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The role of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway in the pulmonary vascular remodeling of pulmonary arterial hypertension in rats 磷脂酰肌醇3-激酶/蛋白激酶B信号通路在肺动脉高压大鼠肺血管重构中的作用
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2022.130
Y. Duan, Ting Wang, Shan Wu, Dong Liu, J. Zhao, Bin Liu
{"title":"The role of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway in the pulmonary vascular remodeling of pulmonary arterial hypertension in rats","authors":"Y. Duan, Ting Wang, Shan Wu, Dong Liu, J. Zhao, Bin Liu","doi":"10.2306/scienceasia1513-1874.2022.130","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2022.130","url":null,"abstract":": This study aimed to investigate the role of the phosphatidylinositol 3-kinase / protein kinase B (PI3K / Akt) signaling pathway in the pulmonary vascular remodeling (PVR) of pulmonary arterial hypertension (PAH) in rats. A PAH model in rats was established through a left pneumonectomy and monocrotaline (MCT) injection, using the transglutaminase 2 (TG2) inhibitor cystamine dihydrochloride for intervention. Thirty healthy male Sprague Dawley rats were randomized into a control group, a model group, and an intervention group ( n = 10 for each group). The mean pulmonary arterial pressure (mPAP) was measured in all groups after 35 days, and the right ventricular hypertrophy index (RVHI) was calculated. Hematoxylin and eosin and lung elastic-fiber staining were used on the rats’ lung tissue in all three groups. The changes in pulmonary blood vessels and lung tissue force and the percentage of medial hypertrophy of small pulmonary arteries (WT%), vessel wall area to total area ratio (WA%), and the neointimal proliferation degree were observed. The Akt messenger RNA (mRNA) expression levels of lung tissues in all three groups were measured using a real-time polymerase chain reaction (RT-PCR) assay, and the protein expression levels of Akt and phosphorylated Akt (p-Akt) in all three groups were measured using a Western blot assay. The results indicated that the PI3K / Akt signaling pathway might play a substantial role in inhibiting pulmonary vascular remodeling (PVR) following intervention with a TG2 inhibitor.","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68621778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and plant growth-promoting activity of endophytic bacteria from sugarcane roots and genome analysis of Gluconacetobacter strain PS25 甘蔗根内生细菌的鉴定、促生长活性及葡萄球菌PS25菌株的基因组分析
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2022.145
K. Sitlaothaworn, T. Budsabun, Manussawee Dechkla, P. Yukphan, S. Tanasupawat, A. Savarajara
{"title":"Identification and plant growth-promoting activity of endophytic bacteria from sugarcane roots and genome analysis of Gluconacetobacter strain PS25","authors":"K. Sitlaothaworn, T. Budsabun, Manussawee Dechkla, P. Yukphan, S. Tanasupawat, A. Savarajara","doi":"10.2306/scienceasia1513-1874.2022.145","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2022.145","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"9 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68621986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The standardized Centella asiatica extract ECa 233 regulates the catalytic activities of ?APP-cleaving secretases in human cell lines 积雪草标准化提取物ECa 233对人细胞系中? app切割分泌酶的催化活性有调节作用
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.014
Mehbuba Nur Protha, Therathep Srisutjarit, A. Dey, S. Maitra, Jean‐François Hernandez, M. Tantisira, Yingrak Boondam, Narawut Pakaprot, B. Vincent
{"title":"The standardized Centella asiatica extract ECa 233 regulates the catalytic activities of ?APP-cleaving secretases in human cell lines","authors":"Mehbuba Nur Protha, Therathep Srisutjarit, A. Dey, S. Maitra, Jean‐François Hernandez, M. Tantisira, Yingrak Boondam, Narawut Pakaprot, B. Vincent","doi":"10.2306/scienceasia1513-1874.2023.014","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.014","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68622564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photosynthesis and photosynthetic electron transport in the soft coral Sarcophyton spp 软珊瑚Sarcophyton spp的光合作用和光合电子传输
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.017
V. Dummee, Suhailar Sma-air, Suksiri Chooklin, Thanongsak Chanmethakul, R. Ritchie
{"title":"Photosynthesis and photosynthetic electron transport in the soft coral Sarcophyton spp","authors":"V. Dummee, Suhailar Sma-air, Suksiri Chooklin, Thanongsak Chanmethakul, R. Ritchie","doi":"10.2306/scienceasia1513-1874.2023.017","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.017","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68622952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shikonin inhibits ER stress in vascular endothelial cells, when induced by H2O2, and promotes vascular regeneration 当H2O2诱导时，紫草素抑制血管内皮细胞的ER应激，并促进血管再生
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.041
Li-li Guo, Yinling Li, Shuang Wen, W. jun Liu, Lei Yang, Yu Wan, Jia xin Liu, Wen e Zhao, Shu-Wei Li
{"title":"Shikonin inhibits ER stress in vascular endothelial cells, when induced by H2O2, and promotes vascular regeneration","authors":"Li-li Guo, Yinling Li, Shuang Wen, W. jun Liu, Lei Yang, Yu Wan, Jia xin Liu, Wen e Zhao, Shu-Wei Li","doi":"10.2306/scienceasia1513-1874.2023.041","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.041","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68624172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A sixth-order finite difference method for solving the generalized Burgers-Fisher and generalized Burgers-Huxley equations 求解广义Burgers-Fisher方程和广义Burgers-Huxley方程的六阶有限差分方法
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.048
Shenglun Liu, Y. Ge, Fang Tian
{"title":"A sixth-order finite difference method for solving the generalized Burgers-Fisher and generalized Burgers-Huxley equations","authors":"Shenglun Liu, Y. Ge, Fang Tian","doi":"10.2306/scienceasia1513-1874.2023.048","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.048","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68626226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic analysis and physicochemical screening of ikarugamycin, fumaquinone, and a new compound, pudicin from Streptomyces sp. 3MP-14 产自Streptomyces sp. 3MP-14的ikarugamycin、fumaquinone和新化合物pudicin的基因组分析和理化筛选
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.067
Nattaporn Klykleung, Hirotaka Matsuo, M. Iwatsuki, Yōko Takahashi, S. Ōmura, Masahiro Yuki, T. Kudo, M. Ohkuma, R. Luechapudiporn, S. Tanasupawat, T. Nakashima
{"title":"Genomic analysis and physicochemical screening of ikarugamycin, fumaquinone, and a new compound, pudicin from Streptomyces sp. 3MP-14","authors":"Nattaporn Klykleung, Hirotaka Matsuo, M. Iwatsuki, Yōko Takahashi, S. Ōmura, Masahiro Yuki, T. Kudo, M. Ohkuma, R. Luechapudiporn, S. Tanasupawat, T. Nakashima","doi":"10.2306/scienceasia1513-1874.2023.067","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.067","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68626662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification, in silico characterization, and expression analysis of NBS-LRR class of R genes against stem and crown rot disease in Trifolium alexandrinum L. 亚历山大三叶草茎腐病和冠腐病抗病基因NBS-LRR类的鉴定、鉴定及表达分析
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.141
Bukhtawer Nasir, S. Ijaz, Imran Ul haq, Nasir Ahmad Khan, A. Habib
{"title":"Identification, in silico characterization, and expression analysis of NBS-LRR class of R genes against stem and crown rot disease in Trifolium alexandrinum L.","authors":"Bukhtawer Nasir, S. Ijaz, Imran Ul haq, Nasir Ahmad Khan, A. Habib","doi":"10.2306/scienceasia1513-1874.2023.141","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.141","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68627168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Geology, mineralization, and alteration of B Prospect of the epithermal Au-Ag deposit in Central Thailand: A study on Chatree?s satellite deposit for future gold exploration 泰国中部浅成低温热液Au-Ag矿床的地质、矿化和蚀变作用——以Chatree？用于未来黄金勘探的卫星矿床
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2022.142
Sirawit Kaewpaluk, A. Salam, Thitiphan Assawincharoenkij, T. Manaka, Sopit Poompuang, Surachat Munsamai, K. Zaw
{"title":"Geology, mineralization, and alteration of B Prospect of the epithermal Au-Ag deposit in Central Thailand: A study on Chatree?s satellite deposit for future gold exploration","authors":"Sirawit Kaewpaluk, A. Salam, Thitiphan Assawincharoenkij, T. Manaka, Sopit Poompuang, Surachat Munsamai, K. Zaw","doi":"10.2306/scienceasia1513-1874.2022.142","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2022.142","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68621795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
On magnifying elements in semigroups of transformations restricted by an equivalence relation with a restricted range 有限值域的等价关系约束变换半群中的放大元素
IF 1.2 4区 综合性期刊
Scienceasia Pub Date : 2023-01-01 DOI: 10.2306/scienceasia1513-1874.2023.024
Thananya Kaewnoi, Phoschanun Ratanaburee, R. Chinram, Montakarn Petapirak
{"title":"On magnifying elements in semigroups of transformations restricted by an equivalence relation with a restricted range","authors":"Thananya Kaewnoi, Phoschanun Ratanaburee, R. Chinram, Montakarn Petapirak","doi":"10.2306/scienceasia1513-1874.2023.024","DOIUrl":"https://doi.org/10.2306/scienceasia1513-1874.2023.024","url":null,"abstract":"","PeriodicalId":21577,"journal":{"name":"Scienceasia","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68623275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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