上海口腔医学最新文献

{"title":"[Analysis of hub genes, pathways and immune checkpoints of CD8+ T cells in metastatic lymph nodes of head and neck squamous cell carcinoma in C3H/He mice].","authors":"Di Zhou, Nan-Nan Han, Hua-Sheng Li, Ming Yan, Min Ruan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the expression of hub genes, pathways and inhibitory immune checkpoints of CD8+ T cells in metastatic lymph nodes of head and neck squamous cell carcinoma(HNSCC) in C3H/He mice.</p><p><strong>Methods: </strong>A popliteal lymph node metastasis model of immunocompetent C3H/He mice was constructed with SCC-7 cell line of HNSCC, and the lymph node metastasis status was determined by immunofluorescence. CD8+ T cells in normal and metastatic lymph nodes were sorted by flow cytometry, and transcriptome sequencing analysis was performed to screen out differentially expressed genes. GO functional enrichment analysis and KEGG pathway enrichment analysis were performed sequentially. Flow cytometry and multiplex immunohistochemical were used to detect the expression of four immune checkpoints of CD8+ T cells in metastatic lymph nodes of tumor-bearing mice. SPSS 26.0 software package was used for statistical analysis.</p><p><strong>Results: </strong>After 4 weeks of foot pad injection of SCC-7 cells, C3H/He mice displayed obvious metastasis in popliteal drainage lymph node. A total of 912 differentially expressed genes were screened out by transcriptome sequencing analysis of CD8+ T cells in normal and metastatic lymph nodes, including three inhibitory immune checkpoint-related genes which were upregulated(Pdcd1, Lag3 and Tigit). Eight tumor-related signaling pathways were screened out by KEGG network analysis, including Toll-like receptor signaling pathway, NF Kappa-B signaling pathway, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway, NOD-like receptor signaling pathway, PD-L1 and PD-1 immune checkpoint pathway in tumors and p53 signaling pathway. Flow cytometry showed high expression level of PD-1 and TIM-3 in CD8+ T cells in mouse metastatic lymph nodes. It was further confirmed by multiplex immunohistochemical that PD-1 was highly expressed in CD8+ T cells in metastatic lymph nodes of patients with HNSCC.</p><p><strong>Conclusions: </strong>Tumor-related signaling pathway of CD8+ T cells in mouse metastatic lymph nodes is significantly activated. The PD-1 expression level of CD8+ T in metastatic lymph nodes of mice and patients with HNSCC is markedly increased. Immunotherapy targeting CD8+ T cells may become a new strategy for the prevention and cure for lymph node metastasis of HNSCC.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"586-593"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The influence of different preset drill radius and tooth position on the compensation gap of zirconium dioxide restoration].","authors":"Ya-Lin Guo, Jing-Yuan Peng, Dong-Dong Qian, Zi-Yu Mei, Xiang-Feng Meng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the influence of different preset drill radius on the drill compensation space of zirconia dioxide restoration and the characteristics of tooth position and anatomical parts of the drill compensation space.</p><p><strong>Methods: </strong>The digital design data of 12 cases of incisor, premolar and molar were randomly selected, and the radius of the needle was preset to 0.3, 0.4, 0.5 and 0.6 mm. Software analysis was performed to obtain four evaluation index values for each group of drill compensation gaps ,including compensation area, the proportion of the drillcompensation area to the preparation area, compensation volume and the maximum value of the compensation. The compensation frequency of the occlusal/incisal edge, axial surface and edge area of 0.5 mm preset radius group were recorded. Data were analyzed by two-way ANOVA and Chi-square test using SPSS 22.0 software package.</p><p><strong>Results: </strong>The preset drill radius and tooth position significantly affect the values of the four evaluation indicators(P＜0.05) of the drill compensation space, among which the four evaluation index values were significantly reduced by the preset radius of the drill (P＜0.05). The probability that the maximum drill compensation thickness value of incisor and molar teeth in the 0.5 mm group and all types of teeth in the 0.6 mm group exceeded 300 μm existed, the frequency of 20 μm gap compensation in the incisor/occlusal edge area, the axial surface area, and the edge area of the preparation decreased in turn(P＜0.05).</p><p><strong>Conclusions: </strong>The preset radius of 0.3-0.4 mm can obtain a reasonable drill compensation gap on the tissue surface of the prosthesis. The occlusal/incisor area of the preparation needs to be carefully prepared to reduce the frequency of gap compensation.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"594-599"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the diagnostic value of X-ray and CBCT 3D reconstruction in adolescent orthodontic patients with impacted teeth].","authors":"Lin-Cheng Gao, Yong-Ping Ma, Lin-Qing Gao, Da-Hua Liu, Chao Wang, Hao Jia","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the value of X-ray and cone-beam CT(CBCT) three-dimensional reconstruction in the diagnosis of impacted teeth in adolescent orthodontic patients.</p><p><strong>Methods: </strong>From May 2021 to May 2024, totally 86 adolescent orthodontic patients with 126 impacted teeth admitted to the Second Hospital of Baoding City were selected for X-ray examination and CBCT 3D reconstruction. The diagnostic efficiency and accuracy of the two methods were evaluated by comparing their ability to reveal the location and adjacent anatomical structures of the impacted teeth. SPSS 26.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>Among the 126 impacted teeth, totally 40 cases (52 teeth) were in the maxillary anterior tooth region, 8 in the maxillary posterior region (12 teeth), 12 with maxillary supernumerary teeth (20 teeth), 14 in the mandibular anterior region (22 teeth), 8 in the mandibular posterior region (14 teeth), and 4 with mandibular supernumerary teeth (6 teeth). The results of CBCT 3D reconstruction were close to operation findings. CBCT 3D reconstruction was superior to X-ray films in most indexes, especially in sensitivity and positive predictive value, showing higher diagnostic efficiency.</p><p><strong>Conclusions: </strong>CBCT three-dimensional reconstruction provides high diagnostic value in the diagnosis of impacted teeth in adolescent orthodontic patients, especially in accurately assessing the position of impacted teeth.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"633-637"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence of temporomandibular joint disc displacement in patients malocclusion].","authors":"Guo-Li Zhou, Ling-Jun Yuan, Hai-Rui Li, Wen-Tao Shi, Bing Fang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prevalence characteristics of temporomandibular joint disc displacement in patients with malocclusion and influencing factors of disc displacement, and to provide reference for orthodontic treatment.</p><p><strong>Methods: </strong>A total of 1 157 consecutive orthodontic cases admitted to the Department of Orthodontics at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2012 to December 2021 were selected retrospectively. Based on temporomandibular joint MRI, the prevalence of disc displacement in orthodontic cases was investigated. The influencical factors of gender, age and skeletal classification on disc displacement was analyzed. SPSS 25.0 software package was used for data analysis.</p><p><strong>Results: </strong>Among 1 157 orthodontic cases, there were 672 cases(58.08%) of disc displacement, and 334 cases(28.87%) had anterior disc displacement. The prevalence of disc displacement in female was significantly higher than that in male. The prevalence of disc displacement in skeletal Class Ⅱ malocclusion was significantly higher than that in skeletal Class Ⅲ malocclusion. In orthodontic cases aged between 10 and 18, the prevalence of disc displacement increased with age.</p><p><strong>Conclusions: </strong>There is a high proportion of abnormal articular disc position in patients with malocclusion. Age, gender(female) and skeletal Class Ⅱ malocclusion have higher correlation with temporomandibular joint disc displacement.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"656-660"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical study on the treatment of Class Ⅱ and ClassⅠmalocclusion in adolescents with mandibular recession using invisible orthodontic appliances without brackets].","authors":"Jiao Yu, Han-Ming Wang, Xiao-Mi Zhu, Zhi-Long Fan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the application value of invisible orthodontic appliance without brackets in the correction of ClassⅡand ClassⅠmalocclusion in adolescents with mandibular recession.</p><p><strong>Methods: </strong>A retrospective collection of clinical data was conducted on 114 adolescent patients with ClassⅡand ClassⅠmalocclusion of mandibular retrusion admitted to Hubei Hospital of Traditional Chinese Medicine from February 2020 to October 2022. They were divided into two groups based on different orthodontic methods, with 57 cases in each group. The control group was treated with Twin block appliances, while the experimental group was treated with invisible appliances without brackets. Both groups of patients were corrected for 12 months. The treatment effects of the two groups were evaluated, and the levels of inflammatory factors [alkaline phosphatase (ALP), matrix metalloproteinase-8 (MMP-8), interleukin-1β (IL-1β)] in gingival crevicular fluid before and after treatment, X-ray cephalometric indicators(SNB angle, ANB angle, Go-Gn, Ar-Go), temporomandibular joint parameters (anterior joint space, posterior joint space, superior joint space, fossa height) and upper airway conditions [nasopharyngeal volume (V-nasopharynx), velopharyngeal volume(V-velopharynx), glossopharyngeal volume (V-glossopharynx)], and the subjective perception scores of wearing orthodontic appliance were compared between the two groups. SPSS 28.0 software package was used for data analysis.</p><p><strong>Results: </strong>There was no significant difference in the orthodontic outcome of the experimental group compared to the control group (P＞0.05). After correction, the levels of IL-1β, MMP-8 and ALP in the gingival crevicular fluid were significantly lower in the experimental group compared to the control group(P＜0.05), but there was no significant difference(P＞0.05) between the two groups in terms of SNB angle, ANB angle, Go Gan, Ar Go, anterior and posterior joint spaces, supraarticular space, and joint socket height. After correction, there was no significant difference(P＞0.05) between the two groups in V-glossopharynx, V-palatopharynx, and V-nasopharynx. The experimental group had significantly higher scores in terms of comfort, compliance, and aesthetics when wearing invisible orthodontic appliances without brackets compared to the control group(P＜0.05).</p><p><strong>Conclusions: </strong>The treatment effect of Twin-block appliance and non-bracket invisible appliance is comparable for Class Ⅱ division Ⅰ malocclusion in adolescents with mandibular retrognathia. Both can improve the morphology of the mandible and dentition, expand the upper airway, but non-bracket invisible appliance can further reduce inflammation and improve patients' comfort.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"661-666"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Molecular mechanisms of let-7c targeting IGF2BP2 to regulate the proliferation of human dental pulp stem cells].","authors":"Yu-Shan Wang, Meng-Xin Sun, Yi-Cheng Yang, Xiao Heng, Yu-Xin Zhang, Jian-Guang Yang, Yan Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect and mechanism of let-7c overexpression on the proliferation of human dental pulp stem cells (hDPSCs).</p><p><strong>Methods: </strong>hDPSCs were isolated and cultured. After transfected with let-7c mimics and inhibitors, transfection efficiency was detected by qRT-PCR, and cell proliferation was detected by cell counting kit-8 (CCK-8). Flow cytometry was applied to determine the cell cycle. The mechanism of let-7c inhibiting cell proliferation was analyzed by Western blot. A cell model targeting insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) was constructed by transient transfection of small interfering RNA(siRNA) and analyzed by bioinformatics and dual luciferase reporter. Bioinformatics analysis and dual luciferase reporter gene assay were performed to investigate whether let-7c directly targeted IGF2BP2. The data were statistically analyzed using SPSS 17.0 software package.</p><p><strong>Results: </strong>Overexpression of let-7c inhibited cell proliferation. Let-7c blocked cell proliferation by regulating the S and G2/M cycles, and directly bound to a group of messenger RNA (mRNA) sequences related to cell cycle regulation, IGF2BP2, and targeting and inhibiting IGF2BP2 expression, with a negative correlation between the two expression levels.</p><p><strong>Conclusions: </strong>let-7c inhibites the proliferation of hDPSCs by targeting and inhibiting IGF2BP2 expression.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"572-579"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of vestibular shield appliances on lip morphological changes in mouth breathing patients].","authors":"Qin-Feng Ding, Ping Nie, Qing-Ling You, Yun-Hui Xia","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the soft tissue position changes in the lower 1/3 of face after application of the vestibular shield for correction of mouth dyspnea.</p><p><strong>Methods: </strong>A total of 32 pediatric patients wearing vestibular shield appliances for mouth breathing correction were reviewed, and the changes of upper and lower lip positions as well as chin position before and after appliance treatment were compared and analysed. GraphPad Prism 6.0 software package was used for data analysis.</p><p><strong>Results: </strong>The values of lateral protrusion N'-Sn-Pog' (facial convexity), nasolabial angle (Cm-Sn-Ls) lower lip protrusion (LL-EP) and upper lip prominence (UL-EP) were significantly reduced, of which UL-EP changes were the most obviously changed parameter. In addition, the chin morphology associated parameters Si-LiPg' and Sn-Gn'-C were significantly improved after treatment as well. No significant differences were observed within gender.</p><p><strong>Conclusions: </strong>Vestibular shield treatment for patients with mouth breathing can effectively improve the lip morphology.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"617-621"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the trueness and tissue surface adaptation of digital and traditional complete denture bases].","authors":"Rui Lin, Man-Li Zhou, Min Min, Xian-Fang Zhang, Wen-Hao Qian","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the trueness of the tissue surface of the complete denture base among the digital cutting complete denture, the digital 3D printing complete denture and the conventional complete denture.</p><p><strong>Methods: </strong>Three edentulous patients were selected, and three complete dentures were made for each case. Cutting dentures (cutting group), 3D printed dentures(printing group) were considered as the experimental groups, traditional dentures (traditional group) were considered as the control group. The tissue surface of complete denture model and denture base were scanned and their 3D data were obtained. Geomagic software was used to fit the model information with the tissue surface information of the denture base. A total of 8 regions were selected in the upper and lower complete dentures, and 10 points were randomly selected in each region. The average value of the absolute deviation value(Dm) of each region was calculated. SPSS 22.0 software package was used to analyze the Dm in a total of 24 regions of the three pairs of dentures.</p><p><strong>Results: </strong>The absolute mean deviation was (0.056±0.025) mm in the cutting group, (0.103±0.038) mm in the printing group, and (0.096±0.039) mm in the traditional group, which were significantly different among the three groups(P＜0.05). The trueness of the ablation group was better than that of the conventional group, and the difference was significant (P＜0.05). The trueness of the printing group was worse than that of the traditional group, and the difference was not significant(P＞0.05).</p><p><strong>Conclusions: </strong>The trueness of cutting dentures is better than that of traditional dentures, while the trueness of 3D printed dentures is not significantly better than that of traditional dentures.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 5","pages":"471-475"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis].","authors":"Li Chen, Zhong-Yue Zhang, Shu-Hua Zhang, Na Yan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the association between tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) gene polymorphism and susceptibility to diabetic periodontitis.</p><p><strong>Methods: </strong>A total of 150 patients with type 2 diabetes were selected from September 2022 to September 2023. The patients were divided into combined group(n=50), non-combined group (n=50) and control group (n=50) according to whether they had periodontitis. Clinical medical records of all subjects were collected, TRAIL G1525A and C1595T gene polymorphisms were detected, and the influencing factors of type 2 diabetic periodontitis were analyzed. Statistical analysis was performed with SPSS 19.0 software package.</p><p><strong>Results: </strong>In combined and non-combined group, the fasting blood glucose(FBG), loss of attachment(AL), gingival crevicular bleeding index (SBI) and blood calcium were significantly lower than those in the control group, and HbA1c and serum alkaline phosphatase(ALP) were significantly higher than those in the control group(P＜0.05). The GG gene frequency of TRAIL G1525A gene in the combined group was significantly higher than that in the non-combined group and control group(P＜0.05). There was no significant difference in genotype distribution of TRAIL C1595T among three groups(P＞0.05).HbA1c, AL, SBI, ALP and TRAIL G1525A polymorphisms were risk factors for periodontitis(P＜0.05). The distribution of TRAIL G1525ALeuGGin with moderate and severe periodontitis was significantly different from that with mild periodontitis (P＜0.05).</p><p><strong>Conclusions: </strong>TRAIL G1525A gene is associated with the susceptibility of diabetic periodontitis, and GG genotype patients with type 2 diabetes have a higher risk of periodontitis.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 5","pages":"481-485"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of personalized oral stents in intensity-modulated radiation therapy treatment].","authors":"Hong-Fei Ye, Pei-Lu Wang, Jie-Qiong Meng, Fang-Fang Sun","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the effects of personalized oral stents in intensity-modulated radiation therapy (IMRT) treatment.</p><p><strong>Methods: </strong>Totally 108 patients with nasopharyngeal carcinoma treated with IMRT at Nanjing Gaochun People's Hospital from January 2021 to December 2023 were selected. Using a random number table method, the patients were divided into experimental group (n=54) using personalized oral stents and control group (n=54) using simple mouthpieces. The dosimetry of clinical target volumes (CTV), normal oral tissues, conformity index (CI), homogeneity index (HI), pain level evaluated by visual analogue scale(VAS ), grades of oral mucositis, xerostomia scores, taste scores, oral health impact profile (OHIP) scores and incidence of complications(dental caries, xerostomia, taste disorders, oral candidiasis, osteomyelitis of the jaw) were compared between the two groups. SPSS 23.0 software package was used for statistical analysis.</p><p><strong>Results: </strong>There was no significant difference between the two groups in average received dose and CI, HI values on CTV and the tongue(P＞0.05); however, the experimental group showed a lower average received dose on the mandible, mandibular teeth, and bilateral parotid glands compared to the control group(P＜0.05). After treatment, the experimental group had significantly lower scores in VAS, grades of oral mucositis, xerostomia evaluation, OHIP and frequency of complications (P＜0.05). The taste scores in the experimental group were significantly higher than that in the control group (P＜0.05).</p><p><strong>Conclusions: </strong>Personalized oral stents significantly reduce the radiation dose to oral sites in IMRT treatment, decrease pain and other oral complications, and improve patients' quality of life.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 5","pages":"533-537"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}