Rhinology最新文献_第6页

The value of beta trace protein in CSF-leakage detection confirmed by endoscopic fluorescein evaluation. 内窥镜荧光素评估证实了β微量蛋白在脑脊液渗漏检测中的价值。

IF 4.8 2区医学

Rhinology Pub Date : 2024-12-01 DOI: 10.4193/Rhin24.160

M Habenbacher, D Sebastnik, U Moser, A Andrianakis, P Kiss, M Alsukayt, J Pock, K Walla, E Maitz, P V Tomazic

引用次数: 0

Differential proteomic expression in non-functional pituitary neuroendocrine tumours and pituitary glands. 非功能性垂体神经内分泌肿瘤和垂体腺的蛋白质组表达差异。

IF 4.8 2区医学

Rhinology Pub Date : 2024-12-01 DOI: 10.4193/Rhin24.216

N G Candy, M Ramezanpour, G Bouras, N Chegeni, T Chataway, R J Ormsby, A K Jukes, S Vreugde, P-J Wormald, A J Psaltis

{"title":"Differential proteomic expression in non-functional pituitary neuroendocrine tumours and pituitary glands.","authors":"N G Candy, M Ramezanpour, G Bouras, N Chegeni, T Chataway, R J Ormsby, A K Jukes, S Vreugde, P-J Wormald, A J Psaltis","doi":"10.4193/Rhin24.216","DOIUrl":"10.4193/Rhin24.216","url":null,"abstract":"Introduction: Pituitary neuroendocrine tumours (PitNETs) are common accounting for 10 to 25 % of all intracranial tumours. This project describes the feasibility of developing a novel membrane-based biomarker that could be used for fluorescent guided surgery. The aim was to catalogue the differential expression of membrane proteins between non-functional PitNETs and pituitary glands.Methodology: Ten pituitary gland tissue specimens were obtained from the National Institute of Health (NIH) NeuroBio-Bank and twenty non-functional PitNETs were obtained from the Northwestern University Nervous System Tumour Bank. Mass spectrometry analysis using an Orbitrap Fusion Lumos Tribrid Mass Spectrometer linked to a Dionex Ultimate 3000 UPLC system was undertaken. Data Dependent Acquisition Mass Spectrometry and Data Independent Acquisition Mass Spectrometry was then completed. Pathway enrichment analysis was performed using clusterProfiler v4.6.0. Functional enrichment analysis was conducted using Gene Ontology terms and Reactome pathways.Results: Differential expression analysis between the two groups revealed a total of 2110 significant differently expressed proteins (DEPs), with 1387 of these also having a Log2 fold change either greater than 1, or less than -1. Of the 2110 DEPs, 925 were upregulated in tumours compared to control, while 1185 were downregulated.Conclusion: We have demonstrated a proteomic comparison between non-functional PitNETs and normal pituitary glands. These results demonstrate differences consistent with contemporary literature but shows that NOTCH3 and PTPRJ are up-regulated in non-functional PitNETs compared to pituitary glands.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"750-758"},"PeriodicalIF":4.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the ciliary beating efficiency in primary diffuse chronic rhinosinusitis. 原发性弥漫性慢性鼻炎患者纤毛跳动效率的特征。

IF 4.8 2区医学

Rhinology Pub Date : 2024-12-01 DOI: 10.4193/Rhin24.101

M Renaud, A Venkatasamy, E Escudier, R Mitri-Frangieh, M Filoche, V Fournier, J-F Papon, A Coste, B Louis, E Bequignon

引用次数: 0

Adherence to olfactory training improves orthonasal and retronasal olfaction in post-COVID-19 olfactory loss. 坚持嗅觉训练可改善 COVID-19 后嗅觉缺失者的正鼻腔和反鼻腔嗅觉。

IF 4.8 2区医学

Rhinology Pub Date : 2024-12-01 DOI: 10.4193/Rhin24.233

P Boscolo-Rizzo, T Hummel, A Menini, A Maniaci, F Uderzo, L Bigolin, G Tirelli

{"title":"Adherence to olfactory training improves orthonasal and retronasal olfaction in post-COVID-19 olfactory loss.","authors":"P Boscolo-Rizzo, T Hummel, A Menini, A Maniaci, F Uderzo, L Bigolin, G Tirelli","doi":"10.4193/Rhin24.233","DOIUrl":"10.4193/Rhin24.233","url":null,"abstract":"Background: Olfactory loss (OL) has emerged as one of the most prevalent and debilitating symptoms of SARS-CoV-2 infection and long-COVID-19. The present prospective observational study aimed to evaluate the efficacy of olfactory training (OT) on orthonasal and retronasal olfactory function in a cohort of individuals with persistent post-COVID-19 OL.Methodology: Participants with post-COVID-19 olfactory impairment underwent 4 months of OT, self-assessing their smell perception and undergoing comprehensive psychophysical evaluation of orthonasal and retronasal olfaction at baseline and after training. Orthonasal olfactory function was assessed using the extended Sniffin' Sticks test battery. Retronasal olfactory function was tested with powdered aromas.Results: Among 114 participants with post-COVID-19 olfactory loss, adherence to OT was 60%. In adherents, the average increase in composite TDI score was 6.0 points compared to 2.6 points in non-adherents. Fifty-seven percent of adherent participants achieved a clinically significant improvement in TDI score (≥ 5.5 points), compared to 22% of non-adherents. In retronasal olfactoryidentification, 56% of adherents achieved a clinically significant improvement (≥ 4 points), compared to 16% of non-adherents.Conclusion: Adherence to a 4-month OT regimen can yield clinically meaningful improvements in both orthonasal and retronasal olfactory function among individuals with persistent post-COVID-19 olfactory dysfunction.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"681-688"},"PeriodicalIF":4.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sphenopalatine ganglion block for pain control after septoplasty: a systematic review and meta-analysis with trial sequential analysis. 用于鼻中隔成形术后疼痛控制的鼻中隔神经节阻滞：系统综述和荟萃分析以及试验序列分析。

IF 4.8 2区医学

Rhinology Pub Date : 2024-12-01 DOI: 10.4193/Rhin24.225

E Albazee, B AlRajhi, A Alfadhli, A M Alharran, M Al-Qudah

{"title":"Sphenopalatine ganglion block for pain control after septoplasty: a systematic review and meta-analysis with trial sequential analysis.","authors":"E Albazee, B AlRajhi, A Alfadhli, A M Alharran, M Al-Qudah","doi":"10.4193/Rhin24.225","DOIUrl":"10.4193/Rhin24.225","url":null,"abstract":"Introduction: Septoplasty corrects a deviated nasal septum (DNS) and improves nasal obstruction. Sphenopalatine ganglion block (SPGB) effectively reduces postoperative pain after septoplasty, but conclusive evidence is still lacking. This systematic review and meta-analysis aim to comprehensively evaluate the analgesic efficacy of SPGB in septoplasty patients.Methods: We systematically searched PubMed/Medline, Scopus, Web of Science, Embase, and CENTRAL from inception to April 10th, 2024. Randomized controlled trials (RCTs) were assessed using the RoB-2 tool. The primary outcomes were postoperative pain scores, analgesic consumption, surgery duration, postoperative nausea and vomiting (PONV), and patient satisfaction. Continuous data were pooled as mean difference (MD), and dichotomous data as risk ratio (RR) with a 95% confidence interval (CI) using STATA software. Additionally, trial sequential analysis (TSA) was conducted.Results: Three RCTs with 180 patients were included. Two RCTs had a 'low risk' of bias, while one RCT had 'some concerns'. The SPGB group had significantly lower postoperative pain within 24 hours compared to controls, particularly after particularly after 1-2 hours (MD = -1.85), 4-6 hours (MD = -2.02), 12 hours (MD = -2.14), and 24 hours (MD = -2.36) TSA confirmed the conclusive evidence. Analgesic use was significantly reduced in the SPGB group. No significant differences were observed in surgery duration or PONV rates between groups. Patient satisfaction was significantly higher in the SPGB group.Conclusion: SPGB demonstrates efficacy and safety in managing postoperative pain in patients undergoing septoplasty for DNS.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"642-651"},"PeriodicalIF":4.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical skills of endoscopic sinus surgery for performance assessment using the Delphi methodology. 使用德尔菲法评估内窥镜鼻窦手术的技术技能。

IF 4.8 2区医学

Rhinology Pub Date : 2024-12-01 DOI: 10.4193/Rhin23.371

M J Guldager, S A Wuyts Andersen, J Melchiors, E Prokopakis, C Hopkins, C von Buchwald

{"title":"Technical skills of endoscopic sinus surgery for performance assessment using the Delphi methodology.","authors":"M J Guldager, S A Wuyts Andersen, J Melchiors, E Prokopakis, C Hopkins, C von Buchwald","doi":"10.4193/Rhin23.371","DOIUrl":"10.4193/Rhin23.371","url":null,"abstract":"Background: In surgical residency, competence has traditionally been defined by a specified number of surgical procedures. Modern advances in medical education and surgical fellowships have challenged this approach. It is widely accepted that a definition of a skill set, enabling a systematic, competency-based assessment is mandatory in surgical education.Methodology: We conducted an international Delphi study with panelists from the European Rhinologic Society, representing 27 countries. Through four rounds, the panel reached consensus on the phrasing of an assessment tool-, for the technical skills of endoscopic sinus surgery (ESS).Results: Thirty panelists participated throughout the study. The median age of the panelists was 54 years (range 31-66 years) with a median experience of 25 years (range 6-40 years). All were experts in the field of endoscopic sinus surgery. Consensus was reached. The final assessment tool consists of 21 items with descriptive anchors.Conclusion: The assessment tool, European Endoscopic Sinus Surgery â€\" Technical Skills Assessment (EE-TSA), enables a competency-based approach to acquiring and maintaining essential elements of endoscopic sinus surgery. The international Delphi panel makes the tool internationally applicable. Further research should gather validity evidence for EE-TSA, enhancing the assessment of ESS by setting a pass/fail-standard ultimately improving surgical outcomes and patient safety.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"710-715"},"PeriodicalIF":4.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory dysfunction in patients with type 2 diabetes mellitus. 2 型糖尿病患者的嗅觉功能障碍。

IF 4.8 2区医学

Rhinology Pub Date : 2024-10-01 DOI: 10.4193/Rhin23.451

A Cardella, A Ferrulli, S Vujosevic, A Preti, F Ambrogi, I Terruzzi, A Cecamore, A Yakirevitch, A Schindler, L Luzi, F Mozzanica

{"title":"Olfactory dysfunction in patients with type 2 diabetes mellitus.","authors":"A Cardella, A Ferrulli, S Vujosevic, A Preti, F Ambrogi, I Terruzzi, A Cecamore, A Yakirevitch, A Schindler, L Luzi, F Mozzanica","doi":"10.4193/Rhin23.451","DOIUrl":"10.4193/Rhin23.451","url":null,"abstract":"Background: diabetic complications and olfactory dysfunction (OD) in patients with type 2 diabetes mellitus (T2DM) seem related. This study aims to evaluate the prevalence of OD in T2DM patients and to analyze its relationship with diabetic complications.Methods: 130 T2DM patients and 100 comparable controls were enrolled. Olfaction was evaluated using the Extended Smell Test (TDI) and the Italian brief Questionnaire of Olfactory Disorders â€\" Brief-IT-QOD. T2DM patients were divided into: \"Group 1\" patients with no complications, and \"Group 2\" patients with at least one diabetic complication. Non-parametric tests were used. Machine learning algorithms were applied to explore which variables were most important in predicting the presence of OD in T2DM.Results: The prevalence of OD was significantly higher in Group 2 than in controls (71.4% vs 30%) and in Group 1 (71.4% vs 43.3%). However, when comparing the TDI scores between Group 1 and 2 the only significant difference was found for the discrimination scale and not for the identification and threshold scales. Brief-IT-QOD scores were significantly higher in Group 2 than in controls. The Random Forest and variable importance algorithms highlighted the relevance of LDL, glycated hemoglobin, type of complication (macrovascular) and age in determining OD in T2DM. The last three variables were included in a nomogram for the prediction of OD risk in T2DM.Conclusions: T2DM patients with diabetic complications are more frequently affected by OD. Poor glycemic control, LDL values, age and presence of macrovascular complications are the more important factors in determining OD in T2DM patients.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"537-547"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia. 美妥珠单抗治疗 CRSwNP/ECRS 和 NP：在日本、中国和俄罗斯进行的 MERIT III 期随机试验。

IF 4.8 2区医学

Rhinology Pub Date : 2024-10-01 DOI: 10.4193/Rhin24.156

S Fujieda, C Wang, M Yoshikawa, M Asako, I Suzaki, C Bachert, J K Han, A Fuller, L Baylis, L Su, E Sasaki, A R Sousa, R Chan, L Zhang

{"title":"Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia.","authors":"S Fujieda, C Wang, M Yoshikawa, M Asako, I Suzaki, C Bachert, J K Han, A Fuller, L Baylis, L Su, E Sasaki, A R Sousa, R Chan, L Zhang","doi":"10.4193/Rhin24.156","DOIUrl":"10.4193/Rhin24.156","url":null,"abstract":"Background: This randomised, double-blind, placebo-controlled, parallel-group, 52-week Phase III study (MERIT; NCT04607005) assessed mepolizumab efficacy and safety in patients with chronic rhinosinusitis with nasal polyps (CRSwNP)/eosinophilic CRS (ECRS) in Japan, Russia, and China, for which data are limited.Methodology: Eligible patients (enrolled at 60 centres) had blood eosinophil count >2%, endoscopic bilateral NP score ≥5, nasal obstruction visual analogue scale (VAS) score >5, ≥2 sinonasal symptoms, and either previous sinus surgery or systemic corticosteroid use/intolerance. Patients were randomised (1:1) to receive mepolizumab 100 mg subcutaneously or placebo every 4 weeks, plus standard of care. Co-primary endpoints: change from baseline in total endoscopic NP score (ENPS) (Week 52) and nasal obstruction VAS score (Weeks 49-52). Post hoc analyses conducted in a modified intent-to-treat (mITT) population excluded patients from two study sites, related to Good Clinical Practice violations by the Site Management Organisation overseeing these sites. These were considered the primary efficacy analyses.Results: In the mITT population, mepolizumab (n=80) versus placebo (n=83) significantly improved nasal obstruction VAS score from baseline to Week 49-52 and was associated with a trend of total ENPS improvements at Week 52. Mepolizumab/placebo on-treatment adverse events (AEs) occurred in 68/84 and 65/85 patients in the safety population (treatment-related AEs: 2/84 and 5/85, respectively), and on-treatment serious AEs in 0/84 and 4/85 patients, respectively (no fatalities reported).Conclusions: Mepolizumab was effective and well-tolerated in patients with CRSwNP/ECRS from Japan, Russia, and China.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"576-589"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and management of orbital apex syndrome: a 10-year multicentre experience. 眶顶综合征的临床特征和治疗：10 年多中心经验。

IF 4.8 2区医学

Rhinology Pub Date : 2024-10-01 DOI: 10.4193/Rhin23.454

Y H Im, Y J Kang, C-S Park, D M Kim, Y C Kim, J-S Kim, H Ra, S H Park, D-W Bae, H R Yum, Y W Chung, S H Hwang

{"title":"Clinical characteristics and management of orbital apex syndrome: a 10-year multicentre experience.","authors":"Y H Im, Y J Kang, C-S Park, D M Kim, Y C Kim, J-S Kim, H Ra, S H Park, D-W Bae, H R Yum, Y W Chung, S H Hwang","doi":"10.4193/Rhin23.454","DOIUrl":"10.4193/Rhin23.454","url":null,"abstract":"Background: Orbital apex syndrome (OAS) is a condition characterised by lesions within the orbital apex, leading to various ophthalmologic symptoms. This study aimed to analyse the clinical characteristics and treatment strategies of OAS with respect to aetiology.Methods: This retrospective analysis utilised data from 5 medical institutions between 2013 and 2022. Patients who were diagnosed with OAS were initially enrolled, but patients who failed to follow up at least 1 month were excluded. The prevalence of initial ophthalmologic symptoms and visual improvement after treatment was compared according to aetiology. Factors related to visual improvement were analysed.Results: Among 73 enrolled patients, the leading aetiology was tumours, followed by fungal infections and inflammation. Visual impairment and proptosis were prevalent in tumour-related OAS cases. Inflammation-related OAS exhibited a higher likelihood of painful eye movements and ophthalmoplegia. Ptosis was most frequently observed in fungal infection-related OAS. Notably, fungal infections emerged as the sole significant factor negatively impacting vision progression. In inflammation-related OAS, the time interval between symptom onset and the administration of steroids was longer in patients without visual improvement, even though there was no statistically significant difference.Conclusions: Tumours were the predominant cause of OAS. Visual impairment was a common manifestation in tumour-related OAS, while fungal infections were strongly associated with a poor visual prognosis. The timely administration of steroids might be helpful for improving vision in patients with inflammation-related OAS. However, further studies are needed to enhance understanding and management of OAS.","PeriodicalId":21361,"journal":{"name":"Rhinology","volume":" ","pages":"612-622"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical research and observations - they do matter. 临床研究和观察--它们的确很重要。

IF 4.8 2区医学

Rhinology Pub Date : 2024-10-01 DOI: 10.4193/Rhin24.905

B N Landis

引用次数: 0