肝和骨髓结节病合并进行性肾衰竭1例:诊断和治疗的挑战。

IF 1.4 4区医学 Q4 RESPIRATORY SYSTEM

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases Pub Date : 2022-12-19 DOI:10.36141/svdld.v39i4.11350

Pierluigi Brugnaro, Francesca Cattelan, Erika Morelli, Andrea Petrucci, Alessandro Marocco, Sandro Panese, Pietro Maria Donisi, Giovanni Capitanio, Mauro Tollot

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引用次数: 0

摘要

结节病是一种全身性肉芽肿性疾病，在30 - 50%的病例中有时以肺外定位为特征。我们描述了一位60岁的意大利男性，他有无法解释的疲劳、腹水炎和进行性肾功能损害的病史。经组织学诊断为肝、骨髓结节病，经皮质类固醇治疗后肾功能迅速改善。不典型的表现和同时累及肝脏、骨髓和肾脏使得肺外结节病的诊断仍然是一个诊断挑战。延迟诊断可能导致严重的器官损害，如进行性严重肾衰竭。

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A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges.

Sarcoidosis is a systemic granulomatous disease, sometimes characterized by an extrapulmonary localization in 30 - 50% of cases. We describe a 60-year-old Italian man with an unexplained history of fatigue, ascitis and progressive renal function impairment. Diagnosis of hepatic and bone marrow sarcoidosis was established by histology, and fast improvement of renal function was obtained after starting corticosteroid therapy. Atypical presentation and simultaneous involvement of liver, bone marrow and kidneys make diagnosis of extrapulmonary sarcoidosis still a diagnostic challenge. Delayed diagnosis could lead to serious organ damage like a progressive severe kidney failure.

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来源期刊

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases 医学-呼吸系统

CiteScore

2.20

自引率

6.20%

发文量

期刊介绍： Sarcoidosis Vasculitis and Diffuse Lung Disease is a quarterly journal founded in 1984 by G. Rizzato. Now directed by R. Baughman (Cincinnati), P. Rottoli (Siena) and S. Tomassetti (Forlì), is the oldest and most prestigious Italian journal in such field.