Seminars in thrombosis and hemostasis最新文献_第2页

Platelet Function in Patients with Disseminated Intravascular Coagulation: Potential Markers for Improving DIC Diagnosis? 弥散性血管内凝血患者的血小板功能：改善DIC诊断的潜在指标？

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-17 DOI: 10.1055/s-0045-1809696

Johanne Duus Petersen, Christine Lodberg Hvas, Julie Brogaard Larsen

{"title":"Platelet Function in Patients with Disseminated Intravascular Coagulation: Potential Markers for Improving DIC Diagnosis?","authors":"Johanne Duus Petersen, Christine Lodberg Hvas, Julie Brogaard Larsen","doi":"10.1055/s-0045-1809696","DOIUrl":"https://doi.org/10.1055/s-0045-1809696","url":null,"abstract":"Disseminated intravascular coagulation (DIC) is a severe complication often associated with critical illness. DIC is characterized by an uncontrolled systemic activation of the hemostatic system, leading to substantial consumption of platelets and coagulation factors. The diagnosis of DIC relies on a combination of clinical findings and laboratory results, yet DIC remains challenging to confirm, especially in early stages. This systematic review investigates the reported associations between platelet function and DIC and evaluates the potential of using platelet function markers as a supplement for DIC diagnosis. PubMed and Embase were searched for relevant literature. Human studies, which included patients with DIC and assessed platelet function using dynamic platelet function assays or soluble markers, were included. In total, 24 studies met the inclusion criteria. We found that DIC patients generally exhibit increased platelet activation in vivo, indicated by elevated plasma levels of soluble markers, while ex vivo platelet aggregation was consistently reduced compared to non-DIC patients and healthy controls; however, not all studies adjusted their results for platelet count. Soluble P-selectin was the most frequently studied plasma marker and was consistently increased in DIC patients; this was most pronounced when adjusted for platelet count. However, there was considerable heterogeneity between studies regarding both study design, patient populations, platelet function assessment, and DIC diagnosis, which complicates the comparison of findings across studies. Future studies accounting for low platelet counts in dynamic function tests are necessary to assess the role of platelet aggregation in relation to DIC.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality. 识别急性肺栓塞患者短期死亡风险的四种风险分层模型的比较分析

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-17 DOI: 10.1055/a-2621-0465

Kwadwo O Bonsu, Stephanie W Young, Tiffany Lee, Hai V Nguyen, Rufaro S Chitsike

{"title":"Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.","authors":"Kwadwo O Bonsu, Stephanie W Young, Tiffany Lee, Hai V Nguyen, Rufaro S Chitsike","doi":"10.1055/a-2621-0465","DOIUrl":"10.1055/a-2621-0465","url":null,"abstract":"Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study included outpatients aged ≥18 years with confirmed PE from June 1, 2014 to May 31, 2019, identified via diagnostic imaging reports. Simplified Pulmonary Embolism Severity Index (sPESI) and Hestia scores were calculated as per original derivation methods. Patients were stratified by four models: sPESI alone, Hestia alone, sPESI plus right ventricular dysfunction (RVD), and Hestia plus RVD. Model accuracy and discriminatory power for 30- and 90-day mortality were assessed by area under the receiver operating curve (AUC). The study comprised 785 outpatients (mean age 65.0 years; 42.2% male). Overall mortality rates were 4.1% at 30 days and 7.8% at 90 days. sPESI identified 31.5% as low risk versus 19.1% by Hestia. All models demonstrated 100% sensitivity and negative predictive value for 30-day mortality, but modest discriminatory power (AUC range: 59.2-67.1). sPESI consistently outperformed other models in both timeframes. Including RVD with sPESI or Hestia did not enhance accuracy and slightly reduced performance. The net reclassification index indicated minor improvement in non-event classification with RVD, but no benefit for identifying deaths. sPESI remains a modest yet effective predictor of mortality risk within 90 days following acute PE, consistently outperforming sPESI + RVD, Hestia alone, and Hestia + RVD at both 30 and 90 days. Adding RVD minimally improved predictive accuracy.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coagulation Abnormalities Associated with COVID-19: A Narrative Review. 与COVID-19相关的凝血异常：叙述性综述

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-17 DOI: 10.1055/a-2619-2485

Massimo Franchini, Daniele Focosi, Pier Mannuccio Mannucci

引用次数: 0

Early Emicizumab Treatment in Acquired Hemophilia A: Impact on Bypassing Agent Use and Length of Hospitalization in an Australian Single-Center Cohort. 早期Emicizumab治疗获得性血友病A：在澳大利亚单中心队列中对旁路药物使用和住院时间的影响

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-17 DOI: 10.1055/a-2622-3483

Gianna Pastore, Jeremy Robertson, Sally Campbell, Jane Mason

引用次数: 0

Automation in Platelet Function Testing: Current Challenges and Future Directions. 血小板功能测试自动化：当前挑战和未来方向。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-17 DOI: 10.1055/a-2622-3545

Federico Boggio, Juri A Giannotta, Anna Lecchi

{"title":"Automation in Platelet Function Testing: Current Challenges and Future Directions.","authors":"Federico Boggio, Juri A Giannotta, Anna Lecchi","doi":"10.1055/a-2622-3545","DOIUrl":"10.1055/a-2622-3545","url":null,"abstract":"Platelet function testing is essential for diagnosing and managing platelet function disorders, but faces significant challenges due to complex protocols and variability in results. While light transmission aggregometry remains the gold standard for assessing platelet aggregation, it suffers from several limitations, including labor-intensive protocols, variability in reagents, and poor standardization. Over the decades, improvements such as lumi-aggregometry, which integrates granule secretion testing, and impedance whole-blood aggregometry, which simplifies sample handling, have addressed some of these challenges. Advanced granule secretion assays, including high-performance liquid chromatography and flow cytometry, have further enhanced diagnostic capabilities, although these techniques still depend on specialized expertise and expensive equipment. Recently, significant advancements have been made with automated aggregometers, such as the Sysmex CS series, and high-throughput 96-well plate assays, which improve consistency, throughput, and reproducibility. Nonetheless, further refinement in standardized reagents and consensus-driven protocols is required. Microfluidic technologies, exemplified by systems like the Total Thrombus Analysis System (T-TAS), incorporate physiological shear conditions and real-time thrombus formation assessment, providing enhanced diagnostic insights into platelet behavior. Despite their automation and clinical feasibility, these flow-based systems still require broader validation for routine clinical implementation. Further developments should prioritize integrating complementary assays, enhancing automation, and advancing miniaturization to improve standardization and diagnostic accuracy. Future technologies combined with artificial intelligence-based data interpretation hold the promise to transform platelet diagnostics, enabling personalized patient care. However, achieving widespread clinical adoption requires ongoing collaboration between clinicians, laboratories, industry, and regulatory bodies.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired Hemophilia A in a Case of Relapsed Immune Thrombotic Thrombocytopenic Purpura. 复发性免疫性血栓性血小板减少性紫癜一例获得性血友病A。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-17 DOI: 10.1055/a-2622-3585

Antonella Tufano, Ciro Miele, Paolo Conca, Ilenia Calcaterra, Cristina Mazzaccara, Paola Rufolo, Greta Chiarelli, Luigi Jr Valletta, Miriam Mazzone, Raffaele Russo, Guido D'Errico, Matteo Di Minno

引用次数: 0

Neutrophil-Mediated Effects on Hemostasis and Thrombosis: Unraveling Their Complex Interaction in Thrombotic Events. 中性粒细胞介导的止血和血栓形成作用：揭示它们在血栓形成事件中的复杂相互作用。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-03 DOI: 10.1055/a-2605-8019

Saeed Hassani, Alieh Fazeli, Akbar Dorgalaleh, Shadi Tabibian, Jalal Lomei, Maedeh Alipour, Masoumeh Kiani Zadeh, Mahmood Shams

{"title":"Neutrophil-Mediated Effects on Hemostasis and Thrombosis: Unraveling Their Complex Interaction in Thrombotic Events.","authors":"Saeed Hassani, Alieh Fazeli, Akbar Dorgalaleh, Shadi Tabibian, Jalal Lomei, Maedeh Alipour, Masoumeh Kiani Zadeh, Mahmood Shams","doi":"10.1055/a-2605-8019","DOIUrl":"https://doi.org/10.1055/a-2605-8019","url":null,"abstract":"Neutrophils are astonishing cells involved in nonspecific immunity, especially against bacterial and fungal infections. Their half-life is short, but despite their important role in nonspecific immunity, they defend the host even after their death by providing secondary structures such as neutrophil extracellular traps (NETs). NETs are a network comprising DNA, histones, and proteins, including elastase, cathepsin G, and myeloperoxidase. In this context, in addition to their primary role in hemostasis, they also play a role in thrombosis, an area that has received less attention. Nonetheless, NETs can promote both venous and arterial thrombus formation (immuno-thrombosis), by their effects on primary and secondary hemostasis; their participation in thrombus formation includes the release of microparticles and components of the inflammasome. Neutrophils in interaction with other cells including platelets can further contribute to thrombosis. Activated platelets can capture neutrophil-derived microparticles containing tissue factor (TF), leading to TF accumulation and increased fibrin deposition. Furthermore, neutrophil inflammasomes as a regulator of the generation of IL-1 family proteins have been shown to augment thrombosis formation in response to hypoxia. Overall, understanding the complex and reciprocal effects of neutrophils with other hemostasis-related cells and components provides important insights into hemostatic mechanisms, and this may open avenues in medical research and potential therapeutic interventions.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Neutrophil Extracellular Traps: A New Strategy for the Treatment of Acute Ischemic Stroke Based on Thrombolysis Resistance. 靶向中性粒细胞胞外陷阱：基于溶栓抵抗治疗急性缺血性脑卒中的新策略。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-03 DOI: 10.1055/a-2609-3457

Genquan Huang, Hao Wu, Bintong Lin, Dezhi Deng, Yuan Liu, Juan Qu, Junjie Xu, Baoxiang Wang

引用次数: 0

Red Blood Cells and Tranexamic Acid in the Inhibition of Fibrinolysis. 红细胞和氨甲环酸对纤维蛋白溶解的抑制作用。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-03 DOI: 10.1055/a-2609-3677

Nikolett Wohner, Kata Balog Virag, Alexandra Raska, Krasimir Kolev

{"title":"Red Blood Cells and Tranexamic Acid in the Inhibition of Fibrinolysis.","authors":"Nikolett Wohner, Kata Balog Virag, Alexandra Raska, Krasimir Kolev","doi":"10.1055/a-2609-3677","DOIUrl":"https://doi.org/10.1055/a-2609-3677","url":null,"abstract":"Tranexamic acid (TXA) is a widely used and cost-effective antifibrinolytic agent that has been utilized for decades in various clinical situations involving bleeding complications. Over time, a growing amount of clinical evidence has emerged, offering a robust basis for its applications.However, in certain clinical scenarios, TXA appears to be less effective, highlighting the need for further research into its mechanisms of action beyond its well-known antifibrinolytic effects. One area of particular interest is the interaction between TXA and blood cells, especially red blood cells (RBCs). This interaction has garnered significant attention due to intriguing findings from large clinical trials, such as the WOMAN-1 and -2 studies, which evaluated the efficacy of TXA in preventing bleeding in postpartum hemorrhage, a major childbirth complication. These trials revealed that TXA was less effective in anemic patients, raising important questions about its broader mechanisms of action.Emerging evidence suggests that the relationship between TXA and blood cells plays a crucial role at various stages of hemostasis, expanding its established role in fibrinolysis inhibition. Recent investigations into the interactions between TXA and RBCs have been particularly compelling and may provide valuable insights for improving clinical outcomes.This review provides a fresh look at the interplay between RBCs, TXA, and the hemostatic system, focusing on basic molecular mechanisms and their potential implications for clinical practice.","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemostasis, Thrombosis, and Vascular Biology in Psychiatric Disorders. 精神疾病中的止血、血栓形成和血管生物学。

IF 3.6 2区医学

Seminars in thrombosis and hemostasis Pub Date : 2025-06-01 Epub Date: 2025-05-14 DOI: 10.1055/s-0045-1805042

Jean-Christophe Gris, Silvia Hoirisch-Clapauch, Benjamin Brenner

引用次数: 0