Serbian Journal of Experimental and Clinical Research最新文献_第5页

Tuberous Sclerosis And Kidney Failure - A Case Report 结节性硬化与肾功能衰竭一例报告

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-03-26 DOI: 10.2478/sjecr-2021-0079

B. Labović, V. Rabrenović, M. Rabrenović, Milica Petrović, Dragan Dulović, Aleksandar Rakonjac, D. Pilcevic, M. Petrovic, J. Tadić

{"title":"Tuberous Sclerosis And Kidney Failure - A Case Report","authors":"B. Labović, V. Rabrenović, M. Rabrenović, Milica Petrović, Dragan Dulović, Aleksandar Rakonjac, D. Pilcevic, M. Petrovic, J. Tadić","doi":"10.2478/sjecr-2021-0079","DOIUrl":"https://doi.org/10.2478/sjecr-2021-0079","url":null,"abstract":"Abstract Introduction: Tuberous sclerosis (TS) is a rare systemic autosomal- dominant genetic disease in which multiple hamartomatous lesions occur in many organs and tissues. Kidney involvement of TS usually includes angiomyolipomas, cysts, rarely kidney tumors, but there is not much description of other kidney involvement (proteinuria, hematuria, advanced kidney failure). We present a patient with preterminal renal failure who is diagnosed with tuberous sclerosis. Case report: A 52-year-old female was admitted to the hospital, due to decreased kidney function with worsening of the general condition and crises of consciousness. During the examination, cutaneous lesions -facial angiofibrolipomas were noticed, the patient was dehydrated and pale. Laboratory analyzes showed elevated parameters of nonspecific inflammation, anemic syndrome, azotemia (Cr 578umol / l, urea 50.1mmol / l, CKD e GFR 10 ml / min / 73m2), leukocyturia, microerythrocyturia, proteinuria 1.5 g / 24h. MSCT of the abdomen indicated hemangiomas of the liver, enlarged kidneys with several hypodense and hyperdense changes - angiomyolipomas. Due to the crisis of consciousness, MSCT of the head was performed, on which cysts and calcifications of the brain were observed. During the treatment, there was a confusing state, agitation, and epilepsy seizure. MRI brain showed multi locular brain cysts with ependymal and subependymal calcified nodules in the lateral ventricles. The applied treatment resulted in a partial recovery of kidney function (CKDeGFR 17 mil / min / 1.73 m2, and further approach in the monitoring and treatment of this patient was multidisciplinary. Chronic renal failure of 4 stages was maintained for a further six-month follow-up. Conclusion: We underline the importance of a multidisciplinary approach in the treatment of patients, bearing in mind that, as in our patient, a rare genetic disease - tuberous sclerosis can be manifested by kidney failure of preterminal rank.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49619873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Aphthous Stomatitis – An Overview 复发性口腔炎-综述

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-03-26 DOI: 10.2478/sjecr-2021-0058

M. Vuletic, Mirjana V Papic, S. Zivanovic, M. Papić

引用次数: 0

Complete Uterine Rupture: A Case Report 完全性子宫破裂1例

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-03-03 DOI: 10.2478/sjecr-2019-0068

K. Uzel

引用次数: 0

Comparison of Different Doses Botulinum Toxin Type a Efficacy in Chronic Anal Fissure Treatment 不同剂量a型肉毒毒素治疗慢性肛裂的疗效比较

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-03-01 DOI: 10.2478/sjecr-2022-0006

N. A. Goloktionov, V. Kashnikov, O. V. Tkalich, Aleksej Alekseevich Ponomarenko, Roman Yurevich Khryukin, I. Kostarev, P. Krstić, S. V. Slozhenikin, Evgenij Alekseevich Zagryadskiy, V. Y. Medvedev, Oksana Yurevna Fomenko, S. V. Nekhrikova, K. I. Arslanbekova, V. Misikov, M. A. Akulov, Aleksandra Sergeevna Orlova, Evgenij Evgenevich Zharkov

{"title":"Comparison of Different Doses Botulinum Toxin Type a Efficacy in Chronic Anal Fissure Treatment","authors":"N. A. Goloktionov, V. Kashnikov, O. V. Tkalich, Aleksej Alekseevich Ponomarenko, Roman Yurevich Khryukin, I. Kostarev, P. Krstić, S. V. Slozhenikin, Evgenij Alekseevich Zagryadskiy, V. Y. Medvedev, Oksana Yurevna Fomenko, S. V. Nekhrikova, K. I. Arslanbekova, V. Misikov, M. A. Akulov, Aleksandra Sergeevna Orlova, Evgenij Evgenevich Zharkov","doi":"10.2478/sjecr-2022-0006","DOIUrl":"https://doi.org/10.2478/sjecr-2022-0006","url":null,"abstract":"Abstract Objective: To compare the results of chronic anal fissure treatment with 10 IU and 40 IU botulinum toxin type A. Patients and methods: 56 patients were enrolled in case-control study divided into 2 groups consistent by the main clinical criteria. 28 patients in the study group had fissure excision in combination with 10 IU botulinum toxin type A (Xeomin) injection into internal anal sphincter, while 28 patients in control group received 40 IU product injections. Results: No statistically significant results in the pain assessment during the day and after bowel movement were obtained (p=0.41 and p=0.93, respectively). The groups were comparable by the frequency of complications such as transient anal incontinence, perianal skin hematoma, acute urinary retention (p>0.05). Complications such as thrombosis of external hemorrhoids and chronic non-healing wounds were most common in the study group (p=0.43 and p=0.0005, respectively). The product dose increase to 40 IU has a more significant effect on the functional treatment results (p=0.0053 and p=0.0002, respectively) and increases the odds for postoperative wound epithelialization 15-fold (p=0.01). Conclusion: 40 IU Botulinum toxin type A shows improvement in the treatment of chronic anal fissure without any increased risk of postoperative complications.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":"23 1","pages":"13 - 28"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45549336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive Crisis in Patients with Acute Intermittent Porphyria 急性间歇性卟啉症患者的高血压危象

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-03-01 DOI: 10.2478/sjecr-2017-0039

Olivera M Andrejić, Rada M Vučić, Violeta Iric Cupic, G. Davidović

{"title":"Hypertensive Crisis in Patients with Acute Intermittent Porphyria","authors":"Olivera M Andrejić, Rada M Vučić, Violeta Iric Cupic, G. Davidović","doi":"10.2478/sjecr-2017-0039","DOIUrl":"https://doi.org/10.2478/sjecr-2017-0039","url":null,"abstract":"Abstract Introduction: Acute intermittent porphyria (AIP) is the most common and the most severe form of acute hepatic porphyria. Case report: Patient, 39 years old, was admitted to the Emergency Department because of abdominal pain. Abdominal pain started 5 days before the admission. The diagnostic research in his hospital showed presence of a stone in the right kidney, and the patient was transported to the other Clinical Centre, where a common urine test showed: high values of delta - aminolevulinic acid and porphobilinogen. The patient was transported to our Clinical Centre. At the admission, abdominal pain decreased, but the patient had a hypertensive crisis with a headache, tearing eyes, swelling, anxiety.Common laboratory tests were in reference range, except creatinine, CRP, arterial blood gas analysis, urine test. The hypertensive crisis was treated by beta blockers and diuretics in maximal doses, but without a positive effect, so we decided to try with Glyceryl trinitrate intravenously. Control blood pressure was 170/100mmHg….130/80mmHg. Discussion: Porphyria can be a diagnostic problem, because one of the manifestations can be abdominal pain. Conclusions: Comorbidities can be critical in the therapy of life threating conditions.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":"23 1","pages":"89 - 91"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44030739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of the Systemic Oxidative Stress in Preeclampsia 子痫前期系统氧化应激的评估

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-03-01 DOI: 10.2478/sjecr-2022-0010

A. Bînă, A. Anechitei, Theia Lelcu, Adina V. Lința, D. Chiriac, A. G. Mocanu, E. Bernad, Z. Popa, M. Craina, D. Muntean, C. Borza, O. Crețu

{"title":"Assessment of the Systemic Oxidative Stress in Preeclampsia","authors":"A. Bînă, A. Anechitei, Theia Lelcu, Adina V. Lința, D. Chiriac, A. G. Mocanu, E. Bernad, Z. Popa, M. Craina, D. Muntean, C. Borza, O. Crețu","doi":"10.2478/sjecr-2022-0010","DOIUrl":"https://doi.org/10.2478/sjecr-2022-0010","url":null,"abstract":"Abstract Preeclampsia (PE) is a major complication of pregnancy with both mother and fetal adverse outcomes. Pregnancy is a state of increased oxidative stress that has been reported to be exacerbated when complicated with preeclampsia. However, conflicting data are available in literature regarding the systemic oxidative stress in PE pregnancies. The present pilot study was purported to assess systemic oxidative stress in preeclamptic vs healthy pregnancies. To this aim plasma derived compounds of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) were determined in mild and severe preeclamptic pregnancies using the Diacron equipment. Both healthy and preeclamptic pregnancies showed high levels of systemic oxidative stress. Paradoxically, significantly higher values of d-ROMs were found in healthy pregnancies as compared to the PE ones. At variance, in preeclamptic pregnancies, a major increase in the plasma antioxidant capacity occurred. In this pilot study, we report an increase in the systemic antioxidant capacity in preeclamptic pregnancies.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":"23 1","pages":"45 - 50"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44882727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Therapy Approach in Patient with Chronic Granulocity Leukemia: Case Report 慢性粒细胞白血病治疗方法的发展：病例报告

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-02-27 DOI: 10.2478/sjecr-2018-0074

P. Krstić, Marija Elez, Biljana Živanović-Todorić, G. Ostojić, B. Balint, M. Malešević, D. Stamatović

{"title":"Development of Therapy Approach in Patient with Chronic Granulocity Leukemia: Case Report","authors":"P. Krstić, Marija Elez, Biljana Živanović-Todorić, G. Ostojić, B. Balint, M. Malešević, D. Stamatović","doi":"10.2478/sjecr-2018-0074","DOIUrl":"https://doi.org/10.2478/sjecr-2018-0074","url":null,"abstract":"Abstract Chronic granulocytic leukemia (CGL), Ph + is a chronic myeloproliferative disorder, which, due to its specificity for many decades, has attracted the attention of researchers of specialties. This disease was among the first malignant haemopathies that received their “ID card” since molecular precisely defined the basic pathological substrate, that origin of the disease. Over the past decades we have witnessed the evolution of the therapeutic approach in the treatment of from oral cystostatic therapy, radiotherapy, through recombinant interferon alpha (IFN-alpha), haematopoeza stem cell transplantation, to the targeted molecular therapy of the tyrosine inhibitor (TKI). In this report we present patient with a diagnosis of Ph + in the early chronic phase at the age of 13 all relevant analyzes. During the past 26 years, all modalities of CGL treatment were applied in patients, according to the time period, concluding with the second generation resulting in complete remission of diseases with excellent quality of life and identical expectations for the future, as well as in healthy population.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46542108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Inflammation in Posterior Capsule Opacification Development 炎症对后囊膜混浊发展的影响

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-02-12 DOI: 10.2478/sjecr-2021-0075

D. Todorović, T. Vulović, N. Petrovic, M. Resan, Sunčica B Srećković

引用次数: 0

The Role of Morphometric Characteristics of Anterior Maxilla in Planning the Interventions Accompanied by Orthodontic Teeth Movement – An Overview 上颌前牙形态计量学特征在正畸牙齿移动干预计划中的作用——综述

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-01-17 DOI: 10.2478/sjecr-2021-0062

A. Arnaut, Djurdjina Colic

{"title":"The Role of Morphometric Characteristics of Anterior Maxilla in Planning the Interventions Accompanied by Orthodontic Teeth Movement – An Overview","authors":"A. Arnaut, Djurdjina Colic","doi":"10.2478/sjecr-2021-0062","DOIUrl":"https://doi.org/10.2478/sjecr-2021-0062","url":null,"abstract":"Abstract The anterior maxilla or premaxilla is part of the upper jaw and the most significant content of this region, from the aspect of orthodontic therapy, are the incisor teeth. The frequency of complications during orthodontic movement of the upper incisors refers to a more detailed evaluation of the anatomical structures of the premaxilla. The aim of this study was to investigate morphological and morphometric characteristics of the anterior maxilla by cone beam computed tomography, which could be of interest for planning orthodontic teeth movement. By reviewing the available literature, we compared the values of the alveolar bone height, the distance between the alveolar crest and enamel – cement boundary, total alveolar bone width, the thickness of the buccal, and palatal plate, nasopalatine canal, and accessory canals of the anterior maxilla. The results of our study show changes in the labial and palatal aspects of the alveolar bone height during orthodontic interventions. Different results of the alveolar bone width are in correlation with gender, age, and type of orthodontic tooth movement. Distance between the nasopalatine canal and maxillary central incisors was estimated at the value from 4 to 6 mm, which is below the recommended value for maximum incisal retraction by Proffit. Research results show variations in shape, length, and diameter of the nasopalatine canal, which indicates individual varieties detected on cone beam computed tomography. Other anatomical structures and measures show an insignificant correlation with orthodontic teeth movement. According to the contradictory results of the available articles, it is required to achieve an individual approach to orthodontic interventions in the area of the anterior maxilla.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49354312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report on a Patient Whose Road Traffic Injury Severity Was Determined by the MAIS (Maximum Abbreviated Injury Scale) Score 用MAIS(最大简略伤害量表)评分确定道路交通伤害严重程度的病例报告

Serbian Journal of Experimental and Clinical Research Pub Date : 2022-01-17 DOI: 10.2478/sjecr-2021-0056

G. Čolaković, S. Andjelić

{"title":"A Case Report on a Patient Whose Road Traffic Injury Severity Was Determined by the MAIS (Maximum Abbreviated Injury Scale) Score","authors":"G. Čolaković, S. Andjelić","doi":"10.2478/sjecr-2021-0056","DOIUrl":"https://doi.org/10.2478/sjecr-2021-0056","url":null,"abstract":"Abstract There are numerous definitions and classifications of severe trauma. Due to the observed heterogeneity in the existing definitions and the lack of a uniform definition of serious bodily injury, in January 2013 the High Level Group on Road Safety EU (HLGRS) published the definition of serious bodily injury in road traffic as a non-fatal injury with Maximum Abbreviated Injury Scale (MAIS) between 3 and 6, including the limit values. However, determining the MAIS score is not easy even for doctors with many years of experience. A female patient, injured as a pedestrian in a traffic accident, was examined prehospitally, and was transported to the hospital in the optimal golden hour from the time of the injury. The patient was intubated and mechanically ventilated in the Critical Care Resuscitation Unit. After the entire diagnostic procedure, diagnoses were made according to the ICD classification of diseases. During further examination, each code of the diagnosis of the disease was assigned an AIS code and the highest AIS score - AIS 5 was determined, which indicated that the patient was critically injured. Our patient's MAIS score was 5. After 39 days she was discharged from hospital. The neurological findings at discharge corresponded to left hemiparesis – ASIA D impairment grade. In conclusion, a novelty in the assessment of severe bodily injury is the introduction of the AIS/MAIS score. However, to avoid a subjective assessment of these scores, AIS dictionaries should be obtained for physicians, or a software solution should be developed to convert ICD-10 diagnoses into the AIS / MAIS injury scale.","PeriodicalId":21582,"journal":{"name":"Serbian Journal of Experimental and Clinical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43031123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0