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Epilepsy associated with low-grade brain glial neoplasms. 癫痫与低级别脑胶质肿瘤相关。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
J Nĕmecková, S Nĕmecek, J Náhlovský, J Parízek, M Sercl
{"title":"Epilepsy associated with low-grade brain glial neoplasms.","authors":"J Nĕmecková,&nbsp;S Nĕmecek,&nbsp;J Náhlovský,&nbsp;J Parízek,&nbsp;M Sercl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 1991-1993, 52 patients underwent surgery for low-grade supratentorial glioma. In 37 of them (astrocytoma 22, oligodentrocytoma 12, oligodendroglioma 2) seizures, often refractory to drug therapy, appeared as the first symptom. These cases were retrospectively analyzed. The patients had partial seizures: simple, complex, or secondarily generalized (preoperative duration: from 3 days to 17 years (mean 2 years); frequency: between 1 and 2/year and over 10/day). Neurological examination either revealed slight focal changes or was normal. Conventional craniotomy and resection of a tumor, without intraoperative electrocorticography, was performed. Partial resection was performed in 73%, subtotal in 5%, \"total\" in 22% of the cases. Postoperatively, 27 patients had focal radiotherapy, 3 of them in combination with chemotherapy. Two patients were reoperated. Out of 33 alive (89%), about two-thirds appear normal by neurological examination and are seizure-free at present (mean follow-up period 28 months). Most remain on antiepileptic drugs at lower doses. Histological and immunohistochemical analyses of resected tissue together suggest that the peripheral zone of cortical tumor infiltration may participate on epileptogenesis.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 4","pages":"175-83"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19668776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum level of IL-6 in patients with primary and secondary Sjögren's syndrome. 原发性和继发性Sjögren综合征患者血清IL-6水平的变化。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
R Slezák, J Krejsek, O Kopecký, H Jelenová
{"title":"Serum level of IL-6 in patients with primary and secondary Sjögren's syndrome.","authors":"R Slezák,&nbsp;J Krejsek,&nbsp;O Kopecký,&nbsp;H Jelenová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The level of interleukin-6 in the serum of 17 patients suffering from the primary Sjögren's syndrome and of 16 with secondary Sjögren's syndrome were determined by means of ELISA. The mean value of IL-6 in primary and secondary Sjögren's syndrome was 2.41 pg/ml (1.45-3.37 pg/ml) and 3.01 pg/ml (1.63-4.39 pg/ml). The normal serum level of IL-6 was below 3.0 pg/ml. The serum level of IL-6 was not elevated in Sjögren's syndrome patient, there was no significant difference in the serum level of IL-6 between both groups of the patients.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 2","pages":"59-60"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19564720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam. N-(3,5-二甲氧基-4-丙氧基苯基-乙基)氮吡啶的惊厥性质及安定和三唑仑对其的影响。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
J Herink
{"title":"Convulsive properties of N-(3,5-dimethoxy-4-propoxyphenyl-ethyl) aziridine and their influencing by diazepam and triazolam.","authors":"J Herink","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Convulsive activity of N-(3,5-dimethoxy-4-propoxy-phenyl-ethyl)-aziridine (FAZ-4), a newly synthetized aziridine compound was studied in rats. There is a lack of tonic component of major paroxysm in comparison with the classical convulsive agent pentylenetetrazol. This effect of FAZ-4 is probably due to the forebrain mechanism without the midbrain involvement. Both anticonvulsants tested suppressed seizures in a different manner, however triazolam exerted stronger anticonvulsive activity than the same dose of diazepam did.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 2","pages":"85-8"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19565242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impedance monitoring in the stereotactic localization of intracranial structures. 阻抗监测在颅内结构立体定位中的应用。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
V Hobza, J Jakubec, J Nĕmecková, S Nĕmecek, M Sercl
{"title":"Impedance monitoring in the stereotactic localization of intracranial structures.","authors":"V Hobza,&nbsp;J Jakubec,&nbsp;J Nĕmecková,&nbsp;S Nĕmecek,&nbsp;M Sercl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Measurement of tissue impedance is a simple objective method for the localization of intracranial structures. Continuous bipolar impedance monitoring was performed during various CT-guided stereotactic procedures in 36 patients with brain pathology. The obtained values of the impedance profile along the trajectory were compared with the tissue density on CT scans or angled coronal and sagital CT reconstructions intraoperatively. The main goal was the selection of optimal biopsy targets and safe probe trajectory. Histologic findings of serial transtumoral biopsy were retrospectively correlated with both CT (or MRI) transposed data and patterns of tissue impedance. Intraoperative impedance monitoring enhanced the accuracy and safety of CT-guided procedures. The histologic examination of representative tissue samples avoids the risks of \"blind\" surgical or radiation management. This technique is reported with 6 illustrative cases.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 1","pages":"33-46"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18576096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraadrenal pheochromocytoma. Extraadrenal嗜铬细胞瘤。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
J Base, J Sváb
{"title":"Extraadrenal pheochromocytoma.","authors":"J Base,&nbsp;J Sváb","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During 35 years we operated on 44 patients with pheochromocytoma, 16 of them had extraadrenal tumors (36%). We operated on 8 men and 8 women. In 5 men there was primary extraadrenal tumor, the same in 7 women. In 3 men and in one woman we operated on recurrence of tumor on another site. Mean age of the whole group was 38.3 years, in patients with recurrence the mean age was 44 years. Time distance between primary tumor and relapse was 3 to 16 years. We operated on 6 tumors on the right side, 10 on the left side. Paragangliomas on the right side were localized as follows: three tumors were under the vena cava, one tumor was dispersed multifocally, two tumors were localized before the vena cava. On the left side there was the following distribution of tumors: two tumors beneath the bifurcation of the aorta, 5 tumors paraaortally, one tumor on the wall of the aorta in the region of renal arteries, three tumors were localized in the hilus of the kidney.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 1","pages":"47-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18576097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histochemical localization of succinate dehydrogenase in intracerebral mouse submandibular gland transplants. 鼠脑内颌下腺移植后琥珀酸脱氢酶的组织化学定位。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
B Pospisilová, O Procházková, I Kubisová, D Slizovă, P Bílek
{"title":"Histochemical localization of succinate dehydrogenase in intracerebral mouse submandibular gland transplants.","authors":"B Pospisilová,&nbsp;O Procházková,&nbsp;I Kubisová,&nbsp;D Slizovă,&nbsp;P Bílek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Histochemical localization of succinate dehydrogenase in developing intracerebral auto- and homotransplants of the mouse submandibular gland was investigated in the course of a 5-month period after transplantation. Eight weeks after grafting, the enzyme pattern in the parenchyma of homotransplants was comparable with the histochemical picture of a fully mature submandibular gland in situ. At this time, numerous acini showed a weak activity, very numerous striated ducts a strong activity, and less frequent developing convoluted granular tubules slightly weaker activity, than in the striated ducts. Beginning histochemical differentiation of convoluted granular tubules was noted only in homotransplants, located in the brain of male recipients. On the other hand, only a weak activity in the cytoplasm of non-differentiated duct--like structures of some autotransplants was seen. Homotransplants of non-differentiated submandibular gland of newborn donors were found to be a more suitable transplantation object capable of postnatal development of gland parenchyma than autografts of fully differentiated gland of adult animals that did not enter the cytodifferentiation stage.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 2","pages":"71-7"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19565239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migraine--a haematological disorder? 偏头痛——一种血液系统疾病?
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
J Malý, M Pecka, D Krajiickova, O Siroký, L Jebavý, M Bláha
{"title":"Migraine--a haematological disorder?","authors":"J Malý,&nbsp;M Pecka,&nbsp;D Krajiickova,&nbsp;O Siroký,&nbsp;L Jebavý,&nbsp;M Bláha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We analysed 22 patients suffering from migraine to evaluate the possible activation of platelet function utilizing the following methods: platelet factor 4, thromboxane B2 and 6 - keto prostaglandin F 1 alpha levels in platelet poor plasma. Laboratory tests were performed on all patients during headache-free period and the results obtained were compared with those of a normal healthy individuals. The mean results obtained in the patients group during pain-free period indicated a significant activation of platelet function when compared with the normal group.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 3","pages":"105-6"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19660225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Czech version of the inventory of learning processes. 捷克版的学习过程清单。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
J Mares, H Skalská, M Rybárová
{"title":"A Czech version of the inventory of learning processes.","authors":"J Mares,&nbsp;H Skalská,&nbsp;M Rybárová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A Czech version of the Schmeck's ILP inventory was administered to 1898 university and college students from Bohemia, Moravia and Slovakia. Factor analysis identified six factors which explained 73% of data variance. The Czech version is shorter as compared to the original and includes 49 items; its reliability is satisfactory. Our experience showed that ILP-CZ inventory could be used in senior classes of secondary (high) schools, and in both undergraduate and graduate studies. The inventory can be used both for screening at the beginning of university and/or college studies and counselling services offered during the study.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 3","pages":"135-9"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19660853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cultivation of neural EGF-responsive precursor cells. 神经egf反应性前体细胞的培养。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
J Mokrý, D Subrtová, S Nĕmecek
{"title":"Cultivation of neural EGF-responsive precursor cells.","authors":"J Mokrý,&nbsp;D Subrtová,&nbsp;S Nĕmecek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We demonstrated that proliferation of dissociated neural E14 and E19 rat precursor cells could be induced by Long-EGF. Dividing EGF-responsive neural progenitor cells stimulated by Long-EGF formed spherical multicellular clusters (neurospheres) which may reach macroscopical size. We have studied the inner organization of cells in semithin sections and revealed that the cell population within the neurosphere is not uniform. These are original findings as other researchers did not process neurospheres histologically. Cells located in a central area possessed neuron-like morphology whereas peripheral cells where differentiated to a lesser degree. Generally, we have observed several apoptotic cells or apoptotic bodies per section. Moreover, the central portion of the neurosphere contained degenerating cells that probably die from worsened nutrition conditions in the large neurosphere. After plating the neurosphere in serum-supplemented medium, cells began to migrate radially from the edge of the neurosphere and differentiate. The cells lying in the vicinity to the cluster mimicked radial glia whereas the cells located at the periphery of the colony took morphology of astroglial cells. These observations suggest EGF-responsive neural precursor cells retained their ability to produce both neuronal and glial phenotypes after prolonged cultivation period.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 4","pages":"167-74"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19668775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the immune status in patients with primary and secondary Sjögren's syndrome. 原发性和继发性Sjögren综合征患者免疫状态的评价。
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove Pub Date : 1995-01-01
R Slezák, J Krejsek, O Kopecký, I Drízhal
{"title":"Evaluation of the immune status in patients with primary and secondary Sjögren's syndrome.","authors":"R Slezák,&nbsp;J Krejsek,&nbsp;O Kopecký,&nbsp;I Drízhal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The total white blood cell count, percentage and total count of lymphocytes, CD3+, CD4+, and CD8+ subpopulations of T-lymphocytes, population of CD20+ B-lymphocytes, the ability of polymorphonuclears to phagocyte yeasts, the ability of polymorphonuclear cells to kill serum-resistant strain of E. coli and O2-dependent killing capacity of polymorphonuclears were evaluated in a group of 10 patients with the sicca syndrome and in a group of 9 patients with secondary Sjögren's syndrome and in a healthy control group. There was found a significant decrease in the relative and absolute counts of CD4+ helper/inducer T cells and in the activity of phygocytic cells in both groups of patients with Sjögren's syndrome as compared with the control group. There was no significant difference in the evaluated parameters between primary and secondary Sjögren's syndrome patients.</p>","PeriodicalId":21432,"journal":{"name":"Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove","volume":"38 1","pages":"11-2"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18576091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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