推进全球气道疾病管理研究：来自事后分析的见解。

IF 4.8 2区医学 Q1 OTORHINOLARYNGOLOGY

Rhinology Pub Date : 2025-02-01 DOI:10.4193/Rhin25.901

S Toppila-Salmi

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引用次数: 0

摘要

慢性鼻窦炎伴鼻息肉（CRSwNP）、哮喘和非甾体抗炎药加重的呼吸系统疾病（N-ERD）经常共存，形成一种复杂的多病性疾病，通常被称为“全局性气道疾病”。这一概念反映了嗜酸性粒细胞炎症的共同病理生理机制，并强调了针对上、下气道表现的综合治疗策略的必要性(1)。严重的CRSwNP、哮喘和N-ERD的负担是巨大的，特别是在生活质量下降、复发性恶化、翻修内窥镜鼻窦手术（ESS）、(2).生物制剂在全球气道疾病治疗方面取得了重大进展。

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Advancing the research on management of global airway disease: insights from a post hoc analysis.

Chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and non-steroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) frequently coexist, forming a complex multimorbid condition often referred to as "global airway disease". This concept reflects shared pathophysiological mechanisms of eosinophilic inflammation and underscores the need for integrated treatment strategies targeting both upper and lower airway manifestations (1). The burden of severe CRSwNP, asthma, and N-ERD is substantial, particularly in terms of reduced quality of life, recurrent exacerbations, revision endoscopic sinus surgeries (ESS), and healthcare utilization (2). Biologics represent a significant advancement in the treatment of global airway diseases.

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来源期刊

Rhinology 医学-耳鼻喉科学

CiteScore

15.80

自引率

9.70%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Rhinology serves as the official Journal of the International Rhinologic Society and is recognized as one of the journals of the European Rhinologic Society. It offers a prominent platform for disseminating rhinologic research, reviews, position papers, task force reports, and guidelines to an international scientific audience. The journal also boasts the prestigious European Position Paper in Rhinosinusitis (EPOS), a highly influential publication first released in 2005 and subsequently updated in 2007, 2012, and most recently in 2020. Employing a double-blind peer review system, Rhinology welcomes original articles, review articles, and letters to the editor.