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Seminars in cutaneous medicine and surgery最新文献

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Pathologic analysis of melanocytic neoplasms. 黑色素细胞肿瘤的病理分析。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2017.054
Jane L Messina, Julie Gibbs
{"title":"Pathologic analysis of melanocytic neoplasms.","authors":"Jane L Messina,&nbsp;Julie Gibbs","doi":"10.12788/j.sder.2017.054","DOIUrl":"https://doi.org/10.12788/j.sder.2017.054","url":null,"abstract":"<p><p>Recent advances in techniques for pathologic evaluation of melanocytic neoplasms, updates in staging, and novel treatment and prognostic assays have brought pathologists to the forefront of the care of the melanoma patient. Specimen procurement, handling, and evaluation are all key to the production of a pathology report that guides the clinician to the proper treatment of the patient. Recent, relevant changes in the pathologic analysis of melanocytic neoplasms, highlighting the AJCC 8th edition guidelines, and pathologic changes related to therapy are discussed herein. Also included is a discussion of molecular assays used to aid in diagnosis of challenging lesions, predict clinical outcome, and predict response to targeted therapy.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":" ","pages":"88-100"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36336623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The role of targeted therapy for melanoma in the immunotherapy era. 免疫治疗时代黑色素瘤靶向治疗的作用。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.021
Ryan J Sullivan
{"title":"The role of targeted therapy for melanoma in the immunotherapy era.","authors":"Ryan J Sullivan","doi":"10.12788/j.sder.2018.021","DOIUrl":"https://doi.org/10.12788/j.sder.2018.021","url":null,"abstract":"<p><p>Over the past 10 years of remarkable development of both molecularly targeted and immune-targeted therapy for the treatment of melanoma, a clear preference of immunotherapy over molecularly targeted therapy has emerged among melanoma treatment providers. Still, the clinical data remain remarkable for patients with BRAF-mutant stage III and IV melanoma, and there seems to be a clear benefit of BRAF-targeted therapy for these patients. The key, then, is to identify the best way to use BRAF-targeted therapy. In this review, the clinical data of molecular-targeted therapy are summarized, mechanisms of resistance to single-agent BRAF and combined BRAF with mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) inhibitor are discussed, and strategies to overcome this resistance are presented; then, we review a number of clinical dilemmas that influence the decision-making of using targeted therapy over immunotherapy, and viceversa, and help define the specific role of targeted therapy in the immunotherapy era.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":" ","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36336626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Adjuvant therapy for resected high-risk melanoma. 切除高危黑色素瘤的辅助治疗。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.022
Justin C Moser, Kenneth F Grossman
{"title":"Adjuvant therapy for resected high-risk melanoma.","authors":"Justin C Moser,&nbsp;Kenneth F Grossman","doi":"10.12788/j.sder.2018.022","DOIUrl":"https://doi.org/10.12788/j.sder.2018.022","url":null,"abstract":"<p><p>Melanoma is an aggressive cancer that arises from melanocytes that can both locally invade surrounding tissues as well as metastasize systemically. If detected early, melanoma can be curable with surgical resection. However, despite complete removal, high-risk resected melanomas have a significant rate of both local and distant recurrence. Curative treatment options are typically limited for patients who develop distant recurrence after resections of their primary melanoma. Therefore, adjuvant therapy is typically given after complete resection of high-risk melanomas to try and reduce the risk of recurrent disease. Adjuvant therapy for high-risk resected melanoma has changed considerably over the past couple of years due to the availability of new melanoma therapies that are active in the metastatic setting. Here, we review the new treatment options and ongoing clinical research for adjuvant therapy.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":" ","pages":"109-111"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36336625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Treating Acne in Adult Women. 治疗成年女性痤疮。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.026
Julie C Harper, Linda F Stein Gold, Andrew F Alexis, Jerry K L Tan
{"title":"Treating Acne in Adult Women.","authors":"Julie C Harper,&nbsp;Linda F Stein Gold,&nbsp;Andrew F Alexis,&nbsp;Jerry K L Tan","doi":"10.12788/j.sder.2018.026","DOIUrl":"https://doi.org/10.12788/j.sder.2018.026","url":null,"abstract":"<p><p>Acne can persist into adulthood or erupt de novo at any point after adolescence. Adult acne is more common in women than in men. Considerations for treating acne in adult women include childbearing potential, pregnancy, lactation, and concomitant skin conditions. Semin Cutan Med Surg 37(supp3):S67-S70 © 2018 published by Frontline Medical Communications.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 3S","pages":"S67-S70"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36472083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights of Skin Disease Education Foundations 42nd Annual Hawaii Dermatology Seminar. 皮肤病教育基金会第42届夏威夷皮肤病研讨会的亮点。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.031
Hilary E Baldwin, Linda F Stein Gold, Kenneth B Gordon, Jeremy B Green, Craig L Leonardi, Roberta D Sengelmann
{"title":"Highlights of Skin Disease Education Foundations 42nd Annual Hawaii Dermatology Seminar.","authors":"Hilary E Baldwin,&nbsp;Linda F Stein Gold,&nbsp;Kenneth B Gordon,&nbsp;Jeremy B Green,&nbsp;Craig L Leonardi,&nbsp;Roberta D Sengelmann","doi":"10.12788/j.sder.2018.031","DOIUrl":"https://doi.org/10.12788/j.sder.2018.031","url":null,"abstract":"<p><p>Updates on managing some of the most common dermatologic conditions for which patients seek care illuminated presentations at the Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar®. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. Treatment of psoriasis has continued to advance, with three interleukin (IL)-17 antagonists approved by the US Food and Drug Administration (FDA) and a fourth in phase 3 trials. An authority on the use of biologics in psoriasis presents current data on the safety and efficacy of these therapies. Tumor necrosis factor (TNF) inhibitors also retain a place in the management of psoriasis, with records of long-term safety. A fourth TNF inhibitor awaits FDA approval for use in psoriasis, offering data on transmission during pregnancy and lactation. An expert on the use of this drug class presents the evidence. Topical therapies remain the cornerstone of care for many patients with psoriasis as well as those with rosacea. Our faculty update readers about new and investigational topical therapies for moderate or severe psoriasis, as well as for acne and rosacea. The current literature on monitoring patients receiving isotretinoin also is summarized. Aesthetic and cosmetic dermatology services form a sizable portion of some practices. Our faculty review data on safety of topical and procedural therapies for cellulite as well as safe injection of facial fillers.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 4S","pages":"S75-S84"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36320434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Acne and Rosacea Therapy. 痤疮和酒渣鼻治疗进展。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.025
Linda F Stein Gold, Andrew F Alexis, Julie C Harper, Jerry K L Tan
{"title":"Advances in Acne and Rosacea Therapy.","authors":"Linda F Stein Gold,&nbsp;Andrew F Alexis,&nbsp;Julie C Harper,&nbsp;Jerry K L Tan","doi":"10.12788/j.sder.2018.025","DOIUrl":"https://doi.org/10.12788/j.sder.2018.025","url":null,"abstract":"<p><p>New topical therapies have demonstrated efficacy in patients with moderate or severe acne who might otherwise have required therapy with systemic antibiotics or isotretinoin. Increasing knowledge about the pathogenesis of acne has facilitated the development of therapies with novel modes of action. New and investigational therapies also are available or in development for the treatment of both the papulopustular and erythematous manifestations of rosacea. Semin Cutan Med Surg 37(supp3):S63-S66 © 2018 published by Frontline Medical Communications.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 3S","pages":"S63-S66"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36472082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Surgical management of melanoma. 黑色素瘤的外科治疗。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.018
Erin E Burke, Vernon K Sondak
{"title":"Surgical management of melanoma.","authors":"Erin E Burke,&nbsp;Vernon K Sondak","doi":"10.12788/j.sder.2018.018","DOIUrl":"https://doi.org/10.12788/j.sder.2018.018","url":null,"abstract":"<p><p>Surgery remains one of the key treatment modalities for melanoma. Wide excision of the primary site with sentinel lymph node biopsy for selected patients has been recognized as the standard surgical approach for patients with early-stage disease. Controversies persist regarding margin width, indications for sentinel lymph node biopsy, and surgical management of regional nodal basins. Additionally, new therapies such as intralesional therapies as well as new systemic therapies are changing the role for surgery in patients with recurrent local-regional as well as metastatic disease. In this chapter, we discuss the current recommendations as well as the topics of debate in the surgical management of melanoma.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":" ","pages":"101-108"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36336624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Introduction. 介绍。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.023
Linda F Stein Gold
{"title":"Introduction.","authors":"Linda F Stein Gold","doi":"10.12788/j.sder.2018.023","DOIUrl":"https://doi.org/10.12788/j.sder.2018.023","url":null,"abstract":"","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 3S","pages":"S59"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36472081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar™ Scientific Abstracts. 皮肤病教育基金会第42届夏威夷皮肤病研讨会™科学摘要。
Seminars in cutaneous medicine and surgery Pub Date : 2018-06-01 DOI: 10.12788/j.sder.2018.013
{"title":"Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar™ Scientific Abstracts.","authors":"","doi":"10.12788/j.sder.2018.013","DOIUrl":"https://doi.org/10.12788/j.sder.2018.013","url":null,"abstract":"","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":" ","pages":"S1-S38"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36062405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular advances in cutaneous T-cell lymphoma. 皮肤t细胞淋巴瘤的分子研究进展。
Seminars in cutaneous medicine and surgery Pub Date : 2018-03-01 DOI: 10.12788/j.sder.2018.007
Armando N Bastidas Torres, Safa Najidh, Cornelis P Tensen, Maarten H Vermeer
{"title":"Molecular advances in cutaneous T-cell lymphoma.","authors":"Armando N Bastidas Torres,&nbsp;Safa Najidh,&nbsp;Cornelis P Tensen,&nbsp;Maarten H Vermeer","doi":"10.12788/j.sder.2018.007","DOIUrl":"https://doi.org/10.12788/j.sder.2018.007","url":null,"abstract":"<p><p>Cutaneous T-cell lymphoma (CTCL) is a group of malignancies derived from skin-homing T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common CTCL variants. In recent years, the genetic landscape of SS/MF has been characterized using genome-wide nextgeneration sequencing approaches. These studies have revealed that genes subjected to oncogenic mutations take part in cell cycle regulation, chromatin modification, Janus kinase (JAK)-signal transducer and activator of transcription protein (STAT) signaling, T-cell receptor (TCR)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, and microtubule associated protein kinase (MAPK) signaling, which suggests that deregulation of these cellular processes underlies lymphomagenesis. These studies provide the groundwork for functional and clinical studies that will lead to better risk assessment and more effective therapeutic approach in CTCL patients.</p>","PeriodicalId":21714,"journal":{"name":"Seminars in cutaneous medicine and surgery","volume":"37 1","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36062784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
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