Revista espanola de fisiologia最新文献_第9页

Increase in cardiac output and PEEP as mechanism of pulmonary optimization. 心排血量和PEEP增加作为肺优化的机制。

Revista espanola de fisiologia Pub Date : 1995-03-01

C Curiel, R Martínez, V Pinto, A Rosales, G D'Empaire, R Sánchez De Leon

{"title":"Increase in cardiac output and PEEP as mechanism of pulmonary optimization.","authors":"C Curiel, R Martínez, V Pinto, A Rosales, G D'Empaire, R Sánchez De Leon","doi":"","DOIUrl":"","url":null,"abstract":"The influence of cardiac output (CO) and PEEP on pulmonary shunt (Qs/Qt) has been the subjects of considerable investigation but findings are controversial. The role of CO and PEEP on 19 isolated rabbit lung preparations perfused with hypoxic mixture (6% CO2, 10% O2, and 84% N2), which resulted in a constant oxygen venous pressure (64 +/- 5.6 mmHg) has been studied. The first group of 11 preparations were used to study the influence of CO modifications with room air ventilation on the Qs/Qt when the CO rises in 48%; in the second group simultaneous modifications in CO and PEEP (0.5 and 10 cm H2O) were performed. A positive correlation (p < 0.01) in Qs/Qt (0.048 +/- 0.04 to 0.12933 +/- 0.09) was found when the CO increased in the first experimental group, the fluid filtration rate (FFR) also increased and the pulmonary vascular resistance (PVR) remained stable. In the second group an increase of 5 and 10 cm H2O of PEEP at constant CO reduced the Qs/Qt (0.0361 +/- 0.02 to 0.0184 +/- 0.006) while it increased the arterio-venous oxygen difference, PVR and FFR. During high CO conditions increase of 5 and 10 cm H2O of PEEP reduced the Qs/Qt (0.099 +/- 0.03 to 0.027 +/- 0.02) and FFR. These data suggest that when the Qs/Qt is increased, the use of PEEP can compensate the ventilation/perfusion alterations and restore pulmonary gas exchange.","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"51 1","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18576746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revista espanola de fisiologia Pub Date : 1995-03-01

J Canal, E Domínguez, M D Torres, J E Campillo, C Pérez

引用次数: 0

Amniotic fluid phospholipids. New predictive values of L/S and PG/S ratios. 羊水磷脂。L/S和PG/S比值的新预测值。

Revista espanola de fisiologia Pub Date : 1995-03-01

J Ruiz-Budría, E Fabre-González, M T Higueras, J L Serrano-Ostáriz

引用次数: 0

Dose-response effects of VIP on the rabbit exocrine pancreatic secretion. Comparison with PACAP-27 actions. VIP对家兔外分泌胰腺分泌的量效效应。与PACAP-27作用的比较。

Revista espanola de fisiologia Pub Date : 1995-03-01

A M Rodríguez-López, I De Dios, L J García, M A López, J J Calvo

{"title":"Dose-response effects of VIP on the rabbit exocrine pancreatic secretion. Comparison with PACAP-27 actions.","authors":"A M Rodríguez-López, I De Dios, L J García, M A López, J J Calvo","doi":"","DOIUrl":"","url":null,"abstract":"A dose-response study of the effects of vasoactive intestinal peptide (VIP) on the exocrine pancreatic secretion of the rabbit has been made. Furthermore, the actions of VIP and pituitary adenylate cyclase activating peptide (PACAP) on the exocrine pancreatic secretion were compared at a similar molar dose. After the infusion of VIP a linear dose-response relationship for pancreatic flow rate and bicarbonate output, up to the dose of 4 micrograms/kg, was observed. VIP acts as a partial agonist of secretin, the rabbit pancreas being less sensitive to VIP compared with other mammals. Moreover, VIP did not significantly stimulate the pancreatic protein output. PACAP stimulated the hydroelectrolyte fraction of the exocrine pancreatic secretion in a similar manner to that of VIP. Unlike what was observed with VIP, PACAP, on the same molar basis, significantly stimulated the protein and amylase outputs. Furthermore, PACAP releases VIP, so that the action of PACAP on the hydroelectrolyte fraction may be partially mediated by VIP; on the other hand, VIP is not involved in the effect of PACAP on the pancreatic enzyme secretion of this species.","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"51 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"1995-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18576743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual evoked potentials in response to pattern reversal in the cat cortex. 猫皮层模式反转的视觉诱发电位反应。

Revista espanola de fisiologia Pub Date : 1994-12-01

J C Pérez-Cobo, M López de Armentia, S Sánchez-Suero, M Pérez-Arroyo

引用次数: 0

Effect of enriched oil diets on some cardiovascular risk factors in rat's recovery from early undernutrition. 富油饮食对早期营养不良大鼠恢复过程中心血管危险因素的影响

Revista espanola de fisiologia Pub Date : 1994-12-01

J M Gutiérrez, A Fernández, A Fueyo, C González, S Fernández, A Menéndez-Patterson

{"title":"Effect of enriched oil diets on some cardiovascular risk factors in rat's recovery from early undernutrition.","authors":"J M Gutiérrez, A Fernández, A Fueyo, C González, S Fernández, A Menéndez-Patterson","doi":"","DOIUrl":"","url":null,"abstract":"This study evaluates the role of soybean and olive oil in the recovery and evolution of some cardiovascular risk factors in rats undernourished in uterus and during lactation. Beginning at 20 days of age, for a period of 130 days, control (C) and malnourished (M) animals were fed three different diets: standard diet (C, M), standard diet enriched with soybean oil (CS, MS) and standard diet enriched with olive oil (CO, MO). Body weight, systolic and diastolic blood pressure, total cholesterol, HDL-cholesterol and triglycerides levels of pups were measured at periods of 15, 30, 90 and 150 days of age. Malnutrition produced a decreased body weight and experimental diets were ineffective in body weight recovery. The controls, however, displayed overweight. Blood pressure values, taken at different ages and under different diets were within normal limits. Plasma triglycerides increased up to 30 days of age with early undernutrition returning, thereafter, to normal limits. Plasma cholesterol level decreased in all animals with age, except in the CS and CO groups, which showed a significant increase in this parameter at 5 months.","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 4","pages":"229-38"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18754737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct transfer of rainbow trout to seawater induces several changes in kidney carbohydrate metabolism. 虹鳟鱼直接转移到海水中引起肾脏碳水化合物代谢的几种变化。

Revista espanola de fisiologia Pub Date : 1994-12-01

J L Soengas, J Fuentes, M D Andrés, M Aldegunde

引用次数: 0

Effect of fluid and salt supplementation in preventing osteopenia in rats after exposure to hypokinesia. 补充水和盐对大鼠运动不足后骨质减少的预防作用。

Revista espanola de fisiologia Pub Date : 1994-12-01

Y G Zorbas, Y F Federenko, M N Togawa

{"title":"Effect of fluid and salt supplementation in preventing osteopenia in rats after exposure to hypokinesia.","authors":"Y G Zorbas, Y F Federenko, M N Togawa","doi":"","DOIUrl":"","url":null,"abstract":"The objective of this investigation was to evaluate the efficacy of fluid and salt supplementation in preventing the development of osteopenia in 150 Wistar male rats (370-390 g) after exposure to 90-days of hypokinesia. They were divided into three equal groups: 1st placed under ordinary vivarium conditions (vivarium control animals); 2nd subjected to hypokinesia (unsupplemented hypokinetic animals, HK); and 3rd submitted again to HK and daily supplemented with water (5 ml/100 g b.w.) and NaCl at 0.9 g % (3 ml/100 g b.w.) orally administered (supplemented hypokinetic animals). The hypokinetic effect was carried out by keeping the rats in small individual wood cages which restricted all their movements without hindering feed and water intake. Determination was made of weight and volume of their entire bone, head and distal epiphysis, as well as density, ash and mineral content. Thickness of the cortical layer and width of the bone marrow canal were measured on frontal and lateral x-ray projections. Histological transverse sections of the femoral diaphysis were prepared from the femoral bone fragments. The concentrations of calcium, phosphorus and creatinine in serum were also measured. The results obtained indicate that the daily administration of fluid and salt supplementation inhibited the progressive development of osteopenia in rats subjected to prolonged restriction of motor activity.","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 4","pages":"245-51"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18754693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peroxisome enzyme modification and oxidative stress in rat by hypolipidemic and antiinflammatory drugs. 降血脂和抗炎药物对大鼠过氧化物酶修饰和氧化应激的影响。

Revista espanola de fisiologia Pub Date : 1994-12-01

A Rivero, J I Monreal, M J Gil

{"title":"Peroxisome enzyme modification and oxidative stress in rat by hypolipidemic and antiinflammatory drugs.","authors":"A Rivero, J I Monreal, M J Gil","doi":"","DOIUrl":"","url":null,"abstract":"Changes in the activities of two peroxisomal enzymes (catalase and thiolase), some parameters related to oxidative situations, such as conjugated dienes, zinc, iron, copper and superoxide dismutase after the administration of two known peroxisome proliferators (clofibrate and acetylsalicylic acid), and two drugs pharmacologically related to the former (probucol and diflunisal) have been studied in male Wistar rats. Administration of the drugs was made by p.o. for 15 days. After the treatment the rats were killed, their livers and brains were taken out, and their blood was collected. Peroxisomes were purified by differential centrifugation followed by ultracentrifugation. Total RNA was also extracted and the acyl CoA oxidase mRNA expression was studied. Clofibrate was inactive on both enzymes studied in liver and diflunisal in brain. However, the acyl CoA oxidase mRNA expression increased by clofibrate treatment. Results are justified by the liposolubility and protein-binding properties of the drugs. Otherwise, the present results show the existence of an increased lipid peroxidation, lower value of superoxide dismutase, and variable results for zinc, copper and iron trace elements. These data evidence an oxidative stress situation in plasma of rats treated with these drugs, probably as a consequence of an increase in some beta-oxidation enzymes, which brings about an overproduction of H2O2.","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 4","pages":"259-68"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18754695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of vitamin C and vitamin E analog on aged fibroblasts. 维生素C和维生素E类似物对衰老成纤维细胞的影响。

Revista espanola de fisiologia Pub Date : 1994-12-01

M Farriol, M Mourelle, S Schwartz

引用次数: 0