Surg 37(supp2):S44-S47.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 2S","pages":"S44-S47"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35973595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Common and Not-So-Common Comorbidities of Psoriasis. 常见和不常见的牛皮癣合并症。
Seminars in cutaneous medicine and surgery Pub Date : 2018-02-01 DOI: 10.12788/j.sder.2018.011
M Alan Menter, April W Armstrong, Kenneth B Gordon, Jashin J Wu
{"title":"Common and Not-So-Common Comorbidities of Psoriasis.","authors":"M Alan Menter,&nbsp;April W Armstrong,&nbsp;Kenneth B Gordon,&nbsp;Jashin J Wu","doi":"10.12788/j.sder.2018.011","DOIUrl":"https://doi.org/10.12788/j.sder.2018.011","url":null,"abstract":"<p><p>Plaque psoriasis is increasingly recognized as a multisystemic disease whose most common comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, overweight/obesity, inflammatory bowel disease, and depression. The presence of such comorbidities affects the therapeutic choices for clinicians. Patients often visit dermatologists more frequently than they do other clinicians, so it is incumbent upon dermatologists to recognize and address early signs of psoriatic comorbidities to prevent further deterioration and improve their patients' quality of life. Semin Cutan Med Surg 37(supp2):S48-S51.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 2S","pages":"S48-S51"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35973599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Introduction. 介绍。
Seminars in cutaneous medicine and surgery Pub Date : 2018-02-01 DOI: 10.12788/j.sder.2018.008
Alan M Menter
{"title":"Introduction.","authors":"Alan M Menter","doi":"10.12788/j.sder.2018.008","DOIUrl":"https://doi.org/10.12788/j.sder.2018.008","url":null,"abstract":"","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 2S","pages":"S38"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35973592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inpatient Dermatology 住院病人皮肤
Seminars in cutaneous medicine and surgery Pub Date : 2018-01-01 DOI: 10.1007/978-3-319-18449-4
M. Rosenbach, K. Wanat, R. Micheletti, Laura A. Taylor
{"title":"Inpatient Dermatology","authors":"M. Rosenbach, K. Wanat, R. Micheletti, Laura A. Taylor","doi":"10.1007/978-3-319-18449-4","DOIUrl":"https://doi.org/10.1007/978-3-319-18449-4","url":null,"abstract":"","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-319-18449-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51005689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Aesthetic Consideration in Women's Health, Introduction. 女性健康中的审美思考，导论。
Seminars in cutaneous medicine and surgery Pub Date : 2018-01-01 DOI: 10.12788/j.sder.2018.
L. M. Bonati, M. Sadeghpour, Nicola A. Quatrano
{"title":"Aesthetic Consideration in Women's Health, Introduction.","authors":"L. M. Bonati, M. Sadeghpour, Nicola A. Quatrano","doi":"10.12788/j.sder.2018.","DOIUrl":"https://doi.org/10.12788/j.sder.2018.","url":null,"abstract":"","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 4 1","pages":"209"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66805541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in fractional technology for skin rejuvenation, skin tightening, drug delivery, and treating scars and skin defects. 在皮肤嫩肤、皮肤紧致、药物输送、疤痕和皮肤缺陷治疗方面的分步技术进展。
Seminars in cutaneous medicine and surgery Pub Date : 2017-12-01 DOI: 10.12788/j.sder.2017.039
Deirdre Connolly, Laura Schilling, Nazanin Saedi
{"title":"Advances in fractional technology for skin rejuvenation, skin tightening, drug delivery, and treating scars and skin defects.","authors":"Deirdre Connolly,&nbsp;Laura Schilling,&nbsp;Nazanin Saedi","doi":"10.12788/j.sder.2017.039","DOIUrl":"https://doi.org/10.12788/j.sder.2017.039","url":null,"abstract":"<p><p>The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. This has started to change the paradigm of what is considered first-line treatment for scarring and rejuvenation. While originally applied to nonablative lasers, fractionation has now been employed in ablative, quality-switched, picosecond, and novel hybrid fractional lasers. Furthermore, other energy-based technologies, such as radiofrequency, have adopted the concept of fractionation in an attempt to optimize the balance of efficacy, downtime, and side effects. Herein, we describe how the ever-expanding repertoire of fractional devices is applied to the treatment of scarring, skin rejuvenation, and tightening. In addition, newer applications, such as transdermal drug delivery, are being developed by using fractional devices. Growing experience with these devices has broadened their relevance to more skin types and body sites than ever. Ultimately, the knowledge of appropriate treatment parameters is paramount and allows for the safe and effective treatment of a variety of patients with numerous devices.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"36 4","pages":"138-147"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35632143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Noninvasive approach to treatment of submental fullness. 无创方法治疗颏下丰满症。
Seminars in cutaneous medicine and surgery Pub Date : 2017-12-01 DOI: 10.12788/j.sder.2017.040
Geeta M Shah, Judah N Greenberg, Elizabeth L Tanzi, Gary D Monheit
{"title":"Noninvasive approach to treatment of submental fullness.","authors":"Geeta M Shah,&nbsp;Judah N Greenberg,&nbsp;Elizabeth L Tanzi,&nbsp;Gary D Monheit","doi":"10.12788/j.sder.2017.040","DOIUrl":"https://doi.org/10.12788/j.sder.2017.040","url":null,"abstract":"<p><p>A recent survey done by the American Society for Dermatologic Surgery indicated that 67% of respondents were bothered by \"excess fat under the chin/neck.\" Accumulation of fat in the preplatysmal compartment of the neck is a common cause for fullness in the submental area. In the past, surgical liposuction was the only option to remove fat in the submental area. Although effective, liposuction does have risks and downtime. Recently, noninvasive options for treatment of submental fat have been introduced. These include treatment with deoxycholic acid, known as Kybella®, and cryolipolysis using the CoolMini™ handpiece. Both of these treatments offer less downtime fewer potential risks than the surgical counterpart. This article summarizes these two procedures and describes noninvasive approaches to treatment of submental fat.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"36 4","pages":"164-169"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35632146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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