Sabouraudia最新文献_第6页

Phaeoannellomyces and the Phaeococcomycetaceae, new dematiaceous blastomycete taxa. phaoannellomyces和phaococcomycetaceae，新母芽菌分类群。

Sabouraudia Pub Date : 1985-05-01 DOI: 10.1080/00362178585380281

Michael R. McGinnis, Wiley A. Schell, John L. Carson

引用次数: 41

Effect of mycolase and amphotericin B on Candida albicans and Candida pseudotropicalis in vitro and in vivo. 霉菌酶和两性霉素B对白色念珠菌和假热带念珠菌体外和体内的影响。

Sabouraudia Pub Date : 1985-05-01 DOI: 10.1080/00362178585380261

L. Chalkley, A. Trinci, A.M.S. Pope

{"title":"Effect of mycolase and amphotericin B on Candida albicans and Candida pseudotropicalis in vitro and in vivo.","authors":"L. Chalkley, A. Trinci, A.M.S. Pope","doi":"10.1080/00362178585380261","DOIUrl":"https://doi.org/10.1080/00362178585380261","url":null,"abstract":"A mixture of enzymes (mycolase) capable of lysing yeast cell walls was prepared from culture filtrates of Physarum polycephalum. The enzymes present in mycolase included chitinase, beta-1,3-glucanases and exo-glycosidases. The pH optima of these enzymes were in the range 3.5-5.0 and they had low activities at pH 7.0. Mycolase produced spheroplasts from Candida pseudotropicalis and, unlike commercial enzyme preparations such as L1, chitinase, beta, 1,3-glucanase and beta-glucosidase, had some candicidal activity in vitro against C. pseudotropicalis and C. albicans. Mycolase potentiated the antifungal activity of amphotericin B against C. pseudotropicalis grown in shake flask culture but did not potentiate the antifungal activity of the antibiotic against similar cultures of C. albicans; indeed antagonism between mycolase and amphotericin B was sometimes observed with the latter yeast. Mycolase caused an approximately two-fold increase in the total and viable counts of cultures of C. albicans inoculated with stationary phase cells. These increases, which were observed within about 30 min, were attributed to mycolase inducing the premature release of viable buds from 'lag' phase cells. Mycolase also increased the rate at which C. albicans formed germ tubes when the yeast was cultured in a medium containing serum. Mycolase alone or in combination with amphotericin B did not appreciably enhance phagocytosis or intracellular killing of the yeasts by unstimulated mouse peritoneal macrophages. Studies on mice infected systemically with C. albicans showed that mycolase only slightly enhanced amphotericin B therapy.","PeriodicalId":21469,"journal":{"name":"Sabouraudia","volume":"65 1","pages":"147-64"},"PeriodicalIF":0.0,"publicationDate":"1985-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90787717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Epidermophyton floccosum infection in a dog from the United States. 美国一只狗的絮状表皮植物感染。

Sabouraudia Pub Date : 1985-04-01

A A Terreni, W B Gregg, P R Morris, A F DiSalvo

引用次数: 0

In-vitro studies with SF 86-327, a new orally active allylamine derivative. 一种新的口服活性烯丙胺衍生物SF 86-327的体外研究。

Sabouraudia Pub Date : 1985-04-01 DOI: 10.1080/00362178585380201

S Shadomy, A Espinel-Ingroff, R J Gebhart