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Scandinavian journal of haematology最新文献

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Homogeneously staining chromosomal region in a case of erythroleukaemia. 均匀染色的染色体区域在一个病例的红白血病。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00834.x
G Kovacs, M Freund, H Poliwoda, H Leithauser, E Thiel
{"title":"Homogeneously staining chromosomal region in a case of erythroleukaemia.","authors":"G Kovacs,&nbsp;M Freund,&nbsp;H Poliwoda,&nbsp;H Leithauser,&nbsp;E Thiel","doi":"10.1111/j.1600-0609.1986.tb00834.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00834.x","url":null,"abstract":"<p><p>Cytogenetical analysis of bone marrow and peripheral blood cells in a case of erythroleukaemia revealed a complex karyotype with a stemline of 44 chromosomes. 1 marker chromosome bearing a homogeneously staining region (hsr) was found in each of the aneuploid cells examined. The hsr was localised to the chromosome regions 15q12 and 15p12. The possible function of amplified DNA sequences and the relationship of hsr to cell proliferation are discussed.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"232-7"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00834.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14583993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Megakaryoblastic transformation of myelofibrosis with expression of the c-sis oncogene. 巨核细胞转化与c-sis癌基因的表达。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00826.x
R E Marcus, J A Hibbin, E Matutes, N Whittle, M D Waterfield, J M Goldman
{"title":"Megakaryoblastic transformation of myelofibrosis with expression of the c-sis oncogene.","authors":"R E Marcus,&nbsp;J A Hibbin,&nbsp;E Matutes,&nbsp;N Whittle,&nbsp;M D Waterfield,&nbsp;J M Goldman","doi":"10.1111/j.1600-0609.1986.tb00826.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00826.x","url":null,"abstract":"<p><p>We describe a case of primary myelofibrosis which terminated in an acute megakaryoblastic leukaemia with massive marrow fibrosis and osteosclerosis. The megakaryocyte lineage of the terminal phase was confirmed by ultrastructural and surface marker studies of the blast cells. The leukaemic phase was associated with the presence of large numbers of progressively more immature megakaryocyte progenitors in the peripheral blood. The expression of c-sis mRNA in these blast cells was significantly higher than in normal mononuclear cells. Activation of the c-sis protooncogene leading to increased production of platelet-derived growth factor could be related to the progressive fibrosis observed.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"186-93"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00826.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13569553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Improvement of post platelet transfusion increments following intravenous immunoglobulin therapy for leukaemic HLA-immunized patients. 白血病hla免疫患者静脉免疫球蛋白治疗后血小板输注增量的改善。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00821.x
H I Atrah, T Sheehan, J Gribben, R J Crawford, J R O'Donnel, G P Sandilands
{"title":"Improvement of post platelet transfusion increments following intravenous immunoglobulin therapy for leukaemic HLA-immunized patients.","authors":"H I Atrah,&nbsp;T Sheehan,&nbsp;J Gribben,&nbsp;R J Crawford,&nbsp;J R O'Donnel,&nbsp;G P Sandilands","doi":"10.1111/j.1600-0609.1986.tb00821.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00821.x","url":null,"abstract":"<p><p>3 patients with acute leukaemia, HLA antibodies and thrombocytopenia refractory to random donor platelet transfusions were treated with high-dose i.v. immunoglobulin. All 3 patients responded favourably with improved post-transfusion recovery of random platelets. In 1 patient, the recovery of transfused histocompatible platelets was also enhanced. Treatment was followed by reduction in the total lymphocyte count and marked changes in lymphocyte subsets in 1 patient.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"160-4"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00821.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14583989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Platelet peroxidase of circulating thrombocytes in acquired refractory anaemias. 获得性难治性贫血中循环血小板过氧化物酶的研究。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00827.x
S Woessner, R Lafuente, L Florensa
{"title":"Platelet peroxidase of circulating thrombocytes in acquired refractory anaemias.","authors":"S Woessner,&nbsp;R Lafuente,&nbsp;L Florensa","doi":"10.1111/j.1600-0609.1986.tb00827.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00827.x","url":null,"abstract":"<p><p>The platelet peroxidase (PPO) content of circulating thrombocytes was determined in 10 healthy controls and in 18 cases of acquired refractory anaemia (2 with refractory anaemia, 4 with sideroblastic refractory anaemia, 8 with refractory anaemia with excess of blasts, 3 with refractory anaemia in transformation and 1 with chronic myelomonocytic leukaemia). The thrombocytes of the controls were invariably PPO-positive. No peroxidase deficiency was found in the 4 patients with sideroblastic refractory anaemia. Of the remaining 14 cases PPO-positive and PPO-negative thrombocytes coexisted in 8. Only in 1 case of refractory anaemia with excess of blasts were circulating platelet peroxidase-positive micromegakaryocytes demonstrated. PPO deficiency seems to be an important dysthrombopoietic feature detectable only at an ultrastructural level.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"194-7"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00827.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14583992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A primary extranodal lymphoma associated with IgM-kappa paraproteinaemia: different secretory capacities of cutaneous and circulating lymphoma cells. 与IgM-kappa副蛋白血症相关的原发性结外淋巴瘤:皮肤和循环淋巴瘤细胞的不同分泌能力。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00831.x
K Saeki, Y Kanayama, M Ohnishi, J Kuyama, S Katagiri, T Tamaki, T Tsubakio, T Yonezawa, S Tarui
{"title":"A primary extranodal lymphoma associated with IgM-kappa paraproteinaemia: different secretory capacities of cutaneous and circulating lymphoma cells.","authors":"K Saeki,&nbsp;Y Kanayama,&nbsp;M Ohnishi,&nbsp;J Kuyama,&nbsp;S Katagiri,&nbsp;T Tamaki,&nbsp;T Tsubakio,&nbsp;T Yonezawa,&nbsp;S Tarui","doi":"10.1111/j.1600-0609.1986.tb00831.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00831.x","url":null,"abstract":"<p><p>We report a patient with non-Hodgkin's lymphoma of small lymphocytic type with IgM-kappa monoclonal gammopathy who developed extranodal involvement with orbital and nasal manifestations, followed by generalized subcutaneous nodules. Immunological study disclosed that the peripheral blood and the subcutaneous nodule were both involved in a common monoclonal proliferation of B cells at various stages of differentiation, including secretory cells which accounted for the serum paraprotein. The secretory capacity was far greater in the peripheral blood than in the subcutaneous tissue. These clinical and immunological manifestations might reflect the physiological behaviour of a particular B cell subset which shows a preference for mucocutaneous sites to secrete IgM in the peripheral blood.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"217-20"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00831.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14217447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evolution of a terminal deoxynucleotidyl transferase-positive lymphoma from a chronic T cell lymphocytosis. 慢性T细胞淋巴细胞增多症的终末脱氧核苷酸转移酶阳性淋巴瘤的演变。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00832.x
D G Oscier, G J Mufti, T J Hamblin, D B Jones, J L Smith
{"title":"Evolution of a terminal deoxynucleotidyl transferase-positive lymphoma from a chronic T cell lymphocytosis.","authors":"D G Oscier,&nbsp;G J Mufti,&nbsp;T J Hamblin,&nbsp;D B Jones,&nbsp;J L Smith","doi":"10.1111/j.1600-0609.1986.tb00832.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00832.x","url":null,"abstract":"<p><p>A 56-yr-old Caucasian man presented with a generalised scaly rash and a peripheral blood lymphocytosis of 5.6 X 10(9)/l. 5 yr later he developed cutaneous nodules, lymphadenopathy and hepatosplenomegaly. Cells with convoluted nuclei and prominent nucleoli were seen in the peripheral blood. He underwent splenectomy and received intensive chemotherapy but died 6 months later with CNS infiltration. At presentation the peripheral blood lymphocytes were E-ve, UCHT1 + ve, and OKT8 + ve. Following transformation, cells in blood, spleen and CSF were E-ve, OKT11 + ve, DR + ve and Tdt + ve. A proportion of these cells had a Sézary-like appearance at E/M. The splenic cells showed functional suppressor activity. This is the first reported case of the evolution of a Tdt + ve lymphoma from a post-thymic T cell lymphocytosis.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"221-8"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00832.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14074753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Adoptive immunotherapy for acute non-lymphocytic leukaemia: a long-term follow up. 急性非淋巴细胞白血病的过继免疫治疗:长期随访。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00820.x
J F Denegri, J W Thomas
{"title":"Adoptive immunotherapy for acute non-lymphocytic leukaemia: a long-term follow up.","authors":"J F Denegri,&nbsp;J W Thomas","doi":"10.1111/j.1600-0609.1986.tb00820.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00820.x","url":null,"abstract":"<p><p>Immune cells cultured in vitro against autologous blast cells were infused twice in 8 patients with ANLL after achieving complete remission. 3 of the 8 patients remained in first remission for 74-94 months and they appeared to be cured of their leukaemia. These 3 patients received significantly higher numbers of in vitro sensitized immune cells as well as having a better recovery of the in vitro cultured cells. The other 5 patients relapsed within a year of diagnosis; 3 of them had had organomegaly and a preceding myeloproliferative disorder at diagnosis. None of 20 ANLL patients in complete remission treated simultaneously with similar chemotherapy at our institution remained in first complete remission, nor were long-term survivors. Adoptive immunotherapy with in vitro sensitized immune cells may be effective treatment in acute leukaemia. The therapeutic potential of infusion of in vitro stimulated autologous immune cells requires further investigation.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"154-9"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00820.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14824062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Successful treatment of acute megakaryoblastic leukaemia. 成功治疗急性巨核细胞白血病。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00819.x
H Ninomiya, M Nakazawa, A Shibuya, Y Aoki, T Nagasawa, T Abe
{"title":"Successful treatment of acute megakaryoblastic leukaemia.","authors":"H Ninomiya,&nbsp;M Nakazawa,&nbsp;A Shibuya,&nbsp;Y Aoki,&nbsp;T Nagasawa,&nbsp;T Abe","doi":"10.1111/j.1600-0609.1986.tb00819.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00819.x","url":null,"abstract":"<p><p>2 patients with acute megakaryoblastic leukaemia (AMKBL) were successfully treated with a combination of aclarubicin hydrochloride (an anthracycline), enocitabine (a derivative of cytosine arabinoside) and 6-mercaptopurine (6-MP) or 6-thioguanine (6-TG). They achieved a complete remission following 1 or 2 courses. They remained well and in complete remission throughout 3 courses of consolidation therapy, a total of 9 weeks. The results of remission induction therapy of AMKBL have been reviewed in the literature. 4 of 7 adult patients, including our cases, treated with 3 drugs, anthracycline, cytosine arabinoside or its derivative and 6-TG or 6-MP, achieved a complete remission. AMKBL may not have so poor a prognosis as previously believed.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"147-53"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00819.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14581055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Bone marrow transplantation in multiple myeloma. 骨髓移植治疗多发性骨髓瘤。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00824.x
S Tura, M Cavo, M Baccarani, P Ricci, M Gobbi
{"title":"Bone marrow transplantation in multiple myeloma.","authors":"S Tura,&nbsp;M Cavo,&nbsp;M Baccarani,&nbsp;P Ricci,&nbsp;M Gobbi","doi":"10.1111/j.1600-0609.1986.tb00824.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00824.x","url":null,"abstract":"<p><p>We report 3 cases of allogeneic bone marrow transplantation in multiple myeloma that we have recently performed. Following conditioning treatment with i.v. cyclophosphamide (60 mg/kg/d, for 2 d), oral melphalan (1.0 mg/kg/d, for 5 d), i.v. BCNU (5.5 mg/kg, in a single dose) and total body irradiation (10 Gy in a single fraction) we observed in all 3 cases the disappearance both of serum M component and of monoclonal bone marrow plasma cells. 1 patient died of acute GVH disease, grade IV, at 2 months, while the other 2 patients are in good health and in unmaintained complete remission at 4 and 20 months, respectively. The usefulness of allogeneic bone marrow transplantation in the management of multiple myeloma is emphasized.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"176-9"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00824.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14640636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Enhancement of in vitro erythropoiesis by peripheral blood mononuclear cells from allogeneic marrow recipients in the early post-transplant period. 异体骨髓受者外周血单个核细胞在移植后早期增强体外红细胞生成。
Scandinavian journal of haematology Pub Date : 1986-02-01 DOI: 10.1111/j.1600-0609.1986.tb00825.x
S Nakao, M Harada, M Ueda, K Kondo, K Odaka, S Ohtake, K Matsue, S Shiobara, T Mori, T Matsuda
{"title":"Enhancement of in vitro erythropoiesis by peripheral blood mononuclear cells from allogeneic marrow recipients in the early post-transplant period.","authors":"S Nakao,&nbsp;M Harada,&nbsp;M Ueda,&nbsp;K Kondo,&nbsp;K Odaka,&nbsp;S Ohtake,&nbsp;K Matsue,&nbsp;S Shiobara,&nbsp;T Mori,&nbsp;T Matsuda","doi":"10.1111/j.1600-0609.1986.tb00825.x","DOIUrl":"https://doi.org/10.1111/j.1600-0609.1986.tb00825.x","url":null,"abstract":"<p><p>The effect of peripheral blood mononuclear cells (PBMCs) from bone marrow recipients on in vitro growth of erythroid burst-forming units (BFU-E) was studied. PBMCs were obtained from 5 allogeneic, 1 syngeneic and 1 autologous bone marrow recipient(s) at different intervals after transplantation. The number of BFU-E was significantly increased when donor bone marrow cells were co-cultured with PBMCs obtained from allogeneic marrow recipients in the early post-transplant period. No effect was observed using PBMCs obtained in the later post-transplant period, PBMCs from a syngeneic marrow recipient, or PBMCs from an autologous marrow recipient. The BFU-E enhancing activity was present among T cells and was abolished by treating them with OKT3 or OKT4 antibody and complement. These observations suggest that chimeric T lymphocytes, probably of the helper/inducer subset, from allogeneic marrow recipients in the early post-transplant period have a potent enhancing effect on in vitro erythropoiesis.</p>","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"36 2","pages":"180-5"},"PeriodicalIF":0.0,"publicationDate":"1986-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0609.1986.tb00825.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14640637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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