Rinsho byori. The Japanese journal of clinical pathology最新文献_第10页

[Severe Fever with Thrombocytopenia Syndrome]. [发热伴血小板减少综合征]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Shintaro Kurihara

引用次数: 0

[Recent Progress of Therapeutic Strategy and Laboratory Examination Against Chronic Liver Diseases]. 慢性肝病的治疗策略及实验室检查研究进展

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Hitoshi Yoshiji

{"title":"[Recent Progress of Therapeutic Strategy and Laboratory Examination Against Chronic Liver Diseases].","authors":"Hitoshi Yoshiji","doi":"","DOIUrl":"","url":null,"abstract":"Chronic liver diseases consist of several etiologies, including hepatitis C virus (HCV), hepatitis B virus (HBV), and non-alcoholic steatohepatitis (NASH). All these diseases can progress to liver cirrhosis and finally hepatocellular carcinoma (HCC). Recently therapies against HCV have markedly improved. Several direct anti-viral agents (DAAs) have been developed that show significant viral eradication efficiency. How- ever, viral eradication does not mean the complete cure of hepatitis C. Several reports have shown that, even after HCV eradication, HCC can occur in some patients, especially in those with advanced liver fibrosis. As well as HCV, patients with HBV have also shown that advanced liver fibrosis is associated with a high rate of HCC development. Accordingly, anti-fibrosis therapy would be one promising approach to improve the prognosis .of chronic liver disease patients. However, to date, no anti-fibrotic agent has been approved in clinical practice. We focused on angiogenesis. Angiogenesis has now been recognized to play an important role in many physiological and pathological events. We found that several clinically available agents exerted a marked anti-fibrotic effect both in basic and clinical studies at least partly mediated by anti-angiogenic activ- ity. Until newly developed agents become available, these clinical agents may offer alternative strategies against chronic liver diseases. [Review].","PeriodicalId":21457,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36824571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Hemolytic Anemia with Excessively Elevated Lactic Dehydrogenase Levels]. [乳酸脱氢酶水平过高的溶血性贫血]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Fumihiko Nakamura, Asumi Koyama, Tomonari Kuribayashi, Masamichi Yoshika

{"title":"[Hemolytic Anemia with Excessively Elevated Lactic Dehydrogenase Levels].","authors":"Fumihiko Nakamura, Asumi Koyama, Tomonari Kuribayashi, Masamichi Yoshika","doi":"","DOIUrl":"","url":null,"abstract":"It has become easier to acquire patients' clinical information from clinical laboratories using the electronic medical record system. However, it is possible that clinical laboratories do not consider abnormal laboratory data when elucidating the pathological mechanism of diseases in patients when their clinical information is obtained from the electronic medical records. In this reversed clinicopathological conference, we analyzed the laboratory data of a patient with elevated lactate dehydrogenase (LD) levels and anemia. Although the presence of hemolysis was clear from the elevated LD levels, anemia, and decreased haptoglobin levels, the ,excessive increase in the LD level suggested a particular mechanism of hemolysis. Drug intake was sus- pected on the basis of a prolonged prothrombin time with a normal activated partial thromboplastin time. At the conference, these findings led to in-depth discussions. We elucidated the pathological mechanism in this patient based only on the laboratory data, with intentionally restricted clinical information, and again recog- nized the importance of analyzing laboratory data thoroughly. Training modules for medical technologists and doctors in clinical laboratories that provide information regarding elucidating pathological mechanisms using laboratory data may prove useful for improving the nature of comments in laboratory data reports. In addition, clinicians should also receive training to elucidate the pathological mechanism of a disease on the basis of only laboratory data, as well as training for diagnosing patients on the basis of clinical information and physical examination findings. [Review].","PeriodicalId":21457,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36824044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Recent Trends in Infection and Related Examinations: Infectious Diseases and Their Control in Other Countries (General Remarks)]. [传染病及有关检查的最新趋势:其他国家传染病及其控制(一般评论)]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Koki Kaku

引用次数: 0

[Dengue Fever]. [登革热]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Meng Ling Moi, Tomohiko Takasaki

引用次数: 0

No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study. 日本人精神疾病与安定结合抑制剂rs2276596 (C/A)多态性无相关性:一项探索性研究

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Eiji Yoshiharia, Shin Narita, Chikako Waga, Maki Numajiri, Yuya Onozawa, Kazuhiko Iwahashi

{"title":"No Relationships between Psychosis and the Diazepam Binding Inhibitor rs2276596 (C/A) Polymorphism in Japanese: An Exploratory Study.","authors":"Eiji Yoshiharia, Shin Narita, Chikako Waga, Maki Numajiri, Yuya Onozawa, Kazuhiko Iwahashi","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Our recent study for the first time reported genotyping method of the diazepam binding inhibitor (DBI) rs2276596 polymorphism using a Polymerase Chain Reaction-Restriction Fragment Length Polymor- phism (PCR-RFLP), and revealed a significant relationships between this polymorphism and alcohol depend- ence. In this study, to facilitate elucidation of the pathogeneses of psychoses including schizophrenia and mood (affective) disorders, we investigated the relationship between the DBI rs2276596 polymorphism (C/A) and psychoses.Method: We analyzed the DBI genotypes using the PCR-RFLP method in healthy controls, and psychotics including schizophrenia and mood (affective) disorders (including recurrent depressive disorder and bipolar affective disorder) (ICD-10: F31, F33).Result: There was no significant difference in the rs2276596 genotype and allele frequencies of the DBI gene between these psychoses and healthy controls.Conclusion: The present data suggested that a mutated allele of the DBI was not one of the risk factors for schizophrenia and mood (affective) disorders, as for the rs2276596 polymorphism. [Original].","PeriodicalId":21457,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36834467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The Role of Laboratory Tests in the Safety Management of Pharmaceuticals -Remarks of the Chairperson-]. [实验室检测在药品安全管理中的作用-主席讲话-]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Masaharu Yamazaki

{"title":"[The Role of Laboratory Tests in the Safety Management of Pharmaceuticals -Remarks of the Chairperson-].","authors":"Masaharu Yamazaki","doi":"","DOIUrl":"","url":null,"abstract":"More than 700,000,000 prescriptions are issued every year for the approximately 18,000 pharmaceutical products in Japan. Consequently, numerous measures have been implemented to ensure the safety and efficacy with which these large quantities of drugs are managed. One of these approaches is the PreAVOID report, which focuses on the prevention and avoidance of adverse reactions and drug interactions by collect- ing and analyzing pharmaceutical care reports compiled by hospital pharmacists. According to the Japanese Society of Hospital Pharmacists, more than 20,000 such reports are issued annually. These reports are screened for abnormal clinical test values to identify which adverse reactions occur at the highest frequencies. While many hospital pharmacists scrutinize these laboratory test sheets, the awareness of clinical laboratory specialists regarding prescribed medicines is not known. We therefore invited specialists who are well versed in matters related to pharmaceutical risk management to this symposium to present the latest topics related to the influence of prescribed medicines on laboratory test values, and to discuss current issues asso- ciated with monitoring adverse events and adverse reactions. In addition, we examined potential strategies for avoiding severe adverse effects by establishing specialist teams and the role of laboratory specialists on such teams. [Review].","PeriodicalId":21457,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36824039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Usefulness of Polyethylene-Glycol Precipitation As a Screening Method for Macroprolactinemia]. [聚乙二醇沉淀法筛选巨催乳素血症的有效性]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Asuka Yamakami, Ryuya Takahashi, Chizumi Fukazawa, Chie Tanaka, Kyoko Takeda

引用次数: 0

[Middle East Respiratory Syndrome (MERS)]. [中东呼吸综合征]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Yoshitsugu Iinuma

{"title":"[Middle East Respiratory Syndrome (MERS)].","authors":"Yoshitsugu Iinuma","doi":"","DOIUrl":"","url":null,"abstract":"Middle East respiratory syndrome (MERS) is an emerging infectious disease of growing global importance, which has caused severe acute respiratory disease in more than 1,700 people, resulting in almost 600 deaths. MERS is caused by a novel betacoronavirus (MERS-CoV). All cases of MERS have been linked through travel to or residence in countries in or near the Arabian Peninsula. Dromedary camels are considered natu- ral reservoirs for MERS-CoV. MERS-CoV is mainly transmitted from infected dromedary camels to human beings, and it is transmitted among human beings by droplets, contact, and perhaps airborne spread. Both community-acquired and hospital-acquired cases have been reported with little human-to-human transmis- sion reported in the community. The largest known outbreak of MERS outside the Arabian Peninsula oc- curred in the Republic of Korea in 2015, with 186 cases. The outbreak was associated with a traveler re- turning from the Arabian Peninsula. Clinical features of MERS range from asymptomatic or mild disease to acute respiratory distress syndrome and multi-organ failure resulting in death, especially in individuals with underlying comorbidities. MERS is suspected in the presence of febrile acute respiratory illness and close contact with MERS-CoV, and can be confirmed by the detection of viral nucleic acid through RT-PCR or se- rology. No specific drug treatment exists for MERS; however, the neutralizing antibodies, ribavirin and interferon have been shown to be potentially useful anti-MERS-CoV drugs. Rigorous infection prevention and control measures with droplet and contact precautions are crucial to prevent the spread in health-care facilities. [Review].","PeriodicalId":21457,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36824568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Measures Against Hepatitis B Virus Reactivation Where Specialist Teams Collaborate]. [专家团队合作预防乙型肝炎病毒复活的措施]。

Rinsho byori. The Japanese journal of clinical pathology Pub Date : 2016-09-01

Masaharu Yamazaki

{"title":"[Measures Against Hepatitis B Virus Reactivation Where Specialist Teams Collaborate].","authors":"Masaharu Yamazaki","doi":"","DOIUrl":"","url":null,"abstract":"Recently, hepatitis B virus (HBV) reactivation has attracted attention as a complication of cancer chemo- therapy or immunosuppressive therapy. To prevent hepatitis B due to HBV reactivation, practical guide- lines were issued in 2009. The guidelines include the relevant diagnostic algorithms for HBV markers (HBsAg, anti-HBc, anti-HBs, and HBV-DNA). Nonetheless, cases of acute liver failure due to HBV reacti- vation have occurred in Japan since 2009, likely because many of the physicians prescribing anti-cancer or immunosuppressive agents have not acted in conformity with the guidelines. The reasons for this non- conformance are considered to be as follows: First, the incidence of HBV reactivation varies markedly be- tween anti-cancer or immunosuppressive agents, and many physicians are simply not aware of this risk. Second, establishing a system for assessing compliance to the guidelines is complicated because it requires integrating both prescription data and HBV marker data, and then feeding back this information to physicians. Several medical faculties have established a survey system by establishing specialist teams comprising a hepatologist, pharmacist, laboratory technician, medical information manager, and other specialists. The multidisciplinary nature of these teams means that the actions of individuals are complemented and supported by the team as a whole and problems are resolved through teamwork. The role of clinical laboratory special- ists is likely to become more important, as their commitment to teamwork means that they are highly capable of supporting the development of clinical risk management initiatives. [Review].","PeriodicalId":21457,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36824042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0