Sarcoidosis, Vasculitis, and Diffuse Lung Diseases最新文献

{"title":"Management of high-degree atrioventricular block in the setting of cardiac sarcoidosis: A therapeutic controversy.","authors":"Kenan Yalta, Muhammet Gurdogan","doi":"10.36141/svdld.v39i4.13721","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.13721","url":null,"abstract":"","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10380764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infliximab decreases inflammatory activity but has no effect on small fiber neuropathy related symptoms in Dutch patients with sarcoidosis","authors":"Lisette Raasing,&nbsp;Oscar J M Vogels,&nbsp;Marcel Veltkamp,&nbsp;Jan C Grutters","doi":"10.36141/svdld.v39i4.12031","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.12031","url":null,"abstract":"<p><strong>Background and aim: </strong>Small fiber neuropathy (SFN) may present as complication in sarcoidosis.(1) SFN can potentially result into a large range of symptoms with a high impact on quality of life.(2) Although treatment of the underlying disease of SFN is paramount, little research has been performed to investigate SFN improvement as consequence of sarcoidosis treatment. This retrospective study investigates whether there is an association between the anti-inflammatory effects of infliximab and SFN-symptoms Methods: The Small Fiber Neuropathy Screening List (SFNSL) was used to measure changes in SFN symptoms during infliximab treatment. Maximal standardized uptake value (SUVmax) from Fluordeoxyglucose Positron Emission Tomography (FDG-PET) was used as a measure for inflammatory activity.</p><p><strong>Results: </strong>36 sarcoidosis patients were eligible for analysis. SFNSL-score showed a mean decrease of -1,9 points (p = 0.446). SUVmax did improve with a mean of -3.7 (p<0.001). No correlation between a decrease of SUVmax and SFNSL screening list could be found (p=0.610).</p><p><strong>Conclusions: </strong>Our data reveal no association between anti-inflammatory effect of infliximab and SFN-related symptoms in patients with sarcoidosis, which contradicts previous case-reports and case-series.(3-6) Given the major negative impact of SFN-related symptoms on the quality of life in patients with sarcoidosis, it is necessary that the possible beneficial effect of anti-inflammatory therapy will be further addressed in future prospective studies.1.</p>","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/de/SVDLD-39-33.PMC9798340.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of computed tomography findings, complete blood count parameters and systemic inflammatory markers for predicting the severity in interstitial lung diseases.","authors":"İbrahim Sulku,&nbsp;Çiğdem Özer Gökaslan","doi":"10.36141/svdld.v39i4.11616","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.11616","url":null,"abstract":"<p><strong>Background and objectives: </strong>The present study aimed to find quantitative and semiquantitative methods to detect the development of fibroproliferative processes at an early stage and predict the severity and prognosis of the disease in interstitial lung diseases (ILDs) using High-Resolution Computed Tomography (HRCT), Pulmonary Function Tests (PFTs) and Complete Blood Count (CBC) parameters.</p><p><strong>Materials and methods: </strong>A total of 63 patients (26 female and 37 male) who were admitted to our hospital between January 2014 and January 2018, whose follow-ups were regular and who underwent HRCT, PFT, and CBC examinations on the same day, were included in our study. The median age of the patients included was 65 years (range: 47-79).</p><p><strong>Results: </strong>There were significant differences among the mild, moderate, and severe form ILD groups created using the Warrick scoring system for NLR, neutrophil count, and PNR values (p = 0.025, 0.035, 0.006, respectively). Also, there were significant differences among the groups for FVC, FEV1/FVC, PAD, RAA, RV/LV ratio, MLnMD, and MLnC values. Correlation analyses between the parameters revealed significant relationships between Warrick Score, and NLR and neutrophil count, PNR, FVC, FEV1/FVC, PAD, RAA, RV/LV ratio, MLnMD, and MLnC .</p><p><strong>Conclusions: </strong>The results of the present study suggested that NLR, neutrophil count, and PNR values could be used as objective evaluation criteria to determine the severity and prognosis in interstitial lung diseases. Also, usage of Warrick Score, FVC, FEV1/FVC, PAD, RAA, RV/LV ratio, MLnMD, and MLnC values could provide quantitative and semiquantitative data for an objective evaluation. Carrying out multicenter studies and creating a scoring system using these parameters could create standardization in determining the prognosis of patients with ILD.</p>","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10372060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chylothorax associated with sarcoidosis: a review of the literature.","authors":"Lilach Israeli-Shani,&nbsp;Daniel King,&nbsp;Gali Epstein Shochet,&nbsp;David Shitrit,&nbsp;Ori Wand","doi":"10.36141/svdld.v39i4.12050","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.12050","url":null,"abstract":"<p><strong>Objective: </strong>To review the medical literature regarding chylothorax associated with sarcoidosis.</p><p><strong>Methods: </strong>A literature review of all reported cases of sarcoidosis-associated chylothorax, we included a novel case report to the analysis.</p><p><strong>Results: </strong>Of sixteen cases included in the study, 10 were women (62.5%), mean age 47±17years. In 6 subjects (37.5%) chylothorax was part of the initial presentation of sarcoidosis. Four subjects (25%) additionally suffered from lymphedema and chylous ascites, and one from chylous ascites only. Thoracic lymphadenopathy was reported for 13/16 subjects (81.3%) and lung parenchymal disease in 8/16 (50%). Compression of the thoracic duct was considered as a causative factor in 10 cases (62.5%). One case was attributed to granulomatous pleural inflammation, one to generalized lymphangiectasia, and no specific causative factors were identified in 4 remaining cases (25%). Overall mortality rate was 18.8% (3/16 subjects). Of note, all the subjects treated with corticosteroids survived.</p><p><strong>Conclusions: </strong>Since the association of sarcoidosis with chylothorax is exceedingly rare, alternative etiologies should be pursued even when chylothorax develops in a subject with preexisting sarcoidosis. However, the possibility of sarcoidosis should be entertained when other etiologies for a newly diagnosed chylothorax are ruled out. A multidisciplinary approach is required for optimal management, both for elucidating the diagnosis and for employing therapy, which could be multimodal. A trial of immunosuppressive therapy with corticosteroids should be considered.</p>","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10380763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Atherogenic indices can predict atherosclerosis in patients with sarcoidosis.","authors":"Luigi Rizzi,&nbsp;Carlo Sabbà,&nbsp;Patrizia Suppressa","doi":"10.36141/svdld.v39i4.13372","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.13372","url":null,"abstract":"We read with great interest the article “Atherogenic indices can predict atherosclerosis in patients with sarcoidosis” (1) recently published on your journal. In this study, authors described the possibility to assess subclinical atherosclerosis in sarcoidosis patients by evaluating atherogenic indices and some specific parameters of common carotid artery Doppler ultrasonography: a morphological one, intima-media thickness (IMT) and a hemodynamic one, peak systolic velocity (PSV). Focusing on PSV, authors found that sarcoidosis group showed higher values of PSV than controls and that PSV was positively correlated with IMT and atherogenic indices; thus, they concluded that also PSV might be considered a useful predictor for atherosclerosis and cardiovascular diseases (CVD) in asymptomatic sarcoidosis patients. This finding, in the opinion of the authors, is based on the concept that PSV values increase at the level of a vascular stenosis such as in the carotid district (2). However, in our opinion PSV could be indicative of an increased risk of atherosclerosis and cardiovascular risk when it shows a tendency to reduction rather than increase. About that, Chuang et al. (3) studied the behavior of PSV and end diastolic velocity (EDV) of common carotid artery in 3146 Taiwanese adults, of which 220 presented ischemic heart disease and 247 presented strokes, during a median follow-up of 12.8 years. They reported that low common carotid PSV and EDV were independently associated with future cardiovascular disease: in detail, PSV (<65 cm/sec vs ≥80 cm/sec) was associated with CVD ( Hazard ratio: 3.23, 95% confidence intervals: 2.51–4.15, p < 0.0001) while EDV (<15 cm/s vs ≥ 20 cm/s) showed even greater accuracy in identifying CVD ( Hazard ratio: 4.54, 95% confidence intervals: 3.51–5.85, p < 0.0001). Similarly, König et al. (4) demonstrated that lower PSV of common carotid artery was associated with coronary heart disease (CHD): the study of a group of 27 patients with established CHD and of 30 individuals without symptoms suggestive of CHD, highlighted that mean PSV values were lower in the first group than in the control group (mean values: 53.6 cm/sec and 62.8 cm/ sec respectively; p = 0.042). Moreover, Park et al. (5) found an inverse correlation between common carotid PSV and IMT in a cohort of 426 healthy adults. In light of these considerations, findings about a higher PSV in sarcoidosis patients than controls and its positive correlation with IMT appear in contrast with the remaining conclusions of the authors that identify sarcoidosis as a probable predisposing factor for atherosclerosis. A possible reason of this discordance can be found in the lack of data inherent to the duration of the disease: in fact, it’s not possible to exclude that sarcoidosis patients included in this study presented a quite recent onset of the disease. Thus, it is reasonable to hypothesize that microvascular damage may not be still completely traceable in the hemodynam","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10380765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous immunoglobulin for acute exacerbation of fibrotic idiopathic interstitial pneumonias.","authors":"Hisao Higo,&nbsp;Hirohisa Ichikawa,&nbsp;Naoki Nakamura,&nbsp;Masanori Fujii,&nbsp;Katsuhiro Matsuoka,&nbsp;Shoko Seki,&nbsp;Takamasa Wada,&nbsp;Noriyuki Suzaki,&nbsp;Takuya Nagata,&nbsp;Yukako Arakawa,&nbsp;Yoshihiro Mori,&nbsp;Masaomi Marukawa,&nbsp;Katsuyuki Kiura,&nbsp;Yoshinobu Maeda,&nbsp;Nobuaki Miyahara","doi":"10.36141/svdld.v39i4.13682","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.13682","url":null,"abstract":"<p><strong>Background and aim: </strong>Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a fatal condition with no established treatment. Intravenous immunoglobulin (IVIG) is a unique therapy with both anti-inflammatory and anti-infective effects. Therefore, we hypothesized that IVIG may have a positive effect on AE of interstitial pneumonia. This study aimed to determine the effect of IVIG in patients with AE of fibrotic idiopathic interstitial pneumonias (IIPs), including IPF.</p><p><strong>Methods: </strong>We retrospectively analyzed consecutive patients who were diagnosed with AE of fibrotic IIPs and treated with pulse corticosteroid therapy (methylprednisolone 500-1000 mg/day for 3 days) between April 2018 and May 2021 at Kagawa Rosai Hospital and KKR Takamatsu Hospital.</p><p><strong>Results: </strong>This study included 52 patients with AE of fibrotic IIPs (IPF,41; fibrotic IIPs other than IPF,11). Thirteen patients received IVIG (5 g/day for 3-5 days) concurrently with pulse corticosteroid therapy. The remaining 39 patients were assigned to the control group. The survival rate on day 90 was significantly higher in the IVIG group than that in the control group (76.9% vs. 38.5%, p = 0.02). IVIG administration (odds ratio [OR], 0.11; 95% confidence interval [CI], 0.02-0.69; p = 0.02) and C- reactive protein (OR, 1.19; 95% CI, 1.06-1.33, p < 0.01) were independently associated with 90-day mortality.</p><p><strong>Conclusions: </strong>The results indicate that administration of IVIG may improve the survival of patients with AE of fibrotic IIPs. We are now conducting a prospective study to confirm the effect of IVIG on AE of IPF since May 2022 (jRCT1061220010).</p>","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/20/SVDLD-39-38.PMC9798342.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10859568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges.","authors":"Pierluigi Brugnaro,&nbsp;Francesca Cattelan,&nbsp;Erika Morelli,&nbsp;Andrea Petrucci,&nbsp;Alessandro Marocco,&nbsp;Sandro Panese,&nbsp;Pietro Maria Donisi,&nbsp;Giovanni Capitanio,&nbsp;Mauro Tollot","doi":"10.36141/svdld.v39i4.11350","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.11350","url":null,"abstract":"<p><p>Sarcoidosis is a systemic granulomatous disease, sometimes characterized by an extrapulmonary localization in 30 - 50% of cases. We describe a 60-year-old Italian man with an unexplained history of fatigue, ascitis and progressive renal function impairment. Diagnosis of hepatic and bone marrow sarcoidosis was established by histology, and fast improvement of renal function was obtained after starting  corticosteroid therapy. Atypical presentation and simultaneous involvement of liver, bone marrow and kidneys make diagnosis of extrapulmonary sarcoidosis still a diagnostic challenge. Delayed diagnosis could lead to serious organ damage like a progressive severe kidney failure.</p>","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10372061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metagenomic sequencing of the bronchoalveolar lavage extracellular virome and cellular transcriptome of sarcoidosis patients does not detect rubella virus.","authors":"Emma L Keeler,&nbsp;Milica Vukmirovic,&nbsp;Xiting Yan,&nbsp;Kristin Gulino,&nbsp;Elodie Ghedin,&nbsp;Naftali Kaminski,&nbsp;Kathleen E Sullivan,&nbsp;Frederic D Bushman,&nbsp;Ronald G Collman,&nbsp;Misha Rosenbach","doi":"10.36141/svdld.v39i4.13407","DOIUrl":"https://doi.org/10.36141/svdld.v39i4.13407","url":null,"abstract":"<p><strong>Background: </strong>  Sarcoidosis is a multisystem granulomatous inflammatory disease of unclear etiology that involves the lung, skin and other organs, with an unknown antigenic trigger. Recently, evidence has been found in both immune deficient and immune competent patients for rubella virus in cutaneous granulomas. These granulomatous lesions share overlapping features with cutaneous sarcoidosis, raising the question of rubella virus in sarcoidosis.</p><p><strong>Objective: </strong>To investigate the presence of rubella virus in sarcoidosis lung samples.</p><p><strong>Methods: </strong>We employed metagenomic sequencing to interrogate extracellular virome preparations and cellular transcriptomes from bronchoalveolar lavage (BAL) of 209 sarcoidosis patients for rubella virus sequences.</p><p><strong>Results: </strong>We found no evidence for rubella virus genomes in acellular fluid or rubella virus gene expression in BAL cells of sarcoidosis patients.</p><p><strong>Conclusions: </strong>These findings argue against rubella virus infection or persistence within the lung at time of sampling as a sarcoidosis trigger.</p>","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/6a/SVDLD-39-40.PMC9798337.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9177841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Syncytial Virus Enhances Hyaluronan Accumulation and TSG-6 Expression in Primary Airway Epithelial Cell and Lung Fibroblast Cocultures","authors":"S. R. Reeves, L. M. Rich, M. White, E. Vanderwall, C. Frevert, T. Wight, J. Debley","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3017","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3017","url":null,"abstract":"","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80184464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Chest Syndrome Is Associated with Obstructive Airway Pattern in Children with Sickle Cell Disease","authors":"A. Alishlash, J. Wolford, V. Tarn, P. Nourani","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3010","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3010","url":null,"abstract":"","PeriodicalId":21394,"journal":{"name":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86374557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}