Scripta Scientifica Medica最新文献

{"title":"The application of virtual reality simulators in laparoscopic surgery training (a review)","authors":"T. Kalinov, A. Zlatarov, Mehmed Hadzhiveli","doi":"10.14748/ssm.v0i0.8079","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.8079","url":null,"abstract":"","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"478 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76528640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network-constrained regularization in computational biology and medicine","authors":"S. Daskalov, K. Bliznakova","doi":"10.14748/ssm.v0i0.7762","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7762","url":null,"abstract":"","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80896590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmenopausal bone health may be influenced by the presence of arterial hypertension and antihypertensive therapy","authors":"R. Dimitrova, K. Hristozov, M. Boyadzhieva","doi":"10.14748/SSM.V0I0.7841","DOIUrl":"https://doi.org/10.14748/SSM.V0I0.7841","url":null,"abstract":"Introduction:  Despite available evidence for a link between bone health and arterial hypertension (AH), the results of clinical trials remain conflicting. Thus, we conducted a cross-sectional study to analyze a possible association between blood pressure (BP), antihypertensive therapy and deteriorating bone health in postmenopausal women.  Materials and Methods:  The study included 84 women from Northeastern Bulgaria. Their mean age was 60.54 ± 7.07 years, and their mean duration of menopause was 11.45 ± 6.62 years. Bone health was assessed by dual-energy X-ray absorptiometry (DEXA) and by analysis of bone metabolic markers.  Results:  A significant negative correlation was established between bone mineral density (BMD) and diastolic BP. On the other hand, AH predominated in the studied population. However, among the subjects diagnosed with osteopenia and osteoporosis, a significantly higher proportion of AH was observed. In addition, differences were found according to the stage of AH and according to the intake of antihypertensive therapy, when assessing BMD and fracture risk. In subjects with newly diagnosed and respectively untreated AH as well as in the group of stage III AH, the lowest BMD and the highest fracture risk were found. Although we reported a significant difference in the mean age of women according to the presence of AH and its stages, after further analysis it was found that the presence of AH is an independent risk factor for bone health in postmenopausal women (OR = 2.14 (0.686–6.703); p = 0.015).  Conclusion:  According to the obtained results, we assumed that AH was risk factor for bone health in postmenopausal women, as it was associated with lower BMD and higher fracture risk. In addition, we found differences according to the stage of AH and antihypertensive therapy, which might be considered in the prevention, prophylaxis and treatment of osteoporosis.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"228 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77062331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical rehabilitation of nasal septum perforation in children","authors":"Adnan Yunusov, Nikolai Daykhes, Hassan Diab, Ekaterina Molodtsova","doi":"10.14748/ssm.v53i2.7998","DOIUrl":"https://doi.org/10.14748/ssm.v53i2.7998","url":null,"abstract":"INTRODUCTION: Technical difficulties and failures are also determined by the fact that it is extremely rare to close the perforation by simple mutual displacement and cross-linking of the flaps of mucoperichondrium. The aim of this article is to develop optimal methods for plastic closure of septum perforations in children based on a retrospective analysis of results of surgical treatment. MATERIALS AND METHODS: Plastic surgery closure of septum perforations using a newly developed method is described for 14 patients aged 6–15 years. DISCUSSION: An analysis of the etiological factors affecting disease development is carried out, and the authors’ technique of closing the subtotal perforations is described in detail, adapted for the child’s age, and for preoperative preparation and postoperative management. In all operated patients, the postoperative pe-riod proceeded smoothly, without complications associated with the operation. A follow-up observation for more than a year after surgery showed no recurrence of septal perforation in patients from both groups. CONCLUSION: A careful analysis of the causes, clinical manifestations, localization and sizes of septum perforation in comparison with the anatomical dimensions of intranasal structures allows one to individually select the optimal surgical method.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82614268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary neutrophil gelatinase-associated lipocalin—an early biomarker for renal injury in patients with beta-thalassemia major","authors":"L. Stoyanova, Triphon G Chervenkov","doi":"10.14748/ssm.v53i3.7378","DOIUrl":"https://doi.org/10.14748/ssm.v53i3.7378","url":null,"abstract":"INTRODUCTION : The iron overload and the development of secondary hemosiderosis in patients with β-thalassemia major (β-TM) lead to organ damages, including kidney disorders from early childhood. Contemporary urinary markers such as neutrophil gelatinase-association lipocalin (NGAL), β2-microglobulin (β2-MG), and N-acetyl-β-D-glucosaminidase (NAG) could be a useful tool for clinicians in diagnosis of early tubular lesions. AIM : The aim of this article is to make an assessment of contemporary urine biomarkers β2-microglobulin, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase in the diagnosis of early renal injury in patients with β-TM. MATERIALS AND METHODS : The current study was conducted by examining 44 patients with β-thalassemia major and 30 controls. All participants were tested for NGAL, β2-MG, and NAG in the first sample morning urine using ELISA method. RESULTS : The results show statistically significant differences between the two examined groups in urinary NGAL. CONCLUSION : Urinary NGAL indicates subclinical kidney injury when the tubular reabsorption of molecules is impaired.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"73 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72547021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usher syndrome—the most common reason for deaf-blindness","authors":"C. Bommert, E. Hristova, C. Grupcheva","doi":"10.14748/ssm.v0i0.7997","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7997","url":null,"abstract":"Deaf-blindness is a serious disability, which affects all aspects of life. The most common condition combining deafness and blindness is the Usher syndrome (USH), which is traditionally divided into three major clinical subtypes, including Usher syndrome type 1, Usher syndrome type 2, and Usher syndrome type 3. The frequency of USH occurrence is often undervalued. To date, five genes for USH1 have been identified, three genes are involved in USH2, and one gene in USH3. In summary, USH can be a multisensory impairment associated with hearing impairment, progressive retinal degeneration, and vestibular dysfunction. Management of these patients requires interdisciplinary approach and collaboration.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90899893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the diagnosis of some common vestibular disorders","authors":"M. Milkov","doi":"10.14748/ssm.v0i0.7999","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7999","url":null,"abstract":"The interest in the diagnosis of common vestibular disorders in children and adults is permanently increas-ing. In this survey, the applications of the main diagnostic methods in this interdisciplinary field are briefly discussed. The diagnostic capacities of the caloric test, video head impulse test, cervical and ocular vestibular evoked myogenic potentials, videonystagmography, electrococheography, magnetic resonance imaging, computed tomography, etc. are summarized. Special attention is paid to some common vestibular disorders such as Menière’s disease, benign paroxysmal positional vertigo, vestibular migraine, vestibular neuritis, and acute vestibular syndrome. United international efforts will contribute to further improvement of the diagnosis of the vestibular disorders, which warrants their adequate treatment. discuss","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78315782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent graft materials in experimental study stage used in the treatment of nasal septum perforation: a review","authors":"Serdal Çelik, Y. Gunduz, M. Kalcıoğlu","doi":"10.14748/SSM.V0I0.7855","DOIUrl":"https://doi.org/10.14748/SSM.V0I0.7855","url":null,"abstract":"Various conservative approaches are being used for the treatment of nasal septum perforations (NSPs); however, for permanent results, it is essential to use surgical methods. For this purpose, many various surgical methods have been tried, but a satisfactory method has not yet been determined. In order to eliminate the commonly encountered failure of surgical methods, new graft materials combined with flaps have been tried recently and successful results have been reported. In this review, we examined the scientific literature using Medline, PubMed, and Google by using the keywords \"nasal septum perforation\", \"animal study\", and \"graft\". According to the results obtained, we compiled graft materials that have been used in experimental stage related to this subject and reported to have achieved successful results, especially when combined with flaps. These materials seem promising for the successful closure of the hard-to-treat NSPs.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90600196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principles of surgical treatment of chronic post-intubation laryngotracheal stenosis in childhood","authors":"V. Vavin, I. Nazhmudinov, T. Garashchenko, D. Polyakov, K. Magomedova","doi":"10.14748/ssm.v0i0.7854","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7854","url":null,"abstract":"Introduction: Post-intubation stenosis of the larynx and trachea in childhood increases annually. This is associated with an increasing number of children with severe pathology of the upper respiratory tract, as well as children requiring artificial ventilation for other reasons. Until now there have been debatable questions about surgical tactics in children with chronic cicatricial laryngeal stenosis. Aim: The aim of this article is to evaluate the effectiveness of different tactics of surgical treatment of children with chronic cicatricial post-intubation stenosis of the larynx, depending on the state of the cartilaginous frame of the larynx. Materials and Methods: We have treated 47 children with chronic cicatricial post-intubation stenosis of the larynx. Preoperative examination included endoscopy and computed tomography of the larynx and trachea. We assessed the cartilaginous framework of the larynx and trachea that influenced the choice of surgical approach. For 20 children with intact laryngeal cartilaginous frame the method of endolaryngeal microsurgery using a CO2 laser was applied. This method allowed to form a wound surface by minimum submucosal resection scar tissue, which made it possible to cover the wound with mucosal microflaps to prevent restenosis. In the surgical treatment of extended stenoses of the middle larynx, there are prerequisites for repeated replacement of the wound with excess scar tissue, which in our observations was avoided by using endoprostheses for a period of 21 days. Despite it, with a lesion of the subglottic part of the larynx, the risk of restenosis remained quite high (5 out of 12 patients), even in the absence of data for damage to the cartilaginous frame of the larynx. In 27 cases of chronic post-intubation cicatricial stenosis of the larynx, in identifying of laryngeal cartilage framework lesion before surgery, extralaryngeal laryngotracheoplasty was performed. Laryngofissure was performed in 18 children, followed by stenting from 6 to 18 months with a T-shaped silicone stent, in 9 cases—one-stage laryngotracheoplasty using auto-cartilage grafts. The applied techniques have shown high efficiency, while the use of autografts made it possible to reduce the stages and duration of surgical treatment. Conclusion: The use of a CO2 laser in combination with balloon laryngoplasty in microsurgical treatment of chronic post-intubation stenosis of the larynx in children significantly expands surgical capabilities due to high accuracy and low level of damage of surrounding tissues.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82307229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aural polyps: What's behind them?","authors":"Alice Lang Silva, F. Selaimen, Isabel Conte, Marcela Lehmkuhl Damiani, Luciana Lima Martins Costa, L. Rosito, S. S. Costa","doi":"10.14748/SSM.V0I0.7850","DOIUrl":"https://doi.org/10.14748/SSM.V0I0.7850","url":null,"abstract":"Introduction: Polyps in the external auditory canal (EAC) may be present due to inflammation induced by chronic otitis media. In many cases, the type of underlying otitis media is a cholesteatoma. Aim: The aim of this article is to determine the etiology of EAC polyps in patients referred to the Otology Division of a tertiary hospital in south Brazil. Materials and Methods: Cross-sectional study was conducted with a cohort of patients with otologic diseases who were evaluated from July 2001 to December 2020. Patients with unilateral or bilateral aural polyps underwent anamnesis and recorded video-otoscopy and had their online medical chart reviewed. Results:  Of the 2432 patients evaluated, 133 (5.4%) had a polyp in the external auditory canal. Of those, 53 were excluded, leaving a final sample of 81 patients (3.3%). Discussion:  Middle ear cholesteatoma (MEC) and non-cholesteatomatous chronic otitis media (NCCOM) were responsible for 86.3% of all polyps evaluated and the majority of diagnoses were established through surgery (76.5%). Conclusion: Symptoms associated with polyps and their aspect do not reveal the most probable etiologies making imaging exams, biopsy and surgery necessary steps in aural polyp investigation.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81746880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}