{"title":"Waiting for Godot or the use of biomarkers in clinical practice","authors":"Emilio Fernández-Egea","doi":"10.1016/j.rpsm.2021.07.003","DOIUrl":"10.1016/j.rpsm.2021.07.003","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989121000690/pdfft?md5=9a774ac2ccac73ee9bf989496b7581d3&pid=1-s2.0-S1888989121000690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84163065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carmen Dasí , Inmaculada Fuentes-Durá , Juan C. Ruiz , Marisa Navarro
{"title":"Forma corta de cuatro subtest de la WAIS-IV para la evaluación de pacientes con diagnóstico de esquizofrenia","authors":"Carmen Dasí , Inmaculada Fuentes-Durá , Juan C. Ruiz , Marisa Navarro","doi":"10.1016/j.rpsm.2019.12.004","DOIUrl":"https://doi.org/10.1016/j.rpsm.2019.12.004","url":null,"abstract":"<div><h3>Introduction</h3><p>The present study aimed to obtain a short form of the Spanish version of the WAIS-IV for patients diagnosed with schizophrenia that requires about half an hour to be administered. The reduced test can be very useful in clinical and research settings when an estimation of the intelligence quotient is required to decide about intervention programmes or to describe the sample.</p></div><div><h3>Materials and methods</h3><p>A sample of 143 patients participated in the study, 91 out of them were the test group, and the other 52 were used for a cross-validation analysis. To increase the content validity, the decision was made to create a short form composed of a subtest of each of the four cognitive domains that the scale measures.</p></div><div><h3>Results</h3><p>Several analyses showed that the best combination was composed of the Information, Block Design, Arithmetic, and Symbol Search subtests. Nine different criteria were calculated to evaluate the quality of the short form.</p></div><div><h3>Conclusions</h3><p>The data showed very good results for the criteria: correlations, difference of means, and cross-validation. The results were satisfactory for: category agreement, band of error, clinical accuracy, and reliability.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989120300173/pdfft?md5=9084896e730d1b95687090350b57261d&pid=1-s2.0-S1888989120300173-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91975857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Rey Souto , Justo Pinzón Espinosa , Eduard Vieta , Antoni Benabarre Hernández
{"title":"Clozapina en pacientes con trastorno esquizoafectivo: una revisión sistemática","authors":"Diana Rey Souto , Justo Pinzón Espinosa , Eduard Vieta , Antoni Benabarre Hernández","doi":"10.1016/j.rpsm.2020.05.003","DOIUrl":"10.1016/j.rpsm.2020.05.003","url":null,"abstract":"<div><p>Schizoaffective disorder is defined by the appearance of positive psychotic symptomatology as well as affective features, even when it is considered a controversial nosologic entity, proving difficult to accord on its definition or diagnostic criteria. Due to these conceptual differences, it has been a challenge to study effective therapeutic measures and, consequently, the availability of data in the current literature, resulting in the extrapolation of clinical guidelines and recommendations initially established for patients with schizophrenia or bipolar disorder. The current study aimed to systematically search and summarize the published evidence to date about the use of clozapine in patients with schizoaffective disorder. Seven studies were identified, that are heterogeneous on their designs and methodology, including samples of patients mixed with bipolar or schizophrenic disorders. The evidence was summarized both in a table and a narrative fashion, suggesting that clozapine may be an effective treatment for both psychotic and affective symptoms, indistinctively of an acute or maintenance phase.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989120300598/pdfft?md5=c702f32be2be6b8173b5fcd8ffab4847&pid=1-s2.0-S1888989120300598-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83511138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María del Carmen Vallejo-Curto , Daniela Rodrigues-Amorim , Laura Jardón-Golmar , María Blanco-Formoso , Tania Rivera-Baltanás , Cynthia Rodriguez-Jamardo , Patricia Fernández-Palleiro , María Álvarez-Ariza , Marta López-García , Alejandro García-Caballero , Elena de las Heras , José Manuel Olivares , Carlos Spuch
{"title":"Perfil proteómico y metabólico de pacientes crónicos con esquizofrenia tras un programa de actividad física: estudio piloto","authors":"María del Carmen Vallejo-Curto , Daniela Rodrigues-Amorim , Laura Jardón-Golmar , María Blanco-Formoso , Tania Rivera-Baltanás , Cynthia Rodriguez-Jamardo , Patricia Fernández-Palleiro , María Álvarez-Ariza , Marta López-García , Alejandro García-Caballero , Elena de las Heras , José Manuel Olivares , Carlos Spuch","doi":"10.1016/j.rpsm.2020.11.001","DOIUrl":"10.1016/j.rpsm.2020.11.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Schizophrenia is a chronic illness often accompanied by metabolic disorders, diabetes, obesity and cardiovascular problems often associated with unhealthy lifestyles, as well as neuroendocrine problems caused by the disease itself. Lifestyle changes, such as regular physical exercise, have a positive effect on metabolic disorders and mental health, although the molecular changes that occur in this type of patient and how they explain the changes in their response are unknown. This study wants to analyze in a novel way the proteins and molecular pathways involved in critical plasmatic proteins in plasma to reveal the pathways involved in the implementation of physical exercise and the changes that occur among patients who participate in such programs with those who leave.</p></div><div><h3>Methods</h3><p>Twenty-one patients with chronic schizophrenia underwent a daily, 6-month aerobic training program. We divided them into a group that completed the program (12 patients) and a second group that left the training program (9 patients). The biochemical and clinical data of each patient were analyzed and the proteomic profile of the plasma was studied using ESI-LC-MS/MS.</p></div><div><h3>Results</h3><p>Proteomic analysis recognizes 21.165 proteins and peptides in each patient, of which we identified 1,812 proteins that varied between both groups linked to the metabolic and biological regulation pathways. After clinical analysis of each patient we found significant differences in weight, BMI, abdominal perimeter, diastolic blood pressure, and HDL cholesterol levels. The main change that vertebrates both groups is the Self-Assessment Anhedonia Scale, where we detected higher levels in the dropout group (no physical activity) compared to the active group.</p></div><div><h3>Conclusion</h3><p>The benefits of physical exercise are clear in chronic patients with schizophrenia, as it substantially improves their BMI, as well as their clinical and biochemical parameters. However, our study reveals the biological and molecular pathways that affect physical exercise in schizophrenia, such as important metabolic proteins such as ApoE and ApoC, proteins involved in neuronal regulation such as tenascin and neurotrophins, neuroinflammatory regulatory pathways such as lipocalin-2 and protein 14-3-3, as well as cytoskeleton proteins of cells such as spectrins and annexines. Understanding these molecular mechanisms opens the door to future therapies in the chronicity of schizophrenia.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1888989120301245/pdfft?md5=302453eb95cf6240092a6d5d86e331f6&pid=1-s2.0-S1888989120301245-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73834814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychiatrists as internists: Some considerations following a COVID-19 redeployment experience","authors":"Jorge Gómez-Arnau, Raúl González-Lucas, Patricia Sánchez-Páez","doi":"10.1016/j.rpsm.2020.07.001","DOIUrl":"10.1016/j.rpsm.2020.07.001","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2020.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9228797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Pablo Carrasco , Borja Herraiz , Laura O. Sanchez , Ana Luengo , Oriol R. Fusalba , Eduardo J. Aguilar
{"title":"COVID-19 lockdown influence in the psychiatric emergencies: Drastic reduction and increase in severe mental disorders","authors":"Juan Pablo Carrasco , Borja Herraiz , Laura O. Sanchez , Ana Luengo , Oriol R. Fusalba , Eduardo J. Aguilar","doi":"10.1016/j.rpsm.2020.11.003","DOIUrl":"10.1016/j.rpsm.2020.11.003","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2020.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9289311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mental health interventions for healthcare workers during the first wave of COVID-19 pandemic in Spain","authors":"Amador Priede , Inés López-Álvarez , Diego Carracedo-Sanchidrián , César González-Blanch","doi":"10.1016/j.rpsm.2021.01.005","DOIUrl":"10.1016/j.rpsm.2021.01.005","url":null,"abstract":"<div><h3>Objective</h3><p>In order to reduce distress associated with working with COVID-19 patients, several psychological intervention programmes for healthcare workers have been developed in Spain. We aimed to describe the main characteristics and components of these programmes for healthcare workers treating COVID-19 patients in Spanish hospitals.</p></div><div><h3>Material and methods</h3><p>An online survey was designed to evaluate the main characteristics of psychological intervention programmes for healthcare workers during the first wave of COVID-19 pandemic.</p></div><div><h3>Results</h3><p>Valid responses were received from 36 hospitals. Most of these programmes offered both in-person and online therapy. The most common aim of these interventions was emotional regulation, which was treated by psychoeducational and cognitive-behavioural techniques in individual interventions. Group interventions mainly used psychoeducation and mindfulness. Only half of the teams that offered in-person interventions received training in the proper use of personal protective equipment.</p></div><div><h3>Conclusions</h3><p>Several hospitals in Spain have developed mental health interventions for healthcare workers during the COVID-19 pandemic, deploying a wide range of therapeutic modalities and techniques. The rapid implementation of these programmes during the pandemic suggests that safety may not have received sufficient attention. The planning and development of interventions for healthcare workers during pandemics merits greater attention by national and regional authorities and institutions.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9235065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jordi Alonso , Gemma Vilagut , Philippe Mortier , Montse Ferrer , Itxaso Alayo , Andrés Aragón-Peña , Enric Aragonès , Mireia Campos , Isabel D. Cura-González , José I. Emparanza , Meritxell Espuga , Maria João Forjaz , Ana González-Pinto , Josep M. Haro , Nieves López-Fresneña , Alma D. Martínez de Salázar , Juan D. Molina , Rafael M. Ortí-Lucas , Mara Parellada , José Maria Pelayo-Terán , Víctor Pérez-Solà
{"title":"Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey","authors":"Jordi Alonso , Gemma Vilagut , Philippe Mortier , Montse Ferrer , Itxaso Alayo , Andrés Aragón-Peña , Enric Aragonès , Mireia Campos , Isabel D. Cura-González , José I. Emparanza , Meritxell Espuga , Maria João Forjaz , Ana González-Pinto , Josep M. Haro , Nieves López-Fresneña , Alma D. Martínez de Salázar , Juan D. Molina , Rafael M. Ortí-Lucas , Mara Parellada , José Maria Pelayo-Terán , Víctor Pérez-Solà","doi":"10.1016/j.rpsm.2020.12.001","DOIUrl":"10.1016/j.rpsm.2020.12.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Healthcare workers are vulnerable to adverse mental health impacts of the COVID-19 pandemic. We assessed prevalence of mental disorders and associated factors during the first wave of the pandemic among healthcare professionals in Spain.</p></div><div><h3>Methods</h3><p>All workers in 18 healthcare institutions (6 AACC) in Spain were invited to web-based surveys assessing individual characteristics, COVID-19 infection status and exposure, and mental health status (May 5 – September 7, 2020). We report: probable current mental disorders (Major Depressive Disorder-MDD- [PHQ-8≥10], Generalized Anxiety Disorder-GAD- [GAD-7≥10], Panic attacks, Posttraumatic Stress Disorder –PTSD- [PCL-5≥7]; and Substance Use Disorder –SUD-[CAGE-AID≥2]. Severe disability assessed by the Sheehan Disability Scale was used to identify probable “disabling” current mental disorders.</p></div><div><h3>Results</h3><p>9,138 healthcare workers participated. Prevalence of screen-positive disorder: 28.1% MDD; 22.5% GAD, 24.0% Panic; 22.2% PTSD; and 6.2% SUD. Overall 45.7% presented any current and 14.5% any disabling current mental disorder. Workers with pre-pandemic lifetime mental disorders had almost twice the prevalence than those without. Adjusting for all other variables, odds of any disabling mental disorder were: prior lifetime disorders (TUS: OR=5.74; 95%CI 2.53-13.03; Mood: OR=3.23; 95%CI:2.27-4.60; Anxiety: OR=3.03; 95%CI:2.53-3.62); age category 18-29 years (OR=1.36; 95%CI:1.02-1.82), caring “all of the time” for COVID-19 patients (OR=5.19; 95%CI: 3.61-7.46), female gender (OR=1.58; 95%CI: 1.27-1.96) and having being in quarantine or isolated (OR= 1.60; 95CI:1.31-1.95).</p></div><div><h3>Conclusions</h3><p>One in seven Spanish healthcare workers screened positive for a disabling mental disorder during the first wave of the COVID-19 pandemic. Workers reporting pre-pandemic lifetime mental disorders, those frequently exposed to COVID-19 patients, infected or quarantined/isolated, female workers, and auxiliary nurses should be considered groups in need of mental health monitoring and support.</p></div>","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2020.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Calling for the integration of children's mental health and protection into COVID-19 responses","authors":"Mireia Solerdelcoll , Celso Arango , Gisela Sugranyes","doi":"10.1016/j.rpsm.2021.02.004","DOIUrl":"10.1016/j.rpsm.2021.02.004","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santiago Ovejero , Maria Luisa Barrigon , Héctor Guadalajara , Eloísa Pérez-Santos , Enrique Baca-Garcia
{"title":"El COVID-19 y la educación de profesionales sanitarios en salud mental: desafíos en la enseñanza práctica","authors":"Santiago Ovejero , Maria Luisa Barrigon , Héctor Guadalajara , Eloísa Pérez-Santos , Enrique Baca-Garcia","doi":"10.1016/j.rpsm.2021.01.001","DOIUrl":"10.1016/j.rpsm.2021.01.001","url":null,"abstract":"","PeriodicalId":21391,"journal":{"name":"Revista de psiquiatria y salud mental","volume":null,"pages":null},"PeriodicalIF":9.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rpsm.2021.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}