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Lipogenic activities in rat liver are subjected to circadian rhythms. 大鼠肝脏的脂肪生成活动受昼夜节律的影响。
Revista espanola de fisiologia Pub Date : 1994-12-01
R Zardoya, A Diez, M C Serradilla, J A Madrid, J M Bautista, A Garrido-Pertierra
{"title":"Lipogenic activities in rat liver are subjected to circadian rhythms.","authors":"R Zardoya,&nbsp;A Diez,&nbsp;M C Serradilla,&nbsp;J A Madrid,&nbsp;J M Bautista,&nbsp;A Garrido-Pertierra","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diurnal variations were investigated in the activities of the key lipogenic enzymes in rat liver under standard experimental conditions. Fatty acid synthetase, acetyl-CoA-carboxylase, and ATP-citrate lyase showed sinusoidal circadian rhythms (statistically sustained), reaching maximum activity at night and minimum during the light period, with a fold increase value of 1.7, 2.2 and 3.2, respectively. Although a non-sinusoidal circadian rhythm was observed in the malic enzyme activity, statistically different time-dependent activity values were detected throughout a day. The observed rhythms run in parallel with that previously reported for glucose-6-phosphate dehydrogenase, suggesting a whole circadian regulation for rat liver lipogenesis.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 4","pages":"239-44"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18754692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovariectomy at different stages of the estrous cycle modifies the pulsatile secretory pattern of prolactin in rat. 在发情周期的不同阶段切除卵巢改变了大鼠催乳素的脉动分泌模式。
Revista espanola de fisiologia Pub Date : 1994-12-01
A Lafuente, J Marcó, A I Esquifino
{"title":"Ovariectomy at different stages of the estrous cycle modifies the pulsatile secretory pattern of prolactin in rat.","authors":"A Lafuente,&nbsp;J Marcó,&nbsp;A I Esquifino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of estrogens in the synchronization of pulsatile prolactin secretion throughout the estrous cycle in the adult female rat is studied. Mean values of prolactin, in sham-operated animals increased from diestrus-2 to proestrus and then decreased to the values found at diestrus-1. Ovariectomy did not modify the pattern which follows mean serum levels of the hormone throughout the estrous cycle; although increased values of prolactin were found at both proestrus and estrus, when compared to control animals. No changes in mean values of the hormone were observed at any other phase of the estrous cycle. The number of peaks was fairly constant in sham-operated rats in any phase of the estrous cycle, but a decrease in its number, after ovariectomy, was observed at proestrus and estrus. The absolute amplitude of the peaks increased numerically but not statistically significant from diestrus-2 to proestrus, then decreasing to diestrus-1 in control animals whereas an increase in the absolute amplitude of the prolactin peaks was detected in proestrus and estrous after ovariectomy. The duration of the prolactin peaks was not changed either by the phase of the estrous cycle or by ovariectomy. The relative amplitude of the prolactin peaks was only changed in rats ovariectomized at diestrus-1, as compared to sham-operated animals. All these data indicated that changes in estrogen/secretion by ovariectomy throughout the estrous cycle of the rat induced a differential effect on the pulsatile pattern of prolactin, being more marked in proestrus and estrus, associated with the highest circulating estrogen levels.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 4","pages":"211-7"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18754735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of D-galactose and L-phenylalanine transport by HgCl2 in rat intestine in vitro. HgCl2体外抑制大鼠肠内d -半乳糖和l -苯丙氨酸转运的研究。
Revista espanola de fisiologia Pub Date : 1994-09-01
A Lugea, A Barber, F Ponz
{"title":"Inhibition of D-galactose and L-phenylalanine transport by HgCl2 in rat intestine in vitro.","authors":"A Lugea,&nbsp;A Barber,&nbsp;F Ponz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of Hg2+ on galactose and phenylalanine uptake has been studied in rat everted intestinal rings incubated for 2 minutes. The presence of 0.5 mM Hg2+ in the incubation medium inhibited the total galactose uptake from 30% to 40% and that of the phenylalanine about 70%. The inhibition was due to a reduction of galactose transport and Na(+)-dependent phenylalanine transport. Hg2+ inhibited the galactose transport in a non-competitive way, with a Vmax diminution without Km modification. The Na(+)-dependent phenylalanine transport was totally blocked in the presence of 1 mM Hg2+. The washing of the intestinal rings with 5 mM EDTA slightly decreased the inhibition produced by 0.5 mM Hg2+ on phenylalanine uptake whereas it did not modify the inhibition of galactose uptake. However, the inhibition of galactose uptake was completely reversed after washing with 10 mM cysteine. Therefore, phenylalanine transport seems to be more sensitive to HgCl2 than galactose transport. The inhibition of these intestinal transport systems by Hg2+ might be due to its interaction with ligands of the transport proteins located in the luminal membrane of enterocytes.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"167-73"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of age and stress from physical activity on the redistribution of lymphocytes. 年龄和体力活动压力对淋巴细胞再分配的影响。
Revista espanola de fisiologia Pub Date : 1994-09-01
E Ortega, A Forner, M Galán, M de la Fuente, C Barriga
{"title":"Influence of age and stress from physical activity on the redistribution of lymphocytes.","authors":"E Ortega,&nbsp;A Forner,&nbsp;M Galán,&nbsp;M de la Fuente,&nbsp;C Barriga","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of age and stress on the redistribution of lymphocytes between the intra- and extra-vascular spaces has been studied. Young (12 +/- 4 weeks) and old (68 +/- 6 weeks) mice were made to swim until exhaustion, with and without a previous period of training. Lymphocyte concentration in the blood and in the peritoneal cavity, was evaluated as well as the weight of spleen and thymus in these animals. In parallel, and as an indicator of the level of stress, quantification was made of the serum corticosterone levels and weight as well as the protein, DNA, and RNA content of the adrenal glands. Results indicate that, after being subjected to stress, the young mice present no changes in lymphocyte number in blood or peritoneal cavity. Old mice, however, after acute physical activity, present a greater lymphocyte content in the intravascular compartment, as well as a fall in the peritoneal lymphocyte concentration and spleen weight. The data could indicate that age modifies the response to stress, with an augmentation of lymphocytes in the intravascular compartment at the expense of the extravascular one.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"159-65"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of continuous light and melatonin on the sexual maturation of the female rat. 连续光照和褪黑素对雌性大鼠性成熟的影响。
Revista espanola de fisiologia Pub Date : 1994-09-01
M D Colmenero, B Díaz, M L Moreno, A Esquifino, B Marín
{"title":"Effect of continuous light and melatonin on the sexual maturation of the female rat.","authors":"M D Colmenero,&nbsp;B Díaz,&nbsp;M L Moreno,&nbsp;A Esquifino,&nbsp;B Marín","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"193-4"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persistent GHRH-induced PRL secretion in Cushing's syndrome, obesity and exogenous hypercortisolism. 持续ghrh诱导的PRL分泌在库欣综合征、肥胖和外源性高皮质醇症中。
Revista espanola de fisiologia Pub Date : 1994-09-01
F Cordido, R Peino, T Martínez-Ramonde
{"title":"Persistent GHRH-induced PRL secretion in Cushing's syndrome, obesity and exogenous hypercortisolism.","authors":"F Cordido,&nbsp;R Peino,&nbsp;T Martínez-Ramonde","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Endogenous Cushing's syndrome, obesity and chronic glucocorticod treatment are characterized by blunted GH secretion. The administration of GHRH is capable of stimulating a small but significant PRL increase in normal subjects. The current study was designed to determine plasma PRL levels in response to GHRH, studied in three different situations characterized by a blunted GH secretion. Obese patients (n = 6) with a weight over 30% of ideal body weight, patients with active Cushing's syndrome, and normal volunteers treated with dexamethasone 22 mg per os over two days before the pituitary challenge were studied. As a control group 18 normal subjects of similar age and sex were studied. GH and PRL was determined at intervals after GHRH (1 microgram/kg). GHRH-induced GH secretion was markedly reduced in patients with obesity, patients with endogenous Cushing's syndrome and volunteers treated with dexamethasone. In contrast, GHRH-induced PRL secretion was not affected in these three clinical situations. In summary, in three situations characterized for an impairment of the somatotroph cell, due to a primary intrinsic defect or to a functional hypothalamic alteration, there is a persistent GHRH-induced PRL secretion, suggesting that prolactin could be released by mammosomatotrophs that function normally in spite of hyposomatotropism.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"139-43"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of cefepime (BMY-28142) on the hemolytic and bactericidal activity of serum in vivo and in vitro. 头孢吡肟(BMY-28142)对体内外血清溶血杀菌活性的影响。
Revista espanola de fisiologia Pub Date : 1994-09-01
M I Pedrera, C Barriga, E Ortega, A B Rodríguez
{"title":"Effect of cefepime (BMY-28142) on the hemolytic and bactericidal activity of serum in vivo and in vitro.","authors":"M I Pedrera,&nbsp;C Barriga,&nbsp;E Ortega,&nbsp;A B Rodríguez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study was undertaken to determine whether cefepime (BMY-28142) could influence the hemolytic and bactericidal activity of serum both in vivo and in vitro. For the in vivo studies, mice (Swiss aged 15 +/- 2 weeks) were studied before and 1, 2, 4, 8, and 12 h after an intramuscular injection of 200 mg/kg of cefepime. Likewise, another group of mice were injected for 7 days with a daily injection of the same dose as before, and sacrificed one hour after the last injection. For the in vitro studies, samples were incubated in the presence and absence of cefepime (1/2, 1/4 and 1/8 MIC against Staphylococcus aureus) (2.5, 1.25 and 0.625 mg/l respectively). The results indicate that cefepime at sublethal concentrations increases the bactericidal activity of serum both in vivo and in vitro against S. aureus, but does not significantly modify the hemolytic activity of the complement.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"153-8"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relation of abnormal composition of lipoproteins to HbA1c levels in non-insulin dependent diabetes. 非胰岛素依赖型糖尿病患者脂蛋白异常组成与HbA1c水平的关系
Revista espanola de fisiologia Pub Date : 1994-09-01
M Sánchez-Cabezudo, S Ródenas, C Cuesta
{"title":"Relation of abnormal composition of lipoproteins to HbA1c levels in non-insulin dependent diabetes.","authors":"M Sánchez-Cabezudo,&nbsp;S Ródenas,&nbsp;C Cuesta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma lipids and VLDL and HDL composition were studied in a control group of 20 non diabetic subjects and in 31 male middle-age patients with non-insulin dependent diabetes treated by oral hypoglycemic agent glibenclamide and a weight maintaining diet. Data for the diabetics were separated based on haemoglobin A1c of less or greater than 7%. VLDL composition abnormalities were more frequent in the diabetic patients with HbA1c of > 7%. VLDL-cholesterol, VLDL-triglycerides and VLDL-phospholipids were high in all diabetics whereas VLDL-apo B increased only in diabetics with HbA1c > 7%. Apo CII and apo CIII levels and also apo CII/apo CIII ratio were also reduced in the diabetic patients with HbA1c levels of more than 7%. Increases in the apo E and apo E/apo C ratio were also seen in the more hyperglycemic diabetics with HbA1c levels > 7%. In contrast apo CII and apo CIII levels and also Apo CII/Apo CIII ratio remained unaltered in diabetic patients with less than 7% HbA1c levels. In these patients increases in the apo E levels were found while the apo E/apo C ratio remained unaltered. All diabetic patients showed increases in HDL-triglycerides and triglyceride/total cholesterol ratio with respect to control. Decreases in HDL-apo AI were also seen in both groups of diabetics, but the HDL-apo AI/HDL-apo AII ratio did not differ from control.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"145-51"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single dose of a non selective beta-adrenergic agonist increases bone protein synthesis. 单剂量非选择性肾上腺素能激动剂可增加骨蛋白合成。
Revista espanola de fisiologia Pub Date : 1994-09-01
M Pascual, J A Martínez, J Larralde
{"title":"A single dose of a non selective beta-adrenergic agonist increases bone protein synthesis.","authors":"M Pascual,&nbsp;J A Martínez,&nbsp;J Larralde","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"191-2"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visual evoked potentials in response to flashes in the cat cortex. 猫皮层对闪光的视觉诱发电位反应。
Revista espanola de fisiologia Pub Date : 1994-09-01
J C Pérez-Cobo, M López de Armentia, S Sánchez-Suero, M Pérez-Arroyo
{"title":"Visual evoked potentials in response to flashes in the cat cortex.","authors":"J C Pérez-Cobo,&nbsp;M López de Armentia,&nbsp;S Sánchez-Suero,&nbsp;M Pérez-Arroyo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A model is presented of visually evoked potentials (VEPs) in the cerebral cortex of cats after binocular stimulation by means of flashes. The VEPs consist of four components: P1, N1, P2 and N2 which appear during the first 100 ms after the stimulation is produced. This model has been found in all the animals used in the experiments and is repeated with small variations at almost all the recording points. After studying the data obtained, a hypothesis is put forward for the possible origin of the four components in the primary visual area.</p>","PeriodicalId":21473,"journal":{"name":"Revista espanola de fisiologia","volume":"50 3","pages":"183-90"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18884670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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