Schizophrenia Bulletin最新文献

{"title":"Towards Enhancing Drug Development Methodology to Treat Cognitive Impairment Associated With Schizophrenia and Other Neuropsychiatric Conditions: Insights From 2 Decades of Clinical Trials","authors":"William P Horan, Amir Kalali, Stephen K Brannan, Wayne Drevets, Matthew Leoni, Atul Mahableshwarkar, William J Martin, Srinivas Rao, Corey Reuteman-Fowler, Colin Sauder, Adam Savitz, Jaskaran Singh, Jane Tiller, Gary Walker, Jens R Wendland, Philip D Harvey","doi":"10.1093/schbul/sbae151","DOIUrl":"https://doi.org/10.1093/schbul/sbae151","url":null,"abstract":"Cognitive impairment is a core feature and leading cause of functional disability in schizophrenia and other neuropsychiatric disorders. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative in the early 2000s marked a pivotal moment for drug development, establishing consensus on methodology for treatment studies, including assessment strategies and trial designs, for cognitive impairment associated with schizophrenia (CIAS). Despite extensive industry-sponsored and academic drug development efforts over the last 2 decades using these strategies no pharmacological treatments have been approved for CIAS. Drawing on pharmaceutical industry experience and scientific developments since the MATRICS initiative, we review lessons learned about the practical and operational complexities of conducting large-scale CIAS clinical trials. Based on this collective experience, we identify elements of the MATRICS guidelines that may warrant reconsideration and suggest some new approaches to streamline the drug development pathway, without weakening standards for evidence. Our goal is to initiate an open exchange among all stakeholders about possible enhancements to drug development methodology that optimize our ability to develop new treatments for cognitive impairment in schizophrenia and other neuropsychiatric disorders.","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"30 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty Years of the NIMH Measurement and Treatment Research to Improve Cognition in Schizophrenia.","authors":"James Gold","doi":"10.1093/schbul/sbae230","DOIUrl":"10.1093/schbul/sbae230","url":null,"abstract":"","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Early Auditory Processing on Negative Symptom Response to Cognitive Remediation for Schizophrenia.","authors":"Alice M Saperstein, Ryan Brennan, Min Qian, Daniel C Javitt, Alice Medalia","doi":"10.1093/schbul/sbaf017","DOIUrl":"https://doi.org/10.1093/schbul/sbaf017","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Early auditory processing (EAP) has increasingly become a focus of efforts to identify markers of treatment response in people with schizophrenia spectrum disorders. Assessment of baseline need provides an opportunity for cognitive remediation (CR) programs that include EAP training to personalize treatment and optimize its impact. CR has been shown to help reduce negative symptoms, but less is known about how EAP tailoring may influence this relationship. This study hypothesized a differential benefit of EAP training on negative symptom reduction for those with and without baseline EAP deficits as defined by performance on the Tone Matching Test.</p><p><strong>Study design: </strong>150 outpatient adults diagnosed with schizophrenia or schizoaffective disorder were classified as having intact (44.7%) or impaired (55.3%) EAP and were randomly assigned to CR that either included EAP training (N = 77) or did not (N = 73). Negative symptom improvement was measured via the Positive and Negative Syndrome Scale posttreatment and 3 months later.</p><p><strong>Study results: </strong>CR resulted in significant negative symptom improvement in the sample overall. Only EAP impaired participants demonstrated significant negative symptom benefit from EAP training. EAP impaired participants who did not receive embedded auditory training had near-zero reductions in negative symptom severity.</p><p><strong>Conclusions: </strong>These findings extend prior research on cognitive remediation as treatment for negative symptoms in people with schizophrenia spectrum disorders. Accumulating evidence suggests that routine assessment of EAP is critical for personalizing and optimizing a response to CR that is clinically significant for both cognitive and negative symptoms.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Metabolic Characteristics and Potential Biomarker Combinations in Schizophrenia Patients With Tardive Dyskinesia.","authors":"Chenghao Lu, Yeqing Dong, Dan Qi, Nannan Liu, Yanzhe Li, Jinghui Chi, Xinxu Wang, Min Zeng, Feng Liu, Shen Li, Jie Li","doi":"10.1093/schbul/sbaf006","DOIUrl":"https://doi.org/10.1093/schbul/sbaf006","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>The pathogenesis of tardive dyskinesia (TD) remains unclear, involving multiple biological pathways. This study aimed to explore biomarkers of TD through untargeted metabolomics for the early identification of TD.</p><p><strong>Study design: </strong>This study recruited 84 schizophrenia (SZ) patients with TD and 160 SZ patients without TD. TD diagnosis was based on the Schooler-Kane criteria, and the severity of TD and psychiatric symptoms were assessed using the Abnormal Involuntary Movement Scale and the Positive and Negative Syndrome Scale. Fasting blood samples were collected from all patients and subjected to untargeted metabolomics analysis using Ultra-high-performance liquid chromatography-high resolution mass spectrometry, allowing for the quantification and profiling of 699 metabolites. Data were analyzed with orthogonal partial least squares discriminant analysis, and receiver-operating characteristic curves.</p><p><strong>Study results: </strong>In TD, 57 metabolites exhibited significant changes (variable importance of projection > 1, false discovery rate-adjusted P < .05), primarily involving amino acids and lipids. These changes predominantly affected the phenylalanine, tyrosine, and tryptophan pathway (impact = 0.5, P = .0252), as well as the phenylalanine metabolism pathway (impact = 0.36, P = .0498). N-Acetyl-l-phenylalanine (B = 2.249, t = 4.56, P < .001, 95% CI, 1.302-3.286) and Succinylcarnitine (AcCa(4:0-DC)) (B = 1.009, t = 3.07, P = .002, 95% CI, 0.362-1.656) are negatively related to the total abnormal involuntary movement scale score. Additionally, 5 differential metabolites had area under the curve (AUC) values greater than 0.7 for diagnosing TD, with the combined diagnostic capability exceeding 0.8 (AUC = 0.817, 95% CI, 0.759-0.875).</p><p><strong>Conclusions: </strong>In TD, disruptions in amino acid and lipid metabolism were predominantly observed. Amino acids and lipid metabolites may be involved in the development of TD. Additionally, a biomarker panel composed of amino acids and lipids can be used for the differential diagnosis of TD.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Relapse in BDNF Receptors Expression in Patients With a First Episode of Schizophrenia.","authors":"Miquel Bioque, Vicent Llorca-Bofí, Karina S MacDowell, Sílvia Amoretti, Gisela Mezquida, Manuel J Cuesta, Covadonga M Diaz-Caneja, Ángela Ibáñez, Rafael Segarra, Ana González-Pinto, Alexandra Roldán, Pilar A Sáiz, Anna Mané, Antonio Lobo, Albert Martínez-Pinteño, Guillermo Cano-Escalera, Esther Berrocoso, Miquel Bernardo","doi":"10.1093/schbul/sbaf012","DOIUrl":"https://doi.org/10.1093/schbul/sbaf012","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Relapsing after a first episode of schizophrenia (FES) is a main predictor of clinical and functional prognosis. Brain-derived neurotrophic factor (BDNF) plays a critical role in neuronal development and plasticity, and its signaling may be altered by successive relapses.</p><p><strong>Design: </strong>We assessed the impact of first relapse in the expression of the 2 isoforms of the BDNF tropomyosin-related kinase B (TrkB) receptor (active full-length TrkB-F and inactive truncated TrkB-T) in peripheral blood mononuclear cells from 53 FES patients in clinical remission followed up for 3 years.</p><p><strong>Results: </strong>The group of participants that relapsed (n = 24) during the follow-up presented a significant decrease in the expression of the active TrkB-F receptor compared to baseline (M = 100 ± 28.13 vs. M = 83.42 ± 33.84, t = 2.5, P = .02), with no changes in the inactive TrkB-T receptor expression nor in BDNF plasma levels. This decrease also led to a significant decline in the F/T ratio (M = 1.13 ± 0.38 vs. 0.94 ± 0.36, t = 2.17, P = .041). No significant differences were found in the receptors' expression nor in plasma levels in the group of cases that remained in remission (n = 29). These results were not associated with baseline differences between the groups in terms of the BDNF signaling pathway biomarkers, clinical or treatment variables.</p><p><strong>Conclusions: </strong>These findings highlight the biological impact that a relapse produces over the systemic BDNF-TrkB signaling pathway, potentially undermining crucial neuronal functions. Identifying the actors involved can help design specific interventions for relapse prevention and improve the functional prognosis of people in the early stages of schizophrenia.</p>","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"87 STUDY ON RELIEVING MENTAL STRESS DISORDER OF RESIDENTS IN GREEN SMART CITY ENVIRONMENT","authors":"Xin Ma","doi":"10.1093/schbul/sbaf007.087","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.087","url":null,"abstract":"Background With the continuous economic growth and the rapid development of urbanization, people are facing a tense pace of life. The pressure in work, study and life seriously affects people’s mental health. The denseness of the urban environment and the fast-paced lifestyle may lead to increased mental stress among residents. The natural restorative environment of green smart cities improves people’s physical and mental health by providing ecological goods and services, relieving stress, and promoting physical activity and social interaction. In order to reveal the time-specific correlation between urban environment and brain structure and function, mental health status and neuropsychological assessment of young people, this study combed the existing researches from four dimensions: smart city green space, population attributes and characteristics, research methods and stress measurement, aiming to provide reference for the research on mental stress relief. Methods The study selected residents from Guangzhou, Zhongshan, Guangdong, and Nanning, Guangxi as research subjects. In the preliminary survey (pre-test), a total of 336 questionnaires were collected, while in the subsequent survey (post test), 300 questionnaires were collected. After matching, 256 valid questionnaires were finally obtained. The study used the Brief Depression Anxiety Stress Scale (DASS-21) to assess the psychological health status of participants. After the questionnaire collection is completed, use SPSS 26.0 software for data entry and analysis. In the data analysis stage, Harman single factor test is used to evaluate whether there are significant common method biases in the questionnaire results. Results In order to explore the causal relationship between green natural exposure, artificial outdoor exposure, and residents’ mental health, researchers conducted correlation analysis on pre - and post test data. The analysis found that there was no significant correlation between the artificial outdoor environment and residents’ levels of depression, anxiety, and stress, while the green natural environment was significantly correlated with these dimensions of mental health (P&amp;lt;0.05). Figure 1 shows the cross-lag analysis results of the relationship between green smart city environment and residents’ mental stress disorders, indicating a significant negative correlation between “green natural exposure T1” and “mental stress level T2”, while the correlation between “mental stress level T1” and “green natural exposure T2” is not significant. This indicates that green natural contact is a pre factor affecting residents’ mental stress levels. Discussion This study analyzed the cross lagged correlation between the environment of green smart cities and residents’ mental stress levels. Compared with artificial outdoor environments, the exposure to green natural environments is more related to residents’ mental health. The pre-test of green natural contact showed a significant n","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"16 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"64 ANALYSIS OF THE EFFECT OF DIGITAL MEDIA ART INTERVENTION ON THE RECOVERY OF SOCIAL FUNCTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIA","authors":"Luman Wang, Xiaozhou Liu*, Yanfang Liang","doi":"10.1093/schbul/sbaf007.064","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.064","url":null,"abstract":"Background Schizophrenia significantly impairs patients’ social functioning, including social interaction, work ability, and daily living skills. Among these, the damage to social functioning is a crucial barrier in the recovery process of patients with schizophrenia. In recent years, Digital Media Art (DMA) has been introduced as an innovative therapeutic approach for patients with schizophrenia. Therefore, this study aims to clarify the impact of DMA on the social functioning of patients with chronic schizophrenia. Methods The study included 100 patients, aged 25 to 60, diagnosed with chronic schizophrenia, with a duration of illness exceeding five years. Patients were randomly divided into Group A (n=50) and Group B (n=50). Group A received standard treatment, while Group B received standard treatment plus a 12-week DMA intervention. The intervention included creative activities using digital tools twice a week. The Scale for the Assessment of Social Functioning (SASF) was used to assess patients’ social functioning, and the MATRICS Consensus Cognitive Battery (MCCB) was used to evaluate cognitive functioning. Data were analyzed using mixed-design ANOVA to compare changes in social and cognitive functioning over time between the two groups. Results The SASF score of group A increased from 57.9 to 63.5 before the intervention. The SASF score of group B increased from 58.2 to 82.4 before the intervention. Group B showed a significant improvement in social functioning (F (1,98) =23.45, P&amp;lt;0.001) and cognitive functioning (F (1,98) =15.67, P&amp;lt;0.001) compared to group A. The SASF score of group B increased from 58.2 to 82.4 before the intervention. Before the intervention, the MCCB score was 65.4 in group A and 64.8 in group B. The difference was not significant (P&amp;gt;0.05). After the intervention, group A scored 69.2 on the MCCB and group B scored 76.3, with a significant difference (P&amp;lt;0.05). The effect sizes of the intervention were more pronounced for social functioning in group B (Cohen’s d=0.89) and more moderate for cognitive functioning (Cohen’s d=0.58). On attention/vigilance (MCCB subscale), the average score for Group A improved only from 8.0 to 8.8, while the average score for Group B improved from 8.1 to 9.5. Subgroup analyses showed that younger patients (&amp;lt;40 years) benefited more from the DMA intervention in terms of social perception and facial emotion recognition. 76% of patients in group A were satisfied with the treatment, and 97% of patients in group B were satisfied with the DMA intervention. Discussion The findings suggest that DMA intervention can significantly enhance the social and cognitive functioning of patients with chronic schizophrenia. The creative and participatory nature of the intervention may provide a motivational boost, leading to better social engagement and cognitive stimulation. The differential effects based on age highlight the importance of tailored interventions. The study’s ","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"1 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"73 THE INTERVENTION OF ART DESIGN THERAPY COMBINED WITH AEROBIC EXERCISE ON SCHIZOPHRENIA AND ITS IMPACT ON PATIENTS’ PHYSICAL HEALTH","authors":"Yimei Zhao","doi":"10.1093/schbul/sbaf007.073","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.073","url":null,"abstract":"Background The clinical manifestations of schizophrenia include perceptual disorders in thinking, emotions, behavior, and lack of coordination in mental activities. The patient population of schizophrenia is mostly young adults, who often suffer from cognitive impairment and mental disabilities due to abnormal factors, environmental factors, and the influence of brain structure. In the intervention of schizophrenia, art design therapy is an emerging nursing intervention method, and aerobic exercise has achieved many results in the intervention of mental illness. The quality of art and design can improve the quality of life of patients by meeting their emotional needs and psychological state, while aerobic exercise can enhance their mentality and self-control ability by strengthening brain neurotransmitters and blood circulation. Therefore, the study will focus on patients with schizophrenia to explore the intervention of art design therapy combined with aerobic exercise on schizophrenia and its impact on patients’ physical health. Methods The study focused on 78 patients with schizophrenia. Patients were randomly divided into two groups, with 39 cases in each group. Two groups were set as the control group and the experimental group, with the control group receiving routine nursing interventions. On the basis of drug intervention and environmental care in the control group, the experimental group added intervention elements of artistic design and aerobic exercise. The intervention lasted for 3 months, and after the intervention, the Brief Psychiatric Assessment Scale and Pittsburgh Sleep Quality Index were used to evaluate the intervention status and physical health of patients in the experimental group and control group, respectively. Results In the experiment, the study compared the anxiety, depression, thinking disorders, and sleep quality indicators of the control group and the experimental group before and after intervention. The specific results are shown in Table 1. From Table 1, it can be seen that after three months of intervention, the anxiety, depression, thinking disorders, and sleep quality indicators of the control group all decreased, but the intervention effect of the experimental group was more significant, with a greater decrease in evaluation indicators. In terms of anxiety and depression indicators, the control group decreased from 22.45±2.24 to 19.34±3.49, while the experimental group decreased from 22.34±2.48 before intervention to 17.16±3.24, and the difference was statistically significant(P&amp;lt;0.05). At the same time, in terms of cognitive impairment indicators, the index of the control group decreased from 23.42±3.53 to 18.63±2.36, while the index of the experimental group decreased from 23.51±2.63 to 15.38±2.94. Finally, in terms of sleep quality indicators, the control group decreased from 2.59±0.24 to 1.79±0.36, while the experimental group decreased from 2.61±0.25 to 1.37±0.54. Discussion From the experimental re","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"24 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21 THE EFFECT OF BASKETBALL PHYSICAL TRAINING IN PHYSICAL EDUCATION ON ALLEVIATING COLLEGE STUDENTS’ PSYCHOLOGICAL ANXIETY","authors":"Wei Shi","doi":"10.1093/schbul/sbaf007.021","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.021","url":null,"abstract":"Background At present, mental health problems have become the main influencing factors affecting the life and study of college students. Psychological anxiety, as a common psychological problem, has had an adverse effect on students’ learning, life and social adaptability. Traditional mental health treatment methods are mostly based on psychological counseling and drug therapy. However, sports, as a non-drug intervention method, have the advantages of low cost and easy implementation in relieving students’ psychology, so it has received widespread attention. Basketball is widely loved by college students because of its moderate intensity and strong fun. Therefore, this study aims to explore the effect of basketball physical training on relieving college students’ psychological anxiety and provide new reference directions for mental health intervention in physical education teaching. Methods The study selected 60 college students with psychological anxiety in a certain university, and used the Self-Rating Anxiety Scale (SAS) to screen the psychological anxiety of college students, and included students with scores above 50 points in the study. All subjects were randomly divided into an experimental group and a control group, with 30 people in each group. The experimental group received special basketball physical training intervention, while the control group only participated in regular sports activities and did not receive special basketball physical training intervention. The study used the SAS scale to evaluate the psychological anxiety levels of the experimental group and the control group, and tested their psychological anxiety in different cycles of sports intervention. At the same time, the emotional changes and sports participation of the two groups of students during the training process were observed. Results The study compared the SAS assessment results of the two groups of patients and analyzed the scale scores of college students under exercise intervention at different periods, as shown in Table 1. Can be seen from Table 1, under different periods of intervention, when the intervention period was 12 weeks, the subject’s scale score was the lowest at only 40.5±3.1, which shows that the psychological anxiety of the subject has been significantly improved after the exercise intervention. At the same time, the scale score of the control group subjects after 12 weeks of exercise intervention was 47.8±3.4, which also shows that exercise intervention can improve the psychological anxiety of college students, but its effect is not as obvious as basketball intervention. Discussion Research results show that basketball physical training can effectively alleviate the psychological anxiety of college students. Although the results of the study can show that basketball physical training has a significant effect on alleviating psychological anxiety among college students, the sample size of the current study is small and single. Therefore, in sub","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"1 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"77 THE POSITIVE INTERVENTION EFFECT OF PSYCHOLOGICAL COUNSELING STRATEGIES COMBINED WITH SOCIAL SUPPORT ON STRESS DISORDERS IN COLLEGE STUDENTS","authors":"Jinsha Zhao, Sha Wu, Jiaxin Du*","doi":"10.1093/schbul/sbaf007.077","DOIUrl":"https://doi.org/10.1093/schbul/sbaf007.077","url":null,"abstract":"Background With the intensification of social competition and the acceleration of people’s pace of life, college students are facing unprecedented pressure. According to relevant survey data in China, over 70% of college students experience varying degrees of psychological pressure, with about 20% of students having significant psychological disorders. Psychological pressure and obstacles not only affect the learning, life, and interpersonal communication of college students, but may also have a negative impact on their future development. Psychological counseling, as an effective psychological intervention method, has achieved good results in helping individuals cope with psychological stress. In this context, the study aims to explore the positive intervention effect of psychological counseling strategies combined with social support on stress disorders in college students, with the hope of providing new ideas and methods for the intervention of psychological stress disorders in college students. Methods This study involved 200 college students with stress disorders, divided equally into an experimental group and a control group, with 100 participants in each group. Before the experiment, a comprehensive psychological assessment was conducted using the “Self Rating Scale for Stress Disorders in College Students”, with a scoring range of [0,5]. The higher the score, the more severe the stress disorder. The experimental group adopted a psychological counseling strategy combined with social support for a period of 8 weeks. Two weeks before the experiment, psychological counselors had one-on-one conversations with college students twice a week for 60 minutes each time to understand background information and establish trust. During weeks 3-8, develop personalized plans based on evaluations, encourage participation in club activities, and incorporate cognitive-behavioral therapy and teaching coping skills. During weeks 4-7, provide the experimental group of college students with 30 minutes communication support with family and friends every 2 weeks. The control group used the same psychological counseling strategy as the experimental group, but did not involve social support interventions. The counseling frequency was once a week, 60 minutes each time, lasting for 8 weeks. Results The pre intervention stress disorder score of the experimental group was 3.5 ± 0.6 points, and the post intervention stress disorder score was 2.1 ± 0.4 points. The difference before and after intervention was statistically significant (P&amp;lt;0.01). The pre intervention stress disorder score of the control group was 3.6 ± 0.5, and the post intervention stress disorder score was 2.8 ± 0.5. The difference before and after intervention was statistically significant (P&amp;lt;0.01). After intervention, the stress disorder scores of the experimental group and the control group showed statistical significance (P&amp;lt;0.01). Discussion The psychological counseling strategy c","PeriodicalId":21530,"journal":{"name":"Schizophrenia Bulletin","volume":"13 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}