IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-06-15 DOI: 10.1007/s00482-026-00953-6

Stefan Floren, Daniel Segelcke, Esther Pogatzki-Zahn

{"title":"[Postoperative pain and sex/gender-current findings of the past decade].","authors":"Stefan Floren, Daniel Segelcke, Esther Pogatzki-Zahn","doi":"10.1007/s00482-026-00953-6","DOIUrl":"10.1007/s00482-026-00953-6","url":null,"abstract":"Background: Sex and gender affect pain perception but their role in postoperative pain remains unclear and is not addressed in current guidelines.Objectives: This scoping review summarizes evidence from the past ten years on sex-related differences in postoperative pain (patient-reported outcome (PRO), opioid consumption) and evaluates their relevance.Materials and methods: Systematic search in Medline® (March 2015-18 August 2025); 106 studies included.Primary outcome: acute pain intensity (≤ 3 weeks).Secondary outcomes: subacute/chronic postsurgical pain and opioid use.Results: Of the 106 studies included, 44 covered acute pain. In most of them women reported higher pain intensity-particularly after thoracic surgery and orthopedic procedures; several analyses confirmed female sex as an independent predictor for postoperative pain. Studies related to subacute pain (5/106) reported slightly higher pain intensity ratings in women, and the results in chronic pain studies (44/106) were mixed, with more severe pain in women after visceral surgeries. While results for acute opioid consumption (16/106) were heterogeneous, for the long-term postoperative course, studies (9/106) consistently reported a higher persistence of analgesic/opioid use in women.Conclusions: Sex is a relevant factor regarding pain-related outcome parameters after surgery, and its impact is influenced by the postoperative timeframe and type of surgery. Further studies with standardized, sex-stratified endpoints are required to enable gender-sensitive patient care.","PeriodicalId":21572,"journal":{"name":"Schmerz","volume":" ","pages":"295-303"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Transgender health, migraine and headache-Underestimated associations, limited data situation]. [变性人健康、偏头痛和头痛——被低估的关联，有限的数据情况]。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-07-15 DOI: 10.1007/s00482-026-00956-3

Armin Scheffler, Dagny Holle-Lee

引用次数: 0

[Migraine in men: biological, psychosocial and clinical characteristics]. 男性偏头痛：生物学、社会心理和临床特征。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-04-17 DOI: 10.1007/s00482-026-00935-8

Carolin Luisa Hoehne, Wiebke Andersen, Bianca Raffaelli

{"title":"[Migraine in men: biological, psychosocial and clinical characteristics].","authors":"Carolin Luisa Hoehne, Wiebke Andersen, Bianca Raffaelli","doi":"10.1007/s00482-026-00935-8","DOIUrl":"10.1007/s00482-026-00935-8","url":null,"abstract":"Background: Migraine affects 15% of the global population, with men being 2-3 times less frequently affected than women and are markedly underrepresented in research and clinical care. The condition is frequently underdiagnosed in men.Objective: The aim of this work is to describe the biological and psychosocial characteristics of migraine in men in order to improve the understanding of sex-related differences and to enhance the diagnostic precision and treatment for men.Material and methods: This article is a narrative review based on a structured literature search in PubMed using relevant search terms related to migraine and sex differences.Results: Biologically, men differ from women through hormonal influences on the calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and transient receptor potential (TRP) signaling pathways, which modulate pain processing. Clinically, men exhibit on average shorter attacks, lower intensity, more frequently dull-pressing pain and fewer vegetative accompanying symptoms. This presentation often leads to misdiagnosis. Additionally, role expectations, stigma and lower help-seeking behavior contribute to symptoms being reported later and underestimated more often. Although modern therapies are similarly effective in both sexes, men receive prophylactic treatment less frequently.Conclusion: The sex-specific biological and psychosocial differences demonstrate that men present with a distinct clinical phenotype of migraine. Greater awareness with respect to these characteristics could enhance the diagnostic accuracy and support more individualized treatment.","PeriodicalId":21572,"journal":{"name":"Schmerz","volume":" ","pages":"283-287"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pain medicine aspects of the updated S2k guideline "Diagnosis and treatment of endometriosis"]. [更新的S2k指南“子宫内膜异位症的诊断和治疗”的疼痛医学方面]。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-06-11 DOI: 10.1007/s00482-026-00950-9

Daniela C Rosenberger, Joachim Erlenwein, Winfried Häuser, Esther Pogatzki-Zahn, Stefanie Burghaus

{"title":"[Pain medicine aspects of the updated S2k guideline \"Diagnosis and treatment of endometriosis\"].","authors":"Daniela C Rosenberger, Joachim Erlenwein, Winfried Häuser, Esther Pogatzki-Zahn, Stefanie Burghaus","doi":"10.1007/s00482-026-00950-9","DOIUrl":"10.1007/s00482-026-00950-9","url":null,"abstract":"Background: The scheduled update of the S2k guideline \"Diagnosis and treatment of endometriosis\", published by the Association of the Scientific Medical Societies in Germany (AWMF; registry number 015/045), was released on April 1, 2025.Methods: The guideline was developed under the coordination of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG), and the Swiss Society for Gynecology and Obstetrics (SGGG), together with 34 scientific societies (including the German Pain Society), professional organizations and associations, and three patient self-help groups. The systematic literature search followed a predefined algorithm and covered the period from 2019 to 2023. In a structured consensus process, 73 recommendations and 25 statements were formulated in accordance with AWMF regulations.Results: Compared to the 2020 guideline, the following changes were made regarding pain management: core therapeutic principles were expanded to include chapters on pharmacological symptomatic pain treatment, psychosomatic therapy, complementary therapy, and additional as well as multimodal treatment approaches. A tiered, multimodal treatment strategy for chronic endometriosis-related pain was recommended.Conclusion: The updated S2k guideline incorporates key concepts of pain medicine, including pain mechanisms (nociceptive, neuropathic, and nociplastic), risk factors for chronification, and biopsychosocial models. Recommendations for pharmacological and non-pharmacological interventions, including tiered multimodal treatment approaches, were developed and agreed upon in an interdisciplinary process based on current evidence and feasibility.","PeriodicalId":21572,"journal":{"name":"Schmerz","volume":" ","pages":"256-263"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Gender differences in children and adolescents with migraine]. [儿童和青少年偏头痛的性别差异]。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-06-10 DOI: 10.1007/s00482-026-00949-2

Laura Zaranek, Gudrun Gossrau

{"title":"[Gender differences in children and adolescents with migraine].","authors":"Laura Zaranek, Gudrun Gossrau","doi":"10.1007/s00482-026-00949-2","DOIUrl":"10.1007/s00482-026-00949-2","url":null,"abstract":"Migraine is a common neurological disorder that affects about 10% of children and adolescents and is associated with reduced school performance and participation in everyday life. The highest incidence of migraine occurs between 10-14 years. With the onset of puberty, girls are increasingly more likely to be affected. Generally, girls in all age groups show a higher prevalence and incidence of migraine, in contrast to tension-type headaches, where gender differences are less pronounced. Girls experience higher levels of migraine-related impairment than boys and are more likely to have comorbid mental health conditions. School-related stress and performance pressure are described primarily by girls as migraine triggers. Gender differences in epidemiology and clinical features have been widely studied in adulthood. Nevertheless, only a few studies deal with gender-specific treatment in childhood and adolescence. In addition to acute pain treatment while avoiding medication overuse, an individualized and multimodal headache therapy is the most important treatment component for recurrent headaches in childhood. Interdisciplinary group therapies enable individualized care for gender-specific circumstances.","PeriodicalId":21572,"journal":{"name":"Schmerz","volume":" ","pages":"277-282"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Endometriosis pain research in Germany : ENDO-PAIN and StEPP-UPP-two new research consortia on endometriosis pain]. [德国子宫内膜异位症疼痛研究：ENDO-PAIN和stepp - upp -两个新的子宫内膜异位症疼痛研究联盟]。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-07-20 DOI: 10.1007/s00482-026-00958-1

Renata Voltolini Velho, Bruno Pradier, Franziska Werner, Esther M Pogatzki-Zahn, Sylvia Mechsner

{"title":"[Endometriosis pain research in Germany : ENDO-PAIN and StEPP-UPP-two new research consortia on endometriosis pain].","authors":"Renata Voltolini Velho, Bruno Pradier, Franziska Werner, Esther M Pogatzki-Zahn, Sylvia Mechsner","doi":"10.1007/s00482-026-00958-1","DOIUrl":"10.1007/s00482-026-00958-1","url":null,"abstract":"Endometriosis is one of the most common causes of chronic pelvic or lower-abdominal pain, yet mechanisms, predictors, and patient-centered treatment pathways remain insufficiently defined. This article summarizes the situation in Germany and presents two complementary research consortia: StEPP-UPP and ENDO-PAIN.StEPP-UPP addresses the clinical heterogeneity of endometriosis pain via a prospective multicenter cohort, standardized patient-reported outcomes, quantitative sensory testing, and multi-omics from blood, stool, and lesions. Explainable artificial intelligence and machine-learning models aim to estimate risk and trajectories of persistent pain, define mechanism-informed subgroups, and support treatment decisions. Preclinical mouse models with non-evoked behavioral metrics plus multiparametric MRI and single-cell analyses provide mechanistic anchoring for clinical signatures.ENDO-PAIN focuses on neuroinflammation and fibrosis as drivers of pain and chronification. Using patient samples, cell cultures, and 3D organoids, it maps immune-stroma interactions, syndecan signaling, and hormone-inflammation axes (for example P4-TGFβ-NFκB-COX-2) to derive biomarker networks and therapeutic targets.Both consortia integrate patient advocacy structurally to ensure patient-relevant endpoints and accessible information. Together they point to three priorities: standardization of data collection and biobanking; stratification along bio-psycho-social profiles and molecular signatures; and interdisciplinary shared decision-making across research, clinics, and people with endometriosis, aiming for mechanistically grounded, data-driven, patient-centered pain medicine.","PeriodicalId":21572,"journal":{"name":"Schmerz","volume":" ","pages":"264-269"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial zum 40. Geburtstag von Der Schmerz. 第40版。“痛苦的生日”。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-07-22 DOI: 10.1007/s00482-026-00954-5

Frank Petzke

引用次数: 0

[Fibromyalgia syndrome-Is the designation as a disorder of women a misinterpretation?] 纤维肌痛综合征——将其定义为女性疾病是一种误解吗？］

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-07-15 DOI: 10.1007/s00482-026-00957-2

Simran Jeet Kaur, Christin Breidenbach, Nurcan Üçeyler

{"title":"[Fibromyalgia syndrome-Is the designation as a disorder of women a misinterpretation?]","authors":"Simran Jeet Kaur, Christin Breidenbach, Nurcan Üçeyler","doi":"10.1007/s00482-026-00957-2","DOIUrl":"10.1007/s00482-026-00957-2","url":null,"abstract":"Background: Fibromyalgia syndrome (FMS) is a chronic pain condition accompanied by further characteristic key symptoms, such as sleep disturbance and fatigue. According to the literature it is often reported to be more frequent in women but the true sex-specific prevalence remains uncertain and potential underlying mechanisms are unknown.Objective: To determine the prevalence of FMS in women and men and assess whether the clinical phenotype differs; if so, to consider possible contributing factors.Material and methods: We conducted a literature search in PubMed from 1 February 1990 to 30 September 2025. Eligibility for inclusion in our systematic review was assessed by applying predefined inclusion and exclusion criteria during screening of titles and abstracts.Results: The search yielded 532 articles, of which 59 were included in the systematic review and among these were 5 animal experimental studies. Men with FMS were examined in 2/54 (3.7%) studies and direct sex comparisons were reported in 15/54 (27.7%). Under these conditions, the reported prevalence of FMS averaged 2.4-6.8% in women and 0.2-2.4% in men. The clinical phenotype was assessed across sexes in 7/54 (13%) studies; additionally, 2/54 (3.7%) cross-sectional studies included only women and 2/54 (3.7%) prospective cross-sectional studies included only men.Conclusion: Current evidence suggests a higher FMS prevalence in women; however, most studies predominantly examined women, direct comparisons are scarce and no studies have investigated pathophysiological sex differences. Future research should address these knowledge gaps.","PeriodicalId":21572,"journal":{"name":"Schmerz","volume":" ","pages":"270-276"},"PeriodicalIF":0.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Congress report-International Headache Congress 2025 : São Paulo, Brasil, 10-13 September 2025]. [大会报告- 2025年国际头痛大会：2025年9月10日至13日，巴西圣保罗]。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2025-11-27 DOI: 10.1007/s00482-025-00915-4

Katharina Kamm, Armin Scheffler

引用次数: 0

Schmerz, Geschlecht und Gender – Annäherung an ein noch (zu) wenig verstandenes Thema. 性别、性别和性：一种被低估的方法。

IF 0.8 4区医学

Schmerz Pub Date : 2026-08-01 Epub Date: 2026-07-22 DOI: 10.1007/s00482-026-00962-5

Esther Pogatzki-Zahn, Bianca Raffaelli

引用次数: 0

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