Seminars in cancer biology最新文献_第8页

Alternative splicing in EMT and TGF-β signaling during cancer progression 癌症进展过程中 EMT 和 TGF-β 信号传递中的替代剪接

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-04-15 DOI: 10.1016/j.semcancer.2024.04.001

Ying E. Zhang, Christina H. Stuelten

{"title":"Alternative splicing in EMT and TGF-β signaling during cancer progression","authors":"Ying E. Zhang, Christina H. Stuelten","doi":"10.1016/j.semcancer.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.semcancer.2024.04.001","url":null,"abstract":"<div><p>Epithelial to mesenchymal transition (EMT) is a physiological process during development where epithelial cells transform to acquire mesenchymal characteristics, which allows them to migrate and colonize secondary tissues. Many cellular signaling pathways and master transcriptional factors exert a myriad of controls to fine tune this vital process to meet various developmental and physiological needs. Adding to the complexity of this network are post-transcriptional and post-translational regulations. Among them, alternative splicing has been shown to play important roles to drive EMT-associated phenotypic changes, including actin cytoskeleton remodeling, cell-cell junction changes, cell motility and invasiveness. In advanced cancers, transforming growth factor-β (TGF-β) is a major inducer of EMT and is associated with tumor cell metastasis, cancer stem cell self-renewal, and drug resistance. This review aims to provide an overview of recent discoveries regarding alternative splicing events and the involvement of splicing factors in the EMT and TGF-β signaling. It will emphasize the importance of various splicing factors involved in EMT and explore their regulatory mechanisms.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"101 ","pages":"Pages 1-11"},"PeriodicalIF":14.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic adaptation of mitochondria and its impact on tumor cell function 线粒体的低氧适应性及其对肿瘤细胞功能的影响

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-30 DOI: 10.1016/j.semcancer.2024.03.004

Martin Benej , Ioanna Papandreou , Nicholas C. Denko

{"title":"Hypoxic adaptation of mitochondria and its impact on tumor cell function","authors":"Martin Benej , Ioanna Papandreou , Nicholas C. Denko","doi":"10.1016/j.semcancer.2024.03.004","DOIUrl":"10.1016/j.semcancer.2024.03.004","url":null,"abstract":"<div><p>Mitochondria are the major sink for oxygen in the cell, consuming it during ATP production. Therefore, when environmental oxygen levels drop in the tumor, significant adaptation is required. Mitochondrial activity is also a major producer of biosynthetic precursors and a regulator of cellular oxidative and reductive balance. Because of the complex biochemistry, mitochondrial adaptation to hypoxia occurs through multiple mechanisms and has significant impact on other cellular processes such as macromolecule synthesis and gene regulation. In tumor hypoxia, mitochondria shift their location in the cell and accelerate the fission and quality control pathways. Hypoxic mitochondria also undergo significant changes to fundamental metabolic pathways of carbon metabolism and electron transport. These metabolic changes further impact the nuclear epigenome because mitochondrial metabolites are used as enzymatic substrates for modifying chromatin. This coordinated response delivers physiological flexibility and increased tumor cell robustness during the environmental stress of low oxygen.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"100 ","pages":"Pages 28-38"},"PeriodicalIF":14.5,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000221/pdfft?md5=e97fd4671caea21daf3822c0f7a9c5d1&pid=1-s2.0-S1044579X24000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Hypoxia-targeting bacteria in cancer therapy 癌症治疗中的低氧靶向细菌

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-29 DOI: 10.1016/j.semcancer.2024.03.003

Verena Staedtke , Nihao Sun , Renyuan Bai

引用次数: 0

Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy 利用转录因子靶向 EMT 和癌症干细胞进行肿瘤调节和治疗。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-19 DOI: 10.1016/j.semcancer.2024.03.002

Abdul Q. Khan , Adria Hasan , Snober S. Mir , Khalid Rashid , Shahab Uddin , Martin Steinhoff

{"title":"Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy","authors":"Abdul Q. Khan , Adria Hasan , Snober S. Mir , Khalid Rashid , Shahab Uddin , Martin Steinhoff","doi":"10.1016/j.semcancer.2024.03.002","DOIUrl":"10.1016/j.semcancer.2024.03.002","url":null,"abstract":"<div><p>Transcription factors (TFs) are essential in controlling gene regulatory networks that determine cellular fate during embryogenesis and tumor development. TFs are the major players in promoting cancer stemness by regulating the function of cancer stem cells (CSCs). Understanding how TFs interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research. CSCs are increasingly recognized for their significance in tumorigenesis and patient prognosis, as they play a significant role in cancer initiation, progression, metastasis, and treatment resistance. However, traditional therapies have limited effectiveness in eliminating this subset of cells, allowing CSCs to persist and potentially form secondary tumors. Recent studies have revealed that cancer cells and tumors with CSC-like features also exhibit genes related to the epithelial-to-mesenchymal transition (EMT). EMT-associated transcription factors (EMT-TFs) like TWIST and Snail/Slug can upregulate EMT-related genes and reprogram cancer cells into a stem-like phenotype. Importantly, the regulation of EMT-TFs, particularly through post-translational modifications (PTMs), plays a significant role in cancer metastasis and the acquisition of stem cell-like features. PTMs, including phosphorylation, ubiquitination, and SUMOylation, can alter the stability, localization, and activity of EMT-TFs, thereby modulating their ability to drive EMT and stemness properties in cancer cells. Although targeting EMT-TFs holds potential in tackling CSCs, current pharmacological approaches to do so directly are unavailable. Therefore, this review aims to explore the role of EMT- and CSC-TFs, their connection and impact in cellular development and cancer, emphasizing the potential of TF networks as targets for therapeutic intervention.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"100 ","pages":"Pages 1-16"},"PeriodicalIF":14.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLUT and HK: Two primary and essential key players in tumor glycolysis GLUT 和 HK：肿瘤糖酵解过程中两个重要的关键角色。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-03-15 DOI: 10.1016/j.semcancer.2024.03.001

Dhiraj Yadav , Anubha Yadav , Sujata Bhattacharya , Akansha Dagar , Vinit Kumar , Reshma Rani

{"title":"GLUT and HK: Two primary and essential key players in tumor glycolysis","authors":"Dhiraj Yadav , Anubha Yadav , Sujata Bhattacharya , Akansha Dagar , Vinit Kumar , Reshma Rani","doi":"10.1016/j.semcancer.2024.03.001","DOIUrl":"10.1016/j.semcancer.2024.03.001","url":null,"abstract":"<div><p>Cancer cells reprogram their metabolism to become \"glycolysis-dominant,\" which enables them to meet their energy and macromolecule needs and enhancing their rate of survival. This glycolytic-dominancy is known as the “Warburg effect”, a significant factor in the growth and invasion of malignant tumors. Many studies confirmed that members of the GLUT family, specifically HK-II from the HK family play a pivotal role in the Warburg effect, and are closely associated with glucose transportation followed by glucose metabolism in cancer cells. Overexpression of GLUTs and HK-II correlates with aggressive tumor behaviour and tumor microenvironment making them attractive therapeutic targets. Several studies have proven that the regulation of GLUTs and HK-II expression improves the treatment outcome for various tumors. Therefore, small molecule inhibitors targeting GLUT and HK-II show promise in sensitizing cancer cells to treatment, either alone or in combination with existing therapies including chemotherapy, radiotherapy, immunotherapy, and photodynamic therapy. Despite existing therapies, viable methods to target the glycolysis of cancer cells are currently lacking to increase the effectiveness of cancer treatment. This review explores the current understanding of GLUT and HK-II in cancer metabolism, recent inhibitor developments, and strategies for future drug development, offering insights into improving cancer treatment efficacy.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"100 ","pages":"Pages 17-27"},"PeriodicalIF":14.5,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cell cycle revisited: DNA replication past S phase preserves genome integrity 细胞周期重温：过了 S 期的 DNA 复制可保持基因组的完整性。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-02-01 DOI: 10.1016/j.semcancer.2024.02.002

Spyridoula Bournaka , Nibal Badra-Fajardo , Marina Arbi , Stavros Taraviras , Zoi Lygerou

引用次数: 0

Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers 细胞外囊泡相关微RNA：作为胃肠道癌症生物标志物的生物学和临床意义。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-02-01 DOI: 10.1016/j.semcancer.2024.02.001

Yuan Li , Silei Sui , Ajay Goel

{"title":"Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers","authors":"Yuan Li , Silei Sui , Ajay Goel","doi":"10.1016/j.semcancer.2024.02.001","DOIUrl":"10.1016/j.semcancer.2024.02.001","url":null,"abstract":"<div><p>Gastrointestinal (GI) cancers, including colorectal, gastric, esophageal, pancreatic, and liver, are associated with high mortality and morbidity rates worldwide. One of the underlying reasons for the poor survival outcomes in patients with these malignancies is late disease detection, typically when the tumor has already advanced and potentially spread to distant organs. Increasing evidence indicates that earlier detection of these cancers is associated with improved survival outcomes and, in some cases, allows curative treatments. Consequently, there is a growing interest in the development of molecular biomarkers that offer promise for screening, diagnosis, treatment selection, response assessment, and predicting the prognosis of these cancers. Extracellular vesicles (EVs) are membranous vesicles released from cells containing a repertoire of biological molecules, including nucleic acids, proteins, lipids, and carbohydrates. MicroRNAs (miRNAs) are the most extensively studied non-coding RNAs, and the deregulation of miRNA levels is a feature of cancer cells. EVs miRNAs can serve as messengers for facilitating interactions between tumor cells and the cellular milieu, including immune cells, endothelial cells, and other tumor cells. Furthermore, recent years have witnessed considerable technological advances that have permitted in-depth sequence profiling of these small non-coding RNAs within EVs for their development as promising cancer biomarkers -particularly non-invasive, liquid biopsy markers in various cancers, including GI cancers. Herein, we summarize and discuss the roles of EV-associated miRNAs as they play a seminal role in GI cancer progression, as well as their promising translational and clinical potential as cancer biomarkers as we usher into the area of precision oncology.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"99 ","pages":"Pages 5-23"},"PeriodicalIF":14.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue on “Excess body weight and cancer: Novel biologic insights and challenges” 关于 "体重过重与癌症：新的生物学见解和挑战"。

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-02-01 DOI: 10.1016/j.semcancer.2024.01.002

Maria Dalamaga, Nikolaos Spyrou

引用次数: 0

The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives 肥胖-自噬-癌症轴：机理认识与治疗前景

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-02-01 DOI: 10.1016/j.semcancer.2024.01.003

Amir Barzegar Behrooz , Marco Cordani , Alessandra Fiore , Massimo Donadelli , Joseph W. Gordon , Daniel J. Klionsky , Saeid Ghavami

{"title":"The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives","authors":"Amir Barzegar Behrooz , Marco Cordani , Alessandra Fiore , Massimo Donadelli , Joseph W. Gordon , Daniel J. Klionsky , Saeid Ghavami","doi":"10.1016/j.semcancer.2024.01.003","DOIUrl":"10.1016/j.semcancer.2024.01.003","url":null,"abstract":"<div><p>Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, and cancer development, with a specific emphasis on how obesity-driven changes affect the regulation of autophagy and subsequent implications for cancer risk. The burgeoning epidemic of obesity underscores the relevance of this research, particularly given the established links between obesity, autophagy, and various cancers. Our exploration delves into hormonal influence, notably INS (insulin) and LEP (leptin), on obesity and autophagy interactions. Further, we draw attention to the latest findings on molecular factors linking obesity to cancer, including hormonal changes, altered metabolism, and secretory autophagy. We posit that targeting autophagy modulation may offer a potent therapeutic approach for obesity-associated cancer, pointing to promising advancements in nanocarrier-based targeted therapies for autophagy modulation. However, we also recognize the challenges inherent to these approaches, particularly concerning their precision, control, and the dual roles autophagy can play in cancer. Future research directions include identifying novel biomarkers, refining targeted therapies, and harmonizing these approaches with precision medicine principles, thereby contributing to a more personalized, effective treatment paradigm for obesity-mediated cancer.</p></div>","PeriodicalId":21594,"journal":{"name":"Seminars in cancer biology","volume":"99 ","pages":"Pages 24-44"},"PeriodicalIF":14.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1044579X24000099/pdfft?md5=8b195c978156e3d1e5deac5220e8982f&pid=1-s2.0-S1044579X24000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Regulating cell cycle-related activities: The right target for cancer therapy 社论：调节细胞周期相关活动：癌症治疗的正确目标

IF 14.5 1区医学

Seminars in cancer biology Pub Date : 2024-01-01 DOI: 10.1016/j.semcancer.2024.01.001

Hang Fai Kwok

引用次数: 0